Folded Synthetic Peptides For Biomedical Applications

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Folded Synthetic Peptides for Biomedical Applications

Author : Alessandro Contini
Publisher : Frontiers Media SA
ISBN 13 : 2889630455
Total Pages : 145 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Folded Synthetic Peptides for Biomedical Applications by : Alessandro Contini

Download or read book Folded Synthetic Peptides for Biomedical Applications written by Alessandro Contini and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
ISBN 13 : 0081007426
Total Pages : 655 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Peptide Applications in Biomedicine, Biotechnology and Bioengineering by : Sotirios Koutsopoulos

Download or read book Peptide Applications in Biomedicine, Biotechnology and Bioengineering written by Sotirios Koutsopoulos and published by Woodhead Publishing. This book was released on 2017-11-16 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Peptides and Peptide-based Biomaterials and their Biomedical Applications

Author : Anwar Sunna
Publisher : Springer
ISBN 13 : 3319660950
Total Pages : 309 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Peptides and Peptide-based Biomaterials and their Biomedical Applications by : Anwar Sunna

Download or read book Peptides and Peptide-based Biomaterials and their Biomedical Applications written by Anwar Sunna and published by Springer. This book was released on 2017-10-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications

Author : Nunzianna Doti
Publisher :
ISBN 13 : 9783036543956
Total Pages : 0 pages
Book Rating : 4.5/5 (439 download)

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Book Synopsis Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications by : Nunzianna Doti

Download or read book Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications written by Nunzianna Doti and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life.

Biologically Active Peptides

Author : David B. Weiner
Publisher : CRC Press
ISBN 13 : 9780877629351
Total Pages : 382 pages
Book Rating : 4.6/5 (293 download)

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Book Synopsis Biologically Active Peptides by : David B. Weiner

Download or read book Biologically Active Peptides written by David B. Weiner and published by CRC Press. This book was released on 1993-11-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Synthetic Peptides and Peptidomimetics

Author : Nunzianna Doti
Publisher : Mdpi AG
ISBN 13 : 9783036543963
Total Pages : 0 pages
Book Rating : 4.5/5 (439 download)

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Book Synopsis Synthetic Peptides and Peptidomimetics by : Nunzianna Doti

Download or read book Synthetic Peptides and Peptidomimetics written by Nunzianna Doti and published by Mdpi AG. This book was released on 2022-06-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life.

Synthesis of Aza- and Α,α-disubstituted Glycinyl Peptides and Application of Their Electronic and Steric Interactions for Controlling Peptide Folding, and for Biomedical Applications

Download Synthesis of Aza- and Α,α-disubstituted Glycinyl Peptides and Application of Their Electronic and Steric Interactions for Controlling Peptide Folding, and for Biomedical Applications PDF Online Free

Author : Fatemeh Mohammadpourmir
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Synthesis of Aza- and Α,α-disubstituted Glycinyl Peptides and Application of Their Electronic and Steric Interactions for Controlling Peptide Folding, and for Biomedical Applications by : Fatemeh Mohammadpourmir

Download or read book Synthesis of Aza- and Α,α-disubstituted Glycinyl Peptides and Application of Their Electronic and Steric Interactions for Controlling Peptide Folding, and for Biomedical Applications written by Fatemeh Mohammadpourmir and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Peptide Synthesis

Author : Jaya Varkey
Publisher : BoD – Books on Demand
ISBN 13 : 1839682574
Total Pages : 120 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Peptide Synthesis by : Jaya Varkey

Download or read book Peptide Synthesis written by Jaya Varkey and published by BoD – Books on Demand. This book was released on 2019-12-18 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide synthesis includes an array of techniques and procedures that enable the preparation of materials ranging from small peptides to large proteins. Many synthetic peptides have commercial and pharmaceutical applications, however, the synthesis of these peptides is a difficult task. This book addresses the common problems relating to the synthesis and applications of synthetic peptides. It discusses novel methods for the efficient synthesis of long chain and difficult peptide sequences and presents detailed analysis of various aspects of solid phase peptide synthesis. It also includes a section on antimicrobial peptides.

Synthetic Peptides

Author : Gregory Grant
Publisher : Oxford University Press
ISBN 13 : 9780198030430
Total Pages : 404 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Synthetic Peptides by : Gregory Grant

Download or read book Synthetic Peptides written by Gregory Grant and published by Oxford University Press. This book was released on 2002-04-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.

Self-Assembled Peptide Nanostructures

Author : Jaime Castillo
Publisher : CRC Press
ISBN 13 : 9814316946
Total Pages : 326 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Self-Assembled Peptide Nanostructures by : Jaime Castillo

Download or read book Self-Assembled Peptide Nanostructures written by Jaime Castillo and published by CRC Press. This book was released on 2012-11-21 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The self-organization of bionanostructures into well-defined functional machineries found in nature has been a priceless source of ideas for researchers. The molecules of life, proteins, DNA, RNA, etc., as well as the structures and forms that these molecules assume serve as rich sources of ideas for scientists or engineers who are interested in developing bio-inspired materials for innovations in biomedical fields. In nature, molecular self-assembly is a process by which complex three-dimensional structures with well-defined functions are constructed, starting from simple building blocks such as proteins and peptides. This book introduces readers to the theory and mechanisms of peptide self-assembly processes. The authors present the more common peptide self-assembled building blocks and discuss how researchers from different fields can apply self-assembling principles to bionanotechnology applications. The advantages and challenges are mentioned together with examples that reflect the state of the art of the use of self-assembled peptide building blocks in nanotechnology.

Synthetic and Enzymatic Modifications of the Peptide Backbone

Author :
Publisher : Academic Press
ISBN 13 : 0128212543
Total Pages : 640 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Synthetic and Enzymatic Modifications of the Peptide Backbone by :

Download or read book Synthetic and Enzymatic Modifications of the Peptide Backbone written by and published by Academic Press. This book was released on 2021-07-27 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods of Enzymology series Updated release includes the latest information on the Synthetic and Enzymatic Modifications of the Peptide Backbone

Self-Assembling Peptide Systems in Biology, Medicine and Engineering

Author : A. Aggeli
Publisher : Springer Science & Business Media
ISBN 13 : 0792370902
Total Pages : 364 pages
Book Rating : 4.7/5 (923 download)

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Book Synopsis Self-Assembling Peptide Systems in Biology, Medicine and Engineering by : A. Aggeli

Download or read book Self-Assembling Peptide Systems in Biology, Medicine and Engineering written by A. Aggeli and published by Springer Science & Business Media. This book was released on 2001-08-31 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first ever text on the intrinsic self-assembling behaviour of peptides and the implications of these properties for a broad range of applications. These include protein conformational diseases, the engineering of nanostructured biodegradable and biocompatible polymeric materials with potential applications in tissue engineering, biomedical devices, industrial fluids and personal care products. This new area of endeavour is outlined in a series of 25 articles summarising lectures presented at the first ever meeting on this topic held in Crete in July 1999. Audience: The articles address generic issues making the text readily amenable to postgraduate students, academics, and research scientists interested in new challenges at the physical sciences - life sciences interface.

Synthetic Peptides as Antigens

Author : S. Muller
Publisher : Elsevier
ISBN 13 : 008085897X
Total Pages : 401 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Synthetic Peptides as Antigens by : S. Muller

Download or read book Synthetic Peptides as Antigens written by S. Muller and published by Elsevier. This book was released on 1999-11-25 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro. It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays. The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.

NIH: An Account of Research in Its Laboratories and Clinics

Author : DeWitt Stetten
Publisher : Academic Press
ISBN 13 : 1483277550
Total Pages : 575 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis NIH: An Account of Research in Its Laboratories and Clinics by : DeWitt Stetten

Download or read book NIH: An Account of Research in Its Laboratories and Clinics written by DeWitt Stetten and published by Academic Press. This book was released on 2014-05-10 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: NIH: An Account of Research in Its Laboratories and Clinics contains collected accounts of the Intramural Research Program, as they happened in the laboratories and clinics, in various installations of the National Institutes of Health across the U.S.A. One paper discusses the etiology of schizophrenia which notes that, based on evidence and expanded adoption studies by Ketty, Rosenthal, and Wender, genetic factors actually contribute to the development of the disease. In developing countries, schizophrenia follows a more benign course. Some papers describe bacteriology, mycology, viral hepatitis, basic immunology, clinical immunology, and the development of enzymology. Researchers studying proteins elucidate on the synthesis and folding of protein chains, protein conformation and dynamics, the semisynthesis and protein function, as well as on sequence analysis and collagen research. Other papers describe the breaking of the genetic code, the progress made from the genetic code to beta thalassemia, to investigations of genetic diseases (such as galactosemia, gout, Lesch-Nyhan disease, mucopolysaccharide storage disease, and sickle cell disease). One paper notes the contribution of the intramural clinical research program of the National Cancer Institute to cancer therapy with emphasis in cancer chemotherapy. Professors in pharmacology, practitioners of general medicine, specialists or researchers dealing with microchemistry, toxicology, drug therapy, or oncology will find the collection valuable.

Enantioselective Synthesis of Beta-Amino Acids

Author : Eusebio Juaristi
Publisher : John Wiley & Sons
ISBN 13 : 0471698474
Total Pages : 658 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Enantioselective Synthesis of Beta-Amino Acids by : Eusebio Juaristi

Download or read book Enantioselective Synthesis of Beta-Amino Acids written by Eusebio Juaristi and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.

Peptide and Protein Design for Biopharmaceutical Applications

Author : Knud Jensen
Publisher : John Wiley & Sons
ISBN 13 : 9780470749715
Total Pages : 306 pages
Book Rating : 4.7/5 (497 download)

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Book Synopsis Peptide and Protein Design for Biopharmaceutical Applications by : Knud Jensen

Download or read book Peptide and Protein Design for Biopharmaceutical Applications written by Knud Jensen and published by John Wiley & Sons. This book was released on 2009-09-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

A New Model for Analyzing Antimicrobial Peptides with Biomedical Applications

Author : Edwin Lowell Cooper
Publisher : IOS Press
ISBN 13 : 9781586032371
Total Pages : 216 pages
Book Rating : 4.0/5 (323 download)

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Book Synopsis A New Model for Analyzing Antimicrobial Peptides with Biomedical Applications by : Edwin Lowell Cooper

Download or read book A New Model for Analyzing Antimicrobial Peptides with Biomedical Applications written by Edwin Lowell Cooper and published by IOS Press. This book was released on 2002 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This book is aimed at two audiences. First, it will present evidence for the earthworm's immune system. Second, the results strongly suggest that certain molecules of the earthworm's immune system may be exploited as natural antibiotics--thus the biomedical applications. There are two advantages for using earthworms. First, they are an inexpensive, non-controversial invertebrate model. Second, in contrast to other invertebrates (e.g. Drosophila, C elegans) they are essential for maintaining the integrity of soil. Earthworms have a highly effective immune system since cancer cannot be induced in them nor does it seem to occur in natural populations. Cytotoxicity of cancer cells has been examined in relation to two earthworm leukocytes based upon: structure; cell differentiation antigens; function revealed by FACS and mAbs. These cells are SMALL (8-11 m) electron dense (SC), positive for human cell adhesion molecules (CD11a, CD45RA, CD45RO, CDw49b, CD54, for?2-microglobulin and for Thy-1; LARGE (12-15 m) electron lucent cells (LC), negative for these same markers. Leukocytes synthesize and secrete lytic molecules (fetidins, CCF-1, lysenin, eiseniapore) participate in recognition of, binding to, killing and sequestration of cancer cells in vitro. Earthworm lytic levels are significantly higher than those of human NK cells. Earthworms possess a highly evolved, unique and efficient immune system that has facilitated long-term survival.