Fabrication And Characterization Of A Plasmonic Biosensor Using Non Spherical Metal Nanoparticles

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Fabrication and Characterization of a Plasmonic Biosensor Using Non-spherical Metal Nanoparticles

Author : Bong-Su Jung
Publisher :
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.:/5 (197 download)

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Book Synopsis Fabrication and Characterization of a Plasmonic Biosensor Using Non-spherical Metal Nanoparticles by : Bong-Su Jung

Download or read book Fabrication and Characterization of a Plasmonic Biosensor Using Non-spherical Metal Nanoparticles written by Bong-Su Jung and published by . This book was released on 2007 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Label-free detection techniques have an important role in many applications, such as situations where few molecules -- rather than low molarity -- need to be detected, such as in single-cell screening. While surface plasmon resonance (SPR) scattering from metal nanoparticles has been shown to achieve significantly higher sensitivity in gene arrays, such an approach has not been demonstrated for protein arrays. SPR-based sensors could either use simple absorption measurement in a UV-Vis spectrometer or possibly surfaceenhanced Raman spectroscopy as the detection mechanism for molecules of interest. However, non-spherical particles are needed to achieve high sensitivity and field enhancement that is a requirement in both techniques, but these shapes are not easy toproduce reproducibly and preserve for extended periods of time. Here I present a carbonbased template-stripping method combined with nanosphere lithography (NSL). This fabrication allows to preserve the sharp features in atomically flat surfaces which are a composite of a non-spherical metal nano-particle (gold or silver) and a transparent embedding material such as glass. The stripping process is residue-free due to the introduction of a sacrificial carbon layer. The nanometer scale flat surface of our template stripping process is also precious for general protein absorption studies, because an inherent material contrast can resolve binding of layers on the 2 nm scale. These nanocomposite surfaces also allow us to tailor well-defined SPR extinction peaks with locations in the visible or infrared spectrum depending on the metal and the particle size and the degree of non-symmetry. As the particle thickness is reduced and the particle bisector length is increased, the peak position of the resonance shifts to the red. Not only the peak position shifts, but also the sensitivity to environmental changes increases. Therefore, the peak position of the resonance spectrum is dependent on the dielectric environmental changes of each particle, and the particle geometries. The resulting silver or gold nanoparticles in the surface of a glass slide are capable of detecting thiol surface modification, and biotin-streptavidin protein binding events. Since each gold or silver particle principally acts as an independent sensor, on the order of a few thousand molecules can be detected, and the sensor can be miniaturized without loss of sensitivity. UNSL-Au metal nanoparticle (MNP) sensors achieve the sensitivity of close to 300 nm/RIU which is higher than any other report of localized surface plasmon resonance (LSPR) sensors except gold nanocrescents. Finite-difference-time-domain (FDTD) and finite-element-method (FEM) numerical calculations display the influence of the sharp features on the resonance peak position. The maximum near-field intensity is dependent on the polarization direction, the sharpness of the feature, and the near-field confinement from the substrate. 3D FDTD simulation shows the local refractive index sensitivity of the gold truncated tetrahedron, which is in agreement with our experimental result. Both experimental and numerical calculations show that each particle can act as its own sensor.

Nanoscale Biosensing

Author : Kyunghee Cho
Publisher :
ISBN 13 : 9781321646061
Total Pages : 120 pages
Book Rating : 4.6/5 (46 download)

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Book Synopsis Nanoscale Biosensing by : Kyunghee Cho

Download or read book Nanoscale Biosensing written by Kyunghee Cho and published by . This book was released on 2015 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in this dissertation covers two types of nanomaterials (nanostructured arrays on surfaces and nanoparticle suspensions) with a unified focus on biosensing applications utilizing surface plasmon resonance (SPR), a surface sensitive phenomenon that occurs at the nanoscale. The first part of the dissertation describes the fabrication of lithographically patterned and electrochemically deposited large-scale arrays of nanorings and split nanorings. The fabrication and characterization of nanoring arrays made from a host of materials such as Ni, Au, Co, and polydopamine are discussed. Additionally, the fabrication of split nanoring arrays with potential applications as a tunable dichroic is explained. The application of plasmonic gold nanoring arrays as a biosensor to detect DNA hybridization with detection capabilities down to 50 pM of DNA follows. The next part of this dissertation shifts focus from nanostructured surfaces to the detection of nanoparticles in suspension using surface plasmon resonance microscopy (SPRM). Specifically, polymeric hydrogel nanoparticles that have been engineered to bind the hexacosa peptide melittin is studied. Point diffraction patterns in sequential real-time SPRM differential reflectivity images are counted to create digital adsorption binding curves of single 220 nm diameter hydrogel nanoparticles from picomolar nanoparticle solutions onto alkanethiol-modified gold surfaces. The SPRM responses from the adsorption of hundreds of individual hydrogel nanoparticles are quantified to measure the loading of melittin, a potential therapeutic compound, into the nanoparticles. Additional bulk fluorescence measurements of melittin uptake into the hydrogel nanoparticles are used to correlate the maximum signal observed by SPRM to the incorporation of approximately 65,000 molecules into each 220 nm hydrogel nanoparticle, corresponding to roughly 4% of its volume.

Nanoscience And Technology: A Collection Of Reviews From Nature Journals

Author : Peter Rodgers
Publisher : World Scientific
ISBN 13 : 9814466867
Total Pages : 367 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Nanoscience And Technology: A Collection Of Reviews From Nature Journals by : Peter Rodgers

Download or read book Nanoscience And Technology: A Collection Of Reviews From Nature Journals written by Peter Rodgers and published by World Scientific. This book was released on 2009-08-21 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 35 review articles on nanoscience and nanotechnology that were first published in Nature Nanotechnology, Nature Materials and a number of other Nature journals. The articles are all written by leading authorities in their field and cover a wide range of areas in nanoscience and technology, from basic research (such as single-molecule devices and new materials) through to applications (in, for example, nanomedicine and data storage).

Design, Fabrication and Characterization of Optical Biosensors Based on (Bloch) Long Range Surface Plasmon Waveguides

Author : Maryam Khodami
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Design, Fabrication and Characterization of Optical Biosensors Based on (Bloch) Long Range Surface Plasmon Waveguides by : Maryam Khodami

Download or read book Design, Fabrication and Characterization of Optical Biosensors Based on (Bloch) Long Range Surface Plasmon Waveguides written by Maryam Khodami and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis by articles, I propose and demonstrate the full design, fabrication and characterization of optical biosensors based on (Bloch) Long Range Surface Plasmon Polaritons (LRSPPs). Gold waveguides embedded in CYTOP with an etched microfluidic channel supporting LRSPPs and gold waveguides on a one-dimensional photonic crystal (1DPC) supporting Bloch LRSPPs are exploited for biosensing applications. Straight gold waveguides embedded in CYTOP supporting LRSPPs as a biosensor, are initially used to measure the kinetics constants of protein-protein interactions. The kinetics constants are extracted from binding curves using the integrated rate equation. Linear and non-linear least squares analysis are employed to obtain the kinetics constants and the results are compared. The device is also used to demonstrate enhanced assay formats (sandwich and inhibition assays) and protein concentrations as low as 10 pg/ml in solution are detected with a signal-to-noise ratio of 20 using this new optical biosensor technology. CYTOP which has a refractive index close to water is the fluoropolymer of choice in current state of the art waveguide biosensors. CYTOP has a low glass transition temperature which introduces limitations in fabrication processes. A truncated 1D photonic crystal can replace a low-index polymer cladding such as CYTOP, to support Bloch LRSPPs within the bandgap of the 1DPC over a limited ranges of wavenumber and wavelength. Motivated by quality issues with end facets, we seek to use grating couplers in a broadside coupling scheme where a laser beam emerging from an optical fiber excites Bloch LRSPPs on a Au stripe on a truncated 1D photonic crystal. Adiabatic and non-adiabatic flared stripes accommodating wide gratings size-matched to an incident Gaussian beam are designed and compared to maximise the coupling efficiency to LRSPPs. The gratings are optimized, initially, through 2D modelling using the vectorial finite element method (FEM). Different 3D grating designs were then investigated via 3D modelling using the vectorial finite difference time domain (FDTD) method. Given their compatibility with planar technologies, gratings and waveguides can be integrated into arrays of biosensors enabling multi-channel biosensing. A multi-channel platform can provide, e.g., additional measurements to improve the reliability in a disease detection problem. Thus, a novel optical biosensor based on Bloch LRSPPs on waveguide arrays integrated with electrochemical biosensors is presented. The structures were fabricated on truncated 1D photonic crystals comprised of 15 period stack of alternating layers of SiO2/Ta2O5. The optical biosensors consist of Au stripes supporting Bloch LRSPPs and integrate grating couplers as input/output means. The Au stripes also operate as a working electrode in conjunction with a neighboring Pt counter electrode to form an electrochemical sensor. The structures were fabricated using bilayer lift-off photolithography and the gratings were fabricated using overlaid e-beam lithography. The planar waveguides are integrated into arrays capable of multichannel biosensing. The wafer is covered with CYTOP as the upper cladding with etched microfluidic channels, and wafer-bonded to a borofloat silica wafer to seal the fluidic channels and enable side fluidic interfaces. The proposed device is capable in principle of simultaneous optical and electrochemical sensing and could be used to address disease detection problems using a multimodal strategy.

