Heparin A Century Of Progress

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Heparin - A Century of Progress

Author : Rebecca Lever
Publisher : Springer Science & Business Media
ISBN 13 : 3642230563
Total Pages : 457 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Heparin - A Century of Progress by : Rebecca Lever

Download or read book Heparin - A Century of Progress written by Rebecca Lever and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

Heparin - A Century of Progress

Author : Rebecca Lever
Publisher : Springer
ISBN 13 : 9783642230578
Total Pages : 462 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Heparin - A Century of Progress by : Rebecca Lever

Download or read book Heparin - A Century of Progress written by Rebecca Lever and published by Springer. This book was released on 2012-05-16 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

The Heparins

Author : David Green
Publisher : Academic Press
ISBN 13 : 0128190698
Total Pages : 214 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Heparins by : David Green

Download or read book The Heparins written by David Green and published by Academic Press. This book was released on 2020-01-13 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Heparins: Properties and Clinical Applications brings the latest information on heparin, one of the world's most widely used drugs. The book describes the fascinating history of the discovery of this biological agent, how it was isolated and characterized, and its use for the treatment of thrombotic disorders. The structures of various heparins are illustrated, with their function as anticoagulants delineated. This comprehensive resource arms researchers and clinicians with a concise and practical source that will assist in biomedical research, medical practice, and in improving patient outcomes. Describes new pharmaceuticals derived from heparin that are devoid of anticoagulant activity, but still retain anti-inflammatory and anti-proliferative properties Discusses the development of non-anticoagulant heparins for the treatment of diseases, including asthma and cancer Presents the history of the discovery of this biological agent, how it was isolated and characterized, and its use for the treatment of thrombotic disorders

Green Sustainable Process for Chemical and Environmental Engineering and Science

Author : Dr. Inamuddin
Publisher : Elsevier
ISBN 13 : 0323951848
Total Pages : 516 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Green Sustainable Process for Chemical and Environmental Engineering and Science by : Dr. Inamuddin

Download or read book Green Sustainable Process for Chemical and Environmental Engineering and Science written by Dr. Inamuddin and published by Elsevier. This book was released on 2023-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Sustainable Process for Chemical and Environmental Engineering and Science: Natural Materials-Based Green Composites 2: Biomass deals with using biomass in the preparation of green composites and focuses on biomass from agro-industrial waste, geopolymers, natural gums, plants, green algae, etc. The book covers applications in allied areas such as energy and environment that process fuels and chemicals, wastewater treatment, coatings and catalysis. The book deals with a broad range of material types, including natural fiber reinforced polymer composites, particulate composites, fiberboard, wood fiber composites, and plywood composites that utilize natural, renewable, and biodegradable agricultural biomass.The book complements Natural Materials-based Green Composites 1: Plant Fibers that includes introductory information and various innovative applications of most important plant fiber-based materials such as wood fibers, vegetable fibers, jute fibers, stalk fibers, and hemp fibers. Focuses on the use of biomass for the preparation of green composites Discusses details about biomass from natural and industrial waste Provides an overview of the applicability of green composites

Advances in Carbohydrate Chemistry and Biochemistry

Author :
Publisher : Academic Press
ISBN 13 : 0128023570
Total Pages : 238 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Advances in Carbohydrate Chemistry and Biochemistry by :

Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by and published by Academic Press. This book was released on 2015-11-24 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Carbohydrate Chemistry and Biochemistry, part of a long running serial that began in 1945, provides critical and informative articles written by research specialists that integrate the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. Each article provides a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts who specialize in carbohydrate chemistry, biochemistry, and research Integrates the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates Informs and updates on all the latest developments in the field

Carbohydrate-Based Therapeutics

Author : Roberto Adamo
Publisher : John Wiley & Sons
ISBN 13 : 3527831339
Total Pages : 421 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Carbohydrate-Based Therapeutics by : Roberto Adamo

