Immunological Engineering

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Immunological Engineering

Author : D.W. Jirsch
Publisher : Springer Science & Business Media
ISBN 13 : 9401161828
Total Pages : 363 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Immunological Engineering by : D.W. Jirsch

Download or read book Immunological Engineering written by D.W. Jirsch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology has become one of the most important of the life sciences. As research unravels the mystery of the lymphocyte, a central role of the immune system in health preservation has become evident. The paediatric immunodeficiency disorders or 'experiments of nature' have demonstrated the division of cellular and humoral immunity; specific functional defects are now readily identified. The tendency of persons with immune dysfunction to develop neoplasms has suggested that surveillance mechanisms within the immune apparatus prevent tumour development. Malignancies, in fact, do seem to provoke certain immune responses, begging numerous therapeutic questions. Transplantation surgery, or the demand for 'new parts' has led to description of those antigens important in tissue-typing. Genetic loci have been found responsible for transplantation antigen display; as well, they influence clinical resistance or susceptibility to a wide variety of infections, auto-immune or neoplastic diseases. Clinicians have been quick to recognize the therapeutic implications of laboratory work and to use this knowledge in disease treatment. Precise patient-tissue matching and immunosuppressive treatment make renal allo transplantation safer and more successful than ever before. Both paediatric and adult immune deficiency states are now often recognized; treatment may involve general immune support or specific manipulations with, perhaps, bone marrow or thymus grafts or treatment with lymphocyte transfer factor. Transplantation of bone marrow has been used not only to correct certain immune defects but to correct marrow failure of diverse origin.

Immunology for Engineers

Author :
Publisher : Elsevier
ISBN 13 : 0443193517
Total Pages : 580 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Immunology for Engineers by :

Download or read book Immunology for Engineers written by and published by Elsevier. This book was released on 2024-05-17 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology for Engineers, Volume 140 consists of chapters from stalwarts of the field, covering topics such as antibody engineering, adjuvant requirement and its methodology for assessment, and the need to develop immunotherapy, etc. Chapters covered in this volume discuss Current Status and Future Prospective of Breast Cancer Immunotherapy, Engineering high affinity antigen binders- beyond antibodies, Platelets and Inter-Cellular Communication in Immune Responses: Dialogue with both Professional and Non-Professional Immune Cells, Chimeric Antigen Receptor (CAR) T cell-based cancer immunotherapy: A boon for cancer-free life, and Molecular insights and promise of Oncolytic Virus based Immunotherapy. - Presents the latest in immunological engineering - Delves into timely topics such as antibody engineering - Covers vaccine engineering amongst many other important topics

Handbook of Immunological Properties of Engineered Nanomaterials

Author : Marina Dobrovolskaia
Publisher : World Scientific
ISBN 13 : 9814390259
Total Pages : 721 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Handbook of Immunological Properties of Engineered Nanomaterials by : Marina Dobrovolskaia

Download or read book Handbook of Immunological Properties of Engineered Nanomaterials written by Marina Dobrovolskaia and published by World Scientific. This book was released on 2013 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Introduction to Antibody Engineering

Author : Florian Rüker
Publisher : Springer Nature
ISBN 13 : 3030546306
Total Pages : 388 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Introduction to Antibody Engineering by : Florian Rüker

Download or read book Introduction to Antibody Engineering written by Florian Rüker and published by Springer Nature. This book was released on 2021-01-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.

Immunomodulatory Biomaterials

Author : Stephen F. Badylak
Publisher : Woodhead Publishing
ISBN 13 : 0128214562
Total Pages : 296 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Immunomodulatory Biomaterials by : Stephen F. Badylak

Download or read book Immunomodulatory Biomaterials written by Stephen F. Badylak and published by Woodhead Publishing. This book was released on 2021-07-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. - Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response - Provides a single reference for understanding and utilizing the host response in biomaterials design - An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Antibody Engineering

Author : Damien Nevoltris
Publisher : Humana
ISBN 13 : 9781493993536
Total Pages : 543 pages
Book Rating : 4.9/5 (935 download)

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Book Synopsis Antibody Engineering by : Damien Nevoltris

Download or read book Antibody Engineering written by Damien Nevoltris and published by Humana. This book was released on 2019-12-10 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Antibody Engineering: Methods and Protocols, Third Edition presents the reader with an extensive toolbox to create the powerful molecules of tomorrow.

