Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Evidence For Heterogeneity In Mild Cognitive Impairment Mci full books in PDF, epub, and Kindle. Read online Evidence For Heterogeneity In Mild Cognitive Impairment Mci ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Lisa Marie Delano-Wood
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.3/5 (129 download)
Download or read book Evidence for Heterogeneity in Mild Cognitive Impairment (MCI) written by Lisa Marie Delano-Wood and published by . This book was released on 2005 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald C. Petersen
Publisher : Oxford University Press
ISBN 13 : 0198028741
Total Pages : 286 pages
Book Rating : 4.1/5 (98 download)
Download or read book Mild Cognitive Impairment written by Ronald C. Petersen and published by Oxford University Press. This book was released on 2003-01-09 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinical investigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose other abilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, full clinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459591
Total Pages : 181 pages
Book Rating : 4.3/5 (94 download)
Download or read book Preventing Cognitive Decline and Dementia written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-05 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.
Author : Angela Tam
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Predicting Alzheimer's Dementia Form Heterogeneous Patterns of Neurodegeneration and Functional Connectivity written by Angela Tam and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "There is a large field of research dedicated to the development of biomarkers for an early diagnosis of Alzheimer's disease (AD). Predicting AD dementia within an individual, especially at a prodromal stage like mild cognitive impairment (MCI), is complicated by the vast amount of heterogeneity present in populations. This thesis explores heterogeneity in brain organization with magnetic resonance imaging (MRI) in order to develop biomarkers to identify individuals who will progress to AD dementia. Chapter 1 provides a brief introduction to the problem at hand and lists the specific aims of this thesis. Chapter 2 provides a review of the literature of biomarker development for AD, with a focus on MRI-based studies and prediction of cognitive trajectories with machine learning. In chapter 3, we present a study that explored whether there were functional connections in resting-state networks that could consistently discriminate between patients with MCI and cognitively normal older adults in the face of heterogeneity from methodological procedures. We identified functional connections that were robustly altered in the default mode network and the cortical-strial-thalamic loop, albeit with small to medium effect sizes, in MCI patients compared to controls in several independent datasets. We also provide sample size estimates to obtain adequate statistical power in a multisite study setting. Chapter 4 presents a study describing resting-state networks at various spatial resolutions in a heterogeneous sample of older adults with and without cognitive impairment. In chapter 5, we describe a study in which we developed a signature based on brain atrophy patterns and cognitive deficits that is highly predictive of future progression to AD dementia in a subgroup of individuals with MCI. By harnessing the heterogeneity in brain structure, we were able to achieve higher positive predictive values and specificity compared to previous works at predicting progression to dementia from the MCI stage. Lastly, a discussion of the contributions and future developments from these studies is presented in chapter 6. This thesis provides novel insights into the heterogeneity of structural and functional brain organization and the use of MRI as a tool to develop biomarkers for AD." --
Author : Joel Stephen Eppig
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.:/5 (11 download)
Download or read book Empirical Identification and Longitudinal Characterization of Mild Cognitive Impairment Subtypes Using Latent Mixture Modeling written by Joel Stephen Eppig and published by . This book was released on 2019 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rationale: Research in conventional mild cognitive impairment (MCI), a prodromal stage between normal aging and Alzheimer's dementia (AD), has demonstrated neuropsychological heterogeneity using clustering techniques. The current dissertation aimed to 1) empirically establish baseline neuropsychological MCI subtypes; 2) explore longitudinal characterization of empirical subtypes using rigorous norms; and 3) examine the probability of transition between subtypes over time. Design: Study 1 included 806 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Unique neuropsychological MCI subtypes and their associations with AD markers were investigated using latent profile analysis (LPA). Study 2 included 825 ADNI participants with baseline MCI that had follow-up at 12-months (n=751) and 24-months (n=639). Demographically-corrected T-scores were derived from the performance of 284 "robust" normal control participants assessed at baseline, 12-, and 24-months. Serial LPAs established neuropsychological subtypes for the MCI participants at each time point. Study 3 employed latent transition analysis to evaluate the likelihood of subtype change over time, as well as the influence of AD-risk factor