Genetic And Molecular Modulations In An Experimental Model Of Inflammatory Bowel Disease

Download Genetic And Molecular Modulations In An Experimental Model Of Inflammatory Bowel Disease full books in PDF, epub, and Kindle. Read online Genetic And Molecular Modulations In An Experimental Model Of Inflammatory Bowel Disease ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Inflammatory Bowel Disease

Author : Stephan R. Targan
Publisher : John Wiley & Sons
ISBN 13 : 1444359118
Total Pages : 1429 pages
Book Rating : 4.4/5 (443 download)

DOWNLOAD NOW!

Book Synopsis Inflammatory Bowel Disease by : Stephan R. Targan

Download or read book Inflammatory Bowel Disease written by Stephan R. Targan and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins

Author : Thomas Kreis
Publisher : Sambrook and Tooze Publications
ISBN 13 : 9780198599586
Total Pages : 646 pages
Book Rating : 4.5/5 (995 download)

DOWNLOAD NOW!

Book Synopsis Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins by : Thomas Kreis

Download or read book Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins written by Thomas Kreis and published by Sambrook and Tooze Publications. This book was released on 1999 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.

Colitis-Associated Cancer

Author : Masato Kusunoki
Publisher : Springer
ISBN 13 : 4431555226
Total Pages : 151 pages
Book Rating : 4.4/5 (315 download)

DOWNLOAD NOW!

Book Synopsis Colitis-Associated Cancer by : Masato Kusunoki

Download or read book Colitis-Associated Cancer written by Masato Kusunoki and published by Springer. This book was released on 2015-10-01 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons.

Molecular Genetics of Inflammatory Bowel Disease

Author : Charlotte Hedin
Publisher : Springer Nature
ISBN 13 : 3030287033
Total Pages : 399 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Molecular Genetics of Inflammatory Bowel Disease by : Charlotte Hedin

Download or read book Molecular Genetics of Inflammatory Bowel Disease written by Charlotte Hedin and published by Springer Nature. This book was released on 2019-12-19 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.

Animals (Scientific Procedures) Act 1986

Author : Great Britain. Home Office
Publisher :
ISBN 13 : 9780105567066
Total Pages : 103 pages
Book Rating : 4.5/5 (67 download)

DOWNLOAD NOW!

Book Synopsis Animals (Scientific Procedures) Act 1986 by : Great Britain. Home Office

Download or read book Animals (Scientific Procedures) Act 1986 written by Great Britain. Home Office and published by . This book was released on 2000 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guidance on the Operation of the Animals (Scientific Procedures) ACT 1986

NLR-protein functions in immunity

Author : Thomas A. Kufer
Publisher : Frontiers Media SA
ISBN 13 : 2889196216
Total Pages : 222 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!

Book Synopsis NLR-protein functions in immunity by : Thomas A. Kufer

Download or read book NLR-protein functions in immunity written by Thomas A. Kufer and published by Frontiers Media SA. This book was released on 2015-07-08 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial defense and adaptive immunity. Recent data however suggests that the biological roles of NLR go beyond the function of classical pattern recognition molecules (PRM) as they have been implicated in essential cellular processes including autophagy, apoptosis, modification of signal transduction and gene transcription as well as reproductive biology. In this research topic, we aim to provide a comprehensive state-of the art overview of the emerging functions of NLR in plant and mammalian immunity, cell biology and reproductive biology. Potential topics may include, but are not limited to the following areas: • Functions of NLRs as PRMs in infection • Cross-talk of NLRs with other PRMs • Signal transduction pathways of NLRs • New functions of NLRs other than pattern recognition • Structural aspects of NLR activation • Mechanisms of NLRs in cell biological processes • Aspects of NLRs in reproductive biology • Functions of NLRs in plant immune responses

Enteric Glia

Author : Brian D. Gulbransen
Publisher : Biota Publishing
ISBN 13 : 1615046615
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)

DOWNLOAD NOW!

Book Synopsis Enteric Glia by : Brian D. Gulbransen

Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Author : B. Kyewski
Publisher : Springer Science & Business Media
ISBN 13 : 3540277021
Total Pages : 331 pages
Book Rating : 4.5/5 (42 download)

DOWNLOAD NOW!

Book Synopsis CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential by : B. Kyewski

Download or read book CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Oxidative Stress

Author : Helmut Sies
Publisher : Academic Press
ISBN 13 : 0128196963
Total Pages : 878 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Oxidative Stress by : Helmut Sies

Download or read book Oxidative Stress written by Helmut Sies and published by Academic Press. This book was released on 2019-11-07 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: - A conceptual framework for studying oxidative stress. - Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). - The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. - Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. - Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine - Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies - Features contributions from international leaders in oxidative stress and redox biology research

Pediatric Inflammatory Bowel Disease

Author : Petar Mamula
Publisher : Springer Science & Business Media
ISBN 13 : 1461450616
Total Pages : 573 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis Pediatric Inflammatory Bowel Disease by : Petar Mamula

Download or read book Pediatric Inflammatory Bowel Disease written by Petar Mamula and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use. Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists.

