Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Histone Deacetylase Inhibitors Hdis
Download Histone Deacetylase Inhibitors Hdis full books in PDF, epub, and Kindle. Read online Histone Deacetylase Inhibitors Hdis ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Histone Deacetylase Inhibitors (HDIs) by : Beverly D. Carson
Download or read book Histone Deacetylase Inhibitors (HDIs) written by Beverly D. Carson and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Book Synopsis Histone Deacetylase Inhibitors (HDIs) by : Beverly D. Carson
Download or read book Histone Deacetylase Inhibitors (HDIs) written by Beverly D. Carson and published by Nova Science Publishers. This book was released on 2015-05-07 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyze the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Book Synopsis Effect of Chromatin Modeling by Histone Deacetylase Inhibitors (HDIs) on Hematopoietic Stem Cell (HSC) Fate by : Dilruba Hilal Gül
Download or read book Effect of Chromatin Modeling by Histone Deacetylase Inhibitors (HDIs) on Hematopoietic Stem Cell (HSC) Fate written by Dilruba Hilal Gül and published by . This book was released on 2005 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Immunotherapy by : Eva Sahakian
Download or read book Cancer Immunotherapy written by Eva Sahakian and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histone deacetylase inhibitors (HDI) have been largely known for their ability to induce cell cycle arrest and apoptosis of tumor cells, effects that have translated into clinically significant antitumor activity against certain malignancies. In addition, there is now increasing evidence that HDIs are also endowed with immunoregulatory properties. Interestingly, while some reports have highlighted the anti-inflammatory effects of these compounds, others have shown pro-inflammatory effects triggered by HDIs in in vitro and in vivo studies. Known targets for HDIs are histone deacetylases (HDACs), enzymes that are recruited to gene promoters where they regulate transcription through histone modifications. Some HDACs, however, can also deacetylate nonhistone proteins, indicating that the role of HDACs in cell biology goes beyond their initial described effects on histones and encompasses now more complex regulatory functions. This complexity, along with the fact that most of the HDI currently in use are pan-HDI (multiple HDAC targets), might explain the divergent immunoregulatory effects of these compounds. Given this conundrum, in this chapter we have summarized the current understanding of the expression/function of specific HDACs in immune cells, knowledge that is providing important insights into their role in immunobiology and also paving the way for the development of more selective and potentially less toxic epigenetic-based approaches to effectively harness antitumor immune responses.
Book Synopsis Histone Deacetylases by : Eric Verdin
Download or read book Histone Deacetylases written by Eric Verdin and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
Book Synopsis Adverse Outcome Pathway on Histone Deacetylase Inhibition Leading to Testicular Atrophy by : Shihori Tanabe
Download or read book Adverse Outcome Pathway on Histone Deacetylase Inhibition Leading to Testicular Atrophy written by Shihori Tanabe and published by . This book was released on 2021 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are suggested as histone deacetylase (HDAC) inhibition as MIE, histone acetylation increase, disrupted cell cycle, apoptosis, and spermatocyte depletion as KEs. The adverse outcome has been defined as testicular atrophy. The HDIs inhibit deacetylation of the histone, leading to an increase in histone acetylation. The apoptosis induced by disrupted cell cycle leads to spermatocyte depletion and testis atrophy. Testicular toxicity is of interest for human health risk assessment especially in terms of reproductive and developmental toxicity, however, the testicular toxicity has not been fully elucidated. This AOP may be one of the pathways induced by HDIs, which suggests the pathway networks of protein hyperacetylations.
Book Synopsis Elucidating the Mechanism of Action of Selective Histone Deacetylase Inhibitors in Cancer by : Christina Elizabeth Wells
Download or read book Elucidating the Mechanism of Action of Selective Histone Deacetylase Inhibitors in Cancer written by Christina Elizabeth Wells and published by . This book was released on 2013 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders by : Shabir Ahmad Ganai
Download or read book Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders written by Shabir Ahmad Ganai and published by Springer. This book was released on 2019-07-02 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.
Book Synopsis Histone Deacetylases: the Biology and Clinical Implication by : Tso-Pang Yao
Download or read book Histone Deacetylases: the Biology and Clinical Implication written by Tso-Pang Yao and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Book Synopsis Histone Deacetylase Inhibitors - Epidrugs for Neurological Disorders by : Shabir Ahmad Ganai
Download or read book Histone Deacetylase Inhibitors - Epidrugs for Neurological Disorders written by Shabir Ahmad Ganai and published by . This book was released on 2019 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors' therapeutic efficacy against various neurological complications.
Book Synopsis HDAC/HAT Function Assessment and Inhibitor Development by : Oliver H. Krämer
Download or read book HDAC/HAT Function Assessment and Inhibitor Development written by Oliver H. Krämer and published by Springer Nature. This book was released on 2022-10-18 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors explore the generation and evaluation of novel histone deacetylase inhibitors and new and improved techniques to assess acetylation-dependent molecular mechanisms in vitro and in vivo. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to further elucidate this vital area of study.
Book Synopsis Histone Deacetylases by : Sibaji Sarkar
Download or read book Histone Deacetylases written by Sibaji Sarkar and published by Humana. This book was released on 2016-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides different methodologies for all classes of histone deacetylases, which includes detailed procedures on Class I and II histone deacetylase inhibitors, SIRT inhibitors, and bromodomain inhibitors. Histone Deacetylases: Methods and Protocols is divided into four sections: Sections A and B describe methodologies used to detect the activity, function, or chromatin location of HDACs 1 through 11, with Section A discussing Class I and Section B discussing class II histone deacetylases; Section C focuses on the methodologies for cloning and characterizing the acetylation of SIRTs 1 through 7; and Section D describes methods related to histone deacetylase inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Histone Deacetylases: Methods and Protocols, is a valuable resource for investigators working on epigenetics, molecular biology, and genetics.
Book Synopsis Histone Deacetylase Inhibitors Induce Reactive Oxygen Species and DNA Damage, and Display Enhanced Activity in DNA Repair Deficient Acute Myeloid Leukemia Expressing Leukemia Associated Fusion Proteins by : Luca Petruccelli
Download or read book Histone Deacetylase Inhibitors Induce Reactive Oxygen Species and DNA Damage, and Display Enhanced Activity in DNA Repair Deficient Acute Myeloid Leukemia Expressing Leukemia Associated Fusion Proteins written by Luca Petruccelli and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Histone deacetylase inhibitors (HDI) have shown promising antitumor activity in preclinical and clinical studies for a broad range of hematological and solid malignancies. Nonetheless, the percentage of patients in any given malignancy who experience a meaningful clinical response remains small. While initial studies with HDIs focused on utilizing these agents to re-sensitize leukemic cells to differentiating stimuli, recent studies have shown HDIs to display significant cytotoxic activity in malignant cells by a number of different mechanisms. One proposed mechanism is the accumulation of DNA damage after HDI treatment, resulting in apoptosis.
Book Synopsis Regulation of Osteoblast Differentiation by Histone Deacetylases by : Tania Marie Schroeder
Download or read book Regulation of Osteoblast Differentiation by Histone Deacetylases written by Tania Marie Schroeder and published by . This book was released on 2005 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Combination of Histone Deacetylase Inhibitors and Oncolytic Viruses for the Treatment of High-grade Gliomas by : Zafir Syed
Download or read book The Combination of Histone Deacetylase Inhibitors and Oncolytic Viruses for the Treatment of High-grade Gliomas written by Zafir Syed and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigating the Role of Histone Deacetylase Inhibitors in Enhancing the Anti-tumor Activity of Oncolytic Vesicular Stomatitis Virus by : Hesham Abdelbary
Download or read book Investigating the Role of Histone Deacetylase Inhibitors in Enhancing the Anti-tumor Activity of Oncolytic Vesicular Stomatitis Virus written by Hesham Abdelbary and published by . This book was released on 2008 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Elucidation of the Mechanisms of Resistance and Sensitivity to Histone Deacetylase Inhibitor, PXD101, in Diffuse Large B-Cell Lymphoma (DLBCL). by : Ana A. Tula Sanchez
Download or read book Elucidation of the Mechanisms of Resistance and Sensitivity to Histone Deacetylase Inhibitor, PXD101, in Diffuse Large B-Cell Lymphoma (DLBCL). written by Ana A. Tula Sanchez and published by . This book was released on 2013 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although curable in the majority of cases, Diffuse Large B-cell Lymphoma (DLBCL), the most prevalent Non-Hodgkin Lymphoma (NHL) throughout the world, is still fatal for 30-40% patients. This patient population could benefit from the addition of new drugs to the current DLBCL chemotherapy regimen. Histone deacetylase inhibitors (HDIs) are a promising group of drugs for the treatment of hematological malignancies. In the current study we tested the HDI PXD101 in a panel of the two most common DLBCL subtypes, GCB (germinal center) and ABC (activated B-cell like), ABC being the least curable subtype. Cell viability assays showed that PXD101 induces antiproliferative effects at submicromolar concentrations in DLBCL cell lines regardless of DLBCL subtype. Flow cytometry demonstrated that upon PXD101 treatment two GCB cell lines (DB and OCILY19) undergo G2M cell cycle arrest followed by apoptosis, while two GCB (SUDHL4 and SUDHL8) and one ABC (U2932) cell line undergo G1 arrest with little apoptosis. Further experiments demonstrated that upon PXD101 removal G1-arresting cells recover their normal proliferative state, while in G2M-arresting cells only 8h exposure to PXD101 is sufficient to induce considerable apoptosis. We classified as PXD101-resistant cell lines that re-enter the cell cycle after drug removal, and PXD101-sensitive cell lines that commit to apoptosis after short periods of drug exposure. Kinase assays established that upon PXD101 treatment G1 phase cyclin dependent kinase 2 (CDK2)-cyclin E complex activity significantly decreases in resistant but not in sensitive cells lines. Furthermore, pull-down assays revealed that CDK inhibitors (CDKIs) p21 and/or p27 in resistant, but not sensitive cell lines persistently bind the CDK2-cyclin E complex throughout PXD101 treatment, thereby explaining why resistant lines stop at the G1 phase. CDKIs induction by PXD101 was p53-independent. This is the first time that an in vitro model of sensitivity and resistance to HDIs in DLBCL is established. We have also performed preliminary genomic and proteomic analysis in DLBCL cell lines treated with PXD101. We anticipate that further analysis of the genomic response and the functional impact of protein acetylation induced by HDIs will offer additional insight into mechanisms of sensitivity and resistance to HDIs in DLBCL.