covariates on transition probabilities. Results: Study 1 produced 3-classes: mixed impairment, amnestic impairment, and cognitively normal neuropsychological subtypes. Amnestic and mixed classes had higher positivities on markers of AD than the cognitively normal class. In Study 2, 4-neuropsychological classes were separately established at baseline, 12-, and 24-months: multi-domain impairment ([MLT]), amnestic impairment (AMN), dysexecutive/below average cognition (DYS/BA), and average cognition (AVG) classes. The MLT and AMN subtypes declined over time on the majority of measures, while the AVG subtype had stable neurpsychological performance. The DYS/BA subtype demonstrated stable memory performance and improvement on language and attention/executive measures. Study 3 indicated a high probability (>86%) for participants of all subtypes to remain in their class over time. Covariates that modestly increased the likelihood of transition between classes included worse functional ability and AD-biomarker positivity. Conclusions: This dissertation research used latent mixture models to establish analogous longitudinal neuropsychological profiles in conventionally diagnosed MCI. Results suggest that individuals are most likely to remain within their subtype across two years, including cognitively normal "false-positives." Future studies should examine empirical MCI subtypes with the use of actuarial methods that may improve diagnostic accuracy.
Author : Roberto Cabeza
Publisher : Oxford University Press
ISBN 13 : 0190660236
Total Pages : 633 pages
Book Rating : 4.1/5 (96 download)
Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2016-10-31 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of the popular Cognitive Neuroscience of Aging provides up-to-date coverage of the most fundamental topics in this discipline. Like the first edition, this volume accessibly and comprehensively reviews the neural mechanisms of cognitive aging appropriate to both professionals and students in a variety of domains, including psychology, neuroscience, neuropsychology, neurology, and psychiatry. The chapters are organized into three sections. The first section focuses on major questions regarding methodological approaches and experimental design. It includes chapters on structural imaging (MRI, DTI), functional imaging (fMRI), and molecular imaging (dopamine PET, etc), and covers multimodal imaging, longitudinal studies, and the interpretation of imaging findings. The second section concentrates on specific cognitive abilities, including attention and inhibitory control, executive functions, memory, and emotion. The third section turns to domains with health and clinical implications, such as the emergence of cognitive deficits in middle age, the role of genetics, the effects of modulatory variables (hypertension, exercise, cognitive engagement), and the distinction between healthy aging and the effects of dementia and depression. Taken together, the chapters in this volume, written by many of the most eminent scientists as well as young stars in this discipline, provide a unified and comprehensive overview of cognitive neuroscience of aging.
Author : Glenn E. Smith
Publisher : Oxford University Press
ISBN 13 : 0199764182
Total Pages : 416 pages
Book Rating : 4.1/5 (997 download)
Download or read book Mild Cognitive Impairment and Dementia written by Glenn E. Smith and published by Oxford University Press. This book was released on 2013-03-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the neuropsychology of common and a few rare neurodegenerative conditions. The mild cognitive impairment prodrome of each condition is highlighted. Chapters include an autopsy-confirmed case presentation from the authors' files, current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging, associated clinical features, differential neuropsychological features and possible interventions.
Author : Marco Sinai
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)
Download or read book Task Switching Ability in Mild Cognitive Impairment written by Marco Sinai and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing evidence of executive function deficits in mild cognitive impairment (MCI) and task switching ability has been shown to predict MCI transition to Alzheimer's disease. We tested task switching ability using a cued task switching paradigm in 27 MCI patients. Sixteen patients could perfume the task (MCI-able) and 11 could not (MCI-unable). Neuropsychological, electrophysiological, neuroanatomical, genetic, demographic, health-related data are presented for the MCI sub-groups and normal controls. The most significant finding of this study is that task-switching ability can be a powerful tool in characterizing this heterogeneous population. We found that most MCI patients exhibit some form of task-switching deficits, but to vastly different degrees. On the one hand there are individuals closer to the normal aging end of the cognitive spectrum; these individuals may present with memory deficits relative to their normal age peers but can compensate these with quasi-intact executive functions and have a high probability of remaining dementia free as long as their executive functions remain adequate. On the other side of the spectrum, there are individuals who perfume poorly on executive tasks as well as having significant episodic memory deficits. These individuals appear to have a high probability of developing AD or dying within four years. iii.
Author : Steven P. Roose
Publisher : Oxford University Press
ISBN 13 : 0195152743
Total Pages : 417 pages
Book Rating : 4.1/5 (951 download)
Download or read book Late-Life Depression written by Steven P. Roose and published by Oxford University Press. This book was released on 2004-07-15 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in an aging world. Illnesses that are prevalent and cause significant morbidity and mortality in older people will consume an increasing share of health care resources. One such illness is depression. This illness has a particularly devastating impact in the elderly because it is often undiagnosed or inadequately treated. Depression not only has a profound impact on quality of life but it is associated with an increased risk of mortality from suicide and vascular disease. In fact for every medical illness studied, e.g. heart disease, diabetes, cancer, individuals who are depressed have a worse prognosis. Research has illuminated the physiological and behavioral effects of depression that accounts for these poor outcomes. The deleterious relationship between depression and other illnesses has changed the concept of late-life depression from a "psychiatric disorder" that is diagnosed and treated by a psychiatrist to a common and serious disorder that is the responsibility of all physicians who care for patients over the age of 60.This is the first volume devoted to the epidemiology, phenomenology, psychobiology, treatment and consequences of late-life depression. Although much has been written about depressive disorders, the focus has been primarily on the illness as experienced in younger adults. The effects of aging on the brain, the physiological and behavioral consequences of recurrent depression, and the impact of other diseases common in the elderly, make late-life depression a distinct entity. There is a compelling need for a separate research program, specialized treatments, and a book dedicated to this disorder. This book will be invaluable to psychiatrists, gerontologists, clinical psychologists, social workers, students, trainees, and others who care for individuals over the age of sixty.
Download or read book Enhancing Detection of Those At-risk for Dementia: a Revised Classification Procedure for Mild Cognitive Impairment written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence for the utility of the Mild Cognitive Impairment (MCI) classification as a predictor of impending dementia in older adults is somewhat limited. Although individuals with MCI show elevated rates of conversion to dementia at the group level, heterogeneity of outcomes is common at the individual level. Using data from a prospective five-year longitudinal investigation of cognitive change in a sample of 262 healthy older adults aged 64 to 92 years, this study was designed to address key limitations in current MCI classification procedures which tend to rely on single occasion assessment (Traditional MCI) by evaluating an alternate operational definition of MCI requiring evidence of persistent cognitive impairment over multiple testing sessions (Persistent MCI), and four subsequent variations of this operational definition. It was hypothesized that: (1) prevalence of Traditional MCI would exceed prevalence of Persistent MCI across all variations in the operational definition, (2a) both the Traditional MCI and Persistent MCI groups would show lower levels of performance and greater decline in both cognitive and functional status over five years relative to Controls, (2b) the magnitude of these differences between those classified as Persistent MCI and Controls would exceed the magnitude of differences between those classified as Traditional MCI and Controls, and (3) the pattern of findings outlined in hypothesis 2 would persist under the four variations of the Traditional MCI and Persistent MCI inclusion criteria. Results were consistent with Hypothesis 1, and partially consistent with Hypotheses 2 and 3. In general, the Persistent MCI groups showed a lower mean baseline level of performance and a steeper trajectory of cognitive decline compared to the Control group and the Traditional MCI groups, although the sample-wide change in cognitive and functional status was small. There was some evidence that the variation of Persistent MCI classification which specifie.
Author : Biraj Bhattarai
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Mild Cognitive Impairment written by Biraj Bhattarai and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterogeneity of symptoms within and among mild cognitive impairment (MCI) individuals often makes it challenging to document cases clinically. Number of diagnostic criteria have been proposed in recent decades. MOCA and MMSE are two tests useful for the assessment of MCI, besides the neuroimaging studies with MRI and PET scan, have provided promising results in the early diagnosis of MCI. Lifestyle changes and cognitive training have been found to be more effective in the treatment of individuals with MCI.
Author :
Publisher :
ISBN 13 :
Total Pages : 43 pages
Book Rating : 4.:/5 (881 download)
Download or read book Spatial Pattern Separation in Mild Cognitive Impairment written by and published by . This book was released on 2014 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mild Cognitive Impairment (MCI) is a transitional state between normal aging and dementia. Of the cognitive abilities that may decline in MCI (e.g., memory, language, executive functioning, visuospatial processing), memory is of particular interest for identifying individuals who may progress and develop Alzheimer's disease (AD). A particular mnemonic mechanism that declines in older adults is spatial pattern separation. Spatial pattern separation reduces the interference among spatially similar memory representations and increases the probability of accurate encoding and retrieval. Examining spatial pattern separation in MCI may provide insight into a specific memory mechanism that is adversely affected by MCI associated pathology. Pattern separation is facilitated by the dentate gyrus (DG) and the CA3 subregions of the hippocampus. Individuals with the clinical subtype amnestic MCI (aMCI) evidence hyperactivity in the DG and CA3 subregions as well as smaller DG and CA3 subregion volumes compared to individuals without MCI. Previous studies in humans have suggested that individuals with MCI are impaired when performing a non-spatial pattern separation task compared to controls; however, no study to date has examined whether individuals with MCI evidence impaired performance on a spatial pattern separation task. The current study used a spatial pattern separation task developed in our laboratory to examine whether individuals with MCI evidence spatial pattern separation deficits compared to age-matched controls. The task involved the presentation of a single circle on a computer screen and then after a delay, the presentation of two circles -- one target circle in the same location as the original circle and one foil circle in a different location. Participants were asked to indicate which of the two circles was in the same location as the original circle. Four possible distances separated the edges of the target and foil circle: 0.0 cm, 0.5 cm, 1.0 cm, or 1.5 cm. Smaller distances between the target and foil circle were hypothesized to result in increased interference and heightened demand for spatial pattern separation. Data were analyzed using a 2 x 4 repeated measures ANOVA with group (MCI, control) as the between subjects variable and separation distance (0 cm, 0.5 cm, 1.0 cm, and 1.5 cm) as the within subject variable. Healthy older adults were predicted to perform significantly better on the spatial pattern separation task compared to individuals with an MCI diagnosis. However, the present analyses revealed no significant differences on the spatial pattern separation task between individuals diagnosed with MCI and healthy older adults. Although the present findings suggest that an MCI diagnosis may not adversely affect spatial pattern separation, future studies examining particular subtypes of MCI (e.g., aMCI) or MCI groups diagnosed using more conservative criteria are needed to further examine the effect of MCI on spatial pattern separation.
Author : Louise Cummings
Publisher : Cambridge University Press
ISBN 13 : 1108476317
Total Pages : 355 pages
Book Rating : 4.1/5 (84 download)
Download or read book Language in Dementia written by Louise Cummings and published by Cambridge University Press. This book was released on 2020-10 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using linguistic data, this book examines language and communication in dementias and their clinical treatment by language pathologists.
Author : Veljko Dubljević
Publisher : Springer Nature
ISBN 13 : 3030620735
Total Pages : 266 pages
Book Rating : 4.0/5 (36 download)
Download or read book Living with Dementia written by Veljko Dubljević and published by Springer Nature. This book was released on 2021-01-22 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses current issues in the neuroscience and ethics of dementia care, including philosophical as well as ethical legal, and social issues (ELSIs), issues in clinical, institutional, and private care-giving, and international perspectives on dementia and care innovations. As such, it is a must-read for anyone interested in a well-researched, thought-provoking overview of current issues in dementia diagnosis, care, and social and legal policy. All contributions reflect the latest neuroscientific research on dementia, either broadly construed or in terms of the etiologies and symptoms of particular forms of dementia. Given its interdisciplinary and international scope, its depth of research, and its qualitative emphasis, the book represents a valuable addition to the available literature on neuroethics, gerontology, and neuroscientific memory research.
