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Author : Peter Vaupel
Publisher : Lubrecht & Cramer, Limited
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tumor Oxygenation written by Peter Vaupel and published by Lubrecht & Cramer, Limited. This book was released on 1995 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : H.J. Machulla
Publisher : Springer Science & Business Media
ISBN 13 : 9401718288
Total Pages : 195 pages
Book Rating : 4.4/5 (17 download)
Download or read book Imaging of Hypoxia written by H.J. Machulla and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem. As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.
Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.8/5 (113 download)
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Author : Véronique Fortier
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)
Download or read book Evaluation of Tumor Hypoxia with Magnetic Resonance Imaging written by Véronique Fortier and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Hypoxia is a common condition in solid tumors that has been shown to decrease the efficacy of radiotherapy and chemotherapy. Tumor hypoxia would be a very valuable characteristic to monitor during cancer radiotherapy treatments as it could enable the development of personalized treatments. However, there is currently no volumetric technique available to map hypoxia in vivo in a non-invasive way. The aim of this thesis was thus to develop a 3D technique to map hypoxia in tissue.In this work, it was hypothesised that hypoxia can be evaluated reliably using magnetic resonance imaging (MRI). More specifically, two MRI-based biomarkers for tissue oxygenation were investigated in this thesis in the presence of fat; magnetic susceptibility and longitudinal relaxation rate ( 1). Oxygen molecules are paramagnetic, which means that their presence modulates the tissue magnetic susceptibility. Oxygen molecules are also 1 lengthening agents and have a larger solubility in fat than in water. These characteristics of oxygen molecules suggest that fat 1 and susceptibility mapping in the presence of fat could both be sensitive to the presence of dissolved oxygen molecules in interstitial fluid of tissue containing fat, as proposed in previous work.Experiments were performed in this work using two different fat-water emulsions mimicking human soft tissues to investigate the sensitivity of the two biomarkers to oxygen level variations. Results obtained first showed that quantitative susceptibility mapping is unlikely to be sensitive to oxygen variations in tissue in vivo, due to the very small change in magnetic susceptibility that is induced by dissolved oxygen molecules, even in the presence of fat. Second, a detailed study of the longitudinal relaxation of fat molecules and water was performed to provide a more detailed understanding of these relaxation times as a function of the fat fraction. Third, building on the study of the longitudinal relaxation of fat molecules, a volumetric fat 1 mapping technique was proposed based on a variable flip angle approach. Fat 1 estimated with this proposed technique was shown to be highly sensitive in fat-water phantoms to variations in oxygen concentration, more so than water 1, consistent with previous work.The fat 1 mapping technique proposed in this work addresses the main limitations of existing techniques to map fat 1 in the context of tumor hypoxia, which are currently limited to single-slice imaging and require long scan times. This proposed technique is thus a promising tool for mapping hypoxia in vivo"--
Author : Nuria Hirsch
Publisher :
ISBN 13 :
Total Pages : 119 pages
Book Rating : 4.:/5 (874 download)
Download or read book BOLD-based Magnetic Resonance Imaging of Hypoxia in the Human Brain written by Nuria Hirsch and published by . This book was released on 2013 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book 2nd workshop on the imaging of hypoxia and functional image guided radiotherapy written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniele M. Gilkes
Publisher : Springer
ISBN 13 : 3030127346
Total Pages : 160 pages
Book Rating : 4.0/5 (31 download)
Download or read book Hypoxia and Cancer Metastasis written by Daniele M. Gilkes and published by Springer. This book was released on 2019-06-14 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
Author : David Mönnich
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (118 download)
Download or read book Modelling and Simulation of Hypoxia Imaging with Positron Emission Tomography written by David Mönnich and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ruslan I. Dmitriev
Publisher : Springer
ISBN 13 : 3319673580
Total Pages : 172 pages
Book Rating : 4.3/5 (196 download)
Download or read book Multi-Parametric Live Cell Microscopy of 3D Tissue Models written by Ruslan I. Dmitriev and published by Springer. This book was released on 2017-10-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an essential overview of existing state-of-the-art quantitative imaging methodologies and protocols (intensity-based ratiometric and FLIM/ PLIM). A variety of applications are covered, including multi-parametric quantitative imaging in intestinal organoid culture, autofluorescence imaging in cancer and stem cell biology, Ca2+ imaging in neural ex vivo tissue models, as well as multi-parametric imaging of pH and viscosity in cancer biology. The current state-of-the-art of 3D tissue models and their compatibility with live cell imaging is also covered. This is an ideal book for specialists working in tissue engineering and designing novel biomaterial.
Author : Keizō Kaneko
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)
Download or read book A Novel Hypoxia Imaging Endoscopy System written by Keizō Kaneko and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Measurement of tumor hypoxia is required for the diagnosis of tumor and the evaluation of therapeutic outcome. Currently, invasive and noninvasive techniques being exploited for tumor hypoxia measurement include polarographic needle electrodes, immunohistochemical (IHC) staining, magnetic resonance imaging (MRI), radionuclide imaging (positron emission tomography [PET] and single-photon emission computed tomography [SPECT]), optical imaging (bioluminescence and fluorescence), and hypoxia imaging endoscopy. This review provides a summary of the modalities available for assessment of tissue oxygenation as well as a discussion of current arguments for and against each modality, with a particular focus on noninvasive hypoxia imaging with emerging agents and new imaging technologies intended to detect molecular events associated with tumor hypoxia.
Author : Lawrence J. Berliner
Publisher : Springer Nature
ISBN 13 : 303047318X
Total Pages : 237 pages
Book Rating : 4.0/5 (34 download)
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Author : Eric J. Hall
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451154186
Total Pages : 908 pages
Book Rating : 4.4/5 (511 download)
Download or read book Radiobiology for the Radiologist written by Eric J. Hall and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: In print since 1972, this seventh edition of Radiobiology for the Radiologist is the most extensively revised to date. It consists of two sections, one for those studying or practicing diagnostic radiolo, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia. Now in full color, this lavishly illustrated new edition is replete with tables and figures that underscore essential concepts. Each chapter concludes with a "summary of pertinent conclusions" to facilitate quick review and help readers retain important information.
Author : Massimo Filippi
Publisher : Cambridge University Press
ISBN 13 : 1107035945
Total Pages : 393 pages
Book Rating : 4.1/5 (7 download)
Download or read book Imaging Acute Neurologic Disease written by Massimo Filippi and published by Cambridge University Press. This book was released on 2014-09-11 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of best practice in using diagnostic imaging in acute neurologic conditions. The symptom-based approach guides the choice of the available imaging tools for efficient, accurate, and cost-effective diagnosis. Effective examination algorithms integrate neurological and imaging concepts with the practical demands and constraints of emergency care.
Author : K. Chughtai
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (847 download)
Download or read book Multimodal Imaging of Hypoxia in Breast Cancer written by K. Chughtai and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert C. Roach
Publisher : Springer
ISBN 13 : 1489976787
Total Pages : 765 pages
Book Rating : 4.4/5 (899 download)
Download or read book Hypoxia written by Robert C. Roach and published by Springer. This book was released on 2016-06-24 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before ‘translational medicine’ was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies. This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include: Epigenetic Variations in Hypoxia High Altitude Adaptation Hypoxia and Sleep Hypoxia and the Brain Molecular Oxygen Sensing Physiological Responses to Hypoxia
Download or read book 4D biological imaging of hypoxia in human tumors written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dmitri B Papkovsky
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014553
Total Pages : 384 pages
Book Rating : 4.7/5 (88 download)
Download or read book Quenched-phosphorescence Detection of Molecular Oxygen written by Dmitri B Papkovsky and published by Royal Society of Chemistry. This book was released on 2018-05-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in recent years in quenched-phosphorescence oxygen sensing, particularly in the materials and applications of this detection technology that are open to commercialization, like uses in brain imaging and food packaging. Prompted by this, the editors have delivered a dedicated book that brings together these developments, provides a comprehensive overview of the different detection methodologies, and representative examples and applications. This book is intended to attract new researchers from various disciplines such as chemistry, physics, biology and medicine, stimulate further progress in the field and assist in developing new applications. Providing a concise summary at the cutting edge, this practical guide for current experts and new potential users will increase awareness of this versatile sensing technology.