Download or read book Carbohydrate-Based Therapeutics written by Roberto Adamo and published by John Wiley & Sons. This book was released on 2023-08-25 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate-Based Therapeutics Comprehensive resource summarizing opportunities and latest progress in design methodologies for carbohydrate-based therapeutics through a disease-oriented approach Carbohydrate-Based Therapeutics covers current progress and explores new frontiers in carbohydrate-based therapeutic applications, utilizing a unique approach by providing a detailed background of diseases coupled with subsequent carbohydrate-based therapies. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and a broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure– activity relationship, and impact on health and diseases. The text also discusses newer topics like nanoparticles, material science, and tissue generation. Carbohydrate-Based Therapeutics includes information on: Antimicrobial carbohydrate-based therapies, covering antibacterial and antiviral vaccines, antifungal therapies, anti-influenza therapeutics, and antiadhesive carbohydrates and glycomimetics Anti-cancer carbohydrate-based therapies, covering cancer vaccines and immunotherapy, and carbohydrate tools in cancer biology Carbohydrate-based therapies in metabolic, neuronal, and immune disorders, covering carbohydrate-based therapeutics for lysosomal disorders and neurodegenerative diseases New frontiers in carbohydrate-based therapies, covering carbohydrates for tissue engineering, antiangiogenic and regenerative medicine Providing comprehensive coverage of foundational knowledge on the subject in a unique and highly accessible format while also exploring the state of the art in the field’s applications, Carbohydrate-Based Therapeutics is an essential resource for medicinal, pharmaceutical, and organic chemists, chemists in industry, biochemists, and biotechnologists.

The Science and Regulations of Naturally Derived Complex Drugs

Author : Ram Sasisekharan
Publisher : Springer
ISBN 13 : 3030117510
Total Pages : 331 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The Science and Regulations of Naturally Derived Complex Drugs by : Ram Sasisekharan

Download or read book The Science and Regulations of Naturally Derived Complex Drugs written by Ram Sasisekharan and published by Springer. This book was released on 2019-04-23 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend throughout the product development cycle from raw material control to clinical study design. The regulatory landscape is rapidly changing as new types of complex mixtures are introduced into clinical trials and to the market (e.g., traditional Chinese medicines and medical marijuana products), while older products are facing generic competition for the first time (e.g., enoxaparin). The future outlook for complex generic drug products, as opposed to the more commonly developed targeted single agent drug products is not clear. The risks pertaining to lack of a full understanding of raw material control, process and controls in manufacture, as well as characterization of a complex mixture were seen vividly during the heparin crisis of 2008. As such powerful lessons have been learned about the regulatory science specific to complex products. The Science and Regulations of Naturally Derived Complex Drugs addresses the interests among industry, academics, and government on the issues surrounding the future development of mixtures for medicinal use.

Tailor-Made Polysaccharides in Biomedical Applications

Author : Amit Kumar Nayak
Publisher : Academic Press
ISBN 13 : 0128213566
Total Pages : 360 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Tailor-Made Polysaccharides in Biomedical Applications by : Amit Kumar Nayak

Download or read book Tailor-Made Polysaccharides in Biomedical Applications written by Amit Kumar Nayak and published by Academic Press. This book was released on 2021-02-15 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tailor-Made Polysaccharides in Biomedical Applications provides extensive details on all the vital precepts, basics, and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industries. This information provides readers with the foundation for understanding and developing high-quality products. The utilization of natural polymeric excipients in numerous healthcare applications demands the replacement of the synthetic polymers with natural polymers. Natural polymers are superior in terms of biocompatibility, biodegradability, economic extraction, and ready availability. Natural polymers are especially useful in that they are a renewable source of raw materials, as long as they are grown sustainably. Among these natural polymers, polysaccharides are considered as excellent excipients because they are nontoxic, stable, and biodegradable. Several research innovations have been carried out using polysaccharides in drug delivery applications. This book offers a comprehensive resource to understand the potential of these materials in forming new drug delivery methods. It will be useful to biomedical researchers, chemical engineers, regulatory scientists, and students who are actively involved in developing pharmaceutical products for biomedical applications by using tailor-made polysaccharides. Provides methodology for the design, development, and selection of tailor-made polysaccharides in biomedical applications, including for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of tailor-made polysaccharides Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides

Heparanase

Author : Israel Vlodavsky
Publisher : Springer Nature
ISBN 13 : 3030345211
Total Pages : 871 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Heparanase by : Israel Vlodavsky

Download or read book Heparanase written by Israel Vlodavsky and published by Springer Nature. This book was released on 2020-04-09 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Wintrobe's Clinical Hematology

Author : Robert J. Means, Jr.
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 197518470X
Total Pages : 6360 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Wintrobe's Clinical Hematology by : Robert J. Means, Jr.

Download or read book Wintrobe's Clinical Hematology written by Robert J. Means, Jr. and published by Lippincott Williams & Wilkins. This book was released on 2023-05-22 with total page 6360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.

Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 868 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Biologics, Biosimilars, and Biobetters

Author : Iqbal Ramzan
Publisher : John Wiley & Sons
ISBN 13 : 1119564662
Total Pages : 328 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Biologics, Biosimilars, and Biobetters by : Iqbal Ramzan

Download or read book Biologics, Biosimilars, and Biobetters written by Iqbal Ramzan and published by John Wiley & Sons. This book was released on 2021-01-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists

NMR in Glycoscience and Glycotechnology

Author : Koichi Kato
Publisher : Royal Society of Chemistry
ISBN 13 : 1788011287
Total Pages : 417 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis NMR in Glycoscience and Glycotechnology by : Koichi Kato

Download or read book NMR in Glycoscience and Glycotechnology written by Koichi Kato and published by Royal Society of Chemistry. This book was released on 2017-05-15 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Wintrobe's Clinical Hematology

Author : John P. Greer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496367138
Total Pages : 2432 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Wintrobe's Clinical Hematology by : John P. Greer

Download or read book Wintrobe's Clinical Hematology written by John P. Greer and published by Lippincott Williams & Wilkins. This book was released on 2018-11-19 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You’ll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them.

Chemistry and Biology of Heparin and Heparan Sulfate

Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 9780080529059
Total Pages : 792 pages
Book Rating : 4.5/5 (29 download)

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Book Synopsis Chemistry and Biology of Heparin and Heparan Sulfate by : Hari G. Garg

Download or read book Chemistry and Biology of Heparin and Heparan Sulfate written by Hari G. Garg and published by Elsevier. This book was released on 2011-10-10 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

CKD-Associated Complications: Progress in the Last Half Century

Author : T. Nakanishi
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318064246
Total Pages : 148 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis CKD-Associated Complications: Progress in the Last Half Century by : T. Nakanishi

Download or read book CKD-Associated Complications: Progress in the Last Half Century written by T. Nakanishi and published by Karger Medical and Scientific Publishers. This book was released on 2019-04-16 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a record of some of the outstanding presentations given at the 63rd Annual Meeting of the Japanese Society for Dialysis Therapy (JSDT). The meeting was held in Kobe in 2018, celebrating the 50-year anniversary of the founding of the JSDT as a voluntary academic association. Therapy for end-stage kidney disease (ESKD) now faces vital issues besides the management of renal anemia and chronic kidney disease-mineral and bone disorder and the selection of the optimal treatment modality for each patient. These issues include the increasing incidence of malnutrition and frailty in the elderly, fragile vascular access, and the balance between medical costs and budgets. Expert members of the JSDT present 15 articles that address these issues. This book serves to promote further progress in understanding the pathogenesis of complications associated with ESKD and providing optimal therapy for patients.

Non-Biological Complex Drugs

Author : Daan J.A. Crommelin
Publisher : Springer
ISBN 13 : 3319162411
Total Pages : 390 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Non-Biological Complex Drugs by : Daan J.A. Crommelin

Download or read book Non-Biological Complex Drugs written by Daan J.A. Crommelin and published by Springer. This book was released on 2015-06-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.