Genetically Engineered Mice Handbook

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Genetically Engineered Mice Handbook

Author : John P. Sundberg
Publisher : CRC Press
ISBN 13 : 1420039075
Total Pages : 336 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Genetically Engineered Mice Handbook by : John P. Sundberg

Download or read book Genetically Engineered Mice Handbook written by John P. Sundberg and published by CRC Press. This book was released on 2016-04-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models. The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities. This essential reference examines commonly used traditional, as well as emerging, technologies To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.

Transgenic Animal Technology

Author : Carl A. Pinkert
Publisher : Gulf Professional Publishing
ISBN 13 : 0125571666
Total Pages : 635 pages
Book Rating : 4.1/5 (255 download)

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Book Synopsis Transgenic Animal Technology by : Carl A. Pinkert

Download or read book Transgenic Animal Technology written by Carl A. Pinkert and published by Gulf Professional Publishing. This book was released on 2002-11-18 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat. One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology. Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer - from molecular methods to whole animal considerations - for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols New section on analysis

Transgenic Animal Technology

Author : Carl A. Pinkert
Publisher : Elsevier
ISBN 13 : 0080574807
Total Pages : 618 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Transgenic Animal Technology by : Carl A. Pinkert

Download or read book Transgenic Animal Technology written by Carl A. Pinkert and published by Elsevier. This book was released on 2012-12-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat. One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology. Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer - from molecular methods to whole animal considerations - for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols New section on analysis

Transgenic Mouse Methods and Protocols

Author : Marten H. Hofker
Publisher : Humana Press
ISBN 13 : 9781607619758
Total Pages : 352 pages
Book Rating : 4.6/5 (197 download)

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Book Synopsis Transgenic Mouse Methods and Protocols by : Marten H. Hofker

Download or read book Transgenic Mouse Methods and Protocols written by Marten H. Hofker and published by Humana Press. This book was released on 2011-08-24 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in the context of a whole organism, making them particularly useful. In Transgenic Mouse Methods and Protocols, Second Edition, expert research explore current advances in the field through detailed laboratory protocols. Chapters provide a general introduction outlining how to deal with mice and how to generate transgenic mouse models, explore the generation of conditional and induced knockout and transgenic mice, and offer alternative routes to studying gene function in mice. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and state of the art, Transgenic Mouse Methods and Protocols, second Edition is the ideal guide for all researchers interested in the latest information about the production and analysis of transgenic and knockout mice.

Guide for the Care and Use of Laboratory Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Genetically Engineered Mice for Cancer Research

Author : Jeffrey E. Green
Publisher : Springer Science & Business Media
ISBN 13 : 0387698035
Total Pages : 639 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Genetically Engineered Mice for Cancer Research by : Jeffrey E. Green

Download or read book Genetically Engineered Mice for Cancer Research written by Jeffrey E. Green and published by Springer Science & Business Media. This book was released on 2011-12-08 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Mouse Phenotypes

Author : Virginia E. Papaioannou
Publisher : CSHL Press
ISBN 13 : 9780879696405
Total Pages : 260 pages
Book Rating : 4.6/5 (964 download)

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Book Synopsis Mouse Phenotypes by : Virginia E. Papaioannou

Download or read book Mouse Phenotypes written by Virginia E. Papaioannou and published by CSHL Press. This book was released on 2005 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides stepâ€“byâ€“step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.

Handbook of Laboratory Animal Science, Second Edition

Author : Jann Hau
Publisher : CRC Press
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Handbook of Laboratory Animal Science, Second Edition by : Jann Hau

Download or read book Handbook of Laboratory Animal Science, Second Edition written by Jann Hau and published by CRC Press. This book was released on 2003 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a text for students specializing in laboratory animal science expands coverage to include material on genetic engineering, phenotype characterization of genetically engineered mice, surgical techniques, monitoring the well-being of animals, and the treatment of pain and suffering in laboratory animals. There is discussion of general methods including experimental design and statistical evaluations, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Safety and security in facilities is examined, and Australasian legislation and regulation are covered. The book is also useful as a reference for biomedical researchers, managers, quality assurance professionals, and technicians. Hau teaches comparative medicine at the University of Uppsala, Sweden; Van Hoosier, at the University of Washington. Annotation copyrighted by Book News, Inc., Portland, OR.

Handbook on Genetically Standardized JAX Mice

Author : Jackson Laboratory (Bar Harbor, Me.)
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.1/5 (286 download)

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Book Synopsis Handbook on Genetically Standardized JAX Mice by : Jackson Laboratory (Bar Harbor, Me.)

