G Protein Coupled Receptors Part B

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G Protein-Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0128151080
Total Pages : 332 pages
Book Rating : 4.1/5 (281 download)

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Download or read book G Protein-Coupled Receptors written by and published by Academic Press. This book was released on 2019-01-05 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in Cells, Measuring GPCR Ubiquitination and Trafficking, Culture of Primary Neurons and its Use in Studying GPCR Trafficking, and much more. Covers the increasingly appreciated cell biology field of G-protein-coupled receptors Includes both established and new technologies Contributed by experts in the field

G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation

Author :
Publisher : Academic Press
ISBN 13 : 0128137754
Total Pages : 200 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation by :

Download or read book G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation written by and published by Academic Press. This book was released on 2018-05-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, and drawn from international sources Offers a wide range of perspectives on specific subjects

G Protein-Coupled Receptors - Part A

Author :
Publisher : Elsevier
ISBN 13 : 0323994326
Total Pages : 232 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis G Protein-Coupled Receptors - Part A by :

Download or read book G Protein-Coupled Receptors - Part A written by and published by Elsevier. This book was released on 2022-11-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs

G Protein-Coupled Receptors in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 9780080911946
Total Pages : 192 pages
Book Rating : 4.9/5 (119 download)

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Book Synopsis G Protein-Coupled Receptors in Health and Disease by :

Download or read book G Protein-Coupled Receptors in Health and Disease written by and published by Academic Press. This book was released on 2009-09-19 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

G Protein-Coupled Receptors - Part A

Author :
Publisher : Elsevier
ISBN 13 : 0323994318
Total Pages : 230 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis G Protein-Coupled Receptors - Part A by :

Download or read book G Protein-Coupled Receptors - Part A written by and published by Elsevier. This book was released on 2022-12 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs

G Protein-Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0128036125
Total Pages : 502 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis G Protein-Coupled Receptors by :

Download or read book G Protein-Coupled Receptors written by and published by Academic Press. This book was released on 2016-02-26 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. Covers the increasingly appreciated cell biology field of G-protein-coupled receptors Includes both established and new technologies Contributed by experts in the field Covers topics such as signaling, trafficking, and regulation

Regulators of G Protein Signaling

Author :
Publisher : Elsevier
ISBN 13 : 0080497276
Total Pages : 560 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Regulators of G Protein Signaling by :

Download or read book Regulators of G Protein Signaling written by and published by Elsevier. This book was released on 2004-11-16 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulators of G Protein Signaling, Part B continues the in-depth treatment of the topic and covers the RSG protein superfamily including RZ, R4, R7, R12, RhoGEF, and GRK, as well as other heterotrimeric G-protein signaling regulators. Table of Contents RZ Subfamily R4 Subfamily R7 Subfamily R12 Subfamily RhoGEF Subfamily GRK Subfamily Other RGS proteins Activators Inhibitors Other Modulators

G Protein-Coupled Receptors

Author : Tiina P. Iismaa
Publisher : Springer Science & Business Media
ISBN 13 : 3662219301
Total Pages : 189 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis G Protein-Coupled Receptors by : Tiina P. Iismaa

Download or read book G Protein-Coupled Receptors written by Tiina P. Iismaa and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.

G Protein Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0123918723
Total Pages : 440 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis G Protein Coupled Receptors by :

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2013-01-17 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

G Protein Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0123918731
Total Pages : 480 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis G Protein Coupled Receptors by :

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2013-01-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

G Protein-Coupled Receptors in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0080911951
Total Pages : 224 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis G Protein-Coupled Receptors in Health and Disease by :

Download or read book G Protein-Coupled Receptors in Health and Disease written by and published by Academic Press. This book was released on 2009-08-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

G Protein-Coupled Receptors

Author : Jesus Giraldo
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733449
Total Pages : 548 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis G Protein-Coupled Receptors by : Jesus Giraldo

Download or read book G Protein-Coupled Receptors written by Jesus Giraldo and published by Royal Society of Chemistry. This book was released on 2011-08-16 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.

G Protein-Coupled Receptors

Author : David Poyner
Publisher : John Wiley & Sons
ISBN 13 : 0470749229
Total Pages : 310 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis G Protein-Coupled Receptors by : David Poyner

Download or read book G Protein-Coupled Receptors written by David Poyner and published by John Wiley & Sons. This book was released on 2009-12-11 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. This book provides an invaluable bench-side guide into the best and most up-to-date techniques for current and future research on GPCRs. With contributions from leading international authorities, this book equips readers with clear and detailed protocols for both well-known and up-and-coming techniques along with hints and tips for success. All the methods have been tried and tested by leading international research labs and are presented in easy-to-follow stages along with a useful overview of each technique. This book is an essential resource for all researchers in molecular biology, biochemistry, pharmacology and for graduate students.

G Protein Pathways, Part A: Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0080884229
Total Pages : 680 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis G Protein Pathways, Part A: Receptors by :

Download or read book G Protein Pathways, Part A: Receptors written by and published by Academic Press. This book was released on 2001-10-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.

G Protein Pathways, Part C: Effector Mechanisms

Author :
Publisher : Elsevier
ISBN 13 : 0080496938
Total Pages : 653 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis G Protein Pathways, Part C: Effector Mechanisms by :

Download or read book G Protein Pathways, Part C: Effector Mechanisms written by and published by Elsevier. This book was released on 2001-10-15 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the trio covering G proteins, features integrated approaches to studying G proteins. Methods pertaining to signaling mechanisms are presented, including theoretical and modeling approaches, biochemistry and molecular biology, and cell biology and physiology. The techniques for studying the structure and function of G proteins are important not only to those with specific research interests in them, but also endocrinologists and pharmacologists conducting research on signaling mechanisms that are increasingly understood to interact with G proteins.

G Protein Pathways, Part B: G Proteins and Their Regulators

Author :
Publisher : Elsevier
ISBN 13 : 008049692X
Total Pages : 813 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis G Protein Pathways, Part B: G Proteins and Their Regulators by :

Download or read book G Protein Pathways, Part B: G Proteins and Their Regulators written by and published by Elsevier. This book was released on 2001-12-18 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers topics such as the structure and identification of functional domains of G proteins, and activation of G proteins by receptors or other regulators. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.

G Protein-Coupled Receptor Screening Assays

Author : Duarte Miguel F. Prazeres
Publisher :
ISBN 13 : 9781493923366
Total Pages : 296 pages
Book Rating : 4.9/5 (233 download)

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Book Synopsis G Protein-Coupled Receptor Screening Assays by : Duarte Miguel F. Prazeres

Download or read book G Protein-Coupled Receptor Screening Assays written by Duarte Miguel F. Prazeres and published by . This book was released on 2015 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume "explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound s efficacy. New discoveries in the field, along with the widely recognized need for better and safer pharmaceutical drugs constitute the main motivation for this book. Readers, both beginners and experienced researchers, will receive an updated overview of not only the established, but also the innovative technologies that promise to advance GPCR drug research. This book is organized into two major parts: the introductory part discusses the necessary foundations for the understanding of GPCR action and the rationale behind the design of the available screening assays; and part two provides detailed protocols for different screening approaches. Written in the highly successful "Methods in Molecular Biology "series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Practical and innovative, "G Protein-Coupled Receptor Screening Assays: Methods and Protocols" reaches out to everyone involved in the discovery of GPCR-active drugs, and provides a transversal overview of the different levels of GPCR signaling addressable in the different screening strategies and presents practical examples of how current assay technologies are contributing to new paradigms in GPCR drug research."