European Partnership On The Assessment Of Risks From Chemicals Parc Focus On New Approach Methodologies Nams In Risk Assessment

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European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment

Author : Terje Svingen
Publisher : Frontiers Media SA
ISBN 13 : 2832553389
Total Pages : 125 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment by : Terje Svingen

Download or read book European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment written by Terje Svingen and published by Frontiers Media SA. This book was released on 2024-08-21 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.

Strategic Asset Management of Water Supply and Wastewater Infrastructures

Author : Helena Alegre
Publisher : IWA Publishing
ISBN 13 : 1843391864
Total Pages : 553 pages
Book Rating : 4.8/5 (433 download)

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Book Synopsis Strategic Asset Management of Water Supply and Wastewater Infrastructures by : Helena Alegre

Download or read book Strategic Asset Management of Water Supply and Wastewater Infrastructures written by Helena Alegre and published by IWA Publishing. This book was released on 2009-09-14 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water and Wastewater companies operating all around the world have faced rising asset management and replacement costs, often to levels that are financially unsustainable. Management of investment needs, while meeting regulatory and other goals, has required: A better understanding of what customers demand from the services they pay for, and the extent to which they are willing to pay for improvements or be compensated for a reduction in performance Development of models to predict asset failure and to identify and concentrate investment on critical assets Improved management systems Improved accounting for costs and benefits and their incorporation within an appropriate cost-benefit framework Incorporation of risk management techniques Utilisation of advanced maintenance techniques including new rehabilitation failure detection technologies Enhancements in pipeline materials, technologies and laying techniques. These papers developed from LESAM 2007 for inclusion in Strategic Asset Management of Water Supply and Wastewater Infrastructures are focused on the techniques, technologies and management approaches aiming at optimising the investment in infrastructure while achieving demanded customer service standards, and they provide an opportunity to gain access to the latest discussion and developments at the leading-edge in this field. This book will be essential reading for utility operators and managers, regulators and consultants.

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book's second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. - Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies - Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease - Features chapter contributions from international leaders in the field

Regulatory Toxicology in the European Union

Author : Tim Marrs
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014049
Total Pages : 638 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Regulatory Toxicology in the European Union by : Tim Marrs

Download or read book Regulatory Toxicology in the European Union written by Tim Marrs and published by Royal Society of Chemistry. This book was released on 2018-02-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.

OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP)

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264304797
Total Pages : 206 pages
Book Rating : 4.2/5 (643 download)

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Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD

Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...

Silent Invaders

Author : Miriam Jacobs And Barbara Dinham
Publisher : Orient Blackswan
ISBN 13 : 9788125025993
Total Pages : 356 pages
Book Rating : 4.0/5 (259 download)

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Book Synopsis Silent Invaders by : Miriam Jacobs And Barbara Dinham

Download or read book Silent Invaders written by Miriam Jacobs And Barbara Dinham and published by Orient Blackswan. This book was released on 2004 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silent Invaders deals with the ubiquitous overuse of pesticides, which has led to unsustainable farming practices, imperiling the health of workers, consumers and the environment. The effects of these legal toxic products are studied from the perspective of women, as in some countries, particularly in the South, women make up 85 per cent or more of pesticide applicators. The volume covers a broad range of issues, from health to the need for regulation, to action that has been taken so far. It contains thirty-two essays written by authors from many nations, including India, and covers topics such as the Union Carbide gas leak at Bhopal twenty years ago (essay 29). The issue of pesticides is of particular interest at the moment due to the Centre for Science and Environment s reports on the presence of pesticide in mineral water and soft drinks.

New TSCA

Author : Lynn L. Bergeson
Publisher : American Bar Association
ISBN 13 : 9781634258333
Total Pages : 329 pages
Book Rating : 4.2/5 (583 download)

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Book Synopsis New TSCA by : Lynn L. Bergeson

Download or read book New TSCA written by Lynn L. Bergeson and published by American Bar Association. This book was released on 2017 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: "With the passage of the Frank R. Lautenberg Chemical Safety for the 21st Century Act on June 22, 2016, the main body of chemical management law in the United States changed dramatically. This guide summarizes the new law, highlights the changes that will have the greatest impact, and offers pertinent analysis on the implementation of the new law."--

Green Toxicology

Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
ISBN 13 : 1839164409
Total Pages : 225 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Green Toxicology by : Alexandra Maertens

Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Big Data in Predictive Toxicology

Author : Daniel Neagu
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160829
Total Pages : 303 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Big Data in Predictive Toxicology by : Daniel Neagu

Download or read book Big Data in Predictive Toxicology written by Daniel Neagu and published by Royal Society of Chemistry. This book was released on 2019-12-04 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the opportunities of new techniques encountered in data science. It addresses the nature of toxicological big data, their storage, analysis and interpretation. It also details how these data can be applied in toxicity prediction, modelling and risk assessment. This title is of particular relevance to researchers and postgraduates working and studying in the fields of computational methods, applied and physical chemistry, cheminformatics, biological sciences, predictive toxicology and safety and hazard assessment.

