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Heterogeneity
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Book Synopsis Heterogeneity in Statistical Genetics by : Derek Gordon
Download or read book Heterogeneity in Statistical Genetics written by Derek Gordon and published by Springer Nature. This book was released on 2020-12-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :204 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Book Synopsis Ecological Heterogeneity by : Jurek Kolasa
Download or read book Ecological Heterogeneity written by Jurek Kolasa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: An attractive, promising, and frustrating feature of ecology is its complex ity, both conceptual and observational. Increasing acknowledgment of the importance of scale testifies to the shifting focus in large areas of ecology. In the rush to explore problems of scale, another general aspect of ecolog ical systems has been given less attention. This aspect, equally important, is heterogeneity. Its importance lies in the ubiquity of heterogeneity as a feature of ecological systems and in the number of questions it raises questions to which answers are not readily available. What is heterogeneity? Does it differ from complexity? What dimensions need be considered to evaluate heterogeneity ade quately? Can heterogeneity be measured at various scales? Is heterogeneity apart of organization of ecological systems? How does it change in time and space? What are the causes of heterogeneity and causes of its change? This volume attempts to answer these questions. It is devoted to iden tification of the meaning, range of applications, problems, and methodol ogy associated with the study of heterogeneity. The coverage is thus broad and rich, and the contributing authors have been encouraged to range widely in discussions and reflections. vi Preface The chapters are grouped into themes. The first group focuses on the conceptual foundations (Chapters 1-5). These papers exarnine the meaning of the term, historical developments, and relations to scale. The second theme is modeling population and interspecific interactions in hetero geneous environments (Chapters 6 and 7).
Book Synopsis Exploitation of Environmental Heterogeneity by Plants by :
Download or read book Exploitation of Environmental Heterogeneity by Plants written by and published by Academic Press. This book was released on 2012-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a new emerging interest in the effects of gaps and patches on succession and biodiversity. This innovative volume is a synthesis of studies of plant responses to temporal and spatial heterogeneity, the exploitation of resources from pulses and patches by plants, and their competition with neighbors in the face of this variability. Aboveground, the book focuses upon the nature of canopy patchiness, consequences of this heterogeneity for the light environment, and the mechanisms by which plants respond to and exploit this patchiness. Belowground, the text explores the heterogeneity of soil environments and how root systems obtain nutrients and water in the context of this temporal and spatial variability. As a new reference in an evolving and growing field, this text is sure to be a valuable tool for researchers and advanced students in plant physiology, ecology, agronomy, and forestry alike.
Author :U. S. Department of Health and Human Services Publisher :Createspace Independent Pub ISBN 13 :9781484997062 Total Pages :226 pages Book Rating :4.9/5 (97 download)
Book Synopsis Comparative Effectiveness Review Methods by : U. S. Department of Health and Human Services
Download or read book Comparative Effectiveness Review Methods written by U. S. Department of Health and Human Services and published by Createspace Independent Pub. This book was released on 2013-05-17 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Agency for Healthcare Research and Quality (AHRQ) commissioned the RTI International–University of North Carolina at Chapel Hill (RTI-UNC) Evidence-based Practice Center (EPC) to explore how systematic review groups have dealt with clinical heterogeneity and to seek out best practices for addressing clinical heterogeneity in systematic reviews (SRs) and comparative effectiveness reviews (CERs). Such best practices, to the extent they exist, may enable AHRQ's EPCs to address critiques from patients, clinicians, policymakers, and other proponents of health care about the extent to which “average” estimates of the benefits and harms of health care interventions apply to individual patients or to small groups of patients sharing similar characteristics. Such users of reviews often assert that EPC reviews typically focus on broad populations and, as a result, often lack information relevant to patient subgroups that are of particular concern to them. More important, even when EPCs evaluate literature on homogeneous groups, there may be varying individual treatment for no apparent reason, indicating that average treatment effect does not point to the best treatment for any given individual. Thus, the health care community is looking for better ways to develop information that may foster better medical care at a “personal” or “individual” level. To address our charge for this methods project, the EPC set out to answer six key questions (KQ). Key questions for methods report on clinical heterogeneity include: 1. What is clinical heterogeneity? a. How has it been defined by various groups? b. How is it distinct from statistical heterogeneity? c. How does it fit with other issues that have been addressed by the AHRQ Methods Manual for CERs? 2. How have systematic reviews dealt with clinical heterogeneity in the key questions? a. What questions have been asked? b. How have they pre-identified population subgroups with common clinical characteristics that modify their intervention-outcome association? c. What are best practices in key questions and how these subgroups have been identified? 3. How have systematic reviews dealt with clinical heterogeneity in the review process? a. What do guidance documents of various systematic review groups recommend? b. How have EPCs handled clinical heterogeneity in their reviews? c. What are best practices in searching for and interpreting results for particular subgroups with common clinical characteristics that may modify their intervention-outcome association? 4. What are critiques in how systematic reviews handle clinical heterogeneity? a. What are critiques from specific reviews (peer and public) on how EPCs handled clinical heterogeneity? b. What general critiques (in the literature) have been made against how systematic reviews handle clinical heterogeneity? 5. What evidence is there to support how to best address clinical heterogeneity in a systematic review? 6. What questions should an EPC work group on clinical heterogeneity address? Heterogeneity (of any type) in EPC reviews is important because its appearance suggests that included studies differed on one or more dimensions such as patient demographics, study designs, coexisting conditions, or other factors. EPCs then need to clarify for clinical and other audiences, collectively referred to as stakeholders, what are the potential causes of the heterogeneity in their results. This will allow the stakeholders to understand whether and to what degree they can apply this information to their own patients or constituents. Of greatest importance for this project was clinical heterogeneity, which we define as the variation in study population characteristics, coexisting conditions, cointerventions, and outcomes evaluated across studies included in an SR or CER that may influence or modify the magnitude of the intervention measure of effect (e.g., odds ratio, risk ratio, risk difference).
Book Synopsis Ecosystem Function in Heterogeneous Landscapes by : Gary M. Lovett
Download or read book Ecosystem Function in Heterogeneous Landscapes written by Gary M. Lovett and published by Springer Science & Business Media. This book was released on 2005-12-15 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking work connects the knowledge of system function developed in ecosystem ecology with landscape ecology's knowledge of spatial structure. The book elucidates the challenges faced by ecosystem scientists working in spatially heterogeneous systems, relevant conceptual approaches used in other disciplines and in different ecosystem types, and the importance of spatial heterogeneity in conservation resource management.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer Nature. This book was released on 2021-05-20 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.
Book Synopsis Heterogeneity in Word-formation Patterns by : Susanne Muehleisen
Download or read book Heterogeneity in Word-formation Patterns written by Susanne Muehleisen and published by John Benjamins Publishing. This book was released on 2010 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Postulated word-formation rules often exclude formations that can nevertheless be found in actual usage. This book presents an in-depth investigation of a highly heterogeneous word-formation pattern in English: the formation of nouns by suffixation with "-ee." Rather than relying on a single semantic or syntactic framework for analysis, the study combines diachronic, cognitive and language-contact perspectives in order to explain the diversity in the formation and establishment of "-ee" words. It also seeks to challenge previous measurements of productivity and proposes a new way to investigate the relationship between actual and possible words. By making use of the largest and most up-to-date electronic corpus the World Wide Web as a data source, this research adds substantially to the number of attested "-ee" words. It furthermore analyses this word-formation pattern in different varieties of English (British vs. American English; Australian English). Due to the multiplicity of approaches and analyses it offers, the study is suitable for courses in English word-formation, lexicology, corpus linguistics and historical linguistics."
Book Synopsis Landscape Heterogeneity and Disturbance by : Monica G. Turner
Download or read book Landscape Heterogeneity and Disturbance written by Monica G. Turner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Landscape pattern is generated by a variety of processes, including disturbances. In turn, the heterogeneity of the landscape may enhance or retard the spread of disturbance. The complex relationship between landscape pattern and disturbance is the subject of this book. It is designed to present an illustrative analysis of the topic, presenting the perspectives of several different disciplines. The book includes conceptual considerations, empirical studies, and management examples. Important features include: hypotheses about the spread of disturbance and the effects of scale changes in landscape studies; the multidisciplinary approach; and the explicit focus on the landscape level. The intended audience comprises graduate students, academics, and professionals interested in landscape ecology. The reader will receive a state-of-the-art treatment of a current topic in landscape ecology.
Book Synopsis Studies in Labor Markets by : Sherwin Rosen
Download or read book Studies in Labor Markets written by Sherwin Rosen and published by University of Chicago Press. This book was released on 2007-12-01 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume present an excellent sampling of the best of current research in labor economics, combining the most sophisticated theory and econometric methods with high-quality data on a variety of problems. Originally presented at a Universities-National Bureau Committee for Economic Research conference on labor markets in 1978, and not published elsewhere, the thirteen papers treat four interrelated themes: labor mobility, job turnover, and life-cycle dynamics; the analysis of unemployment compensation and employment policy; labor market discrimination; and labor market information and investment. The Introduction by Sherwin Rosen provides a thoughtful guide to the contents of the papers and offers suggestions for continuing research.
Book Synopsis Heterogeneity of Function in Numerical Cognition by : Avishai Henik
Download or read book Heterogeneity of Function in Numerical Cognition written by Avishai Henik and published by Academic Press. This book was released on 2018-05-17 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterogeneity of Function in Numerical Cognition presents the latest updates on ongoing research and discussions regarding numerical cognition. With great individual differences in the development or function of numerical cognition at neuroanatomical, neuropsychological, behavioral, and interactional levels, these issues are important for the achievement of a comprehensive understanding of numerical cognition, hence its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills. These functions are essential for the proper development of numerical cognition. Provides an innovative reference on the emerging field of numerical cognition and the branches that converge on this diverse cognitive domain Includes an overview of the multiple disciplines that comprise numerical cognition Focuses on factors that influence numerical cognition, such as language, executive attention, memory and spatial processing Features an innovative organization with each section providing a general overview, developmental research, and evidence from neurocognitive studies
Book Synopsis Inequality and Heterogeneity by : Peter M. Blau
Download or read book Inequality and Heterogeneity written by Peter M. Blau and published by . This book was released on 1977 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contextual Heterogeneity in Entrepreneurship Research by : Laveren, Eddy
Download or read book Contextual Heterogeneity in Entrepreneurship Research written by Laveren, Eddy and published by Edward Elgar Publishing. This book was released on 2021-09-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful book explores the importance and influence of contextual heterogeneity in the field of entrepreneurship research, illuminating the circumstances, conditions or environments that may enable or constrain entrepreneurship.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :030931710X Total Pages :182 pages Book Rating :4.3/5 (93 download)
Book Synopsis The Growing Gap in Life Expectancy by Income by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Growing Gap in Life Expectancy by Income written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-09-17 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. population is aging. Social Security projections suggest that between 2013 and 2050, the population aged 65 and over will almost double, from 45 million to 86 million. One key driver of population aging is ongoing increases in life expectancy. Average U.S. life expectancy was 67 years for males and 73 years for females five decades ago; the averages are now 76 and 81, respectively. It has long been the case that better-educated, higher-income people enjoy longer life expectancies than less-educated, lower-income people. The causes include early life conditions, behavioral factors (such as nutrition, exercise, and smoking behaviors), stress, and access to health care services, all of which can vary across education and income. Our major entitlement programs - Medicare, Medicaid, Social Security, and Supplemental Security Income - have come to deliver disproportionately larger lifetime benefits to higher-income people because, on average, they are increasingly collecting those benefits over more years than others. This report studies the impact the growing gap in life expectancy has on the present value of lifetime benefits that people with higher or lower earnings will receive from major entitlement programs. The analysis presented in The Growing Gap in Life Expectancy by Income goes beyond an examination of the existing literature by providing the first comprehensive estimates of how lifetime benefits are affected by the changing distribution of life expectancy. The report also explores, from a lifetime benefit perspective, how the growing gap in longevity affects traditional policy analyses of reforms to the nation's leading entitlement programs. This in-depth analysis of the economic impacts of the longevity gap will inform debate and assist decision makers, economists, and researchers.
Book Synopsis Accounting for Agent Heterogeneity in Market and Policy Analysis by : Konstantinos Giannakas
Download or read book Accounting for Agent Heterogeneity in Market and Policy Analysis written by Konstantinos Giannakas and published by Lulu.com. This book was released on 2018-12-19 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a multi-market framework of market and policy analysis that explicitly accounts for the empirically relevant heterogeneity in consumer preferences and producer characteristics. The explicit consideration of consumer and producer heterogeneity represents a significant departure from the representative consumer and producer that have been at the center of most of the literature on market and policy analysis, and enables the distributional impacts of changes in market conditions and policies to be fully identified. The framework is used to analyze the system-wide market and welfare impacts of a number of changes in market conditions (like changes in consumer preferences, costs and market structure) and policies (like subsidies and taxes) on one of the products in the system. Consistent with a priori expectations, the use of the framework unveils impacts masked by the conventional market and policy analysis.
Book Synopsis Subjects, Citizens, and Others by : Benno Gammerl
Download or read book Subjects, Citizens, and Others written by Benno Gammerl and published by Berghahn Books. This book was released on 2017-11-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bosnian Muslims, East African Masai, Czech-speaking Austrians, North American indigenous peoples, and Jewish immigrants from across Europe—the nineteenth-century British and Habsburg Empires were characterized by incredible cultural and racial-ethnic diversity. Notwithstanding their many differences, both empires faced similar administrative questions as a result: Who was excluded or admitted? What advantages were granted to which groups? And how could diversity be reconciled with demands for national autonomy and democratic participation? In this pioneering study, Benno Gammerl compares Habsburg and British approaches to governing their diverse populations, analyzing imperial formations to reveal the legal and political conditions that fostered heterogeneity.
Book Synopsis The Ecological Consequences of Environmental Heterogeneity by : British Ecological Society. Symposium
Download or read book The Ecological Consequences of Environmental Heterogeneity written by British Ecological Society. Symposium and published by Cambridge University Press. This book was released on 2000-08 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide-ranging review of the effects of heterogeneity on individuals, populations, communities and biodiversity.
