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Epigenetic Metabolic And Transcriptional Regulation Of Immune Cell Plasticity And Functions In Cancer And Non Cancer Diseases
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Book Synopsis Epigenetic, metabolic, and transcriptional regulation of immune cell plasticity and functions in cancer and non-cancer diseases by : Yun Dai
Download or read book Epigenetic, metabolic, and transcriptional regulation of immune cell plasticity and functions in cancer and non-cancer diseases written by Yun Dai and published by Frontiers Media SA. This book was released on 2023-10-25 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional Regulation in Cancers and Metabolic Diseases by : Wen Zhou
Download or read book Transcriptional Regulation in Cancers and Metabolic Diseases written by Wen Zhou and published by Frontiers Media SA. This book was released on 2015-12-04 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or ‘gain of function’ specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases.
Book Synopsis Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development by : Constanze Bonifer
Download or read book Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development written by Constanze Bonifer and published by Springer Science & Business Media. This book was released on 2014-03-12 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.
Book Synopsis Transcriptional and Chromatin Regulation in Adaptive and Innate Immune Cells by : Keiko Ozato
Download or read book Transcriptional and Chromatin Regulation in Adaptive and Innate Immune Cells written by Keiko Ozato and published by Frontiers Media SA. This book was released on 2020-05-22 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription depends on an ordered sequence of events, starting with (i) setting of the enhancer and chromatin environment, (ii) assembly of DNA binding and general transcription factors, (iii) initiation, elongation, processing of mRNA and termination, followed by (iv) creation of epigenetic marks and memory formation. Highlighting the importance of these activities, more than 10% total genes are dedicated to regulating transcriptional mechanisms. This area of research is highly active and new insights are continuously being added to our knowledge. Cells of the immune system have unique features of gene regulation to support diverse tasks required for innate and adaptive immunity. Innate immunity involves the recognition of external infectious and noxious agents as well as internal cancer cell components, and the elimination of these agents by non-specific mechanisms. Adaptive immunity involves gene rearrangement to achieve highly specific T and B cell responses, imparting the capability of self and non-self discrimination. This requires transcription and epigenetic regulation. Adaptive immunity also employs epigenetic memory, enabling recapitulation of prior transcription. Recent advances in nuclear architecture, chromatin structure, and transcriptional regulation have provided new insights into immune responses. The increased understanding of these molecular mechanisms is now affording opportunities to improve therapeutic strategies for various diseases.
Book Synopsis Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment by : Katherine Chiappinelli
Download or read book Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment written by Katherine Chiappinelli and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Epigenetics and Cancer by : Fazlul H. Sarkar
Download or read book Epigenetics and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2013-05-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Epigenetic Regulation in Cancer Immunity by : Bo Chen
Download or read book Epigenetic Regulation in Cancer Immunity written by Bo Chen and published by Frontiers Media SA. This book was released on 2023-06-21 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Epigenetic Regulation of Cancer - Part A by :
Download or read book Epigenetic Regulation of Cancer - Part A written by and published by Elsevier. This book was released on 2023-09-02 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Epigenetic Regulation of Cancer, a series of volumes from the International Review of Cell and Molecular Biology series, various experts in epigenetics critically cover multiple facets of cancer-associated epigenetic alterations, including the impact of epigenetic deregulation in all steps of oncogenesis as well as promising strategies to therapeutically target cancer-associated epigenetic deregulation. This collection aims at expanding our knowledge on this exciting field of investigation and providing fresh insights as a basis for further investigations that will hopefully translate into an improved clinical management of patients with cancer. The collection provides accurate and critical review articles from invited experts on the selected topic Each review provides the newest insights and remarks on multiple subjects of the topic The volume offers a broad range of perspectives on detailed features
Book Synopsis Gene Regulation and Therapeutics for Cancer by : Surinder K. Batra
Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Book Synopsis Control of Regulatory T cell Stability, Plasticity and Function in Health and Disease by : Margarita Dominguez-Villar
Download or read book Control of Regulatory T cell Stability, Plasticity and Function in Health and Disease written by Margarita Dominguez-Villar and published by Frontiers Media SA. This book was released on 2021-03-08 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Epigenetic Regulation of Cancer - Part B by :
Download or read book Epigenetic Regulation of Cancer - Part B written by and published by Elsevier. This book was released on 2024-04 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.
Book Synopsis Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases by : Barbara Stefanska
Download or read book Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases written by Barbara Stefanska and published by Humana. This book was released on 2016-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab. Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.
Book Synopsis Non-Lymphoid Functions of Regulatory T cells in Health and Disease by : Dipayan Rudra
Download or read book Non-Lymphoid Functions of Regulatory T cells in Health and Disease written by Dipayan Rudra and published by Frontiers Media SA. This book was released on 2023-03-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immune Cell Lineage Reprogramming in Cancer by : Jianmei Wu Leavenworth
Download or read book Immune Cell Lineage Reprogramming in Cancer written by Jianmei Wu Leavenworth and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Book Synopsis Philosophy of Cancer by : Marta Bertolaso
Download or read book Philosophy of Cancer written by Marta Bertolaso and published by Springer. This book was released on 2016-08-24 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.
Book Synopsis Epithelial-Mesenchymal Plasticity in Cancer Metastasis by : Mohit Kumar Jolly
Download or read book Epithelial-Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