Validation of Alternative Methods for Toxicity Testing

Author : Chantra Eskes
Publisher : Springer
ISBN 13 : 3319338269
Total Pages : 418 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Validation of Alternative Methods for Toxicity Testing by : Chantra Eskes

Download or read book Validation of Alternative Methods for Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2016-09-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.

Bats of the United States and Canada

Author : Michael J. Harvey
Publisher : JHU Press
ISBN 13 : 1421403005
Total Pages : 219 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Bats of the United States and Canada by : Michael J. Harvey

Download or read book Bats of the United States and Canada written by Michael J. Harvey and published by JHU Press. This book was released on 2011-12-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Honorable Mention, Popular Science, 2012 PROSE Awards, Professional and Scholarly Publishing Division of the Association of American Publishers The only mammals capable of true flight, bats are among the world’s most fascinating creatures. This accessible guide to the forty-seven species of bats found in the United States and Canada captures and explains the amazing diversity of these marvels of evolution. A wide variety of bat species live in the United States and Canada, ranging from the California leaf-nosed bat to the Florida bonneted bat, from the eastern small-footed bat to the northern long-eared bat. The authors provide an overview of bat classification, biology, feeding behavior, habitats, migration, and reproduction. They discuss the ever-increasing danger bats face from destruction of habitat, wind turbines, chemical toxicants, and devastating diseases like white-nose syndrome, which is killing millions of cave bats in North America. Illustrated species accounts include range maps and useful identification tips. Written by three of the world’s leading bat experts and featuring J. Scott Altenbach's stunning photographs, this fact-filled and easy-to-use book is the most comprehensive and up-to-date account of bats in the U.S. and Canada.

Novel Psychoactive Substances

Author : Ornella Corazza
Publisher : Springer
ISBN 13 : 331960600X
Total Pages : 192 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Novel Psychoactive Substances by : Ornella Corazza

Download or read book Novel Psychoactive Substances written by Ornella Corazza and published by Springer. This book was released on 2017-08-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In light of the recent emergence of Novel Psychoactive Substances (NPS) on a global scale, this book provides a timely analysis of the social and economic impact of the NPS phenomenon, and of the global policy and regulatory responses to it. It presents the first comprehensive overview of the international regulation, policy and market structure of the NPS phenomenon, offering a guide to inform legislative discussions and demonstrating from a comparative perspective the different approaches used to address the rise of NPS to date. It covers topics such as organized crime, drug markets, clinical evidence on NPS, and different regulatory approaches also in less explored settings such as prisons and sport environments. Overall, this highly informative and well-structured repository of different experiences with NPS policy, law and regulation offers an essential primary source of evidence for anyone interested in the area of drug and NPS policy, health economics and p ublic health.

Making Mathematics Come to Life

Author : Oleg A. Ivanov
Publisher : American Mathematical Soc.
ISBN 13 : 0821848089
Total Pages : 349 pages
Book Rating : 4.8/5 (218 download)

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Book Synopsis Making Mathematics Come to Life by : Oleg A. Ivanov

Download or read book Making Mathematics Come to Life written by Oleg A. Ivanov and published by American Mathematical Soc.. This book was released on 2009-12-16 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: ``It is difficult to define the genre of the book. It is not a problem book, nor a textbook, nor a `book for reading about mathematics'. It is most of all reminiscent of a good lecture course, from which a thoughtful student comes away with more than was actually spoken about in the lectures.'' --from the Preface by A. S. Merkurjev If you are acquainted with mathematics at least to the extent of a standard high school curriculum and like it enough to want to learn more, and if, in addition, you are prepared to do some serious work, then you should start studying this book. An understanding of the material of the book requires neither a developed ability to reason abstractly nor skill in using the refined techniques of mathematical analysis. In each chapter elementary problems are considered, accompanied by theoretical material directly related to them. There are over 300 problems in the book, most of which are intended to be solved by the reader. In those places in the book where it is natural to introduce concepts outside the high school syllabus, the corresponding definitions are given with examples. And in order to bring out the meaning of such concepts clearly, appropriate (but not too many) theorems are proved concerning them. Unfortunately, what is sometimes studied at school under the name ``mathematics'' resembles real mathematics not any closer than a plucked flower gathering dust in a herbarium or pressed between the pages of a book resembles that same flower in the meadow besprinkled with dewdrops sparkling in the light of the rising sun.

