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Author : Nicolas Foin
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (93 download)
Download or read book Hemodynamics and Endothelial Cell Biology in Cardiovascular Diseases written by Nicolas Foin and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brett Blackman
Publisher : World Scientific
ISBN 13 : 9814467243
Total Pages : 380 pages
Book Rating : 4.8/5 (144 download)
Download or read book Hemodynamics And Mechanobiology Of Endothelium written by Brett Blackman and published by World Scientific. This book was released on 2010-10-05 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of fluid dynamics, molecular signaling, genomic approach, tissue engineering, stem cell biology, and microfluidics. This is the first book to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.
Author : J. F. Stoltz
Publisher : IOS Press
ISBN 13 : 9781586037758
Total Pages : 222 pages
Book Rating : 4.0/5 (377 download)
Download or read book Cardiovascular Biology written by J. F. Stoltz and published by IOS Press. This book was released on 2007 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. This volume focuses on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte.
Author : Markus Hecker
Publisher : Springer Nature
ISBN 13 : 3030631648
Total Pages : 352 pages
Book Rating : 4.0/5 (36 download)
Download or read book Vascular Mechanobiology in Physiology and Disease written by Markus Hecker and published by Springer Nature. This book was released on 2021-03-10 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
Author : T.V. How
Publisher : Elsevier
ISBN 13 : 0080551564
Total Pages : 449 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in Hemodynamics and Hemorheology, Volume 1 written by T.V. How and published by Elsevier. This book was released on 1996-09-24 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series presents reviews covering all aspects of haemodynamics and haemorheology. Topics covered include the complexities of microcirculation, the rheology of blood and blood vessels, and the mechanics of blood flow in arteries and veins. The contributions aim to reflect the advances being made in experimental techniques and instrumentation for laboratory and clinical measurements and in numerical and mathematical modelling. Emphasis is placed on the scientific and engineering principles involved, but particular attention is also given to the clinical significance of this area of research. Topics covered by this volume include viscoelastic properties of blood and blood analogues; blood flow through narrow tubes; and numerical modelling of blood flow.
Author : A. Wayne Orr
Publisher : Biota Publishing
ISBN 13 : 1615046577
Total Pages : 140 pages
Book Rating : 4.6/5 (15 download)
Download or read book Pathogenesis of Atherosclerosis written by A. Wayne Orr and published by Biota Publishing. This book was released on 2014-07-01 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of fat, inflammatory cells, and fibrotic tissue in the vessel wall, hinders this function, resulting in inadequate perfusion of the target tissue. Hypoxia, or lack of oxygen, rapidly results in cellular dysfunction that profoundly affects the functionality of the overall tissue. Atherosclerosis-associated tissue ischemia and hypoxia because of loss of blood flow underlies several significant disease pathologies including ischemic heart disease, stroke, and peripheral artery disease. In this eBook, we examine the process of atherosclerotic plaque formation both at the cellular level and the level of clinical presentation. Through this book, we hope to impart to the reader a better understanding of how vessel structure, environmental risk factors, and genetic predisposition contribute to atherosclerotic disease and how current and future therapies seek to circumvent the cellular processes contributing to plaque formation to reduce atherosclerotic plaque burden and clinical complications. Table of Contents: List of Videos / Introduction to Atherosclerosis / Epidemiology / Endothelial Cell Activation and Arterial Hemodynamics / Cholesterol and Cardiovascular Disease / Inflammation in Atherosclerosis / Smooth Muscle Cells and Plaque Vulnerability / Diagnosing Atherosclerotic Disease / Treatment and Prevention / Summary and Future Perspectives / References / Author Biographies
Author : M. Simionescu
Publisher : Springer Science & Business Media
ISBN 13 : 1461309379
Total Pages : 460 pages
Book Rating : 4.4/5 (613 download)
Download or read book Endothelial Cell Biology in Health and Disease written by M. Simionescu and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.
Author : Michael A Gimbrone
Publisher : CRC Press
ISBN 13 : 0203303849
Total Pages : 388 pages
Book Rating : 4.2/5 (33 download)
Download or read book Mechanical Forces and the Endothelium written by Michael A Gimbrone and published by CRC Press. This book was released on 1999-08-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Areas addressed in this excellent text include the overall response of the endothelium to hemodynamic forces, and molecular biology with gene regulation taking a central role.
