Hiv Vaccine Research And Development

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The Search for an AIDS Vaccine

Author : Christine Grady
Publisher : Indiana University Press
ISBN 13 : 9780253112729
Total Pages : 220 pages
Book Rating : 4.1/5 (127 download)

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Book Synopsis The Search for an AIDS Vaccine by : Christine Grady

Download or read book The Search for an AIDS Vaccine written by Christine Grady and published by Indiana University Press. This book was released on 1995-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book is a balanced and comprehensive treatment of an important social issue. It is accessible to the general reader and belongs in public as well as academic libraries." -- Religious Studies Review "Painstaking analysis of the knotty ethical problems involved in human-subjects research, and a well-thought-out proposal for a community approach to conducting field trials for an HIV vaccine.... Highly recommended for medical ethicists and anyone concerned about the AIDS epidemic and how HIV research is conducted."Â -- Kirkus Reviews "... a carefully reasoned account of how research for and trial of a preventive vaccine differ from the methods used to discover a therapy."Â -- Booklist "I highly recommend reading this book which I would attest to be a thrilling, ethically challenging, and informative descent into the allopathic solution." -- Ryan Hosken, Bastyr University Library Newsletter "As the scientific effort to produce an efficacious vaccine continues, [Grady's] work provides an ethical compass that will guide us well, regardless of where phase III HIV vaccine trials ultimately occur." -- Journal of the American Medical Association "Highly recommended... " -- AIDS Book Review Journal "A remarkable treatment of a most difficult and complex subject... Grady's book is of special merit because it is simple, readable, and understandable, while conveying in-depth perceptions that are critical to the reader. A useful and essential reference work for those who would engage in the initiative to bring about a resolution of a mighty human health problem." -- Maurice R. Hilleman, Ph.D., D.Sc., Director, Merck Institute for Therapeutic Research "Dr. Grady's important study captures the complexity of the search for an AIDS vaccine with startling clarity. Her insights into the full range of forces that shape our national response to AIDS vaccine development should read like signposts to vaccinologists, AIDS community activists, and most importantly, the Public Health Service. An impressive contribution." -- Derek Hodel, Gay Men's Health Crisis "This book is recommended to medical ethicists, those involved in non-HIV vaccine trials, and all persons involved in HIV vaccine trials, including investigators, sponsors, study subjects and communities at risk." -- Journal of Health Politics, Policy and Law The creation of a vaccine now seems the best hope for controlling AIDS. Yet developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Essential reading for everyone interested in ethics and the conduct of HIV vaccine research.

Adverse reactions to HIV vaccines : medical, ethical, and legal issues.

Author :
Publisher : DIANE Publishing
ISBN 13 : 142892003X
Total Pages : 201 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Adverse reactions to HIV vaccines : medical, ethical, and legal issues. by :

Download or read book Adverse reactions to HIV vaccines : medical, ethical, and legal issues. written by and published by DIANE Publishing. This book was released on 1995 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIDS researchers are investigating new vaccines that would prevent infection with HIV and reduce the spread of AIDS. Some have argued that product liability concerns have discouraged investment in HIV vaccine research and development. The purpose of this OTA background paper is to describe the current state of development of HIV vaccines, and to discuss what is known about adverse reactions that may occur. The background paper provides an overview of ethical issues that arise in the conduct of HIV vaccine trials. The report also discusses alternatives to the current product liability system to encourage the development of HIV vaccines and to fairly compensate those who are harmed as a result of adverse reactions to the vaccine. This background paper was prepared in response to a request from the Subcommittee on Health of the House Ways and Means Committee. It is eleventh in OTA's series of studies on HIV-related issues.

HIV Vaccine Handbook

Author : Bill Snow
Publisher :
ISBN 13 : 9780967801407
Total Pages : 316 pages
Book Rating : 4.8/5 (14 download)

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Book Synopsis HIV Vaccine Handbook by : Bill Snow

Download or read book HIV Vaccine Handbook written by Bill Snow and published by . This book was released on 1999 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

HIV Vaccine Research and Development

Author : International AIDS Vaccine Initiative (IAVI)
Publisher :
ISBN 13 : 9780977312696
Total Pages : pages
Book Rating : 4.3/5 (126 download)

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Book Synopsis HIV Vaccine Research and Development by : International AIDS Vaccine Initiative (IAVI)

Download or read book HIV Vaccine Research and Development written by International AIDS Vaccine Initiative (IAVI) and published by . This book was released on 2006-12-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

HIV Vaccines and Cure

Author : Linqi Zhang
Publisher : Springer
ISBN 13 : 981130484X
Total Pages : 326 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis HIV Vaccines and Cure by : Linqi Zhang

