Identifying And Understanding The Functional Significance Of Cancer Stem Cells In Prostate And Pancreatic Cancer Initiation And Chemoresistance

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Identifying and Understanding the Functional Significance of Cancer Stem Cells in Prostate and Pancreatic Cancer Initiation and Chemoresistance

Author : Antreas Agop Hindoyan
Publisher :
ISBN 13 :
Total Pages : 126 pages
Book Rating : 4.:/5 (86 download)

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Book Synopsis Identifying and Understanding the Functional Significance of Cancer Stem Cells in Prostate and Pancreatic Cancer Initiation and Chemoresistance by : Antreas Agop Hindoyan

Download or read book Identifying and Understanding the Functional Significance of Cancer Stem Cells in Prostate and Pancreatic Cancer Initiation and Chemoresistance written by Antreas Agop Hindoyan and published by . This book was released on 2013 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The functional heterogeneity of cancer phenotypes and responses to therapeutics is a huge obstacle to clinical cures and an intense area of study. A relatively new hypothesis posits the existence of a subpopulation of tumor cells, termed cancer stem cells, which are primarily responsible for tumor propagation and resistance to therapy. Identification of such cells may be important to develop targeted therapies for more effective cancer treatment. This dissertation focuses on the validation and functional study of cancer stem cells associated with human prostate and pancreatic cancers. By leveraging the fact that surgical castration leads to enrichment of stem/progenitor cells in the prostate, we idenitifed CD166 as a novel marker for prostate stem cells. We show that CD166 can further enrich and refine the established prostate stem/progenitor cell and cancer stem cell population in both murine and human systems. While genetic deletion of CD166 would not inhibit the development of the prostate gland or the formation of prostate cancer in our genetically engineered model systems, this protein may serve as an attractive marker for identifying and targeting prostate cancer stem cells. Further attempts were made at identifying stem/progenitor populations for prostate and pancreatic cancer through various discovery and targeted approaches. We found that Lgr5, a marker of stem cells in the gut and skin, is not expressed in prostate and pancreatic epithelial tissue, but only in prostatic stroma. Novel surface markers such as CD138 were found to be highly upregulated in pancreatic tumors, but specificity for cancer stem cells was lacking. Lastly, we studied the functional role of cancer stem cells in gemcitabine therapy resistance in a human pancreatic cancer model. We found that the PI3K and ubiquitin-mediated proteosomal degradation pathways can be used to stratify gemcitabine treatment response in patient tumors. Inhibition of Skp2 expression and therapeutic treatment with PI3K inhibitors proved to be effective sensitiziers to gemcitabine treatment. Importantly, cancer stem cell content and function did not mediate gemcitabine relapse. As such, our studies reveal the cancer stem cell paradigm may be more complicated and cancer context-dependent, and must be rigorously functionally proven prior to clinical adoption.

Cancer Stem Cells: Basic Concept and Therapeutic Implications

Author : Farhadul Islam
Publisher : Springer Nature
ISBN 13 : 9819931851
Total Pages : 375 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Cancer Stem Cells: Basic Concept and Therapeutic Implications by : Farhadul Islam

Download or read book Cancer Stem Cells: Basic Concept and Therapeutic Implications written by Farhadul Islam and published by Springer Nature. This book was released on 2023-07-26 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

Cancer Stem Cells in Solid Tumors

Author : Alison L. Allan
Publisher : Springer Science & Business Media
ISBN 13 : 1617792462
Total Pages : 479 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Cancer Stem Cells in Solid Tumors by : Alison L. Allan

Download or read book Cancer Stem Cells in Solid Tumors written by Alison L. Allan and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Role of Cancer Stem Cells in Cancer Biology and Therapy

Author : Thomas Dittmar
Publisher : CRC Press
ISBN 13 : 1466577363
Total Pages : 330 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Role of Cancer Stem Cells in Cancer Biology and Therapy by : Thomas Dittmar

Download or read book Role of Cancer Stem Cells in Cancer Biology and Therapy written by Thomas Dittmar and published by CRC Press. This book was released on 2016-04-19 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiat

Cancer Stem Cell Markers and Related Network Pathways

Author : Shihori Tanabe
Publisher : Springer Nature
ISBN 13 : 3031129741
Total Pages : 163 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Cancer Stem Cell Markers and Related Network Pathways by : Shihori Tanabe

Download or read book Cancer Stem Cell Markers and Related Network Pathways written by Shihori Tanabe and published by Springer Nature. This book was released on 2023-02-02 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.

