Genome Rearrangements

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Combinatorics of Genome Rearrangements

Author : Guillaume Fertin
Publisher : MIT Press
ISBN 13 : 0262062828
Total Pages : 305 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Combinatorics of Genome Rearrangements by : Guillaume Fertin

Download or read book Combinatorics of Genome Rearrangements written by Guillaume Fertin and published by MIT Press. This book was released on 2009 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required. From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.

Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination

Author :
Publisher : Academic Press
ISBN 13 : 0128144300
Total Pages : 610 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination by :

Download or read book Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination written by and published by Academic Press. This book was released on 2018-02-17 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. Contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability Documents cutting edge methods

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Chromosomal Translocations and Genome Rearrangements in Cancer

Author : Janet D. Rowley
Publisher : Springer
ISBN 13 : 3319199838
Total Pages : 486 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Chromosomal Translocations and Genome Rearrangements in Cancer by : Janet D. Rowley

Download or read book Chromosomal Translocations and Genome Rearrangements in Cancer written by Janet D. Rowley and published by Springer. This book was released on 2015-12-09 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.

Combinatorics of Genome Rearrangements

Author :
Publisher :
ISBN 13 : 9780262258180
Total Pages : 288 pages
Book Rating : 4.2/5 (581 download)

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Book Synopsis Combinatorics of Genome Rearrangements by :

Download or read book Combinatorics of Genome Rearrangements written by and published by . This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically orientated but offering biological explanations when required, this volume offers the first comprehensive survey of a rapidly expanding application of combinatorial optimization.

Genome Rearrangements

Author : Adriana Muñoz
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.:/5 (781 download)

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Book Synopsis Genome Rearrangements by : Adriana Muñoz

Download or read book Genome Rearrangements written by Adriana Muñoz and published by . This book was released on 2010 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Genome Evolution

Author : Laurence Marechal-Drouard
Publisher : Academic Press
ISBN 13 : 0123942799
Total Pages : 486 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Mitochondrial Genome Evolution by : Laurence Marechal-Drouard

Download or read book Mitochondrial Genome Evolution written by Laurence Marechal-Drouard and published by Academic Press. This book was released on 2012-10-03 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on Mitochondrial genome evolution. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology This thematic volume features reviews on mitochondrial genome evolution

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Genomic Disorders

Author : James R. Lupski
Publisher : Springer Science & Business Media
ISBN 13 : 1597450391
Total Pages : 419 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Genomic Disorders by : James R. Lupski

Download or read book Genomic Disorders written by James R. Lupski and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.

Mathematics of Evolution and Phylogeny

Author : Olivier Gascuel
Publisher : OUP Oxford
ISBN 13 : 9780191513732
Total Pages : 444 pages
Book Rating : 4.5/5 (137 download)

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Book Synopsis Mathematics of Evolution and Phylogeny by : Olivier Gascuel

Download or read book Mathematics of Evolution and Phylogeny written by Olivier Gascuel and published by OUP Oxford. This book was released on 2005-02-24 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book considers evolution at different scales: sequences, genes, gene families, organelles, genomes and species. The focus is on the mathematical and computational tools and concepts, which form an essential basis of evolutionary studies, indicate their limitations, and give them orientation. Recent years have witnessed rapid progress in the mathematics of evolution and phylogeny, with models and methods becoming more realistic, powerful, and complex. Aimed at graduates and researchers in phylogenetics, mathematicians, computer scientists and biologists, and including chapters by leading scientists: A. Bergeron, D. Bertrand, D. Bryant, R. Desper, O. Elemento, N. El-Mabrouk, N. Galtier, O. Gascuel, M. Hendy, S. Holmes, K. Huber, A. Meade, J. Mixtacki, B. Moret, E. Mossel, V. Moulton, M. Pagel, M.-A. Poursat, D. Sankoff, M. Steel, J. Stoye, J. Tang, L.-S. Wang, T. Warnow, Z. Yang, this book of contributed chapters explains the basis and covers the recent results in this highly topical area.

Genetic Rearrangement

Author : K. F. Chater
Publisher : Sinauer Associates, Incorporated
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genetic Rearrangement by : K. F. Chater

Download or read book Genetic Rearrangement written by K. F. Chater and published by Sinauer Associates, Incorporated. This book was released on 1983 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Models and Algorithms for Genome Evolution

Author : Cedric Chauve
Publisher : Springer Science & Business Media
ISBN 13 : 1447152980
Total Pages : 329 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Models and Algorithms for Genome Evolution by : Cedric Chauve

Download or read book Models and Algorithms for Genome Evolution written by Cedric Chauve and published by Springer Science & Business Media. This book was released on 2013-09-17 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.

Mobile DNA III

Author : Michael Chandler
Publisher : John Wiley & Sons
ISBN 13 : 1555819214
Total Pages : 1321 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Mobile DNA III by : Michael Chandler

Download or read book Mobile DNA III written by Michael Chandler and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 1321 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of the raw power of genetic material to refashion itself to any purpose... Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability. Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible presents a detailed account of the many different recombination systems that can rearrange genomes examines the tremendous impact of mobile DNA in virtually all organisms Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms. Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

Comparative Genomics

Author : D. Sankoff
Publisher : Springer Science & Business Media
ISBN 13 : 9401143099
Total Pages : 540 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Comparative Genomics by : D. Sankoff

Download or read book Comparative Genomics written by D. Sankoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of genomic rearrangement, focusing on the mechanisms of inversion, translocation, gene and genome duplication and gene transfer and on the patterns that result from them in comparative maps. Includes analyses of genomic sequences in organelles, prokaryotes and eukaryotes as well as comparative maps of the nuclear genomes in higher plants and animals. The book showcases a variety of algorithmic and statistical approaches to rearrangement and map data.

A Tale of Three Next Generation Sequencing Platforms

Author : Applied Research Press
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781515216209
Total Pages : 42 pages
Book Rating : 4.2/5 (162 download)

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Book Synopsis A Tale of Three Next Generation Sequencing Platforms by : Applied Research Press

Download or read book A Tale of Three Next Generation Sequencing Platforms written by Applied Research Press and published by Createspace Independent Publishing Platform. This book was released on 2015-07-24 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent's PGM, Pacific Biosciences' RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support. Proceeds from the sale of this book go to the support of an elderly disabled person.

Self-Organisation and Evolution of Biological and Social Systems

Author : Charlotte Hemelrijk
Publisher : Cambridge University Press
ISBN 13 : 9781139446198
Total Pages : 216 pages
Book Rating : 4.4/5 (461 download)

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Book Synopsis Self-Organisation and Evolution of Biological and Social Systems by : Charlotte Hemelrijk

Download or read book Self-Organisation and Evolution of Biological and Social Systems written by Charlotte Hemelrijk and published by Cambridge University Press. This book was released on 2005-09-29 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-organisation of social systems can be observed at all levels of biological complexity, from cells to organisms and communities. Although individuals are governed by simple rules, their interactions with each other and their environment leads to complex patterns. Self-Organisation and Evolution of Social Systems investigates a broad spectrum of social systems ranging from those of simple single-celled organisms to those of very complex ones, such as humans. It examines groups of all sizes, from small as in certain species of primates, to very large as in some species of fish and social insects. This book deals with numerous aspects of their social organisation, including group formation, task-division, foraging, dominance interactions, infant protection, language and voting. It is recommended reading for all academic researchers and professionals interested in this fascinating field.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: