Handbook of Dystonia, Second Edition

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Author :
Publisher : CRC Press
ISBN 13 : 9781841848518
Total Pages : 0 pages
Book Rating : 4.8/5 (485 download)

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Book Synopsis Handbook of Dystonia, Second Edition by : Mark A. Stacy

Download or read book Handbook of Dystonia, Second Edition written by Mark A. Stacy and published by CRC Press. This book was released on 2012-05-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease. Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. The book offers detailed coverage of every available treatment option for dystonia and includes four categorized sections on medical management, botulinum toxin injections, phenol and neurolytic therapy, and surgical intervention. The book reviews the genetic factors of dystonia and supplies in-depth coverage of the neuroanatomy, neurophysiology, and neuropathology of the disease. It covers secondary causes of dystonia, including drug-induced and psychogenic presentations. It also examines non-motor symptoms relating to movement disorders and analyzes innovative approaches for treatment including deep brain stimulation. New to the Second Edition: Four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and Xeomin Dystonic symptoms associated with Parkinson’s disorders The use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystonia Spasticity and its pathogenesis, evaluation, and treatment with toxins, other injectables and surgical therapies Summarizing what is known about the disorder, the book dramatically improves the recognition and understanding of this debilitating disease.

Handbook of Dystonia

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Author :
Publisher : CRC Press
ISBN 13 : 1841848522
Total Pages : 562 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Handbook of Dystonia by : Mark A. Stacy

Download or read book Handbook of Dystonia written by Mark A. Stacy and published by CRC Press. This book was released on 2012-05-28 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, an

Spasmodic Torticollis Handbook

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Author :
Publisher : Springer Publishing Company
ISBN 13 : 1934559407
Total Pages : 131 pages
Book Rating : 4.9/5 (345 download)

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Book Synopsis Spasmodic Torticollis Handbook by : Karen Frei, MD

Download or read book Spasmodic Torticollis Handbook written by Karen Frei, MD and published by Springer Publishing Company. This book was released on 2003-07-01 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spasmodic torticollis, also known as cervical dystonia, affects about three people in 10,000, or an estimated 85,000 individuals in the United States alone. Despite this, there has been until now a lack of information outside of the professional medical literature for use by individuals with this disorder and their families. This book provides comprehensive information on the disorder for people with spasmodic torticollis and those close to them. Medical terms and concepts are introduced sequentially and then used as building blocks for the later discussion. Beginning with a clear definition of the disorder, opening chapters categorize this neurologic disease as one of the broader category of movement disorders, and differentiate it from other conditions with which it is often confused. The authors then present a stepwise introduction to the relevant anatomy and physiology of the nervous system and neck. They draw on the experiences of their patients to build a progressive depiction of the experiences an individual might have as he or she goes through the initial onset of symptoms, progression of the disorder, seeking medical care, diagnosis, treatment, and subsequent outcome. Personal vignettes from the experiences of selected patients are provided where they illustrate particular points in the discussion. Subsequent chapters discuss various modes of treatment for spasmodic torticollis. Prior to the mid-1980?s, there were no specific treatments for this disorder. Nearly all treatment consisted of using oral medications that were primarily intended for other medical conditions. Since most of these medications are still in use, and a few new ones have been added, a chapter is devoted to detailing them and discussing the general principles of medication therapy. During the past decade, chemodenervation using botulinum toxin has become the primary and most effective treatment for spasmodic torticollis. For those few patients who require surgery, a description is provided of the neurosurgical techniques developed during the last twenty years specifically for its treatment. The final chapter is a manual of therapeutic rehabilitation exercises designed to alleviate the symptoms of spasmodic torticollis. These exercises can be performed by most patients with no assistance and a bare minimum of equipment. Since each person?s case of spasmodic torticollis is different, only certain of the exercises may be appropriate for any given individual. They should be undertaken only after discussion with your physician. These exercises are accompanied by detailed illustrations that emphasize the particular muscles relevant to each posture or movement. About the Authors: Dr. Pathak is a neurologist with a special interest in the neurologic rehabilitation of movement disorders, especially spasmodic torticollis. Dr. Frei is a neurologist specialized in the field of neurogenetics, and has conducted clinical trials on a number of movement disorders, including spasmodic torticollis. Dr. Truong is a neurologist and movement disorders specialist. He has conducted active research in the management of movement disorders, including spasmodic torticollus. He was one of the pioneers in the use of botulinum toxin to manage this condition, and has lectured worldwide on the management of movement disorders.

