Guidelines For Preclinical Evaluation And Clinical Trials In Osteoporosis

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Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis

Author : World Health Organization
Publisher :
ISBN 13 : 9789241545228
Total Pages : 68 pages
Book Rating : 4.5/5 (452 download)

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Book Synopsis Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis by : World Health Organization

Download or read book Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis written by World Health Organization and published by . This book was released on 1998-01-01 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive guidelines for the design, implementation, and interpretation of preclinical studies and clinical trials of agents undergoing investigation for the management of osteoporosis. Noting the magnitude of the public health problem caused by osteoporosis and related fractures, the book responds to the urgent need for a cohesive and rational approach to the search for new therapeutic or preventive agents. Recommended principles and methods reflect the consensus reached by a large number of international experts, representatives of the pharmaceutical industry, and drug regulatory authorities. The book opens with a brief discussion of the current and future public health problem caused by osteoporotic fractures, followed by conceptual and operational definitions of osteoporosis and a recommended classification of four intervention categories that facilitate the definition of treatment objectives and the design of targetted studies. Against this background, the next chapter offers a detailed guide to the aims, design, conduct and interpretation of preclinical studies. Specific recommendations are given for the selection of in vitro and animal models, the design of the study, including dose ranges and duration of treatment, and the most appropriate end-points for assessing efficacy. The most extensive chapter provides a comprehensive description of basic principles and methods to follow during clinical trials. Information ranges from a discussion of problems with the use of bone mineral density to predict fracture risk, through advice on the choice of tests and techniques for measuring the effects of interventions, to a discussion of general principles of trial design, including selection of study population, treatment regimen, duration of studies, sample size, and frequency of measurement. Drawing on these detailed principles and methods, subsequent chapters offer concise guidance specific to phase I and phase II studies, phase III studies in severe osteoporosis, phase III studies in osteoporosis without fragility fractures, and phase III studies in osteopenia. The book concludes with chapters outlining principles and methods for phase III clinical trials in subjects with normal bone mass, and for phase IV studies.

Clinical Trials in Osteoporosis

Author : Derek Pearson
Publisher : Springer Science & Business Media
ISBN 13 : 1447137108
Total Pages : 280 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Clinical Trials in Osteoporosis by : Derek Pearson

Download or read book Clinical Trials in Osteoporosis written by Derek Pearson and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trials in Osteoporosis is a practical handbook on clinical trials in the growing field of osteoporosis. Topics covered include study design, technical issues, data collection, quality assurance, data analysis and presentation. It aims to take the user through the process step-by-step from start to finish, also providing a background on regulatory guidelines, ethical implications, endpoints, current therapies and the ideal drug to use. There are no other books at present that specifically address the issue of clinical trials in osteoporosis. A number of issues dealt with in this book have been brought together in one publication for the first time. Clinical Trials in Osteoporosis is intended to serve as a practical manual for clinicians and scientists coming to the subject new and to provide a standard for existing centers to measure themselves against.

Current Topics In Osteoporosis

Author : Hong-wen Deng
Publisher : World Scientific
ISBN 13 : 9814480983
Total Pages : 562 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Current Topics In Osteoporosis by : Hong-wen Deng

Download or read book Current Topics In Osteoporosis written by Hong-wen Deng and published by World Scientific. This book was released on 2005-05-09 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews important topics in osteoporosis, with the emphasis on both clinical management and basic research of the disease. From the clinical perspective, topics covering pathogenesis, diagnosis, and treatment of osteoporosis are extensively elaborated. Several more chapters complement clinical overview of osteoporosis, that discuss the effects of nutrition and exercise to bone health, the application of biochemical markers in osteoporosis diagnosis, novel potential drug targets for osteoporosis treatment, and osteoporosis in males and in children. As the prevalence of osteoporosis now reaches epidemiological levels, epidemiology and social impacts of osteoporosis is also reviewed in the book. Basic research on osteoporosis is also highlighted in the book, with a number of chapters dedicated to the review of genetics of osteoporosis, animal models for osteoporosis, and statistical methods in osteoporosis study.

Prevention and Management of Osteoporosis

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241209216
Total Pages : 206 pages
Book Rating : 4.2/5 (412 download)

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Book Synopsis Prevention and Management of Osteoporosis by : World Health Organization

Download or read book Prevention and Management of Osteoporosis written by World Health Organization and published by World Health Organization. This book was released on 2003-12-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone is hard tissue that is in a constant state of flux being built up by bone-forming cells called osteoblasts while also being broken down or resorbed by cells known as osteoclasts. During childhood and adolescence bone formation is dominant; bone length and girth increase with age ending at early adulthood when peak bone mass is attained. Males generally exhibit a longer growth period resulting in bones of greater size and overall strength. In males after the age of 20 bone resorbtion becomes predominant and bone mineral content declines about 4% per decade. Females tend to maintain peak mineral content until menopause at which time it declines about 15% per decade. Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility and an increased susceptibility to fractures especially of the hip spine and wrist. Osteoporosis occurs primarily as a result of normal ageing but can arise as a result of impaired development of peak bone mass (e.g. due to delayed puberty or undernutrition) or excessive bone loss during adulthood (e.g. due to estrogen deficiency in women undernutrition or corticosteriod use). Osteoporosis-induced fractures cause a great burden to society. Hip fractures are the most serious as they nearly always result in hospitalization are fatal about 20% of the time and produce permanent disability about half the time. Fracture rates increase rapidly with age and the lifetime risk of fracture in 50 year-old women is about 40% similar to that for coronary heart disease. In 1990 there were 1.7 million hip fractures alone worldwide; with changes in population demographics this figure is expected to rise to 6 million by 2050. To help describe the nature and consequences of osteoporosis as well as strategies for its prevention and management a WHO Scientific Group meeting of international experts was held in Geneva which resulted in this technical report. This monograph describes in detail normal bone development and the causes and risk factors for developing osteoporosis. The burden of osteoporosis is characterized in terms of mortality morbidity and economic costs. Methods for its prevention and treatment are discussed in detail for both pharmacological and non-pharmacological approaches. For each approach the strength of the scientific evidence is listed. The report also provides cost-analysis information for potential interventions and discusses important aspects of developing national policies to deal with osteoporosis. Recommendations are made to the general population care providers health administrators and researchers. Lastly national organizations and support groups are listed by country.

Glucocorticoid-induced Osteoporosis

Author : Andrea Giustina
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572964
Total Pages : 213 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina

Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.

Osteoporosis, Two-Volume Set

Author : Robert Marcus
Publisher : Academic Press
ISBN 13 : 0080538266
Total Pages : 861 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Osteoporosis, Two-Volume Set by : Robert Marcus

Download or read book Osteoporosis, Two-Volume Set written by Robert Marcus and published by Academic Press. This book was released on 2001-09-20 with total page 861 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.Key Features* The source on osteoporosis* Written by expert investigators in their respective fields* Each chapter provides timely, comprehensive, and scholarly discussion* Fully illustrated in color and black & white* Covers everything from basic anatomy and physiology to diagnosis, management and treatment

Aging Bones

Author : Gerald N. Grob
Publisher : JHU Press
ISBN 13 : 1421413191
Total Pages : 305 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Aging Bones by : Gerald N. Grob

Download or read book Aging Bones written by Gerald N. Grob and published by JHU Press. This book was released on 2014-04-15 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: How osteoporosis went from a normal aging process to a disease. In the middle of the twentieth century, few physicians could have predicted that the modern diagnostic category of osteoporosis would emerge to include millions of Americans, predominantly older women. Before World War II, popular attitudes held that the declining physical and mental health of older persons was neither preventable nor reversible and that older people had little to contribute. Moreover, the physiological processes that influenced the health of bones remained mysterious. In Aging Bones, Gerald N. Grob makes a historical inquiry into how this one aspect of aging came to be considered a disease. During the 1950s and 1960s, as more and more people lived to the age of 65, older people emerged as a self-conscious group with distinct interests, and they rejected the pejorative concept of senescence. But they had pressing health needs, and preventing age-related decline became a focus for researchers and clinicians alike. In analyzing how the normal aging of bones was transformed into a medical diagnosis requiring treatment, historian of medicine Grob explores developments in medical science as well as the social, intellectual, economic, demographic, and political changes that transformed American society in the post–World War II decades. Though seemingly straightforward, osteoporosis and its treatment are shaped by illusions about the conquest of disease and aging. These illusions, in turn, are instrumental in shaping our health care system. While bone density tests and osteoporosis treatments are now routinely prescribed, aggressive pharmaceutical intervention has produced results that are inconclusive at best. The fascinating history in Aging Bones will appeal to students and scholars in the history of medicine, health policy, gerontology, endocrinology, and orthopedics, as well as anyone who has been diagnosed with osteoporosis.

Osteoporosis

Author : Royal College of Physicians of London
Publisher : Royal College of Physicians
ISBN 13 : 9781860160790
Total Pages : 126 pages
Book Rating : 4.1/5 (67 download)

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Book Synopsis Osteoporosis by : Royal College of Physicians of London

Download or read book Osteoporosis written by Royal College of Physicians of London and published by Royal College of Physicians. This book was released on 1999 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prevention and Treatment of Osteoporosis in the High-Risk Patient

Author : Cyrus Cooper
Publisher : CRC Press
ISBN 13 : 0203010752
Total Pages : 127 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Prevention and Treatment of Osteoporosis in the High-Risk Patient by : Cyrus Cooper

Download or read book Prevention and Treatment of Osteoporosis in the High-Risk Patient written by Cyrus Cooper and published by CRC Press. This book was released on 2005-01-25 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outcome of recent clinical trials in osteoporosis was the impetus for this volume. In these studies of two bisphosphonates, an interaction between bone mineral density (BMD) and the treatment effect was seen, such that these agents appeared to lose their effect as BMD increased. To practitioners this is counter-intuitive. Why should treatment w