Handbook Of Immunological Properties Of Engineered Nanomaterials (Second Edition) (In 3 Volumes)

Author : Marina A Dobrovolskaia
Publisher : World Scientific
ISBN 13 : 9814699187
Total Pages : 1184 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Handbook Of Immunological Properties Of Engineered Nanomaterials (Second Edition) (In 3 Volumes) by : Marina A Dobrovolskaia

Download or read book Handbook Of Immunological Properties Of Engineered Nanomaterials (Second Edition) (In 3 Volumes) written by Marina A Dobrovolskaia and published by World Scientific. This book was released on 2016-01-28 with total page 1184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called 'corona' around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Library of Congress Subject Headings

Author : Library of Congress. Cataloging Policy and Support Office
Publisher :
ISBN 13 :
Total Pages : 1512 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress. Cataloging Policy and Support Office

Download or read book Library of Congress Subject Headings written by Library of Congress. Cataloging Policy and Support Office and published by . This book was released on 2007 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Library of Congress Subject Headings

Author : Library of Congress
Publisher :
ISBN 13 :
Total Pages : 1174 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress

Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 1998 with total page 1174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Engineered immune cells in cancer immunotherapy (EICCI)

Author : Cristina Maccalli
Publisher : Frontiers Media SA
ISBN 13 : 2832515606
Total Pages : 659 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Engineered immune cells in cancer immunotherapy (EICCI) by : Cristina Maccalli

Download or read book Engineered immune cells in cancer immunotherapy (EICCI) written by Cristina Maccalli and published by Frontiers Media SA. This book was released on 2023-02-28 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Engineered Biomaterials

Author : Rishabha Malviya
Publisher : Springer Nature
ISBN 13 : 9819966981
Total Pages : 623 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Engineered Biomaterials by : Rishabha Malviya

Download or read book Engineered Biomaterials written by Rishabha Malviya and published by Springer Nature. This book was released on 2023-12-28 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent advances focusing on the synthesis methods of engineered biomaterials and their applications. The book discusses recent applications of various approaches and technology in improving the functional properties and biological activities of biopolymers. It includes two major sections: the first section introduces a range of methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of the techniques. The second section covers recent trends and advances in application of engineered biomaterials that assist materials scientists and researchers in mapping out the future of these new improved materials through value addition in order to enhance their use. Contributions in the book are done by prominent researchers from industry, academia, and government/private research laboratories across the globe. The book summarizes in a fairly comprehensive manner many of the recent technical advancements in the area of biopolymers. The book is intended to serve as a reference resource in the area of polymers science.

Supramolecular Structure and Function

Author : Greta Pifat-Mrzljak
Publisher : Springer Science & Business Media
ISBN 13 : 3642709052
Total Pages : 197 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Supramolecular Structure and Function by : Greta Pifat-Mrzljak

Download or read book Supramolecular Structure and Function written by Greta Pifat-Mrzljak and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade we have witnessed not only an increase in knowledge of the "traditional" biophysical problems, but also an understanding of the molecular basis of various biological phenomena. The principles and methods of biophysics now provide an underpin ning of all of the basic biosciences and are the rational language for discussion between scientists of different disciplines. The International School on Biophysics Supramolecular Structure and Function held in Dubrovnik in September 1984 had as its goal to provide comprehensive discussions on a large number of subjects both for younger scientists at the doctoral or postdoctoral level interested in the molecular nature of fundamental biological entities, and for experienced scientists wishing to gain a broader insight into molecular structures and functions. The topics discussed at the School were inter- and intramolecular interactions in biological systems, and the structure, organization, and function of biological macromolecules and supramolecular assemblies. A number of topics were centered around either a biological problem or a physical technique, sometimes giving an unbalanced view of the field under discussion. Some of the topics required previous knowledge of basic biophysical principles, which were then applied to gain greater insight into the molecular functions of diverse supramolecular systems. Although not all the lectures could be prepared for publication in this volume, I hope that it contains valuable up-to-date information on various aspects of the molecular basis of life.

Investigating and harnessing T-cell functions with engineered immune receptors and their ligands

Author : Bruno Laugel
Publisher : Frontiers Media SA
ISBN 13 : 2889194132
Total Pages : 192 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Investigating and harnessing T-cell functions with engineered immune receptors and their ligands by : Bruno Laugel

Download or read book Investigating and harnessing T-cell functions with engineered immune receptors and their ligands written by Bruno Laugel and published by Frontiers Media SA. This book was released on 2015-01-22 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topic aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies.

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309487501
Total Pages : 125 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.

Antibody Engineering Volume 1

Author : Roland E. Kontermann
Publisher : Springer Science & Business Media
ISBN 13 : 3642011446
Total Pages : 770 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Antibody Engineering Volume 1 by : Roland E. Kontermann

Download or read book Antibody Engineering Volume 1 written by Roland E. Kontermann and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Structural Biology in Immunology

Author : Chaim Putterman
Publisher : Academic Press
ISBN 13 : 0128033703
Total Pages : 192 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Structural Biology in Immunology by : Chaim Putterman

Download or read book Structural Biology in Immunology written by Chaim Putterman and published by Academic Press. This book was released on 2018-05-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. - Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules - Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship - Features a collaborative editorial effort, involving clinical immunologists and structural biologists - Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology - Gives interested parties a bridge to learn about computer modeling and structure based design principles

Induction of immune tolerance: Addressing unmet medical need in immune mediated diseases and immune responses to biologics

Author : Amy Rosenberg
Publisher : Frontiers Media SA
ISBN 13 : 283253421X
Total Pages : 190 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Induction of immune tolerance: Addressing unmet medical need in immune mediated diseases and immune responses to biologics by : Amy Rosenberg

Download or read book Induction of immune tolerance: Addressing unmet medical need in immune mediated diseases and immune responses to biologics written by Amy Rosenberg and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: