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Immunobiology Of Organ Transplantation
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Book Synopsis Immunobiology of Organ Transplantation by : David S. Wilkes
Download or read book Immunobiology of Organ Transplantation written by David S. Wilkes and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.
Book Synopsis Transplant Immunology by : Xian C. Li
Download or read book Transplant Immunology written by Xian C. Li and published by John Wiley & Sons. This book was released on 2015-11-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.
Book Synopsis Transplantation Immunology by : Andrea A. Zachary
Download or read book Transplantation Immunology written by Andrea A. Zachary and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.
Book Synopsis Transplantation Immunology by : Philip Hornick
Download or read book Transplantation Immunology written by Philip Hornick and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.
Book Synopsis A History of Transplantation Immunology by : Leslie Brent
Download or read book A History of Transplantation Immunology written by Leslie Brent and published by Academic Press. This book was released on 1996-11-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen
Book Synopsis Transplantation Immunology by : Fritz H. Bach
Download or read book Transplantation Immunology written by Fritz H. Bach and published by Wiley-Liss. This book was released on 1995-08-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided into four sections: Major and Minor Histocompatibility Antigens, Immunobiology of Graft Rejection, Clinical Transplantation, and Frontiers in Transplantation. The first two sections cover present-day understanding of the genetic controls of immunity as well as the two basic concerns of transplantation immunology, namely donor tissue antigens and the host cellular response. The third section deals with clinical aspects of transplantation, while the fourth looks toward future efforts of scientific research in this field—including advances in tolerance and xenotransplantation. A detailed appendix entitled "Molecular Biology for the Clinician" is included to help make the material accessible to readers of all backgrounds. Authored by a wide range of experts in both clinical and research fields, individual chapters cover such topics as: T cell immunity Antigen presentation Alloreactivity Pancreas and islet cell transplantation Allogeneic bone marrow transplantation Models of tolerance induction Xenotransplantation The swine leukocyte antigen (SLA) complex Transplantation Immunology is an ideal teaching text for the fundamental concepts, latest findings, and future directions in this increasingly important field. This volume will appeal to a wide range of clinicians including surgeons and primary-care physicians, as well as scientists in molecular biology and immunology.
Book Synopsis Transplantation Immunology by : Roy Yorke Calne
Download or read book Transplantation Immunology written by Roy Yorke Calne and published by . This book was released on 1984 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a team of clinicians and immunologists who have pioneered many renowned transplantation procedures, this in-depth study explores clinical and experimental aspects of transplantation and details the immensely complex immunological processes involved. The scope of this work reflects the knowledge and experience the contributors bring to their discussion of organ preservation, advances in tissue-typing, rejection of implanted tissue, patient survival, and immunosuppression with drugs such as cyclosporin B.
Book Synopsis Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations by : Giorgio Raimondi
Download or read book Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations written by Giorgio Raimondi and published by Frontiers Media SA. This book was released on 2017-12-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
Book Synopsis Abdominal Solid Organ Transplantation by : Antonio Daniele Pinna
Download or read book Abdominal Solid Organ Transplantation written by Antonio Daniele Pinna and published by Springer. This book was released on 2015-08-20 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and innovative guide to abdominal solid organ transplantation (SOT). It explains the main immunological problems involved in abdominal SOT, reviews indications for liver, kidney, and small bowel transplantation, and provides detailed descriptions of techniques for procurement and transplantation. In addition, technical, infectious, and immunological complications and their treatment are fully described. Special attention is devoted to the indications for and outcomes of combined kidney-liver and kidney-pancreas transplantation. Clear advice is provided on donor selection and donor safety, and the book concludes by examining medical disease and the risk of solid and hematologic malignancies after transplantation. Abdominal SOT has become the treatment of choice for various end-stage chronic diseases of the liver, kidney, and foregut. Improved knowledge of immunology, the introduction of new immunosuppressive agents, and advances in surgical techniques have all increased the number of potential candidates and led to better outcomes. It is therefore unsurprising that more and more surgeons, physicians, and scientists, as well as students and nurses, are becoming interested in abdominal SOT. This book will provide all practitioners with an excellent, up-to-date summary of knowledge in the field.