Cancer Stem Cells: New Horizons in Cancer Therapies

Author : Surajit Pathak
Publisher : Springer Nature
ISBN 13 : 9811551200
Total Pages : 369 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Cancer Stem Cells: New Horizons in Cancer Therapies by : Surajit Pathak

Download or read book Cancer Stem Cells: New Horizons in Cancer Therapies written by Surajit Pathak and published by Springer Nature. This book was released on 2020-10-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Stem Cells and Prostate Cancer

Author : Scott D. Cramer
Publisher : Springer Science & Business Media
ISBN 13 : 1461464986
Total Pages : 185 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Stem Cells and Prostate Cancer by : Scott D. Cramer

Download or read book Stem Cells and Prostate Cancer written by Scott D. Cramer and published by Springer Science & Business Media. This book was released on 2013-04-12 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence demonstrates that normal prostate tissue contains stem cells. There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells. Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer. The purpose of this book is to explore the role of stem cells in prostate cancer, which is becoming an increasingly hot trend in cancer research.

Stem Cells and Cancer

Author : Sadhan Majumder
Publisher : Springer Science & Business Media
ISBN 13 : 0387896112
Total Pages : 304 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Stem Cells and Cancer by : Sadhan Majumder

Download or read book Stem Cells and Cancer written by Sadhan Majumder and published by Springer Science & Business Media. This book was released on 2009-06-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells—and not the major bulk of the tissue—that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy. The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.

Cancer Stem Cells

Author : Stanley Shostak
Publisher : BoD – Books on Demand
ISBN 13 : 9533072253
Total Pages : 476 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Cancer Stem Cells by : Stanley Shostak

Download or read book Cancer Stem Cells written by Stanley Shostak and published by BoD – Books on Demand. This book was released on 2011-03-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells Theories and Practice does not 'boldly go where no one has gone before!' Rather, Cancer Stem Cells Theories and Practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two chapters also tease apart cancer's vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance.

Advances in Cancer Stem Cell Biology

Author : Roberto Scatena
Publisher : Springer Science & Business Media
ISBN 13 : 1461408091
Total Pages : 349 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Cancer Stem Cell Biology by : Roberto Scatena

Download or read book Advances in Cancer Stem Cell Biology written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2011-10-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Cancer Stem Cells

Author : John S. Yu
Publisher : Humana Press
ISBN 13 : 9781607612117
Total Pages : 284 pages
Book Rating : 4.6/5 (121 download)

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Book Synopsis Cancer Stem Cells by : John S. Yu

Download or read book Cancer Stem Cells written by John S. Yu and published by Humana Press. This book was released on 2009-07-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a devastating disease that affects millions of people in the world. Our the- pies for tumors have mostly been based on classical chemotherapy and antiproliferative treatments. More recently, directed therapies against a causative oncogene have led to prominent reduction in tumor rates for some cancers. For instance, chronic myelogenous leukemia that is due to a BCR–ABL translocation can be targeted with Gleevec. Despite these advances in individual tumors, a number of patients are treated for their primary tumors and ultimately relapse. Relapsing tumors can be due to resistance to chemotherapy or to antioncogene drugs. Another hypothesis is that heterogeneity in the tumor leads to an inability of classical chemotherapy to completely eradicate all cells of the tumor. This concept of heterogeneity has led some investigators to propose a cancer stem cell model. As patients are treated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells that remain after classical chemotherapy or the cells that can remake the tumor among the heterogeneous population, this information would have a huge impact on our treatment of cancer.

Experimental Metastasis: Modeling and Analysis

Author : Anastasia Malek
Publisher : Springer Science & Business Media
ISBN 13 : 940077835X
Total Pages : 212 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Experimental Metastasis: Modeling and Analysis by : Anastasia Malek

Download or read book Experimental Metastasis: Modeling and Analysis written by Anastasia Malek and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

Cancer Stem Cells

Author : Otmar D. Wiestler
Publisher : Springer Science & Business Media
ISBN 13 : 3540708529
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Cancer Stem Cells by : Otmar D. Wiestler

Download or read book Cancer Stem Cells written by Otmar D. Wiestler and published by Springer Science & Business Media. This book was released on 2007-09-04 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.

Stem Cells in Cancer: Should We Believe or Not?

Author : Enrique Grande
Publisher : Springer Science & Business
ISBN 13 : 9401787549
Total Pages : 302 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Stem Cells in Cancer: Should We Believe or Not? by : Enrique Grande

Download or read book Stem Cells in Cancer: Should We Believe or Not? written by Enrique Grande and published by Springer Science & Business. This book was released on 2014-04-28 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic. Exploring the latest research including new data from randomized trials, this book examines important proposals over the origin of cancer stem cells such as the possibility that cancer stem cells may arise from mutated stem cells or a fully differentiated cell that may undergo several mutations that drive it back to a stem-like state. The authors consider the role that stem cells seem to have in the onset, development and resistance to classical antitumoral treatments of cancer and discuss possible potential future treatment modalities for the management of advanced cancer patients. The question, "Are stem cells involved in cancer?" may not have a simple answer, but ongoing investigations, in-depth consideration and a broad spectrum of information can be found in this book, allowing the reader to arrive at his or her own answer. This book will appeal to researchers in the field of oncology and cancer research and biomedical scientists with an interest in stem cells.

Defining the Epigenetic Landscape and Functional Dependencies of Pancreatic Cancer Stem Cells

Author : Lesley Paige Ferguson
Publisher :
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Defining the Epigenetic Landscape and Functional Dependencies of Pancreatic Cancer Stem Cells by : Lesley Paige Ferguson

Download or read book Defining the Epigenetic Landscape and Functional Dependencies of Pancreatic Cancer Stem Cells written by Lesley Paige Ferguson and published by . This book was released on 2021 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in cancer treatment, resistance to therapy and metastatic progression remain critical drivers of mortality. One central mechanism underlying therapy resistance and metastasis is tumor heterogeneity. Within the tumor bulk, genetic and epigenetic diversity fuel variable responses to therapy and a spectrum of invasive potential. In particular, rare subpopulations of tumor cells that reactivate developmental signals are uniquely primed for therapy resistance and metastatic success. These cells, often referred to as cancer stem cells, are enriched for the ability to self-renew in the face of therapy, driving eventual relapse. Deepening our understanding of the molecular dependencies of these aggressive cells may provide new opportunities for therapeutic intervention. In collaboration with a fellow graduate student (Nikki Lytle) who led this project, we used transcriptional and epigenetic profiling paralleled by a genome-wide CRISPR analysis to map the molecular dependencies of pancreatic cancer stem cells. This integrated approach revealed an unexpected utilization of immuno-regulatory signals by pancreatic cancer cells, and identified the nuclear hormone receptor (ROR[gamma]) as a targetable dependency in pancreatic cancer stem cells. We expanded preclinical work to test ROR[gamma] inhibitors, providing new evidence that clinical grade ROR[gamma] inhibitors can block pancreatic cancer growth and deplete cancer stem cells in vivo. These studies also revealed a unique epigenetic landscape in cancer stem cells, suggesting upstream epigenetic regulation of stem cell fate. Thus, to follow this work, I used a curated functional screen for stem cell-enriched epigenetic factors, ultimately identifying the SWI/SNF subunit SMARCD3 as an epigenetic dependency in pancreatic cancer stem cells. Using diverse genetic mouse models, I showed that Smarcd3 dependency is bimodal, with a preferential impact in established tumors, improving survival and chemosensitivity in vivo. Finally, I leveraged genetically engineered mouse models to identify and test clinical inhibitors that target cancer stem cells. Using a genetic reporter for the stem cell signal Msi2, I helped conduct an image-based screen and found that clinical inhibitors of MEK signaling inhibited Msi2 and blocked CSC growth in vivo. Together, these studies generate a comprehensive molecular profile of the landscape and functional requirements of pancreatic cancer stem cells that may be used to identify new therapeutic targets in the future.

Cancer Stem Cells Theories and Practice

Author : Applied Research Applied Research Press
Publisher : CreateSpace
ISBN 13 : 9781505202380
Total Pages : 430 pages
Book Rating : 4.2/5 (23 download)

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Book Synopsis Cancer Stem Cells Theories and Practice by : Applied Research Applied Research Press

Download or read book Cancer Stem Cells Theories and Practice written by Applied Research Applied Research Press and published by CreateSpace. This book was released on 2014-11-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells Theories and Practice does not 'boldly go where no one has gone before!' Rather, Cancer Stem Cells Theories and Practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two chapters also tease apart cancer's vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance. Chapters include: The Dark Side of Cellular Plasticity: Stem Cells in Development and Cancer, From where do Cancer-Initiating Cells Originate?, Connections between Genomic Instability and Cancer Stem Cells, Cancer Stem Cells as a Result of a Reprogramming-Like Mechanism, Breast Cancer Stem Cells, Glioma Stem Cells: Cell Culture, Markers and Targets for New Combination Therapies, Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas, Prostate and Colon Cancer Stem Cells as a Target for Anti-Cancer Drug Development, Importance of Stromal Stem Cells in Prostate Carcinogenesis Process, Cancer Stem Cells and Their Niche, The Stem Cell Niche: The Black Master of Cancer, Cancer Stem Cells Promote Tumor Neovascularization, Potential Signaling Pathways Activated in Cancer Stem Cells in Breast Cancer, Signalling Pathways Driving Cancer Stem Cells: Hedgehog Pathway, MicroRNAs: Small but Critical Regulators of Cancer Stem Cells, MicroRNAs and Cancer Stem Cells in Medulloblastoma, The Rocky Road from Cancer Stem Cell Discovery to Diagnostic Applicability, Drugs that Kill Cancer Stem-like Cells, Cancer Stem Cells as a New Opportunity for Therapeutic Intervention, Targeting Signal Pathways Active in Leukemic Stem Cells to Overcome Drug Resistance, Cancer Stem Cells and Chemoresistance, and Cancer Stem Cells in Drug Resistance and Drug Screening: Can We Exploit the Cancer Stem Cell Paradigm in Search for New Antitumor Agents?

The Cancer Stem Cell Niche

Author : Susie Nilsson
Publisher : Academic Press
ISBN 13 : 0323853250
Total Pages : 246 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis The Cancer Stem Cell Niche by : Susie Nilsson

Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche