Genome Analysis In Eukaryotes

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The Pangenome

Author : Hervé Tettelin
Publisher : Springer Nature
ISBN 13 : 3030382818
Total Pages : 311 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis The Pangenome by : Hervé Tettelin

Download or read book The Pangenome written by Hervé Tettelin and published by Springer Nature. This book was released on 2020-04-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Genome Analysis in Eukaryotes

Author : Rabindra N. Chatterjee
Publisher : Springer Science & Business Media
ISBN 13 : 3662118297
Total Pages : 262 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Genome Analysis in Eukaryotes by : Rabindra N. Chatterjee

Download or read book Genome Analysis in Eukaryotes written by Rabindra N. Chatterjee and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decades a breakthrough in the understanding of the mechanisms controlling development has been achieved. This has been possible, in great part, by the use of various experimental approaches. This book focuses on topics concerning some of the processes involved in development, the main emphasis being on the genetic and molecular mechanisms in the evolutionary context. Drosophila is used as an experimental model for the genetic approach to the understanding of behaviour.

Genetic Analysis

Author : Philip Mark Meneely
Publisher : Oxford University Press
ISBN 13 : 0199681260
Total Pages : 580 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Genetic Analysis by : Philip Mark Meneely

Download or read book Genetic Analysis written by Philip Mark Meneely and published by Oxford University Press. This book was released on 2014 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its unique integration of genetics and molecular biology, this text probes fascinating questions that explore how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations, the analysis of gene expression and activity, a discussion of the genetic structure of natural populations, and more.

Genetic Analysis

Author : Philip Meneely
Publisher : Oxford University Press, USA
ISBN 13 : 0198809905
Total Pages : 491 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Genetic Analysis by : Philip Meneely

Download or read book Genetic Analysis written by Philip Meneely and published by Oxford University Press, USA. This book was released on 2020-02-11 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics. Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.

Genome Analysis in Eukaryotes

Author : R. N. Chatterjee
Publisher : Springer Verlag
ISBN 13 : 9780387635248
Total Pages : 255 pages
Book Rating : 4.6/5 (352 download)

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Book Synopsis Genome Analysis in Eukaryotes by : R. N. Chatterjee

Download or read book Genome Analysis in Eukaryotes written by R. N. Chatterjee and published by Springer Verlag. This book was released on 1998-01-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sequence — Evolution — Function

Author : Eugene V. Koonin
Publisher : Springer Science & Business Media
ISBN 13 : 1475737831
Total Pages : 482 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Sequence — Evolution — Function by : Eugene V. Koonin

Download or read book Sequence — Evolution — Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Mapping and Sequencing the Human Genome

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Principles of Genome Analysis and Genomics

Author : Sandy B. Primrose
Publisher : John Wiley & Sons
ISBN 13 : 144431128X
Total Pages : 288 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Principles of Genome Analysis and Genomics by : Sandy B. Primrose

Download or read book Principles of Genome Analysis and Genomics written by Sandy B. Primrose and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the first draft of the human genome project in the publicdomain and full analyses of model genomes now available, thesubject matter of 'Principles of Genome Analysis and Genomics' iseven 'hotter' now than when the first two editions were publishedin 1995 and 1998. In the new edition of this very practical guideto the different techniques and theory behind genomes and genomeanalysis, Sandy Primrose and new author Richard Twyman provide afresh look at this topic. In the light of recent excitingadvancements in the field, the authors have completely revised andrewritten many parts of the new edition with the addition of fivenew chapters. Aimed at upper level students, it is essential thatin this extremely fast moving topic area the text is up to date andrelevant. Completely revised new edition of an establishedtextbook. Features new chapters and examples from exciting new researchin genomics, including the human genome project. Excellent new co-author in Richard Twyman, also co-author ofthe new edition of hugely popular Principles of GeneManipulation. Accompanying web-page to help students deal with this difficulttopic at www.blackwellpublishing.com/primrose

Genomics and Evolution of Microbial Eukaryotes

Author : Laura Katz Olson
Publisher : Oxford University Press, USA
ISBN 13 : 0198569742
Total Pages : 256 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Genomics and Evolution of Microbial Eukaryotes by : Laura Katz Olson

Download or read book Genomics and Evolution of Microbial Eukaryotes written by Laura Katz Olson and published by Oxford University Press, USA. This book was released on 2006-09-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a unique combination of recently-emerged information on eukaryotic microbes, evolution and genomics. Eukaryotes, cells with nuclei, evolved as microbes and have existed on Earth for approximately 2 billion years. Although currently relatively understudied, eukaryotic microorganisms are of critical importance to ecosystems (through their involvement in global biogeochemical cycles), human health (they include some of the deadliest pathogens), and our desire tounderstand global biodiversity. Recent advances, particularly in DNA sequencing technologies, are making eukaryotic microbes more accessible through genome analyses. Insights from these studies are challenging previously held theories of genome evolution, based on studies of a limited number of plants,animals and fungi.

Genomics and Evolution of Microbial Eukaryotes

Author : Laura A Katz
Publisher : OUP Oxford
ISBN 13 : 0191513857
Total Pages : 256 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Genomics and Evolution of Microbial Eukaryotes by : Laura A Katz

Download or read book Genomics and Evolution of Microbial Eukaryotes written by Laura A Katz and published by OUP Oxford. This book was released on 2006-09-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics and Evolution of Eukaryotic Microbes synthesizes the rapidly emerging fields of eukaryotic diversity and genome evolution. Eukaryotes (cells with nuclei) evolved as microbes and have existed on Earth for approximately two billion years. The tremendous diversity of eukaryotic microbes (protists) is often overlooked by those who study the macroscopic eukaryotic lineages: plants, animals, and fungi. Yet, eukaryotic microbes are of critical importance to ecosystems, human health, and our desire to understand biodiversity on Earth. By bringing together groundbreaking data from genome studies of diverse eukaryotic microbes, this book elucidates the many novelties among eukaryotic genomes and provides a single resource for otherwise widely dispersed information. Eukaryotic microorganisms impact both our health and our environment. These organisms include some of the deadliest known pathogens such as Plasmodium falciparum, a causative agent of malaria, and Entamoeba histolytica an agent of dysentery. Eukaryotic microbes also play a significant role in environments through their involvement in global biogeochemical cycles. Such roles are perhaps best exemplified by the coccolithophores, including the species Emiliania huxleyi, which can create 'blooms' in the oceans that are visible from outer space (i.e. as large as the state of Alaska). Despite the great importance and breadth of eukaryotic microbes (the vast majority of major ukaryotic lineages are microbial, with plants, animals and fungi representing just three of an estimated 60-200 major lineages), our understanding of their diversity and phylogeny is only now rapidly expanding, in part bolstered by genomic studies. This book presents analyses and interpretations from experts in the field. Recent advances, particularly in DNA sequencing technologies, have made eukaryotic microbes more accessible to genome analyses. Unravelling the wealth of information on eukaryotic genomes will invariably revolutionize our understanding of eukaryotes, including their physiology, systematics, and ecology.

Organelles, Genomes and Eukaryote Phylogeny

Author : Robert P Hirt
Publisher : CRC Press
ISBN 13 : 0203508939
Total Pages : 462 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Organelles, Genomes and Eukaryote Phylogeny by : Robert P Hirt

Download or read book Organelles, Genomes and Eukaryote Phylogeny written by Robert P Hirt and published by CRC Press. This book was released on 2004-06-28 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent revolution in molecular biology has spread through every field of biology including systematics and evolution. Researchers can now analyze the genomes of different species relatively quickly, and this is generating a great deal of data and theories about relationships between taxa as well as how they originated and diversified. Org

The Yeast Two-hybrid System

Author : Paul L. Bartel
Publisher : Oxford University Press, USA
ISBN 13 : 9780195109382
Total Pages : 362 pages
Book Rating : 4.1/5 (93 download)

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Book Synopsis The Yeast Two-hybrid System by : Paul L. Bartel

Download or read book The Yeast Two-hybrid System written by Paul L. Bartel and published by Oxford University Press, USA. This book was released on 1997 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and variations of the technique.

Pan-genomics: Applications, Challenges, and Future Prospects

Author : Debmalya Barh
Publisher : Academic Press
ISBN 13 : 0128170778
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Pan-genomics: Applications, Challenges, and Future Prospects by : Debmalya Barh

Download or read book Pan-genomics: Applications, Challenges, and Future Prospects written by Debmalya Barh and published by Academic Press. This book was released on 2020-03-06 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives Discusses current bioinformatics tools and strategies for exploiting pangenomics data Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability

Advanced Genetic Analysis

Author : Philip Meneely
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advanced Genetic Analysis by : Philip Meneely

Download or read book Advanced Genetic Analysis written by Philip Meneely and published by Oxford University Press, USA. This book was released on 2009-01-15 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Genetic Analysis explores the question "How can the principles of genetics be used as analytical tools to solve biological problems?" Drawing on the latest experimental tools, including microarrays, RNAi, and bioinformatics approaches, it provides a state-of-the-art review of the field, but in a truly student-friendly manner.

Genome and Genomics

Author : K. V. Chaitanya
Publisher : Springer Nature
ISBN 13 : 9811507023
Total Pages : 319 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Genome and Genomics by : K. V. Chaitanya

Download or read book Genome and Genomics written by K. V. Chaitanya and published by Springer Nature. This book was released on 2019-11-17 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.

Gene Prediction

Author : Martin Kollmar
Publisher : Humana Press
ISBN 13 : 9781493991723
Total Pages : 284 pages
Book Rating : 4.9/5 (917 download)

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Book Synopsis Gene Prediction by : Martin Kollmar

Download or read book Gene Prediction written by Martin Kollmar and published by Humana Press. This book was released on 2019-05-19 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume introduces software used for gene prediction with focus on eukaryotic genomes. The chapters in this book describe software and web server usage as applied in common use-cases, and explain ways to simplify re-annotation of long available genome assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary computational requirements, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Gene Prediction: Methods and Protocols is a valuable resource for researchers and research groups working on the assembly and annotation of single species or small groups of species. Chapter 3 is available open access under a CC BY 4.0 license via link.springer.com.

Genomes 4

Author : T. A. Brown
Publisher : Garland Science
ISBN 13 : 1351851284
Total Pages : 963 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Genomes 4 by : T. A. Brown

Download or read book Genomes 4 written by T. A. Brown and published by Garland Science. This book was released on 2018-12-07 with total page 963 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.