Venoms To Drugs

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Venoms to Drugs

Author : Glenn F. King
Publisher : Royal Society of Chemistry
ISBN 13 : 1782624376
Total Pages : 320 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Venoms to Drugs by : Glenn F. King

Download or read book Venoms to Drugs written by Glenn F. King and published by Royal Society of Chemistry. This book was released on 2015-01-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Venoms to Drugs

Author : Glenn F. King
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737878
Total Pages : 320 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Venoms to Drugs by : Glenn F. King

Spider Venoms

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400763883
Total Pages : 0 pages
Book Rating : 4.7/5 (638 download)

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Book Synopsis Spider Venoms by : P. Gopalakrishnakone

Download or read book Spider Venoms written by P. Gopalakrishnakone and published by Springer. This book was released on 2016-05-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Venom

Author : Ronald Jenner
Publisher : Smithsonian Institution
ISBN 13 : 1588344541
Total Pages : 207 pages
Book Rating : 4.5/5 (883 download)

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Book Synopsis Venom by : Ronald Jenner

Download or read book Venom written by Ronald Jenner and published by Smithsonian Institution. This book was released on 2017-10-17 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Venom brings readers face to face with some of the most dangerous creatures on the planet, including jellyfish, snakes, and wasps, as it uncovers the story of venom. The book explores how venom is used for predation, defense, competition, and communication by an incredible diversity of species. It examines the unique methods that these species have evolved to create and deliver their deadly toxins. The book traces venom back to its origin in early jellyfish and sea anemones, and reveals how venoms have evolved dozens of times independently all across the animal kingdom since that time. And finally, it examines the relationships between these dangerous creatures and humans. Humans have not only learned to live with them, but also to benefit from them: scientists increasingly are harnessing the power of venom to create new drugs, treatments, and anti-venoms.

Venoms of the Hymenoptera

Author : Tom Piek
Publisher : Elsevier
ISBN 13 : 1483263703
Total Pages : 580 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Venoms of the Hymenoptera by : Tom Piek

Download or read book Venoms of the Hymenoptera written by Tom Piek and published by Elsevier. This book was released on 2013-10-22 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.

Pills, Potions and Poisons : How Drugs Work

Author : Trevor Stone
Publisher : OUP Oxford
ISBN 13 : 9780191587849
Total Pages : 502 pages
Book Rating : 4.5/5 (878 download)

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Book Synopsis Pills, Potions and Poisons : How Drugs Work by : Trevor Stone

Download or read book Pills, Potions and Poisons : How Drugs Work written by Trevor Stone and published by OUP Oxford. This book was released on 2000-03-16 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.

Toxins and Drug Discovery

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400764514
Total Pages : 0 pages
Book Rating : 4.7/5 (645 download)

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Book Synopsis Toxins and Drug Discovery by : P. Gopalakrishnakone

Download or read book Toxins and Drug Discovery written by P. Gopalakrishnakone and published by Springer. This book was released on 2019-09-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Venoms, Animal and Microbial Toxins

Author : Jean-Marc Sabatier
Publisher : Frontiers Media SA
ISBN 13 : 2889669912
Total Pages : 252 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Venoms, Animal and Microbial Toxins by : Jean-Marc Sabatier

Download or read book Venoms, Animal and Microbial Toxins written by Jean-Marc Sabatier and published by Frontiers Media SA. This book was released on 2021-07-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery

Download Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery PDF Online Free

Author : Michelle Yap
Publisher : Frontiers Media SA
ISBN 13 : 2832545238
Total Pages : 165 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery by : Michelle Yap

Download or read book Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery written by Michelle Yap and published by Frontiers Media SA. This book was released on 2024-02-23 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.

Animal Toxins

Author : Findlay E. Russell
Publisher :
ISBN 13 :
Total Pages : 462 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Animal Toxins by : Findlay E. Russell

Download or read book Animal Toxins written by Findlay E. Russell and published by . This book was released on 1967 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Meyler's Side Effects of Drugs

Author : Jeffrey K. Aronson
Publisher : Elsevier
ISBN 13 : 0444537163
Total Pages : 7629 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Meyler's Side Effects of Drugs by : Jeffrey K. Aronson

Download or read book Meyler's Side Effects of Drugs written by Jeffrey K. Aronson and published by Elsevier. This book was released on 2015-10-15 with total page 7629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

The Sting of the Wild

Author : Justin O. Schmidt
Publisher : Johns Hopkins University Press
ISBN 13 : 1421425645
Total Pages : 281 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Sting of the Wild by : Justin O. Schmidt

Download or read book The Sting of the Wild written by Justin O. Schmidt and published by Johns Hopkins University Press. This book was released on 2018-02-01 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: With colorful descriptions of each venom’s sensation and a story that leaves you tingling with awe, The Sting of the Wild’s one-of-a-kind style will fire your imagination.

Venom and Toxin as Targeted Therapy

Author : Hang Fai (Henry) Kwok
Publisher : MDPI
ISBN 13 : 3039211897
Total Pages : 178 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Venom and Toxin as Targeted Therapy by : Hang Fai (Henry) Kwok

Download or read book Venom and Toxin as Targeted Therapy written by Hang Fai (Henry) Kwok and published by MDPI. This book was released on 2019-10-01 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Handbook of Venoms and Toxins of Reptiles

Author : Stephen P. Mackessy
Publisher : CRC Press
ISBN 13 : 0429623453
Total Pages : 912 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Handbook of Venoms and Toxins of Reptiles by : Stephen P. Mackessy

Download or read book Handbook of Venoms and Toxins of Reptiles written by Stephen P. Mackessy and published by CRC Press. This book was released on 2021-05-24 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Toxins and Hemostasis

Author : R. Manjunatha Kini
Publisher : Springer Science & Business Media
ISBN 13 : 9048192951
Total Pages : 790 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Toxins and Hemostasis by : R. Manjunatha Kini

Download or read book Toxins and Hemostasis written by R. Manjunatha Kini and published by Springer Science & Business Media. This book was released on 2010-10-19 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere with cardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains’, several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.

Toxicity Bibliography

Author :
Publisher :
ISBN 13 :
Total Pages : 754 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Toxicity Bibliography by :

Download or read book Toxicity Bibliography written by and published by . This book was released on 1973 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dale's Pharmacology Condensed E-Book

Author : Clive P. Page
Publisher : Elsevier Health Sciences
ISBN 13 : 0702078190
Total Pages : 176 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Dale's Pharmacology Condensed E-Book by : Clive P. Page

Download or read book Dale's Pharmacology Condensed E-Book written by Clive P. Page and published by Elsevier Health Sciences. This book was released on 2019-12-25 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the essential basic science and principles of pharmacology using concise text and diagrams, Dale’s Pharmacology Condensed, 3rd Edition, presents the key facts and concepts that are key to understanding how drugs work and their underlying pathophysiological processes. Each of the 50 short chapters provides an organized, consistent approach to efficient learning and retention of complex information. This concise text is an ideal companion volume to Rang and Dale’s Pharmacology, as well as a stand-alone condensed textbook or review book for exams. All content has been thoroughly revised and updated, with new coverage of fast-moving therapeutic areas such as cancer treatments, dermatology and immune mediated diseases, and new developments in pharmacological principles such as biased agonism. Each two-page (or less) chapter condenses key information from Rang and Dale’s Pharmacology to provide the necessary core knowledge, as well as essential therapeutic information. New editors are experienced teachers who provide a clear focus on what today’s students need to know. Ideal for exam preparation with explanatory diagrams throughout, important drugs identified with bold type, and 50 multiple choice questions for self-assessment and review.