Handbook of Botulinum Toxin Treatment

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Author :
Publisher : Wiley-Blackwell
ISBN 13 : 9780632059577
Total Pages : 476 pages
Book Rating : 4.0/5 (595 download)

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Book Synopsis Handbook of Botulinum Toxin Treatment by : A. P. Moore

Download or read book Handbook of Botulinum Toxin Treatment written by A. P. Moore and published by Wiley-Blackwell. This book was released on 2003-01-17 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Botulinum toxin A is a remarkably versatile treatment with a steadily expanding list of indications, which include strabismus, hemifacial spasm, focal dystonias such as spasmodic torticollis, dysphonia and writer’s cramp, as well as adult and childhood spasticity. Recent innovations include its use in some types of pain, in autonomic and gastrointestinal disorders, and in cosmetic medicine, such as hyperhidrosis, hypersalivation, rectal fissure, achalasia and facial wrinkles. Botulinum toxin is arguably the safest and most effective treatment in movement disorders since the introduction of levodopa, and is an increasingly important option in many other fields. The long-awaited second edition of the Handbook of Botulinum Toxin Treatment brings the reader up to date with the many advances in background knowledge and in clinical practice in both the established and the newer indications, including the use of a second serotype botulinum toxin B. The book is an introduction and practical guide for doctors and paramedical staff who use botulinum toxin or who may want to refer patients or care for patients being treated elsewhere. Initial chapters provide historical and general information. The rest of the book concentrates on the different conditions treated with botulinum toxin. Chapters follow a standard format with a pragmatic approach based on the wide experience of the authors.

HANDBOOK OF NEUROLOGICAL EXAMINATION, SECOND EDITION

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Author :
Publisher : PHI Learning Pvt. Ltd.
ISBN 13 : 8119364007
Total Pages : 310 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis HANDBOOK OF NEUROLOGICAL EXAMINATION, SECOND EDITION by : KUMAR, NAVNEET

Download or read book HANDBOOK OF NEUROLOGICAL EXAMINATION, SECOND EDITION written by KUMAR, NAVNEET and published by PHI Learning Pvt. Ltd.. This book was released on 2023-08-01 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a dearth of books on neurological examination that give a comprehensive analysis of the subject. Dr. Navneet Kumar, with his expertise and vast teaching as well as practising experience, provides tips to the students and practitioners to conduct neurological examination of the patients in a scientific and systematic manner. He shows with, great skill, how the examination of first impression and gait, history taking, and examination of higher mental functions including speech are to be conducted. The book, in the Second Edition, has been updated and enhanced by introducing more illustrations and visuals for clear understanding and diagnosis of diseases and disorders. The text focuses on the examination of all the cranial nerves (First to Twelfth), the motor system, movement disorders, the sensory system, the autonomic nervous system, and bladder dysfunction, with equal deftness, besides other important concepts. This systematically organised book provides different approaches to examine the unconscious patient, and special neurological situations, the methods of neurological investigation, as well as the methods of case sheet writing. Primarily intended as a practical handbook for the students of MBBS, MD (Medicine), DNB (Medicine), Paediatrics and Psychiatry, the book would also be of great value to the students pursuing DM (Neurology) and M.Ch. (Neurosurgery) as well as practising physicians and neurologists. KEY FEATURES • Gives anatomical details of all cranial nerves. • Highlights common problems in neurology, generally not mentioned in any other handbook. • Provides about 200 real photographs and diagrams, and also a large number of tables to illustrate the concepts. • Includes a thorough analysis of neurological investigations. TARGET AUDIENCE • MBBS / MD (Medicine) / DNB (Medicine) • Paediatrics & Psychiatry • DM (Neurology) / M.Ch. (Neurosurgery)

