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From Genotype To Phenotype
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Book Synopsis Phenotypes and Genotypes by : Florian Frommlet
Download or read book Phenotypes and Genotypes written by Florian Frommlet and published by Springer. This book was released on 2016-02-12 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
Book Synopsis Epigenetics by : Benedikt Hallgrimsson Ph.D.
Download or read book Epigenetics written by Benedikt Hallgrimsson Ph.D. and published by Univ of California Press. This book was released on 2011-04-11 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
Book Synopsis Problems and Solutions for Strachan and Read's Human Molecular Genetics 2 by : David James Matthes
Download or read book Problems and Solutions for Strachan and Read's Human Molecular Genetics 2 written by David James Matthes and published by . This book was released on 2001 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis From Genotype to Phenotype by : Sue Malcolm
Download or read book From Genotype to Phenotype written by Sue Malcolm and published by Gulf Professional Publishing. This book was released on 2001-11-19 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition builds on the success of the first by reviewing the increased understanding of the mechanisms of gene action in humans, focusing particularly on those derived from the study of genetic diseases. It deals mainly with the fundamental aspects of gene arrangement and expression rather than mutation. As well as updating and revising material from the first edition, it covers methods of exploring gene function and contains a range of chapters on specific systems which raise issues of special interest such as imprinting or homologous genes within clusters.
Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-11-21 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Book Synopsis Neurofibromatosis Type 1 by : Meena Upadhyaya
Download or read book Neurofibromatosis Type 1 written by Meena Upadhyaya and published by Springer Science & Business Media. This book was released on 2013-01-29 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Book Synopsis A Probabilistic Model of the Genotype/Phenotype Relationship by : Jean-Pierre Hugot
Download or read book A Probabilistic Model of the Genotype/Phenotype Relationship written by Jean-Pierre Hugot and published by CRC Press. This book was released on 2018-06-19 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Probabilistic Model of the Genotype/Phenotype Relationship provides a new hypothesis on the relationship between genotype and phenotype. The main idea of the book is that this relationship is probabilistic, in other words, the genotype does not fully explain the phenotype. This idea is developed and discussed using the current knowledge on complex genetic diseases, phenotypic plasticity, canalization and others.
Book Synopsis Principles of Biology by : Lisa Bartee
Download or read book Principles of Biology written by Lisa Bartee and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.
Book Synopsis The Extended Phenotype by : Richard Dawkins
Download or read book The Extended Phenotype written by Richard Dawkins and published by Oxford University Press. This book was released on 2016 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated debate. Written in part as a response, The Extended Phenotype gave a deeper clarification of the central concept of the gene as the unit of selection; but it did much more besides. In it, Dawkins extended the gene's eye view to argue that the genes that sit within an organism have an influence that reaches out beyond the visible traits in that body - the phenotype - to the wider environment, which can include other individuals. So, for instance, the genes of the beaver drive it to gather twigs to produce the substantial physical structure of a dam; and the genes of the cuckoo chick produce effects that manipulate the behaviour of the host bird, making it nurture the intruder as one of its own. This notion of the extended phenotype has proved to be highly influential in the way we understand evolution and the natural world. It represents a key scientific contribution to evolutionary biology, and it continues to play an important role in research in the life sciences. The Extended Phenotype is a conceptually deep book that forms important reading for biologists and students. But Dawkins' clear exposition is accessible to all who are prepared to put in a little effort. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.
Book Synopsis Gene Expression and Phenotypic Traits by : Yuan-Chuan Chen
Download or read book Gene Expression and Phenotypic Traits written by Yuan-Chuan Chen and published by BoD – Books on Demand. This book was released on 2020-04-01 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.
Book Synopsis Genetics for Surgeons by : Patrick John Morrison
Download or read book Genetics for Surgeons written by Patrick John Morrison and published by Remedica. This book was released on 2005 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).
Book Synopsis Systems Genetics by : Florian Markowetz
Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Download or read book The $1,000 Genome written by Kevin Davies and published by Simon and Schuster. This book was released on 2015-08-18 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence--a comprehensive map of the 3 billion letters in our DNA--is rapidly and inevitably dropping to just $1,000. Dozens of men and women--scientists, entrepreneurs, celebrities, and patients--have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer's or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions--and many more--by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure.
Download or read book A Life Decoded written by J. Craig Venter and published by Penguin. This book was released on 2007-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The triumphant memoir of the man behind one of the greatest feats in scientific history Of all the scientific achievements of the past century, perhaps none can match the deciphering of the human genetic code, both for its technical brilliance and for its implications for our future. In A Life Decoded, J. Craig Venter traces his rise from an uninspired student to one of the most fascinating and controversial figures in science today. Here, Venter relates the unparalleled drama of the quest to decode the human genome?a goal he predicted he could achieve years earlier and more cheaply than the government-sponsored Human Genome Project, and one that he fulfilled in 2001. A thrilling story of detection, A Life Decoded is also a revealing, and often troubling, look at how science is practiced today.
Book Synopsis The Rye Genome by : M. Timothy Rabanus-Wallace
Download or read book The Rye Genome written by M. Timothy Rabanus-Wallace and published by Springer Nature. This book was released on 2021-10-25 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book celebrates the dawn of the rye genomics era with concise, comprehensive, and accessible reviews on the current state of rye genomic research, written by experts in the field for students, researchers and growers. To most, rye is the key ingredient in a flavoursome bread or their favourite American whisky. To a farmer, rye is the remarkable grain that tolerates the harshest winters and the most unforgiving soils, befitting its legacy as the life-giving seed that fed the ancient civilisations of northern Eurasia. Since the mid-1900s, scientists have employed genetic approaches to better understand and utilize rye, but only since the technological advances of the mid-2010s has the possibility of addressing questions using rye genome assemblies become a reality. Alongside the secret of its unique survival abilities, rye genomics has accelerated research on a host of intriguing topics such as the complex history of rye’s domestication by humans, the nature of genes that switch fertility on and off, the function and origin of accessory chromosomes, and the evolution of selfish DNA.
Download or read book Neurogenetics, Part II written by and published by Elsevier. This book was released on 2018-01-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. Contains comprehensive coverage of neurogenetics Details the latest science and its impact on our understanding of neurological, psychiatric disorders Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community
Book Synopsis Concepts of Biology by : Samantha Fowler
Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
