Hydroxychloroquine And Chloroquine Retinopathy

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Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309672104
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by : National Academies of Sciences, Engineering, and Medicine

Download or read book Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-04-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Fundus Autofluorescence

Author : Noemi Lois
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451152809
Total Pages : 303 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Fundus Autofluorescence by : Noemi Lois

Download or read book Fundus Autofluorescence written by Noemi Lois and published by Lippincott Williams & Wilkins. This book was released on 2012-02-13 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring over 250 illustrations, this detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in evaluation of retinal disease. Chapters describe the techniques available to image and quantify fundus autofluorescence and the autofluorescence patterns observed in the healthy eye and in various retinal diseases. Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool and its clinical utility in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also discusses the value of fundus autofluorescence in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition. A companion Website will offer the fully searchable text and an image bank.

Fluorescence Lifetime Imaging Ophthalmoscopy

Author : Martin Zinkernagel
Publisher : Springer
ISBN 13 : 3030228789
Total Pages : 123 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Fluorescence Lifetime Imaging Ophthalmoscopy by : Martin Zinkernagel

Download or read book Fluorescence Lifetime Imaging Ophthalmoscopy written by Martin Zinkernagel and published by Springer. This book was released on 2019-07-29 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.

Atlas of Inherited Retinal Diseases

Author : Stephen H. Tsang
Publisher : Springer
ISBN 13 : 3319950460
Total Pages : 262 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Atlas of Inherited Retinal Diseases by : Stephen H. Tsang

Download or read book Atlas of Inherited Retinal Diseases written by Stephen H. Tsang and published by Springer. This book was released on 2018-12-21 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.

Ryan's Retina E-Book

Author : Charles P. Wilkinson
Publisher : Elsevier Health Sciences
ISBN 13 : 0323401988
Total Pages : 2893 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Ryan's Retina E-Book by : Charles P. Wilkinson

Download or read book Ryan's Retina E-Book written by Charles P. Wilkinson and published by Elsevier Health Sciences. This book was released on 2017-04-17 with total page 2893 pages. Available in PDF, EPUB and Kindle. Book excerpt: The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 290 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Hydroxychloroquine and Chloroquine Retinopathy

Author : David J. Browning
Publisher : Springer
ISBN 13 : 149390597X
Total Pages : 303 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Hydroxychloroquine and Chloroquine Retinopathy by : David J. Browning

Download or read book Hydroxychloroquine and Chloroquine Retinopathy written by David J. Browning and published by Springer. This book was released on 2014-05-09 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a “must-have” resource for physicians who use these drugs.

Macular Dystrophies

Author : Giuseppe Querques
Publisher : Springer
ISBN 13 : 3319266217
Total Pages : 128 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Macular Dystrophies by : Giuseppe Querques

Download or read book Macular Dystrophies written by Giuseppe Querques and published by Springer. This book was released on 2016-02-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.

Ophthalmic Toxicology

Author : G. C. Y. Chiou
Publisher : CRC Press
ISBN 13 : 9781439809983
Total Pages : 398 pages
Book Rating : 4.8/5 (99 download)

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Book Synopsis Ophthalmic Toxicology by : G. C. Y. Chiou

Download or read book Ophthalmic Toxicology written by G. C. Y. Chiou and published by CRC Press. This book was released on 1999-07-01 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t

Retina and Vitreous

Author :
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Retina and Vitreous by :

Download or read book Retina and Vitreous written by and published by . This book was released on 1989 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Lupus Encyclopedia

Author : Donald E. Thomas Jr.
Publisher : JHU Press
ISBN 13 : 1421446855
Total Pages : 845 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Lupus Encyclopedia by : Donald E. Thomas Jr.

