Genetic Mosaics and Cell Differentiation

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Publisher : Springer Science & Business Media
ISBN 13 : 354035803X
Total Pages : 323 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Genetic Mosaics and Cell Differentiation by : W. J. Gehring

Download or read book Genetic Mosaics and Cell Differentiation written by W. J. Gehring and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship of cell lineage and differentiation is one of the most intriguing problems in developmental biology. In most higher organisms, the analysis of the cell lineage has to rely on indirect methods. Only in the most suitable systems, like the nematodes, can the pattern of cell division be determined by direct observation under the microscope. In cases where this is not possible, the fate of the cells has to be examined by using cell markers. Most suitable for this purpose are genetic markers, provided that they do not interfere with the developmental pathway to be studied. However, suitable genetic markers and techniques for generating genetic mosaics are available in a few organisms only. Therefore, this volume is largely concerned with Drosophila and the mouse, which have been studied most extensively. In 1929 STURTEVANT introduced the analysis of gynandromorphs into devel opmental genetics. However, this important contribution remained largely unnoticed until the late sixties, when the potential of this technique for deter mining embryonic fate maps and the number of primordial cells was exploited, and the methodology extended to the mapping of mutational foci. Mitotic recombination was demostrated by STER:-

Genetic Mosaics and Cell Differentiation

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540088820
Total Pages : 315 pages
Book Rating : 4.0/5 (888 download)

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Book Synopsis Genetic Mosaics and Cell Differentiation by : Walter J. Gehring

Download or read book Genetic Mosaics and Cell Differentiation written by Walter J. Gehring and published by Springer Science & Business Media. This book was released on 1978 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetics Mosaics and Cell Differentiation

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Author :
Publisher :
ISBN 13 :
Total Pages : 315 pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis Genetics Mosaics and Cell Differentiation by : Walter J. Gehring

Download or read book Genetics Mosaics and Cell Differentiation written by Walter J. Gehring and published by . This book was released on 1978 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Differentiation of Cells

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Author :
Publisher : Hodder Education
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Differentiation of Cells by : Norman Maclean

Download or read book The Differentiation of Cells written by Norman Maclean and published by Hodder Education. This book was released on 1977 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Females Are Mosaics

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Publisher : Oxford University Press
ISBN 13 : 0190208473
Total Pages : 296 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Females Are Mosaics by : Barbara Migeon

Download or read book Females Are Mosaics written by Barbara Migeon and published by Oxford University Press. This book was released on 2007-03-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The fathers copy works in some cells, while the mothers copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women. Females are Mosaics will be valuable to geneticists, biologists, and all health professionals interested in women's health.

Results and Problems in Cell Differentiation

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Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.X/5 (1 download)

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Book Synopsis Results and Problems in Cell Differentiation by : W. Beermann

Download or read book Results and Problems in Cell Differentiation written by W. Beermann and published by . This book was released on 1968 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Mosaicism

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Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527571165
Total Pages : 160 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis Genetic Mosaicism by : János Szabad

Download or read book Genetic Mosaicism written by János Szabad and published by Cambridge Scholars Publishing. This book was released on 2021-06-17 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of green and yellow ornamental plants around us, dark spots on our skin, people with brown and blue mosaic irises, and white-spotted dogs and horses are all well-known phenomena of life, and are recognisable genetic mosaics. Although such genetics mosaics live with us (and, in fact, we are all a genetic mosaics), little is known about the genetic bases of their origin. This book provides a general overview of the mechanisms that lead to the formation of different types of mosaics, listing an ample collection of examples to illustrate the impact of the genetic mosaics on our life. The book will appeal to the reader interested in understanding the relationship between genetic events and mosaicism, especially undergraduate and graduate students and medical doctors, as well as experts engaged in horticulture and animal breeding.

Genetic Mosaics and Chimeras in Mammals

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Publisher : Springer Science & Business Media
ISBN 13 : 1468433903
Total Pages : 480 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Genetic Mosaics and Chimeras in Mammals by : L. B. Russell

Download or read book Genetic Mosaics and Chimeras in Mammals written by L. B. Russell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Hierarchical Genome and Differentiation Waves

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Publisher : World Scientific
ISBN 13 : 9789810222680
Total Pages : 936 pages
Book Rating : 4.2/5 (226 download)

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Book Synopsis The Hierarchical Genome and Differentiation Waves by : Richard Gordon

Download or read book The Hierarchical Genome and Differentiation Waves written by Richard Gordon and published by World Scientific. This book was released on 1999 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.

Gene Expression During Cell Differentiation

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Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Gene Expression During Cell Differentiation by : John Bertrand Gurdon

Download or read book Gene Expression During Cell Differentiation written by John Bertrand Gurdon and published by . This book was released on 1973 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mosaicism in Human Skin

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Publisher : Springer Nature
ISBN 13 : 3030899373
Total Pages : 252 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Mosaicism in Human Skin by : Rudolf Happle

Download or read book Mosaicism in Human Skin written by Rudolf Happle and published by Springer Nature. This book was released on 2022-11-24 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians.

Stem Cells and the Future of Regenerative Medicine

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Publisher : National Academies Press
ISBN 13 : 0309170427
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine

Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Cytogenomics

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Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Exploring the Biological Contributions to Human Health

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Publisher : National Academies Press
ISBN 13 : 0309132975
Total Pages : 287 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Biological Contributions to Human Health by : Institute of Medicine

Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Genetic Mosaics and Cell Differenciation

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Publisher :
ISBN 13 :
Total Pages : 315 pages
Book Rating : 4.:/5 (85 download)

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Book Synopsis Genetic Mosaics and Cell Differenciation by : Walter J. Gehring

Download or read book Genetic Mosaics and Cell Differenciation written by Walter J. Gehring and published by . This book was released on 1978 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drosophila Eye Development

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540425908
Total Pages : 296 pages
Book Rating : 4.4/5 (259 download)

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Book Synopsis Drosophila Eye Development by : Kevin Moses

Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2002-03-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.

Genetics for Surgeons

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Publisher : Remedica
ISBN 13 : 1901346692
Total Pages : 237 pages
Book Rating : 4.9/5 (13 download)

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Book Synopsis Genetics for Surgeons by : Patrick John Morrison

Download or read book Genetics for Surgeons written by Patrick John Morrison and published by Remedica. This book was released on 2005 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).