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Author : Christof Geldmacher
Publisher : Frontiers Media SA
ISBN 13 : 2889741869
Total Pages : 370 pages
Book Rating : 4.8/5 (897 download)
Download or read book Immunological Biomarkers for Tuberculosis written by Christof Geldmacher and published by Frontiers Media SA. This book was released on 2022-01-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Juraj Ivanyi
Publisher : Frontiers Media SA
ISBN 13 : 2889194515
Total Pages : 120 pages
Book Rating : 4.8/5 (891 download)
Download or read book Significance of antigen and epitope specificity in tuberculosis written by Juraj Ivanyi and published by Frontiers Media SA. This book was released on 2014-12-04 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis.
Author : Basel Karo
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Tuberculosis/HIV Co-infection in Low-incidence Settings: Insight Into Immunological Biomarkers for Tuberculosis Preventive Therapy written by Basel Karo and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Julie G. Burel
Publisher : Frontiers Media SA
ISBN 13 : 2889744051
Total Pages : 169 pages
Book Rating : 4.8/5 (897 download)
Download or read book Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans written by Julie G. Burel and published by Frontiers Media SA. This book was released on 2022-02-16 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Biomarkers for TB Treatment Response and Cure written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rogelio Hernandez Pando
Publisher : Frontiers Media SA
ISBN 13 : 2889669017
Total Pages : 181 pages
Book Rating : 4.8/5 (896 download)
Download or read book Advances in Immunotherapeutic Approaches to Tuberculosis written by Rogelio Hernandez Pando and published by Frontiers Media SA. This book was released on 2021-07-02 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author : WHO
Publisher : World Health Organization
ISBN 13 : 9241548908
Total Pages : 38 pages
Book Rating : 4.2/5 (415 download)
Download or read book Guidelines on the Management of Latent Tuberculosis Infection written by WHO and published by World Health Organization. This book was released on 2015-01-15 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Latent tuberculosis infection (LTBI), defined as a state of persistent immune response to prior-acquired Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB, affects about one-third of the world's population. Approximately 10% of people with LTBI will develop active TB disease in their lifetime, with the majority developing it within the first five years after initial infection. Currently available treatments have an efficacy ranging from 60% to 90%. Systematic testing and treatment of LTBI in at-risk populations is a critical component of WHO's eight-point framework adapted from the End TB Strategy to target pre-elimination and, ultimately, elimination in low incidence countries. OVERVIEW: Recognizing the importance of expanding the response to LTBI, in 2014 WHO developed Guidelines on the Management of Latent Tuberculosis Infection. The guidelines are primarily targeted at high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100 000 population, because they are most likely to benefit from it due to their current TB epidemiology and resource availability. The overall objective of the guidelines is to provide public health approach guidance on evidence-based practices for testing, treating and managing LTBI in individuals with the highest risk of progression to active disease. Specific objectives include identifying and prioritizing at-risk population groups for targeted intervention of LTBI testing and treatment, including defining an algorithm, and recommending specific treatment options. The guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management based on available resources, epidemiology of TB including intensity of transmission, the health-care delivery system of the country, and other national and local determinants.
Author : Gillian Lee Beamer
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.:/5 (63 download)
Download or read book Immunologic Mechanisms and Predictors of Susceptibility to Mycobacterium Tuberculosis written by Gillian Lee Beamer and published by . This book was released on 2009 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to low IFN-[gamma] and low CCL5, elevated levels of IL-10 in the lungs predicted reactivation TB approximately 4-8 weeks prior to disease onset in M.tb susceptible mice. Furthermore, IL-10 was shown to be a single cause of reactivation TB, as disease progression was delayed and protective immunity was enhanced by IL-10 blockade in vivo. Overall, these results indicate that single immune mediators may be used as biomarkers of TB disease progression in humans, and furthermore, that appropriately timed immunotherapeutic intervention may prevent the transition from controlled M.tb infection to active TB disease.
Author : Vishwanath Venketaraman
Publisher : Springer
ISBN 13 : 3319973673
Total Pages : 149 pages
Book Rating : 4.3/5 (199 download)
Download or read book Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection written by Vishwanath Venketaraman and published by Springer. This book was released on 2018-09-26 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, approximately one third of the world’s population is latently infected with Mycobacterium tuberculosis (M. tb [LTBI]), of whom about 9 million have active tuberculosis (TB). It is estimated that approximately 2 million individuals die each year from active TB. An estimated 14.4% of these individuals have HIV and M. tb co-infection. TB has long been known to be one of the leading causes of death in HIV-infected individuals. Recent evidence now indicates that individuals with type 2 diabetes, the elderly, and chronic smokers are also increasingly susceptible to TB infection, the ability of their immune system to fight off active TB infection having been compromised by their condition. This book therefore aims to provide a detailed review of recent advances in the research that involves characterizing the host’s immune responses against TB infection in conditions such as HIV, diabetes, chronic cigarette smoking and aging, and strategies to restore favorable immune responses against this deadly pathogen.
Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128226110
Total Pages : 284 pages
Book Rating : 4.1/5 (282 download)
Download or read book Nanotechnology Based Approaches for Tuberculosis Treatment written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-06-10 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers
Download or read book Computational and Empirical Studies Predict Mycobacterium Tuberculosis-specific T Cells as a Biomarker for Infection Outcome written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Identifying biomarkers for tuberculosis (TB) is an ongoing challenge in developing immunological correlates of infection outcome and protection. Biomarker discovery is also necessary for aiding design and testing of new treatments and vaccines. To effectively predict biomarkers for infection progression in any disease, including TB, large amounts of experimental data are required to reach statistical power and make accurate predictions. We took a two-pronged approach using both experimental and computational modeling to address this problem. We first collected 200 blood samples over a 2-year period from 28 non-human primates (NHP) infected with a low dose of Mycobacterium tuberculosis. We identified T cells and the cytokines that they were producing (single and multiple) from each sample along with monkey status and infection progression data. Machine learning techniques were used to interrogate the experimental NHP datasets without identifying any potential TB biomarker. In parallel, we used our extensive novel NHP datasets to build and calibrate a multi-organ computational model that combines what is occurring at the site of infection (e.g., lung) at a single granuloma scale with blood level readouts that can be tracked in monkeys and humans. We then generated a large in silico repository of in silico granulomas coupled to lymph node and blood dynamics and developed an in silico tool to scale granuloma level results to a full host scale to identify what best predicts Mycobacterium tuberculosis (Mtb) infection outcomes. The analysis of in silico blood measures identifies Mtb-specific frequencies of effector T cell phenotypes at various time points post infection as promising indicators of infection outcome. As a result, we emphasize that pairing wetlab and computational approaches holds great promise to accelerate TB biomarker discovery.
Author : National Collaborating Centre for Chronic Conditions (Great Britain)
Publisher : Royal College of Physicians
ISBN 13 : 9781860162770
Total Pages : 232 pages
Book Rating : 4.1/5 (627 download)
Download or read book Tuberculosis written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by Royal College of Physicians. This book was released on 2006 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tuberculosis Programs written by and published by . This book was released on with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vaishnavi Satish Kaipilyawar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Download or read book Development of Biomarkers and Investigation of Host Immune Responses in Tuberculosis written by Vaishnavi Satish Kaipilyawar and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : World Health Organization
Publisher :
ISBN 13 : 9789241565394
Total Pages : 0 pages
Book Rating : 4.5/5 (653 download)
Download or read book Global Tuberculosis Report 2016 written by World Health Organization and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This global tuberculosis report is the first to be produced in the era of the SDGs and the End TB Strategy. It provides an assessment of the TB epidemic and progress in TB diagnosis, treatment, and prevention efforts as well as an overview of TB-specific financing and research. It also discusses the broader agenda of universal health coverage, social protection, and other SDGs that have an impact on health. Data was available for 202 countries and territories that account for over 99% of the world's population and TB cases.
Author : Joel Fleury Djoba Siawaya
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (313 download)
Download or read book Immune Parameters as Biomarkers of Mycobacterium Tuberculosis Sterilization During Anti-tuberculosis Treatment written by Joel Fleury Djoba Siawaya and published by . This book was released on 2008 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
