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Generation And Interpretation Of Morphogen Gradients
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Book Synopsis Generation and Interpretation of Morphogen Gradients by : James Briscoe
Download or read book Generation and Interpretation of Morphogen Gradients written by James Briscoe and published by . This book was released on 2010 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signalling by morphogens such as the Hedgehog family, Notch, Wingless/Wnt and various growth factors is essential during embryogenesis. The establishment of concentration gradients of these morphogens plays a key role during developmental patterning in all multicellular organisms, assuring that distinct cell/tissue types and organs appear at the right place in the right time during embryogenesis. Regulation of morphogen synthesis, trafficking and diffusion are all known to play a part in setting up these gradients, and a complex web of signaling mechanisms ensures that specific responses occur at the correct threshold concentration in the recipient cells whose fate depends on these morphogens.
Book Synopsis Precision and Robustness in the Interpretation of Morphogen Gradients by : Peng Cheng Zhang
Download or read book Precision and Robustness in the Interpretation of Morphogen Gradients written by Peng Cheng Zhang and published by . This book was released on 2015 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental pattern formation is orchestrated by diffusible signaling molecules, termed morphogens, that form gradients from which cells can determine positionally appropriate fates. Stochasticity in morphogen binding, signal transduction, and gene expression create local cell-to-cell variability in the readout of morphogen gradients. However, little is known about the actual levels of noise in morphogen gradient responses, or the mechanisms that might control it. To investigate this, I quantified the transcriptional activity noise, protein expression noise, and protein half-life of optomotor blind (omb), one of the downstream targets of the morphogen Dpp in the Drosophila larval wing imaginal disc. Using combined fluorescence in situ hybridization (FISH) with intronic probes, immunofluorescence, image segmentation and image analysis, I observed a very high level of transcriptional variability characterized by coefficients of variation (CV) as high as ~110%, in the cells in which omb plays a central role in specifying the location of wing vein primordium L5. However, the half-life of the Omb protein was found to be very long, ~ 6 hours, which would be expected to provide significant temporal filtering of the transcriptional noise. I showed that the reduction in noise from transcript to protein is sufficient to account for the precision of the positional information that patterns vein L5. I also investigated why the positioning of vein L5 is remarkably robust to genetic manipulation that change the shape of the Dpp morphogen gradient. I observed that patters of Dpp signaling and Omb expression are not constant during larval development, but change continuously, and not always in concert with each other. By taking into account the long half-life of Omb it was possible to build a model that explains both these movements and the remarkable robustness of L5 patterning to changes in Dpp gradient shape.
Book Synopsis Morphogenetic Gradients and Development by : James Briscoe
Download or read book Morphogenetic Gradients and Development written by James Briscoe and published by Academic Press. This book was released on 2020-03 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gradients and Tissue Patterning, Volume 137 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.
Book Synopsis Morphogen Gradients by : Julien Dubrulle
Download or read book Morphogen Gradients written by Julien Dubrulle and published by Humana Press. This book was released on 2018-10-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book presents methods focusing on the visualization of morphogen gradients, the analysis of their biophysical and biological properties, and the theoretical aspects underlying their functions. The study of morphogen gradients combines biophysics, cell and developmental biology, and applied mathematics approaches to understand their formation, their biological functions, and the prediction of their behavior in space and time, and this volume serves as a practical, hands-on guide to the field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and helpful, Morphogen Gradients: Methods and Protocols is an ideal collection for researchers in this vital area of study.
Book Synopsis Patterning and Cell Type Specification in the Developing CNS and PNS by :
Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Branching Morphogenesis by : Jamie Davies
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Book Synopsis Essential Developmental Biology by : Jonathan M. W. Slack
Download or read book Essential Developmental Biology written by Jonathan M. W. Slack and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Developmental Biology is a comprehensive, richly illustrated introduction to all aspects of developmental biology. Written in a clear and accessible style, the third edition of this popular textbook has been expanded and updated In addition, an accompanying website provides instructional materials for both student and lecturer use, including animated developmental processes, a photo gallery of selected model organisms, and all artwork in downloadable format. With an emphasis throughout on the evidence underpinning the main conclusions, this book is an essential text for both introductory and more advanced courses in developmental biology. Shortlisted for the Society of Biology Book Awards 2013 in the Undergraduate Textbook category. Reviews of the Second Edition: "The second edition is a must have for anyone interested in development biology. New findings in hot fields such as stem cells, regeneration, and aging should make it attractive to a wide readership. Overall, the book is concise, well structured, and illustrated. I can highly recommend it." —Peter Gruss, Max Planck Society "I have always found Jonathan Slack's writing thoughtful, provocative, and engaging, and simply fun to read. This effort is no exception. Every student of developmental biology should experience his holistic yet analytical view of the subject." —Margaret Saha, College of William & Mary
Book Synopsis Mammalian Development by : Patrick P. L. Tam
Download or read book Mammalian Development written by Patrick P. L. Tam and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A subject collection from Cold Spring Harbor perspectives in biology."
