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Author : Jenny Louise Aveyard
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (17 download)
Download or read book Gold Nanoparticles for Biomolecular Assays written by Jenny Louise Aveyard and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiong Liu
Publisher :
ISBN 13 :
Total Pages : 193 pages
Book Rating : 4.:/5 (95 download)
Download or read book Gold Nanoparticles written by Xiong Liu and published by . This book was released on 2009 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents a systematic study on gold nanoparticles: from their chemical synthesis, modification of surface functionalities, optical properties studies with emphasis on the absorption and scattering properties, to applications of gold nanoparticles in biomolecular detection, imaging and photothermal therapy. In chapter 2, we studied the kinetics of gold nanoparticle growth under Brust-Shiffrin reaction conditions. In chapter 3, we further examined the reaction mechanism and growth kinetics of gold nanoparticles using oleylamine as both a reducing reagent and particle growth passivation ligand. From these two projects, important understanding was revealed on gold nanoparticle formation and growth mechanism. Chapter 4 describes the synthesis of a monofunctional gold nanoparticle through a solid phase place exchange reaction. From Chapter 5, we moved to the optical property study of gold nanoparticles, particularly the absorption and scattering phenomenon. In this work a systematic analysis on the extinction coefficient of gold nanoparticles was performed, providing meaningful references for applications based on optical absorption properties of gold nanoparticles. In Chapter 6 and Chapter 7, we developed a one-step homogeneous immunoassay for protein detection and analysis based on the strong light scattering of gold nanoparticles and dynamic light scattering detection technique. In Chapter 8, we further improved the stability of gold nanoparticle bioconjugates using a poly(ethylene glycol)-coated gold nanoparticles and further tested this nanoparticle in the one-step homogeneous immunoassay. Finally in Chapter 9, we demonstrated the application of gold nanoparticles for in vitro bioimaging and photothermal therapy of a lung cancer cell. In summary, this dissertation presents a comprehensive study on the synthesis, surface modification, property study of gold nanoparticles and their applications in biomolecular imaging and analysis.
Author :
Publisher : Elsevier
ISBN 13 : 0323139027
Total Pages : 517 pages
Book Rating : 4.3/5 (231 download)
Download or read book Colloidal Gold written by and published by Elsevier. This book was released on 2012-12-02 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its introduction in 1971, the development and application of colloidal gold as a marker in electron microscopy has been phenomenal. Colloidal gold has become the method of choice in immunocytochemistry and many areas of cell biology. This universal method is applicable to most microscopical systems including optical microscopy; scanning, transmission, and high voltage electron microscopy; photoelectron, photon, fluorescent darkfield, and epipolarization microscopy. Colloidal gold allows high and low resolution studies, enzyme and nucleic acid labeling, study of dynamic cellular processes, and virus detection. This book is among the first available to cover the principles and methodology of colloidal gold in microscopy. - Methods are described step by step, to enable researchers to learn these complex procedures solely by reference to these books - Problems and limitations of techniques are discussed - Guides users to avoid problems and choose the correct procedures for specific applications - Contributors are eminent authorities in their fields
Author : Catherine Louis
Publisher : World Scientific
ISBN 13 : 1786341263
Total Pages : 681 pages
Book Rating : 4.7/5 (863 download)
Download or read book Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) written by Catherine Louis and published by World Scientific. This book was released on 2017-06-02 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Physics, Chemistry and Biology offers an overview of recent research into gold nanoparticles, covering their discovery, usage and contemporary practical applications.This Second Edition begins with a history of over 2000 years of the use of gold nanoparticles, with a review of the specific properties which make gold unique. Updated chapters include gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties and their future technological applications. New chapters have been included, and reveal the growing impact of plasmonics in research, with an introduction to quantum plasmonics, plasmon assisted catalysis and electro-photon conversion. The growing field of nanoparticles for health is also addressed with a study of gold nanoparticles as radiosensibiliser for radiotherapy, and of gold nanoparticle functionalisation. This new edition also considers the relevance of bimetallic nanoparticles for specific applications.World-class scientists provide the most up-to-date findings for an introduction to gold nanoparticles within the related areas of chemistry, biology, material science, optics and physics. It is perfectly suited to advanced level students and researchers looking to enhance their knowledge in the study of gold nanoparticles.
Author : Pere-Joan Cardona
Publisher : BoD – Books on Demand
ISBN 13 : 953307938X
Total Pages : 566 pages
Book Rating : 4.5/5 (33 download)
Download or read book Understanding Tuberculosis written by Pere-Joan Cardona and published by BoD – Books on Demand. This book was released on 2012-02-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is a disease that is transmitted through aerosol. This is the reason why it is estimated that a third of humankind is already infected by Mycobacterium tuberculosis. The vast majority of the infected do not know about their status. Mycobacterium tuberculosis is a silent pathogen, causing no symptomatology at all during the infection. In addition, infected people cannot cause further infections. Unfortunately, an estimated 10 per cent of the infected population has the probability to develop the disease, making it very difficult to eradicate. Once in this stage, the bacilli can be transmitted to other persons and the development of clinical symptoms is very progressive. Therefore the diagnosis, especially the discrimination between infection and disease, is a real challenge. In this book, we present the experience of worldwide specialists on the diagnosis, along with its lights and shadows.
Author : Warren C.W. Chan
Publisher : Springer Science & Business Media
ISBN 13 : 0387767134
Total Pages : 223 pages
Book Rating : 4.3/5 (877 download)
Download or read book Bio-Applications of Nanoparticles written by Warren C.W. Chan and published by Springer Science & Business Media. This book was released on 2009-09-29 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book highlights the central players in the Bionanotechnology field - which are the nanostructures and biomolecules. It provides broad examples of current developments in Bionanotechnology research and is an excellent introduction to the field. The book describes how nanostructures are synthesized and details the wide variety of nanostructures available for biological research and applications. Examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. The final chapters of the book describe the toxicity of nanostructures.
Author : Lev Dykman
Publisher : CRC Press
ISBN 13 : 1351360477
Total Pages : 365 pages
Book Rating : 4.3/5 (513 download)
Download or read book Gold Nanoparticles in Biomedical Applications written by Lev Dykman and published by CRC Press. This book was released on 2017-12-12 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.
Author : Iole Venditti
Publisher : MDPI
ISBN 13 : 3039288334
Total Pages : 124 pages
Book Rating : 4.0/5 (392 download)
Download or read book Nanostructured Materials based on Noble Metals for Advanced Biological Applications written by Iole Venditti and published by MDPI. This book was released on 2020-06-23 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Special Issue “Nanostructured Materials Based on Noble Metals for Advanced Biological Applications” highlights the recent progress in gold and silver nanomaterials preparation/synthesis as well as their innovative applications in advanced applications, such as in nanomedicine and nanosensors. It is nowadays generally accepted that nanostructured noble metals allow the production of highly competitive materials. In fact, a specific design and rather simple and reliable preparation techniques can be used to obtain optimized material uses and possibilities for their reusability. One expects amazing future developments for these nanotechnologies from research laboratories to key industrial areas. The Guest Editor and the MDPI staff are therefore pleased to offer this Special Issue to interested readers, including researchers, graduate and PhD students as well as postdoctoral researchers, but also to the entire community interested in the wide world of nanomaterials.
Author : Greg T. Hermanson
Publisher : Academic Press
ISBN 13 : 0080568726
Total Pages : 1233 pages
Book Rating : 4.0/5 (85 download)
Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 2010-07-26 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions
Author : Mikhail Soloviev
Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.3/5 (121 download)
Download or read book Nanoparticles in Biology and Medicine written by Mikhail Soloviev and published by Methods in Molecular Biology. This book was released on 2012-07-13 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern fascination with micro- and nano-sized materials can actually be traced back further to the 1960s and ‘70s when the first few reported attempts were made to use nanoparticles for controlled drug delivery. In Nanoparticles in Biology and Medicine: Methods and Protocols, experts in the field present a wide range of methods for synthesis, surface modification, characterization, and application of nano-sized materials (nanoparticles) in life science and medical fields, mostly for drug delivery. The methods presented cover all stages of nanoparticle manufacturing, modification, analysis, and applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanoparticles in Biology and Medicine: Methods and Protocols will help the beginner become familiar with this fascinating field and will provide scientists at all levels of expertise with easy-to-follow practical advice needed to make, modify, and analyze nanoparticles of their choice and to use them in a wide range of biomedical and pharmaceutical applications, including functional protein studies, drug delivery, immunochemistry, imaging, and many others.
Author :
Publisher : Elsevier
ISBN 13 : 0444632867
Total Pages : 645 pages
Book Rating : 4.4/5 (446 download)
Download or read book Gold Nanoparticles in Analytical Chemistry written by and published by Elsevier. This book was released on 2014-10-21 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical nanoscience and nanotechnology is a growing topic that is expected to have a great impact in the field of analytical chemistry. Many of the exceptional properties of gold nanoparticles make them suitable for different analytical applications and these applications allow extrapolations for their use in other fields as well. In analytical chemistry gold nanoparticles play two main roles, namely: i) As target analytes in the realm of the analysis of the nanoworld; and ii) As tools to improve analytical processes, such as the use of gold nanoparticles as components of electrodes, in spectroscopic techniques and (bio)chemical sensors and lateral flow sensors. This book is a comprehensive review of the role of gold nanoparticles in analytical nanoscience and nanotechnology, with chapters devoted to their synthesis, physico-chemical characteristics, derivatization and potential toxicity. The main microscopic, spectroscopic and separation techniques for the characterization are reviewed as well as the developments for their determination in environmental, biological and agrifood samples. - Provides an integral approach devoted to a specific nanoparticle - Considers gold nanoparticles as target analytes, as analytical tools and their relationships - Organizes the material in a novel way
Author : Ignác Capek
Publisher : John Wiley & Sons
ISBN 13 : 1118072146
Total Pages : 672 pages
Book Rating : 4.1/5 (18 download)
Download or read book DNA Engineered Noble Metal Nanoparticles written by Ignác Capek and published by John Wiley & Sons. This book was released on 2015-04-13 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA's chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.
Author : Michael J. Welch
Publisher : Taylor & Francis
ISBN 13 : 1439841969
Total Pages : 378 pages
Book Rating : 4.4/5 (398 download)
Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by Taylor & Francis. This book was released on 2012-02-24 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies t
Author : Mitsuhiro Ebara
Publisher : Springer
ISBN 13 : 4431544003
Total Pages : 380 pages
Book Rating : 4.4/5 (315 download)
Download or read book Smart Biomaterials written by Mitsuhiro Ebara and published by Springer. This book was released on 2014-05-28 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
Author : Jacob Laurence Rogowski
Publisher :
ISBN 13 :
Total Pages : 73 pages
Book Rating : 4.:/5 (973 download)
Download or read book Colorimetric Identification of Proteins Using Gold Nanoparticles written by Jacob Laurence Rogowski and published by . This book was released on 2016 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the principal executive biomolecules of life. Their existence is required to drive and regulate countless physiological and biochemical activities within the cell. The study of biochemistry and biology are therefore frequently concerned with monitoring the presence, distribution, and function of proteins. Conventional protein identification assays are often labour-intensive and rely on the use of expensive antibodies. The development of new protein biosensors that incorporate nanotechnology, specifically gold nanoparticles (AuNPs), may allow for facile detection, identification, and quantification of proteins due to their colorimetric output. Unlike other strategies that use antibody-functionalized gold nanoparticles, the pairing of non-functionalized nanoparticles with spectroscopic analysis may further reduce the cost of analysis and make this technology viable for consumer-level applications. This thesis focuses on the development of a gold nanoparticle biosensor for the detection, identification, and quantification of proteins. The underlying principle is based on the aggregation of non-functionalized gold nanoparticles in the presence of proteins. The physicochemical characteristics of these gold nanoparticles can be manipulated to alter their response to different proteins. In order to achieve identification based on non-specific interactions, a “chemical nose” strategy is followed, whereby different gold-nanoparticles produce different individual responses, and their collective response defines a unique signature for a given protein. A review of current literature presents the variety of biological, chemical, and physical factors that can affect protein-nanoparticle interactions, and their resultant effect on colloidal stability. This review also highlights the complexity with which these factors can interact and identifies key considerations for maintaining or controlling colloidal stability in various applications. The experiments herein address the role of shape and surfactant-type on aggregation of gold nanoparticles. Shape has previously been shown to affect protein-nanoparticle interactions, but to our knowledge has not been exploited for protein sensing applications. The role of surfactant on protein-gold nanoparticle interactions is not well studied and provides a novel avenue for investigation. This work demonstrates that both these parameters can be used to alter protein-nanoparticle interactions, thereby permitting “chemical nose”-type detection of proteins. Overall, these studies highlight how modifying protein-nanoparticle interactions can be used for the benefit of biosensing in research and clinical settings. In addition to biosensing, this manner of investigation can serve as a powerful tool to study protein-nanoparticle interactions, with widespread implications in medicine, environmental protection, and water treatment.
Author : Subash C.B. Gopinath
Publisher : Elsevier
ISBN 13 : 0128139013
Total Pages : 354 pages
Book Rating : 4.1/5 (281 download)
Download or read book Nanobiosensors for Biomolecular Targeting written by Subash C.B. Gopinath and published by Elsevier. This book was released on 2018-10-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiosensors for Bio-molecular Targeting presents the latest analytical methods for the detection of different substances in the range of small molecules to whole cells, exploring the advantages and disadvantages of each method. Biosensors combine the component of biological origin and physicochemical detector to show the presence of analytes in a given sample. The use of bionanotechnology has led to a significant advancement in the progression of nanobiosensors and has been effectively used for biomedical diagnosis. - Explains the detection techniques used by nanosensors, exploring the strengths and weaknesses of each for the detection of disease - Shows how biosensors are used to detect various types of biomolecules - Demonstrates how the use of nanomaterials makes biosensors both cheaper and more efficient
Author : Günter Mayer
Publisher : Humana
ISBN 13 : 9781493931965
Total Pages : 0 pages
Book Rating : 4.9/5 (319 download)
Download or read book Nucleic Acid Aptamers written by Günter Mayer and published by Humana. This book was released on 2015-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides protocol references covering recent developments in the aptamer field. Within the last decade, aptamers have become more and more popular, and their sophisticated biophysical properties together with their ability to be easily modified and, thus, adapted to various regimens makes them a very promising class of compounds. Divided into three sections, the book covers selection, a series of analytical methods to assess biophysical properties of aptamer-target interactions, as well as various applications of aptamers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and easy to follow, Nucleic Acid Aptamers: Selection, Characterization, and Application provides a state-of-the-art summary of recent developments in the aptamer field and will be a helpful resource for scientists in the life sciences working with aptamers as tools to elucidate biological systems.