Download or read book HIV Vaccines and Cure written by Linqi Zhang and published by Springer. This book was released on 2018-07-20 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

The Search for an AIDS Vaccine

Author : Christine Grady
Publisher : Indiana University Press
ISBN 13 : 9780253112729
Total Pages : 220 pages
Book Rating : 4.1/5 (127 download)

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Book Synopsis The Search for an AIDS Vaccine by : Christine Grady

Adverse Reactions to HIV Vaccines

Author :
Publisher : Office of Technology Assessment
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Adverse Reactions to HIV Vaccines by :

Download or read book Adverse Reactions to HIV Vaccines written by and published by Office of Technology Assessment. This book was released on 1995 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hope for the Future : Developing an Hiv/aids Vaccine

Author :
Publisher : DIANE Publishing
ISBN 13 : 1422333000
Total Pages : 80 pages
Book Rating : 4.4/5 (223 download)

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Book Synopsis Hope for the Future : Developing an Hiv/aids Vaccine by :

Download or read book Hope for the Future : Developing an Hiv/aids Vaccine written by and published by DIANE Publishing. This book was released on with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Vaccines

Author : Kayvon Modjarrad
Publisher : Academic Press
ISBN 13 : 0128025425
Total Pages : 211 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Human Vaccines by : Kayvon Modjarrad

Download or read book Human Vaccines written by Kayvon Modjarrad and published by Academic Press. This book was released on 2016-10-15 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology. Introduces new topics in vaccine immunology in the context vaccine design and production Consolidates the growing body of knowledge on new vaccine technologies that have only emerged in the past 2 – 3 decades Reviews the currently licensed vaccines that have utilized leading-edge technologies and how this has translated into improved efficacy and safety Provides a broad overview of innovative vaccine technologies, including immunological aspects

Shots in the Dark

Author : Jon Cohen
Publisher : W. W. Norton & Company
ISBN 13 : 9780393322255
Total Pages : 468 pages
Book Rating : 4.3/5 (222 download)

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Book Synopsis Shots in the Dark by : Jon Cohen

Download or read book Shots in the Dark written by Jon Cohen and published by W. W. Norton & Company. This book was released on 2001 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1984 it was announced that an AIDS vaccine would be ready for testing in two years. More than 15 years later only one vaccine has made it to a field trial. This text explains the reasons for this slow progress.

Hope for the Future

Author : United States. Congress. Senate. Committee on Foreign Relations
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Hope for the Future by : United States. Congress. Senate. Committee on Foreign Relations

Download or read book Hope for the Future written by United States. Congress. Senate. Committee on Foreign Relations and published by . This book was released on 2006 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Resources for HIV Vaccine Research and Development

Author : National Institute of Allergy and Infectious Diseases (U.S.)
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (532 download)

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Book Synopsis Resources for HIV Vaccine Research and Development by : National Institute of Allergy and Infectious Diseases (U.S.)

Download or read book Resources for HIV Vaccine Research and Development written by National Institute of Allergy and Infectious Diseases (U.S.) and published by . This book was released on 2003 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Paradigm Changes Are Required in HIV Vaccine Research

Author : Marc H. V. Van Regenmortel
Publisher : Frontiers Media SA
ISBN 13 : 2889197271
Total Pages : 76 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Paradigm Changes Are Required in HIV Vaccine Research by : Marc H. V. Van Regenmortel