Book Synopsis Cell Polarity in Development and Disease by : Douglas W Houston
Download or read book Cell Polarity in Development and Disease written by Douglas W Houston and published by Academic Press. This book was released on 2017-11-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs
Book Synopsis Symmetry In Plants by : Denis Barabe
Download or read book Symmetry In Plants written by Denis Barabe and published by World Scientific. This book was released on 1998-03-26 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with biological, mathematical, descriptive, causal and systemic phyllotaxis. It aims at reflecting the widest possible range of ideas and research closely related to phyllotaxis and contains 30 well illustrated chapters.The book has three parts of equal importance. The first two parts concern data collecting, pattern recognition and pattern generation to which students of phyllotaxis are well accustomed. The third part is devoted to the problem of origins of phyllotactic patterns, giving the field of phyllotaxis the universality it requires to be fully understood.Phyllotaxis-like patterns are found in places where genes are not necessarily present. Part III concerns general comparative morphology, homologies with phyllotactic patterns, and recent trends on evolution that can help to understand phyllotaxis.The distinguished researchers who accepted to participate in the production of this book, strongly contributed to the field of phyllotaxis in the past and have devoted a lot of their time to the fascinating subject coming up with most valuable findings, or are newcomers with original ideas that may be very relevant for the future of the field. The book summarizes and updates their contributions, and promotes new avenues in the treatment of phyllotaxis.This book on mathematical and biological phyllotaxis is the first collective book ever. A landmark in the history of phyllotaxis.
Book Synopsis From Egg to Embryo by : J. M. W. Slack
Download or read book From Egg to Embryo written by J. M. W. Slack and published by CUP Archive. This book was released on 1983 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the development of the animal embryo starting from the fertilised egg. The emphasis is on the problem of pattern formation: how cells in different regions of the embryo become programmed to form the various structures of the body in the correct relative positions.
Book Synopsis Models of Biological Pattern Formation by : Hans Meinhardt
Download or read book Models of Biological Pattern Formation written by Hans Meinhardt and published by . This book was released on 1982 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis E. coli in Motion by : Howard C. Berg
Download or read book E. coli in Motion written by Howard C. Berg and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Escherichia coli, commonly referred to as E. coli, has been the organism of choice for molecular genetics for decades. Its machinery and mobile behavior is one of the most fascinating topics for cell scientists. Scientists and engineers, not trained in microbiology, and who would like to learn more about living machines, can see it as a unique example. This cross-disciplinary monograph covers more than thirty years of research and is accessible to graduate students and scientists alike.
Book Synopsis Development and Reproduction in Humans and Animal Model Species by : Werner A. Mueller
Download or read book Development and Reproduction in Humans and Animal Model Species written by Werner A. Mueller and published by Springer. This book was released on 2015-01-03 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes human development including sexual reproduction and stem cell research with the development of model organisms that are accessible to genetic and experimental analysis in readily understandable texts and 315 multi-colored graphics. The introductory account of model organisms selected from the entire animal kingdom presents general principles, which are then outlined in subsequent chapters devoted to, for example, sexual development; genes controlling development and their contemporary molecular-analysis methods; production of clones and transgenic animals; development of the nervous and circulatory systems; regenerative medicine and ageing. Finally the evolution of developmental toolkits and novelties is discussed including the genetic basis of the enlargement of the human forebrain. Separate boxes are devoted to controversial questions such as the benefits and problems of prenatal diagnostics or the construction of ancient body plans.
Book Synopsis Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS by : E.A. Grove
Download or read book Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS written by E.A. Grove and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biophysics written by William Bialek and published by Princeton University Press. This book was released on 2012-12-17 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: A physicist's guide to the phenomena of life Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology—from the discovery of DNA's structure to imaging of the human brain—have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles—the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes
