Identification And Functional Characterization Of Novel Venom Components

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Identification and Functional Characterization of Novel Venom Components

Author : Steven D. Aird
Publisher : MDPI
ISBN 13 : 3039364677
Total Pages : 210 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Identification and Functional Characterization of Novel Venom Components by : Steven D. Aird

Download or read book Identification and Functional Characterization of Novel Venom Components written by Steven D. Aird and published by MDPI. This book was released on 2020-12-29 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout most of the 20th century, the toxinological literature consisted largely of pharmacological and functional characterizations of crude venoms and venom constituents, often constituents that could not be identified unambiguously. The advent of amino acid composition analysis in the 1950s enabled the first forays into physical characterizations of purified toxins, though these remained few in number until the 1970s. Then, the tryptic and chymotryptic cleavage of venom proteins coupled with manual Edman degradation began to provide the first complete sequences, particularly of three-finger toxins. Polyacrylamide gel electrophoresis and improved resins for liquid chromatography permitted improved purification and better gross structural characterization of venom components. The early 1980s witnessed the advent of automated Edman degradation, and entire sequences of longer proteins began to be reported in the literature. Then, the molecular biology revolution enabled the generation of cDNA sequences of more and larger proteins, followed by mass-spectrometry-based proteomics and quantitative high-throughput DNA sequencing and genomics. Today, we face an unprecedented situation in which our capacity to generate sequence/structural data has completely overwhelmed our capacity to functionally characterize venom constituents. This Special Issue of Toxins includes 11 publications addressing the discovery and functional characterization of novel venom constituents of vertebrate and invertebrate venoms.

Identification and Functional Characterization of Novel Venom Components

Author : Steven D. Aird
Publisher :
ISBN 13 : 9783039364688
Total Pages : 210 pages
Book Rating : 4.3/5 (646 download)

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Book Synopsis Identification and Functional Characterization of Novel Venom Components by : Steven D. Aird

Download or read book Identification and Functional Characterization of Novel Venom Components written by Steven D. Aird and published by . This book was released on 2020 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout most of the 20th century, the toxinological literature consisted largely of pharmacological and functional characterizations of crude venoms and venom constituents, often constituents that could not be identified unambiguously. The advent of amino acid composition analysis in the 1950s enabled the first forays into physical characterizations of purified toxins, though these remained few in number until the 1970s. Then, the tryptic and chymotryptic cleavage of venom proteins coupled with manual Edman degradation began to provide the first complete sequences, particularly of three-finger toxins. Polyacrylamide gel electrophoresis and improved resins for liquid chromatography permitted improved purification and better gross structural characterization of venom components. The early 1980s witnessed the advent of automated Edman degradation, and entire sequences of longer proteins began to be reported in the literature. Then, the molecular biology revolution enabled the generation of cDNA sequences of more and larger proteins, followed by mass-spectrometry-based proteomics and quantitative high-throughput DNA sequencing and genomics. Today, we face an unprecedented situation in which our capacity to generate sequence/structural data has completely overwhelmed our capacity to functionally characterize venom constituents. This Special Issue of Toxins includes 11 publications addressing the discovery and functional characterization of novel venom constituents of vertebrate and invertebrate venoms.

Snake Venom Metalloproteinases

Author : Jay Fox
Publisher : MDPI
ISBN 13 : 3038424269
Total Pages : 277 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Snake Venom Metalloproteinases by : Jay Fox

Download or read book Snake Venom Metalloproteinases written by Jay Fox and published by MDPI. This book was released on 2018-07-10 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Snake Venom Metalloproteinases" that was published in Toxins

Arthropod Venom Components and Their Potential Usage

Author : Katsuhiro Konno
Publisher : MDPI
ISBN 13 : 3039285408
Total Pages : 404 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Arthropod Venom Components and Their Potential Usage by : Katsuhiro Konno

Download or read book Arthropod Venom Components and Their Potential Usage written by Katsuhiro Konno and published by MDPI. This book was released on 2020-03-25 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.