Sensing and Imaging Biomolecules with Plasmonic Nanoparticle Assemblies Coupled with Darkfield Microscopy

Author : Nguyen Hoang Le
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Sensing and Imaging Biomolecules with Plasmonic Nanoparticle Assemblies Coupled with Darkfield Microscopy by : Nguyen Hoang Le

Download or read book Sensing and Imaging Biomolecules with Plasmonic Nanoparticle Assemblies Coupled with Darkfield Microscopy written by Nguyen Hoang Le and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noble metal nanoparticles exhibit unique optical properties arising from the resonant oscillations of their conduction electrons with light. This phenomenon is called localized surface plasmon resonance (LSPR). The LSPR frequency is extremely sensitive to the size, shape, refractive index at the metal-dielectric interface, and other nearby metal nanoparticles. In an assembly of proximal nanoparticles, the LSPR of individual particles can couple to yield enhanced light scattering and large spectral shifts, which are useful for many applications including diagnostics and sensing. This dissertation presents a complex nanostructure comprising a core gold nanoparticle surrounded by multiple satellite gold nanoparticles for biosensing application. Chapter 2 introduces the fabrication and characterization of the core-satellite assemblies via a layer-by-layer process. Using ATP-aptamer as the linker, we demonstrated the detection of ATP based on the disassembly of the nanostructure, which can be readily captured by darkfield microscopy. The detection limit, dynamic range, and sensitivity can be tuned by controlling the size of the assembly. We found that the aptamer-linked nanoparticle assemblies were selective to only ATP, and not other adenine-containing compounds. Additionally, sensing of ATP in buffer and in bulk cell lysates was demonstrated. Chapter 3 presents the methodology for detecting ATP directly from lysed cells, down to the single-cell level without the need for purification or extraction. The intracellular ATP levels of two ovarian cancer cell lines were quantified to elucidate the differences and cellular distribution, and the potential of the stick-and-peel platform for mapping the microenvironment of 2D heterogeneous surfaces was demonstrated. In chapter 4, the optical properties of nanoparticle assemblies were tuned by changing the morphology of the nano building block, where the incorporation of gold nanoshells as satellites led to an extended redshift of LSPR to a much longer wavelength compared with using solid gold nanoparticles as satellites. This tunability in the LSPR of the assemblies allows for color-based analysis and color-coding of the plasmonic sensors. Lastly, Chapter 5 outlines the development of a multiplexed assay using the nanoparticle assemblies. Two types of assemblies, targeting either ATP or a nucleic acid (DNA-210), were fabricated with different DNA linkers in the same sensing area. The multiplexing was demonstrated by the selective disassembly process. Moreover, the ability to tune the optical properties of nanostructures using different morphologies was integrated; two different morphology of nanostructures, i.e. solid-solid and solid-shell nanostructures, for two targets, ATP and DNA-210, respectively, were fabricated. Based on a difference in scattered color, two types of biosensors among thousands of nanoparticle assemblies can be easily identified. Finally, we demonstrated duplex detection based on the change in the scattering intensity and the color read-out. Reflecting on the contributions of our work, this dissertation advances the fundamental knowledge and practical design of chip-based sensing platforms comprising complex plasmonic nanostructures. The work contributes to the sensing field by addressing some of the challenges in point-of-care or point-of-need measurement applications and provides an alternative bioanalytical tool for single-cell based analysis.

Fabrication and Characterization of Innovative Bottom-up Plasmonic Nanostructures

Author : Sezin Yüksel
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Fabrication and Characterization of Innovative Bottom-up Plasmonic Nanostructures by : Sezin Yüksel

Download or read book Fabrication and Characterization of Innovative Bottom-up Plasmonic Nanostructures written by Sezin Yüksel and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The present thesis introduces the research of various fabrication strategies of bottom-up plasmonic nanostructures for the bio-analytical application. First, a novel label-free P. ramorum detection platform was realized employing SERS. This invasive plant pathogen was successfully detected and the entire analysis chain including, sample preparation, DNA isolation, amplification and hybridization on SERS-active silver substrate-immobilized adenine-free capture probes is introduced in the thesis. Later, the above introduced silver plasmonic arrays, so called EGNPs, were coated with the dielectric material Al2O3 using atomic layer deposition (ALD). These procedure increased their sensitivity, specificity and shelf-life. Second, hierarchically designed 3D flower-like hybrid nanostructures were developed by combining the metastable property of EGNPs substrates with plasma enhanced atomic layer deposition (PE-ALD). The resulting ultra-stable nanostructures were established as an efficient SERS-template substrate. Finally, an alternative silver nanoparticle synthesizing method using microwave radiation was proposed. This employs as a reliable, rapid, simple, reproducible and environmental friendly bottom-up fabrication strategy. The approach was implemented to the glass capillaries. An ultra-sensitive and high reproducible novel SERS-based capillary platform was developed and applied for the trace detection of THC. For this purpose, not only the physical, material and optical properties of these developed nanostructures were characterized but also their SERS efficiency was studied in detail. The developed novel SERS-active nanostructures show improved SERS performance in terms of high SERS reproducibility, surface uniformity, easy synthesis, cost-effectiveness, easy handling and high signal to noise ratio. Finally, the great potential of those novel SERS-active substrates in the field of biochemical and trace detection of an illegal drug were highlighted.

Plasmonics and Plasmonic Metamaterials

Author : Gennady Shvets
Publisher : World Scientific
ISBN 13 : 9814355275
Total Pages : 469 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Plasmonics and Plasmonic Metamaterials by : Gennady Shvets

Download or read book Plasmonics and Plasmonic Metamaterials written by Gennady Shvets and published by World Scientific. This book was released on 2012 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of the works of leading experts worldwide in the rapidly developing fields of plasmonics and metamaterials. These developments are promising to revolutionize ways of generating, controlling and processing light in the nanoscale. The technological applications range from nano-lasers to optical nano-waveguides to artificial media with unusual and exotic optical properties unattainable in natural materials. The volume cuts across all relevant disciplines and covers experiments, measurements, fabrication, physical and mathematical analysis, as well as computer simulation.

Localized Surface Plasmon Resonance for Biosensing Lab-on-a-chip Applications

Author : Srdjan S. Acomovic
Publisher :
ISBN 13 :
Total Pages : 189 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Localized Surface Plasmon Resonance for Biosensing Lab-on-a-chip Applications by : Srdjan S. Acomovic

Download or read book Localized Surface Plasmon Resonance for Biosensing Lab-on-a-chip Applications written by Srdjan S. Acomovic and published by . This book was released on 2013 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent times, metallic nanoparticle plasmonics coupled with applications towards biosensing has gathered momentum to the point where commercial R&D are investing large resources in developing the so-called localized surface plasmon resonance (LSPR) biosensors. Conceptually, the main motivation for the research presented within this thesis is achievement of fully-operational LSPR biosensor interfaced with the state-of-the-art microfluidics, allowing for very precise control of sample manipulation and stable read-out. LSPR sensors are specifficaly engineered by electron beam lithography nanofabrication technique, where nanoparticle interactions are optimized to exhibit increased sensitivity and higher signal-to-noise ratio. However, the overall performance of LSPR lab-on-a-chip device depends critically on the biorecognition layer preparation in combination with surface passivation. As an introduction, the principles of plasmonic biosensing are identified encompassing both Surface Plasmon Resonance (SPR) and Localized SPR. Being successfully implemented into commercial product, the governing physics of SPR is compared to LSPR in chapter 1, together with advantages and disadvantages of both. Chapter 2 describes methods necessary for LSPR biosensor development, beginning with nano-fabrication methods, the modelling tool (COMSOL Multiphisics), while the basics of micro-fabrication in microfluidics conclude this chapter, where passive and active microfluidics networks are discerned. Particularly attractive optical properties are exhibited by closely-coupled nanoparticles (dimers), with the dielectric gap of below tens of nm, which were theoretically predicted to be very suitable as LSPR biosensing substrates. Chapter 3 is subjected to optical characterization (dependence on the size of the dielectric gap) of nanofabricated dimer arrays. The acquired data demonstrate the advantages of the nanofabrication methods presented in chapter 2 and the technique for fast and reliable determination of nanoparticle characteristic parameters. The initial biosensing-like experiments presented in chapter 4 (no integration with microfluidics) proved for the first time, the theoretical predictions of higher sensitivity, yielding additionally the specific response as function of analyte size and dielectric gap between nanoparticles. The overall response of different dimer arrays (various gaps) provides information about adopted conformation of analyte protein once immobilized. Broad resonances of dimers feature higher noise when employing them for the real-time LSPR biosensing. As a way to circumvent such problem, the feasibility of employing far-field interaction within the nanoparticle array to spectrally narrow resonance is investigated in chapter 5 by optimizing the array periodicity and introducing thin waveguiding layers. Finally, the concluding chapter 6 is dedicated to a full assembly of a Lab-on-a-chip (LOC) LSPR biosensor, starting with interfacing plasmonic substrates with compatible active microfluidic networks, allowing the precise sample delivery and multiplexing. The prototype device consisting of 8 individual sensors is presented with typical modes of operation. The bulk refractive index determination of various samples demonstrates the working principle of such device. Finally, various strategies of biorecognition layer formation are discussed within the on-going research.

Optical Biosensors

Author : Frances S. Ligler
Publisher : Elsevier
ISBN 13 : 0080564941
Total Pages : 721 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Optical Biosensors by : Frances S. Ligler

Download or read book Optical Biosensors written by Frances S. Ligler and published by Elsevier. This book was released on 2011-10-13 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field. Comprehensive analysis and review of the underlying principles by optical biosensors Updates and informs on all the latest developments and hot topic areas Evaluates current methods showing the advantages and disadvantages of various systems involved

Nanomaterials

Author : Igor Linkov
Publisher : Springer Science & Business Media
ISBN 13 : 1402094914
Total Pages : 459 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nanomaterials by : Igor Linkov

Download or read book Nanomaterials written by Igor Linkov and published by Springer Science & Business Media. This book was released on 2008-12-26 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential questions regarding the risks associated with the development and use of wide-ranging technologies enabled through engineered nanomaterials. For example, with over 600 consumer products available globally, what information exists that describes their risk to human health and the environment? What en- neering or use controls can be deployed to minimize the potential environmental health and safety impacts of nanomaterials throughout the manufacturing and product lifecycles? How can the potential environmental and health benefits of nanotechnology be realized and maximized? The idea for this book was conceived at the NATO Advanced Research Workshop (ARW) on “Nanomaterials: Environmental Risks and Benefits and Emerging Consumer Products. ” This meeting – held in Algarve, Portugal, in April 2008 – started with building a foundation to harmonize risks and benefits associated with nanomaterials to develop risk management approaches and policies. More than 70 experts, from 19 countries, in the fields of risk assessment, decision-analysis, and security discussed the current state-of-knowledge with regard to nanomaterial risk and benefits. The discussion focused on the adequacy of available risk assessment tools to guide nanomaterial applications in industry and risk governance. The workshop had five primary purposes: Describe the potential benefits of nanotechnology enabled commercial products. Identify and describe what is known about environmental and human health risks of nanomaterials and approaches to assess their safety. Assess the suitability of multicriteria decision analysis for reconciling the benefits and risks of nanotechnology.

Metal-Enhanced Fluorescence

Author : Chris D. Geddes
Publisher : John Wiley & Sons
ISBN 13 : 0470642785
Total Pages : 655 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Metal-Enhanced Fluorescence by : Chris D. Geddes

Download or read book Metal-Enhanced Fluorescence written by Chris D. Geddes and published by John Wiley & Sons. This book was released on 2010-06-22 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how metal-enhanced fluorescence is changing traditional concepts of fluorescence This book collects and analyzes all the current trends, opinions, and emerging hot topics in the field of metal-enhanced fluorescence (MEF). Readers learn how this emerging technology enhances the utility of current fluorescence-based approaches. For example, MEF can be used to better detect and track specific molecules that may be present in very low quantities in either clinical samples or biological systems. Author Chris Geddes, a noted pioneer in the field, not only explains the fundamentals of metal-enhanced fluorescence, but also the significance of all the most recent findings and models in the field. Metal-enhanced fluorescence refers to the use of metal colloids and nanoscale metallic particles in fluorescence systems. It offers researchers the opportunity to modify the basic properties of fluorophores in both near- and far-field fluorescence formats. Benefits of metal-enhanced fluorescence compared to traditional fluorescence include: Increased efficiency of fluorescence emission Increased detection sensitivity Protect against fluorophore photobleaching Applicability to almost any molecule, including both intrinsic and extrinsic chromophores Following a discussion of the principles and fundamentals, the author examines the process and applications of metal-enhanced fluorescence. Throughout the book, references lead to the primary literature, facilitating in-depth investigations into particular topics. Guiding readers from the basics to state-of-the-technology applications, this book is recommended for all chemists, physicists, and biomedical engineers working in the field of fluorescence.

Metal Nanoparticles

Author : Daniel L. Fedlheim
Publisher : CRC Press
ISBN 13 : 9780585404394
Total Pages : 348 pages
Book Rating : 4.4/5 (43 download)

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Book Synopsis Metal Nanoparticles by : Daniel L. Fedlheim

Download or read book Metal Nanoparticles written by Daniel L. Fedlheim and published by CRC Press. This book was released on 2001-10-26 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art reference, Metal Nanoparticles offers the latest research on the synthesis, characterization, and applications of nanoparticles. Following an introduction of structural, optical, electronic, and electrochemical properties of nanoparticles, the book elaborates on nanoclusters, hyper-Raleigh scattering, nanoarrays, and several applications including single electron devices, chemical sensors, biomolecule sensors, and DNA detection. The text emphasizes how size, shape, and surface chemistry affect particle performance throughout. Topics include synthesis and formation of nanoclusters, nanosphere lithography, modeling of nanoparticle optical properties, and biomolecule sensors.

The Molecules of Life

Author : Kuriyan, John
Publisher : W.W. Norton & Company
ISBN 13 : 0815341881
Total Pages : 15 pages
Book Rating : 4.8/5 (153 download)

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Book Synopsis The Molecules of Life by : Kuriyan, John

Download or read book The Molecules of Life written by Kuriyan, John and published by W.W. Norton & Company. This book was released on 2012-07-25 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.

Plasmonics: Fundamentals and Applications

Author : Stefan Alexander Maier
Publisher : Springer Science & Business Media
ISBN 13 : 0387378251
Total Pages : 234 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Plasmonics: Fundamentals and Applications by : Stefan Alexander Maier

Download or read book Plasmonics: Fundamentals and Applications written by Stefan Alexander Maier and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered a major field of photonics, plasmonics offers the potential to confine and guide light below the diffraction limit and promises a new generation of highly miniaturized photonic devices. This book combines a comprehensive introduction with an extensive overview of the current state of the art. Coverage includes plasmon waveguides, cavities for field-enhancement, nonlinear processes and the emerging field of active plasmonics studying interactions of surface plasmons with active media.

Surface Plasmon Nanophotonics

Author : Mark L. Brongersma
Publisher : Springer
ISBN 13 : 1402043333
Total Pages : 270 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Surface Plasmon Nanophotonics by : Mark L. Brongersma

Download or read book Surface Plasmon Nanophotonics written by Mark L. Brongersma and published by Springer. This book was released on 2007-09-18 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses a new class of photonic devices, known as surface plasmon nanophotonic structures. The book highlights several exciting new discoveries, while providing a clear discussion of the underlying physics, the nanofabrication issues, and the materials considerations involved in designing plasmonic devices with new functionality. Chapters written by the leaders in the field of plasmonics provide a solid background to each topic.

Nanobiosensors

Author : Alexandru Grumezescu
Publisher : Academic Press
ISBN 13 : 0128043725
Total Pages : 928 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nanobiosensors by : Alexandru Grumezescu

Download or read book Nanobiosensors written by Alexandru Grumezescu and published by Academic Press. This book was released on 2016-09-28 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiosensors: Nanotechnology in the Agri-Food Industry, Volume 8, provides the latest information on the increasing demand for robust, rapid, inexpensive, and safe alternative technologies that monitor, test, and detect harmful or potentially dangerous foods. Due to their high sensitivity and selectivity, nanobiosensors have attracted attention for their use in monitoring not only biological contaminants in food, but also potential chemical and physical hazards. This book offers a broad overview regarding the current progress made in the field of nanosensors, including cutting-edge technological progress and the impact of these devices on the food industry. Special attention is given to the detection of microbial contaminants and harmful metabolotes, such as toxins and hormones, which have a great impact on both humans and animal health and feed. Includes the most up-to-date information on nanoparticles based biosensors and quantum dots for biological detection Provides application methods and techniques for research analysis for bacteriological detection and food testing Presents studies using analytical tools to improve food safety and quality analysis

Gold Nanoparticles in Biomedical Applications

Author : Lev Dykman
Publisher : CRC Press
ISBN 13 : 1351360477
Total Pages : 365 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Gold Nanoparticles in Biomedical Applications by : Lev Dykman

Download or read book Gold Nanoparticles in Biomedical Applications written by Lev Dykman and published by CRC Press. This book was released on 2017-12-12 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.