Author : Rory R. Koenen
Publisher : Frontiers Media SA
ISBN 13 : 288945620X
Total Pages : 118 pages
Book Rating : 4.8/5 (894 download)
Download or read book Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases written by Rory R. Koenen and published by Frontiers Media SA. This book was released on 2018-10-19 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
Author : John A Bevan
Publisher : Springer
ISBN 13 : 1461475279
Total Pages : 376 pages
Book Rating : 4.4/5 (614 download)
Download or read book Flow-Dependent Regulation of Vascular Function written by John A Bevan and published by Springer. This book was released on 2013-05-27 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exactly sixty years ago Schretzenmayer provided the first experimental proof that changes in blood ftow can affect the diameter oflarge arteries. Since then, support has been growing for the idea that intraluminal blood ftow plays an important role in regulating not only the tone of blood vessels, but also their caliber and structure. Investigations of the&e phenomena have been given a strong impetus by the discovery that the endothelium can modulate the tone of underlying vascular smooth muscle via the release of a number of vasoactive substances. Investigators often diverge in their opinions regarding the nature of the vascular wall response to blood ftow and the mechanisms involved. This book is the first summary of our state of knowledge and the nature of the research carried out on ftow-related changes. Early chapters review involvement of shear-stress-dependent events in the circulation as a whole. They cover the biophysical principles of ftuid transport, the cellular signal transduction path ways, and the molecular biology and biochemistry of ftow-induced changes in endothelial cells. Later chapters provide an in-depth summary of the regula tion of vascular muscle tone by ftow. They include historical perspectives, evi dence that ftow-induced vasodilation is primarily endothelium-dependent and that it can induce constriction, and details on ftow-dependent regulation in regional vascular beds. Several chapters emphasize the endothelial activation by shear stress and its importance in the control offtow in the microcirculation.
Author : Malcolm J Lewis
Publisher : CRC Press
ISBN 13 : 1000725340
Total Pages : 272 pages
Book Rating : 4.0/5 (7 download)
Download or read book Endothelial Modulation of Cardiac Function written by Malcolm J Lewis and published by CRC Press. This book was released on 2020-01-29 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paracrine and autocrine regulation of cardiac function by "endothelial" mediators is becoming important both physiologically and pathophysiologically. This volume brings the researcher completely up to date with all aspects of endothelial regulation and cardiac function. Acknowledged experts in each field have contributed, making this work indispensable for researchers and of great interest to the clinical cardiologist. The Endothelial Cell Research Series publishes significant reviews by experts in the field. The individual volumes provide invaluable guides to researchers studying endothelial cells and are effective reference texts for anyone working in the general areas of vascular biology and neurotransmission. Endothelium was originally considered to be an inert lining for the blood vessels, but during the last fifteen years, this view has had to be completely revised. It is now accepted that the endothelium plays an important role in many diverse functions. This volume concentrates on the effect of the endothelium on cardiac function. It has been widely demonstrated that the endothelium exerts a paracrine influence on contraction of adjacent cardiac muscle through the release of several mediators, such as endothelin and nitric oxide. Recent studies also show that the effects of such mediators upon the heart are not limited to contraction alone.
Author : Thomas Luescher
Publisher : Springer Science & Business Media
ISBN 13 : 3642798039
Total Pages : 340 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Endothelium in Cardiovascular Disease written by Thomas Luescher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the endothelium plays such an important role in the pathophysiology of the circulatory system, the readers attention is directed here towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.
Author : Protasio L. Da Luz
Publisher : Academic Press
ISBN 13 : 0128125519
Total Pages : 760 pages
Book Rating : 4.1/5 (281 download)
Download or read book Endothelium and Cardiovascular Diseases written by Protasio L. Da Luz and published by Academic Press. This book was released on 2018-02-03 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Hellmut G. Augustin
Publisher : Springer Science & Business Media
ISBN 13 : 9783540213970
Total Pages : 414 pages
Book Rating : 4.2/5 (139 download)
Download or read book Methods in Endothelial Cell Biology written by Hellmut G. Augustin and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.
Author : Jaap Diederik Van Buul
Publisher : Frontiers Media SA
ISBN 13 : 2889663523
Total Pages : 152 pages
Book Rating : 4.8/5 (896 download)
Download or read book Endothelial Dynamics in Health and Disease written by Jaap Diederik Van Buul and published by Frontiers Media SA. This book was released on 2021-01-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kazuo Tanishita
Publisher : Springer
ISBN 13 : 4431548017
Total Pages : 400 pages
Book Rating : 4.4/5 (315 download)
Download or read book Vascular Engineering written by Kazuo Tanishita and published by Springer. This book was released on 2016-03-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