Download or read book Handbook on Genetically Standardized JAX Mice written by Jackson Laboratory (Bar Harbor, Me.) and published by . This book was released on 1968 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Author : Wanda M. Haschek
Publisher : Academic Press
ISBN 13 : 0124157653
Total Pages : 3054 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Haschek and Rousseaux's Handbook of Toxicologic Pathology by : Wanda M. Haschek

Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology written by Wanda M. Haschek and published by Academic Press. This book was released on 2013-05-01 with total page 3054 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Handbook of Laboratory Animal Science: Animal models

Author : Jann Hau
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Handbook of Laboratory Animal Science: Animal models by : Jann Hau

Download or read book Handbook of Laboratory Animal Science: Animal models written by Jann Hau and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a text for students specializing in laboratory animal science expands coverage to include material on genetic engineering, phenotype characterization of genetically engineered mice, surgical techniques, monitoring the well-being of animals, and the treatment of pain and suffering in laboratory animals. There is discussion of general methods including experimental design and statistical evaluations, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Safety and security in facilities is examined, and Australasian legislation and regulation are covered. The book is also useful as a reference for biomedical researchers, managers, quality assurance professionals, and technicians. Hau teaches comparative medicine at the University of Uppsala, Sweden; Van Hoosier, at the University of Washington. Annotation copyrighted by Book News, Inc., Portland, OR.

Handbook of Mouse Mutations with Skin and Hair Abnormalities

Author : John P. Sundberg
Publisher : CRC Press
ISBN 13 : 1000142329
Total Pages : 582 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Handbook of Mouse Mutations with Skin and Hair Abnormalities by : John P. Sundberg

Download or read book Handbook of Mouse Mutations with Skin and Hair Abnormalities written by John P. Sundberg and published by CRC Press. This book was released on 2020-08-26 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Guide to Techniques in Mouse Development, Part B

Author : Paul Wassarman
Publisher : Academic Press
ISBN 13 : 9780123848819
Total Pages : 628 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Guide to Techniques in Mouse Development, Part B by : Paul Wassarman

Download or read book Guide to Techniques in Mouse Development, Part B written by Paul Wassarman and published by Academic Press. This book was released on 2010-09-24 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. This volume is Part B of an update of volume 225, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993. Comprehensively covers new techniques for the cryopreservation of gametes and embryos, production of transgenic and null (knockout) animals (use of ES cells), generation of conditional/inducible mutant animals, use of gene-trap mutagenesis, analysis of allele-specific expression, use of new reporter constructs, humanizing of transgenic animals, transcript profiling of mouse development, imaging of mouse development, and rederivation of animals and use of mouse genomics.

Pathology of Genetically Engineered and Other Mutant Mice

Author : John P. Sundberg
Publisher : John Wiley & Sons
ISBN 13 : 1119624576
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Pathology of Genetically Engineered and Other Mutant Mice by : John P. Sundberg

Download or read book Pathology of Genetically Engineered and Other Mutant Mice written by John P. Sundberg and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Harkness and Wagner's Biology and Medicine of Rabbits and Rodents

Author : John E. Harkness
Publisher : John Wiley & Sons
ISBN 13 : 1118708903
Total Pages : 487 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Harkness and Wagner's Biology and Medicine of Rabbits and Rodents by : John E. Harkness

Download or read book Harkness and Wagner's Biology and Medicine of Rabbits and Rodents written by John E. Harkness and published by John Wiley & Sons. This book was released on 2013-03-22 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Harkness and Wagner's Biology and Medicine of Rabbits and Rodents, Fifth Edition is a practical reference in small mammal husbandry and health, encompassing the fields of laboratory animal medicine and pet practice. Part of ACLAM's series of laboratory animal books, this text offers concise but complete coverage on rabbits and the most common rodent species, with an emphasis on biology, clinical procedures, clinical signs, and diseases and conditions. By providing useful, accessible assessment and diagnostic information, Harkness and Wagner's Biology and Medicine of Rabbits and Rodents aids the practitioner in diagnosing and treating conditions in small mammals.

Handbook of Laboratory Animal Science: Animal models

Author : Jann Hau
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Handbook of Laboratory Animal Science: Animal models by : Jann Hau

Download or read book Handbook of Laboratory Animal Science: Animal models written by Jann Hau and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guide to Techniques in Mouse Development, Part A

Author : Paul M. Wassarman
Publisher : Academic Press
ISBN 13 : 9780123848833
Total Pages : 482 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Guide to Techniques in Mouse Development, Part A by : Paul M. Wassarman

Download or read book Guide to Techniques in Mouse Development, Part A written by Paul M. Wassarman and published by Academic Press. This book was released on 2010 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: 17 years have passed since the first edition of the "Guide to Techniques in Mouse Development" (volume 225) was puolished. During this time development of technology used to investigate mouse development has not stood still, with enormous advances occurring in genomics, transgenic and ES cell methodology, and reprogramming, culminating with development of IPS cells. At both the cellular and molecular levels, a great many technological advances have been made that permit investigators to probe ever more deeply into all aspects of mouse development.