Author : Michael J. Valenzuela
Publisher : HarperCollins Australia
ISBN 13 : 0733330223
Total Pages : 63 pages
Book Rating : 4.7/5 (333 download)
Download or read book Maintain Your Brain written by Michael J. Valenzuela and published by HarperCollins Australia. This book was released on 2011 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: You CAN take practical steps to avoid dementia - and this book from an Australian expert shows you how. Within twenty years, dementia is set to overtake heart disease as the number one cause of death in Australia. Recent studies show that almost half our adult population already have a family member or friend with the illness. those statistics seem rather grim, but there is GOOD NEWS! We don't need to accept dementia as an inevitable part of ageing. the main forms of dementia affecting people today are not inherited, and there are practical steps you can take right now that will not only help prevent dementia but also improve the overall health of your mind and body. In MAINtAIN YOUR BRAIN, leading Australian expert Dr Michael Valenzuela addresses all the common (and not-so-common) questions people have about dementia, and explains complex cutting-edge medical discoveries in a way that is clear and easy to understand. His practical advice is based on years of first-hand research and experience, and covers everything from blood pressure, diet and cholesterol to mental activity and physical exercise. Featuring plenty of simple tips, summaries and even recipes, this book is essential reading for anyone who wants to enjoy a healthy, active and happy life well into old age.
Author : Elizabeth K. Warrington
Publisher :
ISBN 13 : 9780749134020
Total Pages : 0 pages
Book Rating : 4.1/5 (34 download)
Download or read book The Visual Object and Space Perception Battery written by Elizabeth K. Warrington and published by . This book was released on 1991 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel Gopher
Publisher : MIT Press
ISBN 13 : 9780262071888
Total Pages : 842 pages
Book Rating : 4.0/5 (718 download)
Download or read book Attention and Performance XVII written by Daniel Gopher and published by MIT Press. This book was released on 1999 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1966 the first meeting of the Association for the Study of Attention and Performance was held in the Netherlands to promote the emerging science of cognitive psychology. This volume is based on the most recent conference, held in Israel thirty years later. The focus of the conference was the interaction between theory and application. The organizers chose the specific topic, cognitive regulation of performance, because it is an area where contemporary theories of cognitive processes meet the everyday challenges posed by human interactions with complex systems. Present-day technological systems impose on the operator a variety of supervisory functions, such as input and output monitoring, allocation of cognitive resources, choice of strategies, and regulation of cognitive operations. A challenge for engineers and designers is to accommodate the cognitive requirements called for by these systems. The book is divided into four sections: the presentation and representation of information, cognitive regulation of acquisition and performance, consciousness and behavior, and special populations: aging and neurological disorders. Contributors Nicole D. Anderson, Moshe Bar, Lynn Bardell, Alice E. Barnes, Irving Biederman, Robert A. Bjork, Richard A. Block, Fergus I. M. Craik, Heiner Deubel, John Dunlosky, Ido Erev, Ronald Fisher, John M. Flach, Barry Goettl, Morris Goldsmith, Daniel Gopher, Lynn Hasher, Okihide Hikosaka, Larry L. Jacoby, Peter Kalocsai, Colleen Kelley, David E. Kieras, Roberta Klatzky, Asher Koriat, Arthur F. Kramer, Elisabetta Ladavas, John L. Larish, Susan J. Lederman, John Long, Cynthia P. May, Guiliana Mazzoni, Brian McElree, David Meyer, Satoru Miyauchi, Neville Moray, Louis Narens, Thomas O. Nelson, Raymond S. Nickerson, Lynne Reder, J. Wesley Regian, Ian Robertson, Wolfgang Schneider, Christian D. Schunn, Wayne Shebilske, Shinsuke Shimojo, Suresh Subramaniam, Tom N. Trainham, Jehoshua Tsal, Timothy A. Weber, Christopher Wickens, Rose T. Zacks, Dan Zakay