Download or read book The Lupus Encyclopedia written by Donald E. Thomas Jr. and published by JHU Press. This book was released on 2023-09-05 with total page 845 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now completely updated! The best-selling, most comprehensive guide to lupus, its complications, and management. Lupus is an autoimmune disease that can attack any body organ. It is three times more common in the United States today than it was in the 1980s, so there is an increased need for accurate, practical information on this potentially devastating disease. Lupus expert and clinician Donald E. Thomas, Jr., MD, provides all the helpful information patients need so they can understand and treat this disease. Highlighting amazing advancements in the diagnosis and treatment of lupus, this edition includes new and expanded information on: • The latest FDA-approved medications • How lupus affects different body parts • Advanced labs that improve lupus diagnosis and treatment • The role of the microbiome and anti-inflammatory diets • Updated recommendations for those who are pregnant or breastfeeding • Childhood-onset lupus • The interaction between COVID-19 and lupus • Non-drug treatments, complementary medicine, and medical cannabis The gold standard since it was first published and carefully reviewed by experts in the field, the latest edition of The Lupus Encyclopedia is essential for patients, health care providers, and families. Bonus content on insurance issues and information about working with lupus and disability is also available online. Endorsed by The Lupus Foundation of America Contributors: Jemima Albayda, MD; Divya Angra, MD; Alan N. Baer, MD; Sasha Bernatsky, MD, PhD; George Bertsias, MD, PhD; Ashira D. Blazer, MD; Ian Bruce, MD; Jill Buyon, MD; Yashaar Chaichian, MD; Maria Chou, MD; Sharon Christie, Esq; Angelique N. Collamer, MD; Ashté Collins, MD; Caitlin O. Cruz, MD; Mark M. Cruz, MD; Dana DiRenzo, MD; Jess D. Edison, MD; Titilola Falasinnu, PhD; Andrea Fava, MD; Cheri Frey, MD; Neda F. Gould, PhD; Nishant Gupta, MD; Sarthak Gupta, MD; Sarfaraz Hasni, MD; David Hunt, MD; Mariana J. Kaplan, MD; Alfred Kim, MD; Deborah Lyu Kim, DO; Rukmini Konatalapalli, MD; Fotios Koumpouras, MD; Vasileios C. Kyttaris, MD; Jerik Leung, MPH; Hector A. Medina, MD; Timothy Niewold, MD; Julie Nusbaum, MD; Ginette Okoye, MD; Sarah L. Patterson, MD; Ziv Paz, MD; Darryn Potosky, MD; Rachel C. Robbins, MD; Neha S. Shah, MD; Matthew A. Sherman, MD; Yevgeniy Sheyn, MD; Julia F. Simard, ScD; Jonathan Solomon, MD; Rodger Stitt, MD; George Stojan, MD; Sangeeta Sule, MD; Barbara Taylor, CPPM, CRHC; George Tsokos, MD; Ian Ward, MD; Emma Weeding, MD; Arthur Weinstein, MD; Sean A. Whelton, MD

Encyclopedia of Ophthalmology

Author : Ursula Schmidt-Erfurth
Publisher :
ISBN 13 : 9783642359514
Total Pages : pages
Book Rating : 4.3/5 (595 download)

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Book Synopsis Encyclopedia of Ophthalmology by : Ursula Schmidt-Erfurth

Download or read book Encyclopedia of Ophthalmology written by Ursula Schmidt-Erfurth and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Guide

Author : F a Davis
Publisher :
ISBN 13 :
Total Pages : 26 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Drug Guide by : F a Davis

Download or read book Drug Guide written by F a Davis and published by . This book was released on 2021-06-17 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 DRUG BOOK for Nursing Students! "This is the perfect drug book for nursing school! All the information on the meds is in-depth and all that you need to know."-Abby W. SAFETY FIRST! Davis's Drug Guide for Nurses(R), Seventeenth Edition delivers all the information you need to administer medications safely across the lifespan-well-organized monographs for hundreds of generic and thousands of trade-name drugs. FREE DIGITAL ACCESS Redeem the access code to unlock your one-year, free subscription to DrugGuide.com, Davis's Drug Guide Online, powered by Unbound Medicine. You'll have access to more than 1,700 monographs from your desktop, laptop, or any mobile device with a web browser. Search the complete 5,000-drug database and appendices quickly and efficiently. Build your knowledge with extensively cross-referenced drugs. Keep up to date with FDA drug news. LIFE-SAVING GUIDANCE ... AT A GLANCE New! The AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults #1 Drug Guide for patient safety Red tab for high alert medications, plus in-depth high alert and patient safety coverage Red, capitalized letters for life-threatening side effects REMS (Risk Evaluation and Mitigation Strategies) icon Drug-drug, drug-food, drug-natural product interactions Special considerations for patient populations. Geri heading identifies special concerns for older adults. OB and Lact headings highlight information for pregnant and breastfeeding patients. Pedi heading identifies concerns for children. Rep heading identifies considerations for patients of reproductive age. IV Administration subheads Pharmacogenomic content Canadian-specific content In-depth guidance for patient and family teaching FREE LEARNING, CARE PLANNING, AND PATIENT EDUCATION TOOLS Online at FADavis.com Audio Library of 1,200+ drug names help you pronounce important terms Two tutorials, each with a self-test Preventing Medication Errors Psychotropic Drugs Easy-to-Use Calculators Body mass index (BMI) Metric conversions IV drip rates Dosage/KG Fahrenheit/Celsius Interactive Case Studies - brief, real-life scenarios that are followed by a series of questions Audio podcasts delivering information on... Risk Evaluation Mitigation Systems (REMS) How to use Davis's Drug Guide for Nurses(R) Detecting and managing ADRs Evidence-based practice and Pharmacotherapeutics Pharmacogenomics Medication errors Special dosing considerations Educating patients about Safe Medication Use Video clips illustrating the safe administration of medications ONLINE REVIEWS OF THE 16TH EDITION OF DAVIS'S DRUG GUIDE FOR NURSES Five Stars. "I LOVE that this includes nursing interventions, patient teaching and an online access code. Highly recommend."-E.G. Accurate and up to date. "Top notch for nursing students! Includes many things other drug guides l