Venoms, Animal and Microbial Toxins, Volume II

Author : Jean-Marc Sabatier
Publisher : Frontiers Media SA
ISBN 13 : 2832501141
Total Pages : 271 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Venoms, Animal and Microbial Toxins, Volume II by : Jean-Marc Sabatier

Download or read book Venoms, Animal and Microbial Toxins, Volume II written by Jean-Marc Sabatier and published by Frontiers Media SA. This book was released on 2022-09-29 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Snake Venoms

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400764095
Total Pages : 0 pages
Book Rating : 4.7/5 (64 download)

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Book Synopsis Snake Venoms by : P. Gopalakrishnakone

Download or read book Snake Venoms written by P. Gopalakrishnakone and published by Springer. This book was released on 2017-02-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design

Author : Victor I. Tsetlin
Publisher : Frontiers Media SA
ISBN 13 : 2889661865
Total Pages : 135 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design by : Victor I. Tsetlin

Download or read book From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design written by Victor I. Tsetlin and published by Frontiers Media SA. This book was released on 2020-12-09 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Handbook of Venoms and Toxins of Reptiles

Author : Stephen P. Mackessy
Publisher : CRC Press
ISBN 13 : 0429623453
Total Pages : 912 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Handbook of Venoms and Toxins of Reptiles by : Stephen P. Mackessy

Download or read book Handbook of Venoms and Toxins of Reptiles written by Stephen P. Mackessy and published by CRC Press. This book was released on 2021-05-24 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Venoms of the Hymenoptera

Author : Tom Piek
Publisher : Elsevier
ISBN 13 : 1483263703
Total Pages : 583 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Venoms of the Hymenoptera by : Tom Piek

Download or read book Venoms of the Hymenoptera written by Tom Piek and published by Elsevier. This book was released on 2013-10-22 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.

Handbook of Venoms and Toxins of Reptiles

Author : Stephen P. Mackessy
Publisher : CRC Press
ISBN 13 : 1420008668
Total Pages : 548 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Venoms and Toxins of Reptiles by : Stephen P. Mackessy

Download or read book Handbook of Venoms and Toxins of Reptiles written by Stephen P. Mackessy and published by CRC Press. This book was released on 2016-04-19 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Venoms and Toxins of Reptiles offers "one-stop shopping" to all biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation. This book

Venoms to Drugs

Author : Glenn King
Publisher : Royal Society of Chemistry
ISBN 13 : 1849736634
Total Pages : 338 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Venoms to Drugs by : Glenn King

Download or read book Venoms to Drugs written by Glenn King and published by Royal Society of Chemistry. This book was released on 2015-02-11 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book will provide an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book will provide the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

An Integrated View of the Molecular Recognition and Toxinology

Author : Gandhi Radis-Baptista
Publisher : BoD – Books on Demand
ISBN 13 : 9535111515
Total Pages : 548 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis An Integrated View of the Molecular Recognition and Toxinology by : Gandhi Radis-Baptista

Download or read book An Integrated View of the Molecular Recognition and Toxinology written by Gandhi Radis-Baptista and published by BoD – Books on Demand. This book was released on 2013-07-01 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of molecular interaction and recognition offers a window of opportunity for the pharmaceutical industry and clinical medicine. Thus, this book brings examples of two interconnected themes - molecular recognition and toxinology concerning to the integration between analytical procedures and biomedical applications.

Ion Channels as Marine Drug Targets

Author : Jean-Marc Sabatier
Publisher : MDPI
ISBN 13 : 3039437976
Total Pages : 134 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Ion Channels as Marine Drug Targets by : Jean-Marc Sabatier

Download or read book Ion Channels as Marine Drug Targets written by Jean-Marc Sabatier and published by MDPI. This book was released on 2020-12-23 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.

Structure-function Relationship of K+ Ion Channel Toxins

Author : Isabelle Huys
Publisher : Leuven University Press
ISBN 13 : 9789058673534
Total Pages : 240 pages
Book Rating : 4.6/5 (735 download)

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Book Synopsis Structure-function Relationship of K+ Ion Channel Toxins by : Isabelle Huys

Download or read book Structure-function Relationship of K+ Ion Channel Toxins written by Isabelle Huys and published by Leuven University Press. This book was released on 2004 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Many fundamental processes underlying nerve and muscle excitation, hormone secretion, learning and memory, cell proliferation, sensory transduction and regulation of blood pressure and osmotic balance, are attributed to a div"

Toxins and Drug Discovery

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400764514
Total Pages : 0 pages
Book Rating : 4.7/5 (645 download)

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Book Synopsis Toxins and Drug Discovery by : P. Gopalakrishnakone

Download or read book Toxins and Drug Discovery written by P. Gopalakrishnakone and published by Springer. This book was released on 2019-09-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Handbook of Biologically Active Peptides

Author : Abba Kastin
Publisher : Academic Press
ISBN 13 : 0123850967
Total Pages : 2033 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Handbook of Biologically Active Peptides by : Abba Kastin

Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Academic Press. This book was released on 2013-01-26 with total page 2033 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. - Presents all aspects of biologically active peptides in one resource - Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides - Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides - Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications