Incretin Biology - a Practical Guide

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Author :
Publisher : World Scientific
ISBN 13 : 1783267372
Total Pages : 201 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Incretin Biology - a Practical Guide by : G. U. Y. A. RUTTER

Download or read book Incretin Biology - a Practical Guide written by G. U. Y. A. RUTTER and published by World Scientific. This book was released on 2015-10-22 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed.Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs -- many based on incretin action -- have been added to the therapeutic armoury.Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice.Incretin Biology -- A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject.

The Entero-insular Axis

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Author :
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Entero-insular Axis by : Werner Creutzfeldt

Download or read book The Entero-insular Axis written by Werner Creutzfeldt and published by S. Karger AG (Switzerland). This book was released on 1980 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Topics In Osteoporosis

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Publisher : World Scientific
ISBN 13 : 9814480983
Total Pages : 562 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Current Topics In Osteoporosis by : Hong-wen Deng

Download or read book Current Topics In Osteoporosis written by Hong-wen Deng and published by World Scientific. This book was released on 2005-05-09 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews important topics in osteoporosis, with the emphasis on both clinical management and basic research of the disease. From the clinical perspective, topics covering pathogenesis, diagnosis, and treatment of osteoporosis are extensively elaborated. Several more chapters complement clinical overview of osteoporosis, that discuss the effects of nutrition and exercise to bone health, the application of biochemical markers in osteoporosis diagnosis, novel potential drug targets for osteoporosis treatment, and osteoporosis in males and in children. As the prevalence of osteoporosis now reaches epidemiological levels, epidemiology and social impacts of osteoporosis is also reviewed in the book. Basic research on osteoporosis is also highlighted in the book, with a number of chapters dedicated to the review of genetics of osteoporosis, animal models for osteoporosis, and statistical methods in osteoporosis study.

Mechanisms of Insulin Action

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Publisher : Springer Science & Business Media
ISBN 13 : 0387722041
Total Pages : 223 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel

Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Polycystic Ovary Syndrome

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Publisher : Springer Science & Business Media
ISBN 13 : 1597451088
Total Pages : 361 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Polycystic Ovary Syndrome by : Andrea Dunaif

Download or read book Polycystic Ovary Syndrome written by Andrea Dunaif and published by Springer Science & Business Media. This book was released on 2008-01-12 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

Essential Endocrinology and Diabetes

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118764137
Total Pages : 331 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Essential Endocrinology and Diabetes by : Richard I. G. Holt

Download or read book Essential Endocrinology and Diabetes written by Richard I. G. Holt and published by John Wiley & Sons. This book was released on 2021-03-04 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details. Essential Endocrinology and Diabetes provides the accurate and up-to-date knowledge required for treating all areas of endocrinology and diabetes, covering the latest research, clinical guidelines, investigational methods, and therapies. This classic text explains the vital aspects of endocrine physiology in a succinct and easy-to-use format, with full-colour illustrations, clinical images, and case studies to assist readers in applying theory to practice. The text covers the principles of endocrinology, clinical endocrinology, and clinical diabetes and obesity, and has been revised throughout to present the most recent developments in the field. The seventh edition includes new and updated material on the latest molecular techniques, approaches to clinical investigation and diagnostics, next generation sequencing technology, and positron emission tomography (PET). The treatment of type 1 diabetes and type 2 diabetes has been updated with clinical algorithms and reflects significant advances such as incretin-based therapies, SGLT2 inhibitors, the development of better insulins, and technologies that support self-management. Provides students and practitioners with comprehensive and authoritative information on all major aspects of endocrine physiology Covers diagnosis, management, and complications of clinical disorders such as endocrine neoplasia, and type 1 diabetes and type 2 diabetes Explains the core principle of feedback regulation, which is vital for the correct interpretation of many clinical tests Features case histories, learning objectives, ‘recap’ links to chapter content, cross-referencing guides, key information boxes, and chapter summaries Essential Endocrinology and Diabetes, Seventh Edition is the ideal textbook for medical and biomedical students, junior doctors, and clinicians looking to refresh their knowledge of endocrine science. For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This title is also available as an e-book. For more details, please see www.wiley.com/buy/9781118763964

Handbook of Biomolecules

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Author :
Publisher : Elsevier
ISBN 13 : 0323985300
Total Pages : 670 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Handbook of Biomolecules by : Chandrabhan Verma

Download or read book Handbook of Biomolecules written by Chandrabhan Verma and published by Elsevier. This book was released on 2023-05-23 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biomolecules: Fundamentals, Properties and Applications is a comprehensive resource covering new developments in biomolecules and biomaterials and their industrial applications in the fields of bioengineering, biomedical engineering, biotechnology, biochemistry, and their detection methods using biosensors. This book covers the fundamentals of biomolecules, their roll in living organism, structure, sources, important characteristics, and the industrial applications of these biomaterials. Sections explore amino acids, carbohydrates, nucleic acids, proteins, lipids, metabolites and natural products, then go on to discuss purification techniques and detection methods. Applications in biomolecular engineering, biochemistry and biomedical engineering, among others, are discussed before concluding with coverage of biomolecules as anticorrosion materials. Provides the chronological advancement of biomolecules, their biochemical reaction, and many modern industrial applications in engineering and science Serves as a valuable source for researchers interested in the fundamentals, basics and modern applications of biomolecules Covers both synthetic and natural biomolecule synthesis and purification processes and their modern applications Bridges the gap between the fundamental science of biomolecular chemistry and the relevant technology and industrial applications

Practical Clinical Ultrasonic Diagnosis

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Author :
Publisher : World Scientific
ISBN 13 : 9814497932
Total Pages : 487 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Practical Clinical Ultrasonic Diagnosis by : Liwu Lin

Download or read book Practical Clinical Ultrasonic Diagnosis written by Liwu Lin and published by World Scientific. This book was released on 1997-08-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written by several authors based on their wide experience and on materials painstakingly accumulated through many years of practice. The result is a comprehensive volume which deals with detailed aspects of clinical ultrasonic diagnosis.The scope of this book covers the clinical ultrasonic diagnosis of diseases of the liver, biliary system, pancreas, spleen, gastrointestinal tract, kidney, urethra, bladder, adrenal gland, prostate gland, scrotum, heart, chest and even the use of clinical ultrasonic diagnosis in the department of obstetrics and gynecology. This book has three special features. Firstly, the anatomic and pathological changes caused by common diseases of these organs and their corresponding ultrasonograms are described in detail. Secondly, the diseases of organs such as the heart, abdomen, chest as well as in the department of obstetrics and gynecology, are described in a concise and systematic manner for easy reading. Finally, this book includes over 400 illustrations of the typical images of different kinds of diseases, accompanied by their corresponding line drawings.This book is therefore invaluable to specialists, clinical doctors and to trainees using ultrasonic diagnosis.

Diabetes in America

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Author :
Publisher :
ISBN 13 :
Total Pages : 804 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Diabetes in America by :

Download or read book Diabetes in America written by and published by . This book was released on 1995 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Practical Guide to Diabetes Mellitus

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Author :
Publisher : JAYPEE BROTHERS PUBLISHERS
ISBN 13 : 9350905973
Total Pages : 467 pages
Book Rating : 4.3/5 (59 download)

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Book Synopsis A Practical Guide to Diabetes Mellitus by : Nihal Thomas

Download or read book A Practical Guide to Diabetes Mellitus written by Nihal Thomas and published by JAYPEE BROTHERS PUBLISHERS. This book was released on 2012-12-15 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Edition of A Practical Guide to Diabetes Mellitus offers a unique combination of rigorous pathophysiology with very practical approaches to diabetes prevention and control. This outstanding textbook will equip a cadre of doctors and other health care professionals to deliver high quality care to vulnerable populations around India and far beyond. Based on research as well as clinical practice, the text describes diabetes in relation to physiology, ocular, cardiovascular, neuropathy, pregnancy, emergencies, childhood diabetes, etc. Each chapter beings with a brief outline of the disease concerned followed by introduction, definition/terminology, classification, treatment, conclusion and ending with set of question for self-assessment. Covers step wise images describes insulin administration in subcutaneous and using pen devices in the chapter: Insulin therapy: practical aspects. Feet, Footcare and Neuroarthropathy chapter deals with etiology and pathophysiology and is divided into three parts: Ulceration, Neuroarthropathy and Peripheral Artery Occlusive(PAD) diseases. Infection in diabetes chapter focuses on infection related to head and neck, genitourinary, skin and soft tissue, pulmonology and abdominal. Recent advances includes application of new drugs like Taspoglutide, Albiglutide, Lixisenatide, Newer DPP-IV inhibitors, along with new insulin receptor activators, PPAR agonists, new hepatic targets for glycemic control in diabetes. This book contains more than 300 coloured images and illustrations, 40 clinical cases, 50 questions for quick revision along with answers to the self-assessments question given at the end of book."

Principles of Diabetes Mellitus

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9781402071140
Total Pages : 788 pages
Book Rating : 4.0/5 (711 download)

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Book Synopsis Principles of Diabetes Mellitus by : Leonid Poretsky

Download or read book Principles of Diabetes Mellitus written by Leonid Poretsky and published by Springer Science & Business Media. This book was released on 2002 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.

Pediatric Endocrinology

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Publisher :
ISBN 13 :
Total Pages : 826 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pediatric Endocrinology by : M. Sperling

Download or read book Pediatric Endocrinology written by M. Sperling and published by . This book was released on 2002 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: This New Edition is today's most comprehensive, definitive reference in the field, incorporating all of today's explosive discoveries in basic and clinical endocrinology. Its reliable, cutting-edge guidance for a full range of problems is combined with a wealth of information on the physiological, biochemical, and genetic basis at the molecular biological level. Dr. Mark A. Sperling and 33 contributing experts bring readers the benefits of discovery at the bench and its application at the bedside. New chapters, extensive revisions, and compelling updates will keep readers at the forefront of the diagnosis and management of endocrine disease in children. Incorporates the explosive growth in molecular biology as it relates to developmental and pediatric endocrinology. Extensively revised and updated chapters throughout reflect the latest information. Coverage of up-to-the-minute topics in the field, including molecular, biochemical, and clinical basis of hyperinsulinemic hypoglycemia of infancy and childhood diabetes mellitus energy balance/obesity growth hormone paradigms of mechanisms of hormone action, and others Contributions from new authors from distinguished institutions Numerous brand-new illustrations depict the most current information, particularly the basic science/genetic basis of certain entities

Handbook of Drug-Nutrient Interactions

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Publisher : Springer Science & Business Media
ISBN 13 : 160327362X
Total Pages : 823 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Handbook of Drug-Nutrient Interactions by : Joseph I. Boullata

Download or read book Handbook of Drug-Nutrient Interactions written by Joseph I. Boullata and published by Springer Science & Business Media. This book was released on 2010-03-17 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

Physiology and Pathophysiology of Temperature Regulation

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Author :
Publisher : World Scientific
ISBN 13 : 9789810231729
Total Pages : 316 pages
Book Rating : 4.2/5 (317 download)

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Book Synopsis Physiology and Pathophysiology of Temperature Regulation by : Clark M. Blatteis

Download or read book Physiology and Pathophysiology of Temperature Regulation written by Clark M. Blatteis and published by World Scientific. This book was released on 1998 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a user-friendly monograph designed for medical students as well as graduate students and postdoctoral trainees in medicine and other health-related sciences who need a comprehensive overview of thermoregulation. It presents the bases of the modern concepts in thermal physiology and pathophysiology, bringing together the disciplines encompassed by this highly integrative field ? physiology, anatomy, biophysics, molecular and cellular biology, pharmacology, neuroscience, pathology, medicine, and others ? into a clear and concise form that can be read comfortably in a relatively short time. This text was conceived by the Commission on Thermal Physiology of the International Union of Physiological Sciences in response to its concern over the inadequate and outdated coverage of this topic in traditional textbooks. The membership of this Commission comprises international experts in each of the subfields of thermal physiology, with extensive research and teaching experience in their respective specialties. They are the authors of the chapters of this indispendable textbook.

The Diabetes Textbook

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Author :
Publisher : Springer
ISBN 13 : 3030118150
Total Pages : 1040 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The Diabetes Textbook by : Joel Rodriguez-Saldana

Download or read book The Diabetes Textbook written by Joel Rodriguez-Saldana and published by Springer. This book was released on 2019-06-27 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.

Basic Skills in Interpreting Laboratory Data

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Author :
Publisher : ASHP
ISBN 13 : 1585283452
Total Pages : 1248 pages
Book Rating : 4.5/5 (852 download)

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Book Synopsis Basic Skills in Interpreting Laboratory Data by : Mary Lee

Download or read book Basic Skills in Interpreting Laboratory Data written by Mary Lee and published by ASHP. This book was released on 2013-06-01 with total page 1248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Skills in Interpreting Laboratory Data, Fifth Edition, is the classic and most popular pharmacy laboratory text because it is the only reference on this subject written by pharmacists, for pharmacists. Students find this guide a clear and useful introduction to the fundamentals of interpreting laboratory test results. The book enhances the skills pharmacists need by providing essential information on common laboratory tests used to screen for or diagnose diseases and monitor the effectiveness and safety of treatment and disease severity. Each chapter contains learning objectives, case studies, bibliographies, and charts that summarize the causes of high and low test results. New for this edition: Updated and expanded Quick View tables in each chapter now match those in the popular quick-reference, Interpreting Laboratory Data: A Point-of-Care Guide New glossary of acronyms is right up front for a streamlined reference Normal value ranges of all tests have been standardized by an expert pathologist New and updated cases in each chapter apply your Basic Skills in clinical situations Reorganized to highlight the application of concepts by body system, and in special populations Basic Skills in Interpreting Laboratory Data offers features that will help pharmacy students not only understand and engage with the material but also will streamline the transition from classroom to practice setting. After studying with this trusted text, students and pharmacists will more effectively monitor patient therapy, evaluate test results, and improve outcomes through optimal and focused pharmacotherapy.

Hepatocellular Carcinoma

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Author :
Publisher : World Scientific
ISBN 13 : 9812770054
Total Pages : 864 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Hepatocellular Carcinoma by : W. Y. Lau

Download or read book Hepatocellular Carcinoma written by W. Y. Lau and published by World Scientific. This book was released on 2008-01-01 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Epidemiology / Trishe Y.-M. Leong and Anthony S.-Y. Leong -- 2. Liver terminology and anatomy / Steven M. Strasberg -- 3. Assessment of liver function / Darren V. Mann -- 4. Prevention / Michael C. Kew -- 5. Screening / Morris Sherman -- 6. Presentation and diagnosis / Dario Ribero, Gareth Morris-Stiff and Jean-Nicolas Vauthey -- 7. Tumor markers / John Y. H. Chan and Zhi Wang -- 8. Imaging / Simon S. M. Ho and Simon C. H. Yu -- 9. Pathology / Anthony S.-Y. Leong, Trishe Y.-M. Leong and Pongsak Wannakrairot -- 10. Molecular aspects / John Y. H. Chan, Kenneth K. H. Lee, Yiu-Loon Chui and Macus T. Kuo -- 11. Staging / Justin M. Burns and Frederick L. Greene -- 12. Selection of patients for liver resection / Eric C. H. Lai, W. Y. Lau and Darren V. Mann -- 13. Problems associated with liver resection in cirrhotic patients / Cheng-Chung Wu -- 14. Preoperative portal vein embolization / Takuya Hashimoto and Masatoshi Makuuchi -- 15. Intraoperative ultrasound / Guido Torzilli and Henri Bismuth -- 16. Surgical treatment / Jacques Belghiti -- 17. Anterior approach using the hanging technique / Jacques Belghiti and Barbara Alkofer -- 18. Segment-based liver resection / W. Y. Lau and Eric C. H. Lai -- 19. Intrahepatic glissonian approach / Bernard Launois and Khoon Hean Tay -- 20. Ultrasonically guided segmentectomy and subsegmentectomy / Taku Aoki, Norihiro Kokudo and Masatoshi Makuuchi -- 21. Isolated caudate lobe resection (resection of couinaud segment 1) / Shu-You Peng -- 22. Laparoscopic Liver Resection / Rong Liu -- 23. Techniques of vascular control and protective strategies for parenchymal transection / Markus K. Müller, Henrik Petrowsky and Pierre-Alain Clavien -- 24. Techniques of liver transection / Eric T. Castaldo and C. Wright Pinson -- 25. Radiofrequency-assisted liver resection / Long R. Jiao and Nagy A. Habib -- 26. Cytoreductive (tumor-debulking) surgery / Eric C. H. Lai and W. Y. Lau -- 27. Cryosurgery / George Petrou and David L. Morris -- 28. Liver transplantation / Chao-Long Chen and Allan M. Concejero / 29. Local ablative therapy / Tito Livraghi -- 30. Regional therapy / W. Y. Lau and Eric C. H. Lai -- 31. Systemic chemotherapy / Thomas W. T. Leung -- 32. Neoadjuvant/adjuvant/chemoprevention therapy and tumor downstaging / W. Y. Lau and Eric C. H. Lai -- 33. Management of portal vein tumor thrombus / W. Y. Lau, Eric C. H. Lai and Simon C. H. Yu -- 34. Palliative care / Winnie Yeo and Anthony T. C. Chan -- 35. Management of specific complications / Eric C. H. Lai and W. Y. Lau -- 36. Management of acute liver failure / A. R. Nitin Rao -- 37. Extracorporeal energy therapy / Eric C. H. Lai and W. Y. Lau