Manual of Botulinum Toxin Therapy

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1107654335
Total Pages : 321 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Manual of Botulinum Toxin Therapy by : Daniel Truong

Download or read book Manual of Botulinum Toxin Therapy written by Daniel Truong and published by Cambridge University Press. This book was released on 2014-01-23 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated throughout, the second edition of the Manual of Botulinum Toxin Therapy provides practical guidance on the use of Botox in a wide variety of disorders. New chapters have been added on the use of botulinum toxin in wound healing, in focal hand dystonia and in thoracic outlet syndrome, as well as others. There are new chapters on the use of botulinum toxins in conjunction with ultrasound guidance. Using clear line-drawings the Manual describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxins used in different muscle groups. Throughout the emphasis is on technique and the book can be used as both a teaching aid and in bedside guidance. The manual will be of use to neurologists, otolaryngologists, urologists, ophthalmologists, dermatologists, internists, pain management specialists, rehabilitation specialists and plastic surgeons, and any other clinicians discovering the potential of botulinum toxin.

Handbook of Neurologic Rating Scales, 2nd Edition

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Author :
Publisher : Demos Medical Publishing
ISBN 13 : 9781617050312
Total Pages : 466 pages
Book Rating : 4.0/5 (53 download)

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Book Synopsis Handbook of Neurologic Rating Scales, 2nd Edition by :

Download or read book Handbook of Neurologic Rating Scales, 2nd Edition written by and published by Demos Medical Publishing. This book was released on with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Rating scales are used daily by everyone involved in the management of patients with neurologic disease and in the design and management of neurologic clinical trials. Now there is a single source for the wide range of scales used in specific neurologic diseases and neurorehabilitation. You will refer to this volume constantly! The first edition of the Handbook of Neurologic Rating Scales quickly became an invaluable reference work on the increasing array of scales for measuring neurologic disease. In the brief few years since the first edition the importance of this book has only increased. New Chapters Include Scales On: Generic and general use Pediatric neurology and rehabilitation Peripheral neuropathy and pain Ataxia HIV/AIDS And instruments for diagnosing headaches. Formal measurement of the effects of neurologic disease and of treatment effects, beyond the description of changes on the standard neurologic examination, is a relatively recent development. Controlled clinical trials and outcomes research are at the heart of modern information-based medicine, and neurologic scales are essential tools in clinical trials designed to provide this information. A Resource for Clinical Trials The Handbook of Neurologic Rating Scales provides a resource for clinicians and clinical investigators in the broad field of neurology and neurologic rehabilitation to help them: evaluate the clinical trials literature by providing information on the scales being used evaluate and select appropriate and efficient scales for clinical trials and outcomes research, and provide information that will help them to develop new scales or measures or to improve existing ones. A Resource for Evaluating Disease Status Outcomes research is playing an increasingly important role in clinical management and neurorehabilitation, and these also depend largely on measurement of disease status and change. In this era of managed care, neurologists must produce outcomes data demonstrating the effectiveness of neurologic care if the specialty is to survive, and certainly if it is to thrive. Even effective therapies are likely to fall by the wayside if studies to prove their effectiveness are not done. Comprehensive and Standardized Information on All Scales Each chapter in this volume contains the scales of importance and in current use, including a sequence of scale descriptions and specific scales in a standard format, as well as a summary and recommendations indicating which scales are most useful for specific purposes and whether a combination of scales is particularly useful or if better scales are needed. Each entry notes: the purpose for which the scale was developed and its current uses if they differ from those for which it was developed a detailed description of the scale information about validation, such as: Does the scale have face validity? i.e., does it appear to measure what it purports to measure? how and by whom the scale is administered the time needed to administer and score the scale the scale itself or, when the scale is proprietary or too long for inclusion, a description and key references special considerations, including unusual measures needed to obtain a valid score or problems in administering the test in specific patients advantages, or what makes the scale good or useful. Disadvantages, or what makes the scale difficult to use or impairs its reliability key references, including the original publication of the scale and its validation Downloadable PDFs of the scales contained in the Handbook of Neurologic Rating Scales are included with the purchase of this book. The password to download the files can be found in the book itself.

Principles and Practice of Movement Disorders E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 1437737706
Total Pages : 557 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Principles and Practice of Movement Disorders E-Book by : Joseph Jankovic

Download or read book Principles and Practice of Movement Disorders E-Book written by Joseph Jankovic and published by Elsevier Health Sciences. This book was released on 2011-04-01 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com.

Movement Disorders in Childhood

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Author :
Publisher : Academic Press
ISBN 13 : 0124115802
Total Pages : 601 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Movement Disorders in Childhood by : Harvey S. Singer

Download or read book Movement Disorders in Childhood written by Harvey S. Singer and published by Academic Press. This book was released on 2015-10-27 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement Disorders in Childhood, Second Edition, provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. Over the past several decades, advances in genetics, neuroimaging, neurophysiology, and other areas of neuroscience have provided new understanding of the underlying etiologies and mechanisms of these conditions as well as new opportunities for more accurate diagnosis and effective treatment. This new edition builds upon the success of the first edition, with comprehensive scientific and clinical updates of all chapters. In addition, there are new chapters on hereditary spastic paraplegia, quantitative motor assessments, autoimmune disorders, and movement disorders in the developmental neuropsychiatric disorders ADHD, OCD, and autism. Additional materials are provided on the latest in drug treatments, computer based strategies for genetic diagnosis, and helpful videos for phenomenology. - Provides the only current reference specifically focused on childhood movement disorders - Investigates the underlying etiologies and mechanisms of these disorders - Completely revised and updated with new materials and a more disease-oriented approach - New coverage of genetics and movement disorders, immunology and movement disorders, and an introduction to the latest quantitative analysis - New videos of instructive and unusual childhood movement disorders - 2016 BMA Medical Book Awards Highly Commended in Neurology

Connectomic Deep Brain Stimulation

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Publisher : Academic Press
ISBN 13 : 0128218622
Total Pages : 602 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Connectomic Deep Brain Stimulation by : Andreas Horn

Download or read book Connectomic Deep Brain Stimulation written by Andreas Horn and published by Academic Press. This book was released on 2021-09-10 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson's Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. - Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery - Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) - Presents references (key articles, books and protocols) for additional detailed study - Provides data analysis boxes in each chapter to help with data interpretation

Handbook of Basal Ganglia Structure and Function

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Publisher : Academic Press
ISBN 13 : 9780123747679
Total Pages : 693 pages
Book Rating : 4.7/5 (476 download)

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Book Synopsis Handbook of Basal Ganglia Structure and Function by : Heinz Steiner

Download or read book Handbook of Basal Ganglia Structure and Function written by Heinz Steiner and published by Academic Press. This book was released on 2010 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Basal Ganglia comprise a group of forebrain nuclei which are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control, cognition, and mnemonic functions, and the importance of these nuclei for normal brain function and behavior is emphasized by the numerous disorders associated with basal ganglia dysfunction - Parkinson's, Tourette's, Huntington's, cerebral palsy, ADHD, OCD, and others. the Handbook provides a comprehensive overview of the structural and functional organization of the basal ganglia, w

Functional Movement Disorder

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Author :
Publisher : Springer Nature
ISBN 13 : 3030864952
Total Pages : 455 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Functional Movement Disorder by : Kathrin LaFaver

