Histone Mutations And Cancer

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Histone Mutations and Cancer

Author : Dong Fang
Publisher : Springer Nature
ISBN 13 : 9811581045
Total Pages : 102 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Histone Mutations and Cancer by : Dong Fang

Download or read book Histone Mutations and Cancer written by Dong Fang and published by Springer Nature. This book was released on 2020-11-06 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

Introduction to Epigenetics

Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Introduction to Epigenetics by : Renato Paro

Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

The Histone Code and Beyond

Author : Shelley L. Berger
Publisher : Springer Science & Business Media
ISBN 13 : 354037633X
Total Pages : 223 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis The Histone Code and Beyond by : Shelley L. Berger

Download or read book The Histone Code and Beyond written by Shelley L. Berger and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

DNA and Histone Methylation as Cancer Targets

Author : Atsushi Kaneda
Publisher : Springer
ISBN 13 : 3319597868
Total Pages : 624 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis DNA and Histone Methylation as Cancer Targets by : Atsushi Kaneda

Download or read book DNA and Histone Methylation as Cancer Targets written by Atsushi Kaneda and published by Springer. This book was released on 2017-09-04 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Clinical Epigenetics

Author : Luke B. Hesson
Publisher : Springer Nature
ISBN 13 : 9811389586
Total Pages : 265 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Clinical Epigenetics by : Luke B. Hesson

Download or read book Clinical Epigenetics written by Luke B. Hesson and published by Springer Nature. This book was released on 2019-08-31 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Epigenetics and Cancer

Author :
Publisher : Academic Press
ISBN 13 : 9780123808653
Total Pages : 314 pages
Book Rating : 4.8/5 (86 download)

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Book Synopsis Epigenetics and Cancer by :

Download or read book Epigenetics and Cancer written by and published by Academic Press. This book was released on 2010-11-23 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Histone Modifications in Therapy

Author : Pedro Castelo-Branco
Publisher : Academic Press
ISBN 13 : 0128167408
Total Pages : 492 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Histone Modifications in Therapy by : Pedro Castelo-Branco

Download or read book Histone Modifications in Therapy written by Pedro Castelo-Branco and published by Academic Press. This book was released on 2020-08-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists

Cancer Epigenetics

Author : Trygve Tollefsbol
Publisher : CRC Press
ISBN 13 : 1420045806
Total Pages : 472 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cancer Epigenetics by : Trygve Tollefsbol

Download or read book Cancer Epigenetics written by Trygve Tollefsbol and published by CRC Press. This book was released on 2008-09-19 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de

Cancer Genomics for the Clinician

Author : Ramaswamy Govindan, MD
Publisher : Springer Publishing Company
ISBN 13 : 082616868X
Total Pages : 184 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Cancer Genomics for the Clinician by : Ramaswamy Govindan, MD

Download or read book Cancer Genomics for the Clinician written by Ramaswamy Govindan, MD and published by Springer Publishing Company. This book was released on 2019-01-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook

Human Skin Cancers

Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
ISBN 13 : 1789230942
Total Pages : 214 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Human Skin Cancers by : Miroslav Blumenberg

Download or read book Human Skin Cancers written by Miroslav Blumenberg and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

Systems Analysis of Chromatin-Related Protein Complexes in Cancer

Author : Andrew Emili
Publisher : Springer Science & Business Media
ISBN 13 : 1461479312
Total Pages : 320 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Systems Analysis of Chromatin-Related Protein Complexes in Cancer by : Andrew Emili

Download or read book Systems Analysis of Chromatin-Related Protein Complexes in Cancer written by Andrew Emili and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Epigenetic Regulation in Overcoming Chemoresistance

Author : Chunfu Wu
Publisher : Academic Press
ISBN 13 : 012823685X
Total Pages : 146 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epigenetic Regulation in Overcoming Chemoresistance by : Chunfu Wu

Download or read book Epigenetic Regulation in Overcoming Chemoresistance written by Chunfu Wu and published by Academic Press. This book was released on 2021-06-26 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consult Encompasses multiple clinical trial summary diagrams to help readers quickly and clearly get information from clinical trials Provides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance

Chromatin and Genomic Instability in Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0323855628
Total Pages : 286 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Chromatin and Genomic Instability in Cancer by :

Download or read book Chromatin and Genomic Instability in Cancer written by and published by Academic Press. This book was released on 2021-09-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects

Epigenetic Advancements in Cancer

Author : Manoj K. Mishra
Publisher : Springer
ISBN 13 : 3319249517
Total Pages : 246 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Epigenetic Advancements in Cancer by : Manoj K. Mishra

Download or read book Epigenetic Advancements in Cancer written by Manoj K. Mishra and published by Springer. This book was released on 2016-05-04 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.

Epigenetics Territory and Cancer

Author : Parvin Mehdipour
Publisher : Springer
ISBN 13 : 9401796394
Total Pages : 539 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Epigenetics Territory and Cancer by : Parvin Mehdipour

Download or read book Epigenetics Territory and Cancer written by Parvin Mehdipour and published by Springer. This book was released on 2015-03-18 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Epigenetics in Cancer

Author : Wiley
Publisher : John Wiley & Sons
ISBN 13 : 1118734394
Total Pages : 240 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Epigenetics in Cancer by : Wiley

Download or read book Epigenetics in Cancer written by Wiley and published by John Wiley & Sons. This book was released on 2013-07-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins. Aberrant DNA methylation is also frequently associated with human aging and diseases, such as cancer. This collection of overviews and laboratory protocols provides crucial, distilled information about the roles of epigenetics in cancer development. The overviews are geared for research scientists who need to learn more about the current understanding of epigenetic variation in humans and how the processes of DNA methylation and histone modification are regulated. The protocols give step-by-step instructions on how to detect DNA methylation using various methods such as MAPit, CHARM (arrays) and methylation-specific PCR. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the fields of genetics, genomics, and oncogenesis for students or interdisciplinary collaborators.