Genetic Diseases of the Eye

Author : Elias I. Traboulsi
Publisher : OUP USA
ISBN 13 : 0195326148
Total Pages : 940 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Genetic Diseases of the Eye by : Elias I. Traboulsi

Download or read book Genetic Diseases of the Eye written by Elias I. Traboulsi and published by OUP USA. This book was released on 2012-01-12 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book takes a clinical approach to the patient with a genetic disease that affects the eye. The chapters on particular types of diseases follow the same organizational format, covering history, pathogenesis and etiology, epidemiology, classification, clinical manifestations and diagnosis, and treatment. The recent progress achieved in the molecular genetics of eye disease is fully reflected throughout the book. It is written by leading experts in the field and provides clinical, molecular genetic and management information on common and rare diseases. The chapters are heavily illustrated and provide a good Atlas for the practicing ophthalmologist or geneticist.

CDC Yellow Book 2018: Health Information for International Travel

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
ISBN 13 : 0190628634
Total Pages : 705 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis CDC Yellow Book 2018: Health Information for International Travel by : Centers for Disease Control and Prevention CDC

Download or read book CDC Yellow Book 2018: Health Information for International Travel written by Centers for Disease Control and Prevention CDC and published by Oxford University Press. This book was released on 2017-04-17 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Pediatric Ophthalmology and Strabismus

Author : David Taylor
Publisher : Saunders Limited
ISBN 13 : 9780702027086
Total Pages : 1170 pages
Book Rating : 4.0/5 (27 download)

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Book Synopsis Pediatric Ophthalmology and Strabismus by : David Taylor

Download or read book Pediatric Ophthalmology and Strabismus written by David Taylor and published by Saunders Limited. This book was released on 2005 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a marvelous book, which provides comprehensive coverage of the field. I predict it will be the 'Gold Standard' text for this field for the foreseeable future." (Ocular Surgery News) This thoroughly revised New Edition is a uniquely comprehensive reference on pediatric ophthalmic conditions and strabismus. Leading international experts guide the reader from epidemiological conditions and developmental aspects through diagnostic and investigative guidelines, and from general principles of management to a detailed consideration of specific disease states. They present clinical conditions systematically- providing a 2-5-page analysis, guidelines as to the probable cause(s), and full references for further study. The BONUS CD-ROM allows users to incorporate all of the images from the text into their presentations! Is a unique one-stop source of information on all pediatric ophthalmic conditions. Includes a unique section on practical problems of actual clinical cases. Offers balanced views of etiology, diagnosis, and management. Provides over 850 high-quality illustrations (over 1,650 in full color) throughout the text. Emphasizes a holistic approach to patient management that considers the family and aids in compliance. Provides new chapters and an entirely new section on amblyopia and strabismus. Features the state-of-the-art in research and procedure with thorough updating throughout. Incorporates an all-new design and layout, and specially commissioned line artworks for greater consistency and easier access to information. Includes a CD-ROM which contains references from the book that are linked directly to PubMed, and nearly all of the book's images, easily downloadable for use in electronic presentations.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.