Pocket Reference to Osteoporosis

Author : Serge Livio Ferrari
Publisher : Springer
ISBN 13 : 3319267574
Total Pages : 103 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Pocket Reference to Osteoporosis by : Serge Livio Ferrari

Download or read book Pocket Reference to Osteoporosis written by Serge Livio Ferrari and published by Springer. This book was released on 2018-12-28 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book responds to the daily needs of all clinicians treating patients with osteoporosis and provides a key reference guide for any challenges that arise in clinical practice. This book also covers the genetics of the disease, clinical presentation, diagnosis, and current and upcoming treatment recommendations in accordance with the latest international guidelines. Osteoporosis is a disease in which the density and quality of bone are greatly reduced, and as bones become more porous and fragile the risk of fracture increases greatly. It is one of the most common metabolic bone diseases globally with one in three women and one in five men at risk of an osteoporotic fracture, and can result in devastating physical, psychosocial, and economic consequences. However, in spite of this osteoporosis can often be overlooked and undertreated, thus there is a real need to raise awareness of this disease.

Safe and Effective Medicines for Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309225493
Total Pages : 432 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Safe and Effective Medicines for Children by : Institute of Medicine

Download or read book Safe and Effective Medicines for Children written by Institute of Medicine and published by National Academies Press. This book was released on 2012-10-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

Rare Diseases and Orphan Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Author : Klaus Olgaard
Publisher : Oxford University Press, USA
ISBN 13 : 0199559171
Total Pages : 617 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease by : Klaus Olgaard

Download or read book The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease written by Klaus Olgaard and published by Oxford University Press, USA. This book was released on 2010-06-10 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts.

Technical Report Series

Author :
Publisher :
ISBN 13 :
Total Pages : 684 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Technical Report Series by :

Download or read book Technical Report Series written by and published by . This book was released on 1950 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bulletin de L'Organisation Mondiale de la Santé

Author : World Health Organization
Publisher :
ISBN 13 :
Total Pages : 1142 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Bulletin de L'Organisation Mondiale de la Santé by : World Health Organization

Download or read book Bulletin de L'Organisation Mondiale de la Santé written by World Health Organization and published by . This book was released on 1999 with total page 1142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Early Diagnosis and Treatment of Endocrine Disorders

Author : Robert S. Bar
Publisher : Springer Science & Business Media
ISBN 13 : 159259378X
Total Pages : 340 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Early Diagnosis and Treatment of Endocrine Disorders by : Robert S. Bar

Download or read book Early Diagnosis and Treatment of Endocrine Disorders written by Robert S. Bar and published by Springer Science & Business Media. This book was released on 2003-04-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most endocrine diseases can be treated successfully, and the patient's state of well-being can usually be improved. Not surprisingly, the earlier the diagnosis is made the more positive the clinical response. Early Diagnosis and Treatment (~f Endocrine Disorders focuses on early signs and symptoms of endocrine disorders and surveys the appropriate tests to document the diseases as well as current recommendations for therapy. Each chapterreviews the pathophysiology of the endocrine disease-important for understanding each disorder as well as the rationale for early therapy-and the basis for the early recognition and treatment of each condition. Although the practicing endocrinologist is likely to be quite knowledgeable regarding many of these diseases, Early Diagnosis and Treatment of Endocrine Disorders includes treatment of those conditions only recently classified as endocrine disorders, such as polycystic ovarian syndrome, obesity, and hypogonadism. The book also provides new approaches that are urgently needed to slow the epidemic of type 2 diabetes, which should be an overriding concern for all clinicians. Until now, no other endocrinology text has focused primarily on the details of early recognition and therapy of endocrine disorders. The information in Early Diagnosis and Treatment of Endocrine Disorders is presented in an orderly and easy-to-follow manner, which should greatly facilitate the early recognition of endocrine diseases by medical students, house staff, primary care physicians, and endocrinologists, the four groups of clinical personnel to which this book is specificall y directed.

Rockwood and Green's Fractures in Adults

Author : Paul Tornetta III
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975211618
Total Pages : 8998 pages
Book Rating : 4.9/5 (752 download)

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Book Synopsis Rockwood and Green's Fractures in Adults by : Paul Tornetta III

Download or read book Rockwood and Green's Fractures in Adults written by Paul Tornetta III and published by Lippincott Williams & Wilkins. This book was released on 2024-08-15 with total page 8998 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its first edition over 60 years ago, Rockwood and Green’s Fractures in Adults has been the go-to reference for treating a wide range of fractures in adult patients. The landmark, two-volume tenth edition continues this tradition with two new international editors, a refreshed mix of contributors, and revised content throughout, bringing you fully up to date with today’s techniques and technologies for treating fractures in orthopaedics. Drs. Paul Tornetta III, William M. Ricci, Robert F. Ostrum, Michael D. McKee, Benjamin J. Ollivere, and Victor A. de Ridder lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.