Crohn's Disease and Ulcerative Colitis

Author : Daniel C. Baumgart
Publisher : Springer
ISBN 13 : 3319337033
Total Pages : 671 pages
Book Rating : 4.3/5 (193 download)

DOWNLOAD NOW!

Book Synopsis Crohn's Disease and Ulcerative Colitis by : Daniel C. Baumgart

Download or read book Crohn's Disease and Ulcerative Colitis written by Daniel C. Baumgart and published by Springer. This book was released on 2017-03-01 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

Induction and Modulation of Gastrointestinal Inflammation

Author : A. Stallmach
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387473
Total Pages : 350 pages
Book Rating : 4.3/5 (874 download)

DOWNLOAD NOW!

Book Synopsis Induction and Modulation of Gastrointestinal Inflammation by : A. Stallmach

Download or read book Induction and Modulation of Gastrointestinal Inflammation written by A. Stallmach and published by Springer Science & Business Media. This book was released on 1998-12-31 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the proceedings of Falk Symposium No. 104, organized in collaboration with the Society of Mucosal Immunology, and held in Saarbrucken, Germany, March 5-7 1998, is centered around the immunological mechanisms of mucosal protection and their disturbances leading to intestinal inflammation and destruction. This is a rapidly expanding field involving recent knowledge of basic immunology and cell biology as well as clinical observations. The conference and this book summarize very recent data in this field and suggest strategies for future research and clinical applications, and will be of interest to both basic scientists and clinicians.

Bile Acids and Their Receptors

Author : Stefano Fiorucci
Publisher : Springer Nature
ISBN 13 : 3030220052
Total Pages : 374 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Bile Acids and Their Receptors by : Stefano Fiorucci

Download or read book Bile Acids and Their Receptors written by Stefano Fiorucci and published by Springer Nature. This book was released on 2019-09-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

Poisons

Author : David J. George
Publisher : Taylor & Francis
ISBN 13 : 1315354489
Total Pages : 242 pages
Book Rating : 4.3/5 (153 download)

DOWNLOAD NOW!

Book Synopsis Poisons by : David J. George

Download or read book Poisons written by David J. George and published by Taylor & Francis. This book was released on 2017-11-13 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book on recognition and investigation of criminal poisoning for investigators of all backgrounds and stages of their careers. Poisons: An Introduction for Forensic Investigators is a concise yet comprehensive overview of toxicants and unanticipated circumstances in which poisoning occurs. This book expands awareness of poisoning possibilities, heightens recognition of the toxic potential of many substances, and provides information to aid in focusing investigations. Poisons discusses life-threatening toxic substances and agents that modify behavior to achieve criminal goals. These include drugs that facilitate sexual assaults and robberies, and those found in medical child abuse and drug-product tampering. More than 230 case studies illustrate both unintentional and intentional poisoning and highlight situations where poisoning may not immediately be apparent. Information is included in pertinent criminal poisoning cases to illustrate the temperament of poisoners, their relationship to victims, their basis for poison selection, and their method of administration. Since Poisons is written by a single author, the discussions, format, educational level, and terminology remain consistent to aid crime scene investigators, homicide detectives, forensic scientists, death investigators, toxicologists, medical examiners, attorneys, and students. The book's more than 650 references are an asset to frame knowledge as well as a resource to return to again and again.

The Exposome

Author : Gary W. Miller
Publisher : Elsevier
ISBN 13 : 0124172180
Total Pages : 118 pages
Book Rating : 4.1/5 (241 download)

DOWNLOAD NOW!

Book Synopsis The Exposome by : Gary W. Miller

Download or read book The Exposome written by Gary W. Miller and published by Elsevier. This book was released on 2013-11-16 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Inflammation and the Microcirculation

Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)

DOWNLOAD NOW!

Book Synopsis Inflammation and the Microcirculation by : D. Neil Granger

Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Molecular Genetics of Inflammatory Bowel Disease

Author : Mauro D'Amato
Publisher : Springer Science & Business Media
ISBN 13 : 1461482569
Total Pages : 344 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis Molecular Genetics of Inflammatory Bowel Disease by : Mauro D'Amato

Download or read book Molecular Genetics of Inflammatory Bowel Disease written by Mauro D'Amato and published by Springer Science & Business Media. This book was released on 2013-10-05 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).