Download or read book Paradigm Changes Are Required in HIV Vaccine Research written by Marc H. V. Van Regenmortel and published by Frontiers Media SA. This book was released on 2015-12-08 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his 1962 book "The Structure of Scientific Revolutions", Thomas Kuhn famously argued that researchers in every field of scientific enquiry always operate under a set of presuppositions known as paradigms that are rarely explicitly stated. In the field of HIV vaccine research, several prevailing paradigms led scientists for many years to pursue unfruitful lines of investigations that impeded significant progress. The uncritical acceptance of reigning paradigms makes scientists reluctant to abandon their mistaken assumptions even when they obtain results that are not consistent with the paradigms. The following five paradigms which disregard the degeneracy of the immune system were particularly harmful. 1) There is a primary and intrinsic epitope specific for each B cell receptor and for the corresponding monoclonal antibody. In reality, there is no single, intrinsic or "real" epitope for any antibody but only a diverse group of potential ligands. 2) Reactions with monoclonal antibodies are more specific than the combined reactivity of polyclonal antibodies. In reality, a polyclonal antiserum has greater specificity for a multiepitopic protein because different antibodies in the antiserum recognize separate epitopes on the same protein, giving rise to an additive specificity effect. By focusing vaccine design on single epitope-Mab pairs, the beneficial neutralizing synergy that occurs with polyclonal antibody responses is overlooked. 3) The HIV epitope identified by solving the crystallographic structure of a broadly neutralizing Mab – HIV Env complex should be able, when used as immunogen, to elicit antibodies endowed with the same neutralizing capacity as the Mab. Since every anti HIV bnMab is polyspecific, the single epitope identified in the complex is not necessarily the one that elicited the bnMab. Since hypermutated Mabs used in crystallographic studies differ from their germline-like receptor version present before somatic hypermutation, the identified epitope will not be an effective vaccine immunogen. 4) Effective vaccine immunogenicity can be predicted from the antigenic binding capacity of viral epitopes. Most fragments of a viral antigen can induce antibodies that react with the immunogen, but this is irrelevant for vaccination since these antibodies rarely recognize the cognate, intact antigen and even more rarely neutralize the infectivity of the viral pathogen that harbors the antigen. 5) The rational design of vaccine immunogens using reverse vaccinology is superior to the trial-and-error screening of vaccine candidates able to induce protective immunity. One epitope can be designed to increase its structural complementarity to one particular bnMab, but such antigen design is only masquerading as immunogen design because it is assumed that antigenic reactivity necessarily entails the immunogenic capacity to elicit neutralizing antibodies. When HIV Env epitopes, engineered to react with a bnMab are used to select from human donors rare memory B cells secreting bnAbs, this represents antigen design and not immunogen design. The aim of this Research Topic is to replace previous misleading paradigms by novel ones that better fit our current understanding of immunological specificity and will help HIV vaccine development.

Vaccine Research and Development

Author : Koff
Publisher : CRC Press
ISBN 13 : 9780824786199
Total Pages : 268 pages
Book Rating : 4.7/5 (861 download)

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Book Synopsis Vaccine Research and Development by : Koff

Download or read book Vaccine Research and Development written by Koff and published by CRC Press. This book was released on 1992-01-22 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serving as a complementary series to AIDS Research Reviews - edited by Drs. Wayne C. Koff, Flossie Wong-Staal, and Ronald C. Kennedy (Marcel Dekker, Inc.) - this new series reviews significant advances in immunization research and addresses scientific and public policy challenges for moving candidate vaccines from the laboratory to the population.;Exploring recent progress in immunology, vaccine development and improvement, and clinical trials, Vaccine Research and Developments: analyzes the capacity of lipophilic components to chemically modify peptide and protein antigens and augment their immunogenicity; discusses the potential of noninfectious packaging mutants to serve as prototype vaccines; provides a novel presentation system for peptide vaccines through the multiple antigen peptide approach; examines the current status and future prospects for contraceptive vaccines and offers perspectives for improving pertussis vaccines; furnishes a comprehensive update of vaccine clinical trials; and describes the legal policy aspects involved in developing HIV vaccines.;Containing over 915 useful references, Vaccine Research and Developments is for immunologists, microbiologists and virologists, molecular and cell biologists, infectious disease specialists, pharmacologists, government and industry drug regulatory personnel, and graduate level students in these disciplines.

Ethical Considerations in HIV Preventive Vaccine Research

Author :
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.:/5 (8 download)

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Book Synopsis Ethical Considerations in HIV Preventive Vaccine Research by :

Download or read book Ethical Considerations in HIV Preventive Vaccine Research written by and published by . This book was released on 2000 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document highlights, from UNAID'S perspective, some of the critical elements that must be considered in HIV vaccine development activities.

The Use of Incentives to Accelerate HIV Vaccine Research & Development

Author : Jennifer Faith Baron
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (613 download)

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Book Synopsis The Use of Incentives to Accelerate HIV Vaccine Research & Development by : Jennifer Faith Baron

Download or read book The Use of Incentives to Accelerate HIV Vaccine Research & Development written by Jennifer Faith Baron and published by . This book was released on 2005 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

R&D Models

Author : Paul Wilson
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis R&D Models by : Paul Wilson

Download or read book R&D Models written by Paul Wilson and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A preventive HIV vaccine offers the best hope for ending the AIDS pandemic. Scientific evidence suggests that an HIV vaccine is possible, and funding for HIV vaccine research and development (R&D) has increased substantially in recent years. The speed of progress toward an HIV vaccine will depend on the management of the effort as well as on its scale, however, and organizational issues have been the subject of vigorous debate. With this paper, we seek to shed light on these debates by examining the history of vaccine development, as well as some examples of large R&D initiatives in other areas. We focus on two issues: the roles of the public and private sectors, and the merits and risks of strong central direction of R&D. We also consider the scientific, regulatory, and institutional changes that complicate extrapolation from past experience to the case of HIV vaccines. Our analysis draws on extensive interviews with experts in the field as well as a literature review.