Book Synopsis Current and Future Immunosuppressive Therapies Following Transplantation by : Giuseppe Remuzzi
Download or read book Current and Future Immunosuppressive Therapies Following Transplantation written by Giuseppe Remuzzi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.
Book Synopsis Transplantation Immunology: Methods and Protocols by : Kayla Streep
Download or read book Transplantation Immunology: Methods and Protocols written by Kayla Streep and published by . This book was released on 2020-09-22 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation refers to the process of moving cells, tissues or organs from one part of the body to another, whether within the same person, or between a donor and a recipient. It is usually a life-saving intervention and is a major operation. However, the transplanted tissue or organ may be rejected by the immune system. Rejection is an adaptive immune response of the body that can occur due to the mechanisms of cellular immunity or humoral immunity. Different transplanted tissues favor different rejection mechanisms. Acute rejection occurs in all transplants unless immunosuppression has been achieved. An exception to this is transplantation between identical twins. Hyperacute rejection response sets in within minutes after a transplant, which if unattended may trigger a systemic inflammatory response syndrome. Rapid clumping, particularly the agglutination of red blood cells, is a common risk in kidney transplants. Chronic rejection can arise when there is a long-term loss of function in the transplanted organ. This loss in function arises due to fibrosis of the blood vessels of the transplanted tissues. This is responsible for the long-term morbidity witnessed in lung-transplant recipients. Transplant rejection can be lowered by using immunosuppressant drugs after transplantation and by prior determination of the molecular similitude between donor and recipient. This book provides comprehensive insights into the field of transplantation immunology. It presents researches and studies performed by experts across the globe on the methods and protocols of transplantation. It is a vital tool for all researching and studying this field.
Book Synopsis Primer on Transplantation by : American Society of Transplantation
Download or read book Primer on Transplantation written by American Society of Transplantation and published by John Wiley & Sons. This book was released on 2011-03-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online
Book Synopsis Rejection and Tolerance by : J.-L. Touraine
Download or read book Rejection and Tolerance written by J.-L. Touraine and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rejection and Tolerance is the latest subject in the Continuing Education series, organized by Fondation Marcel Mérieux and Université Claude Bernard in Lyon. The annual subject is chosen to reflect the status of the topical issues of the year, as taught by leading international experts. The contribution of transplantation and clinical immunology to advanced medicine is considerable and promising. The annual volumes in this series keep the reader abreast of these developments.
Book Synopsis Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives by : Caner Süsal
Download or read book Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives written by Caner Süsal and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Oxford Textbook of Fundamentals of Surgery by : William E. G. Thomas
Download or read book Oxford Textbook of Fundamentals of Surgery written by William E. G. Thomas and published by Oxford University Press. This book was released on 2016-07-28 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.
Book Synopsis A History of Organ Transplantation by : David Hamilton
Download or read book A History of Organ Transplantation written by David Hamilton and published by University of Pittsburgh Pre. This book was released on 2013-12-21 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: A History of Organ Transplantation is a comprehensive and ambitious exploration of transplant surgery—which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple interactions with other fields, including biology, ethics, law, government, and technology. Exploring the medical, scientific, and surgical events that led to modern transplant techniques, Hamilton argues that progress in successful transplantation required a unique combination of multiple methods, bold surgical empiricism, and major immunological insights in order for surgeons to develop an understanding of the body's most complex and mysterious mechanisms. Surgical progress was nonlinear, sometimes reverting and sometimes significantly advancing through luck, serendipity, or helpful accidents of nature. The first book of its kind, A History of Organ Transplantation examines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This well-executed volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included.
Book Synopsis Retransplantation by : J.-L. Touraine
Download or read book Retransplantation written by J.-L. Touraine and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Symposium Fondation Marcel Mérieux