Download or read book Functional Movement Disorder written by Kathrin LaFaver and published by Springer Nature. This book was released on 2022-02-23 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical manual for clinical practitioners seeking to take an interdisciplinary and multidisciplinary approach to the diagnosis and management of functional movement disorder (FMD). It discusses case vignettes, reviews the diagnostic approach, provides an update on available treatments, highlights clinical pearls and details references for further reading. Organized into three parts, the book begins with a framework for conceptualizing FMD - including its historical context, the biopsychosocial model and an integrated neurologic-psychiatric perspective towards overcoming mind-body dualism. Part II then provides a comprehensive overview of different FMD presentations including tremor, dystonia, gait disorders, and limb weakness, as well as common non-motor issues such as pain and cognitive symptoms. The book concludes with chapters on updated practices in delivering the diagnosis, working with patients and care partners to achieve shared understanding of a complex condition, as well as an overview of evidence-based and evolving treatments. Supplemented with high-quality patient videos, Functional Movement Disorder is written for practicing neurologists, psychiatrists, psychologists, allied mental health professionals, and rehabilitation experts with an interest in learning more about diagnosis and management of FMD.

Treatment of Dystonia

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1316997936
Total Pages : 481 pages
Book Rating : 4.3/5 (169 download)

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Book Synopsis Treatment of Dystonia by : Dirk Dressler

Download or read book Treatment of Dystonia written by Dirk Dressler and published by Cambridge University Press. This book was released on 2018-06-07 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of dystonia is advancing rapidly. This comprehensive reference work provides an effective guide to this challenging group of disorders, offering an overview of the current and emerging treatment options for all manifestations. Treatments for the many forms of dystonia differ substantially in pediatrics and adults - both are covered in detail in this book. Approaches include botulinum toxin therapy, deep brain stimulation, oral drug applications, rehabilitation, and behavioral and experimental therapies. Special emphasis is also given to combining different treatment modalities in order to achieve optimal effect. Treatment of Dystonia brings together peer-reviewed articles, written by experts and based on work presented at international conferences. By enabling the physician to select and combine the best therapies, it is an essential resource for neurologists, neurosurgeons and physical therapists.

Parkinson's Disease and Other Movement Disorders

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Author :
Publisher : Oxford University Press, USA
ISBN 13 : 019856984X
Total Pages : 336 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Parkinson's Disease and Other Movement Disorders by : Mark Edwards

Download or read book Parkinson's Disease and Other Movement Disorders written by Mark Edwards and published by Oxford University Press, USA. This book was released on 2008 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reference on the management of Parkinson's disease and other movement disorders, this book offers practical advice on the classification and diagnosis of patients, and available treatment options.

Marsden's Book of Movement Disorders

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Author :
Publisher : Oxford University Press
ISBN 13 : 0191502243
Total Pages : 1512 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Marsden's Book of Movement Disorders by : Ivan Donaldson

Download or read book Marsden's Book of Movement Disorders written by Ivan Donaldson and published by Oxford University Press. This book was released on 2012-03-29 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.

Handbook of Bioequivalence Testing, Second Edition

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Author :
Publisher : CRC Press
ISBN 13 : 1482226375
Total Pages : 1012 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Handbook of Bioequivalence Testing, Second Edition by : Sarfaraz K. Niazi

Download or read book Handbook of Bioequivalence Testing, Second Edition written by Sarfaraz K. Niazi and published by CRC Press. This book was released on 2014-10-29 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval—including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs—allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.

Understanding Parkinson's Disease

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Author :
Publisher :
ISBN 13 : 1886039003
Total Pages : 159 pages
Book Rating : 4.8/5 (86 download)

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Book Synopsis Understanding Parkinson's Disease by : David Lee Cram

Download or read book Understanding Parkinson's Disease written by David Lee Cram and published by . This book was released on 2009 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inspiring guide on both the basics of the illness and ways to stay more active from two unique perspectives--that of a physician and as a person with Parkinson's.