Cognitive Enhancement in Psychiatric Disorders

Author : Tomiki Sumiyoshi
Publisher : Frontiers Media SA
ISBN 13 : 2889630552
Total Pages : 261 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Cognitive Enhancement in Psychiatric Disorders by : Tomiki Sumiyoshi

Download or read book Cognitive Enhancement in Psychiatric Disorders written by Tomiki Sumiyoshi and published by Frontiers Media SA. This book was released on 2019-11-25 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disturbances of various domains of cognitive function have been shown to provide a major determinant of outcome for patients with psychiatric conditions. Cognitive impairment is present in an array of diseases, including schizophrenia (with its prodromal stage), mood disorder, autism spectrum disorder, obsessive-compulsive disorder, anxiety disorder, post-traumatic disorder, and eating disorder. In an effort to develop effective therapeutics for cognitive impairment, bridging of preclinical and clinical evidence has been attempted. This edited Book will provide a forum for researchers and clinicians interested in the phenomenology, underlying mechanisms, and treatment of cognitive impairment associated with psychiatric illnesses. Twenty-eight contributions from 8 countries in Europe, Middle East, Asia, North America, and South America represent studies dealing with genetic, molecular, imaging, physiological, psychological, and behavioral issues. Information in this Book will facilitate the development of therapeutics of greater clinical value.

OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264076247
Total Pages : 33 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...

Regulating Chemical Risks

Author : Johan Eriksson
Publisher : Springer Science & Business Media
ISBN 13 : 9048194288
Total Pages : 347 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Regulating Chemical Risks by : Johan Eriksson

Download or read book Regulating Chemical Risks written by Johan Eriksson and published by Springer Science & Business Media. This book was released on 2010-08-18 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents research on current trends in chemical regulations – a fa- growing, complex, and increasingly internationalized field. The book grew out from a multidisciplinary research project entitled ‘Regulating Chemical Risks in the Baltic Sea Area: Science, Politics, and the Media’, led by Michael Gilek at Södertörn University, Sweden. This research project involved scholars and experts from natural as well as social sciences, based at Södertörn University, Swedish Royal Institute of Technology (KTH), Karolinska Institutet, and Umeå University. The project group organized a multidisciplinary research conference on chemical risk regulations, held in Stockholm, August 15–17, 2007. Most of the contributions published in this book were, in draft form, first presented at this conference. The conference, like the ensuing edited volume, expanded the geographical focus beyond the Baltic Sea area to include wider European, and to some extent also global trends. Many thanks to all project colleagues and conference participants! We are very grateful for the generous financial support received from The Foundation for Baltic and East European Studies (Östersjöstiftelsen), The Swedish Research Council Formas, and from Södertörn University. Without this support the present book would not have been possible. Special thanks to all of our fellow contributors, all of whom have submitted to- cal papers based on high-quality research. Many thanks also to Tobias Evers, who assisted us with technical editing. Finally, we are grateful for the professionalism shown by our editors at Springer.

Orthogeriatrics

Author : Paolo Falaschi
Publisher : Springer Nature
ISBN 13 : 3030481263
Total Pages : 355 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Orthogeriatrics by : Paolo Falaschi

Download or read book Orthogeriatrics written by Paolo Falaschi and published by Springer Nature. This book was released on 2021 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new open access edition supported by the Fragility Fracture Network aims at giving the widest possible dissemination on fragility fracture (especially hip fracture) management and notably in countries where this expertise is sorely needed. It has been extensively revised and updated by the experts of this network to provide a unique and reliable content in one single volume. Throughout the book, attention is given to the difficult question of how to provide best practice in countries where the discipline of geriatric medicine is not well established and resources for secondary prevention are scarce. The revised and updated chapters on the epidemiology of hip fractures, osteoporosis, sarcopenia, surgery, anaesthesia, medical management of frailty, peri-operative complications, rehabilitation and nursing are supplemented by six new chapters. These include an overview of the multidisciplinary approach to fragility fractures and new contributions on pre-hospital care, treatment in the emergency room, falls prevention, nutrition and systems for audit. The reader will have an exhaustive overview and will gain essential, practical knowledge on how best to manage fractures in elderly patients and how to develop clinical systems that do so reliably.