Engineering The Tumor Microenvironment

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Biomaterials for 3D Tumor Modeling

Author : Subhas C. Kundu
Publisher : Elsevier
ISBN 13 : 012818129X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials for 3D Tumor Modeling by : Subhas C. Kundu

Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. - Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles - Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types - Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomechanics in Oncology

Author : Cheng Dong
Publisher : Springer
ISBN 13 : 3319952943
Total Pages : 378 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Biomechanics in Oncology by : Cheng Dong

Download or read book Biomechanics in Oncology written by Cheng Dong and published by Springer. This book was released on 2018-10-27 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Physics Of Cancer, The: Research Advances

Author : Bernard S Gerstman
Publisher : World Scientific
ISBN 13 : 9811223505
Total Pages : 279 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Physics Of Cancer, The: Research Advances by : Bernard S Gerstman

Download or read book Physics Of Cancer, The: Research Advances written by Bernard S Gerstman and published by World Scientific. This book was released on 2020-12-03 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer deaths per capita have decreased in recent years, but the improvement is attributed to prevention, not treatment. The difficulty in treating cancer may be due to its 'complexity', in the mathematical physics sense of the word. Tumors evolve and spread in response to internal and external factors that involve feedback mechanisms and nonlinear behavior. Investigations of the nonlinear interactions among cells, and between cells and their environment, are crucial for developing a sufficiently detailed understanding of the system's emergent phenomenology to be able to control the behavior. In the case of cancer, controlling the system's behavior will mean the ability to treat and cure the disease. Physicists have been studying various complex, nonlinear systems for many years using a variety of techniques. These investigations have provided insights that allow physicists to make unique contributions towards the treatment of cancer.This interdisciplinary book presents recent advancements in physicists' research on cancer. The work presented in this volume uses a variety of physical, biochemical, mathematical, theoretical, and computational techniques to gain a deeper molecular and cellular understanding of the horrific disease that is cancer.

Patient-Derived Xenograft Models of Human Cancer

Author : Yuzhuo Wang
Publisher : Springer
ISBN 13 : 3319558250
Total Pages : 212 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Patient-Derived Xenograft Models of Human Cancer by : Yuzhuo Wang

Download or read book Patient-Derived Xenograft Models of Human Cancer written by Yuzhuo Wang and published by Springer. This book was released on 2017-06-27 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Advances In Tissue Engineering

Author : Julia M Polak
Publisher : World Scientific
ISBN 13 : 1908978902
Total Pages : 947 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis Advances In Tissue Engineering by : Julia M Polak

Download or read book Advances In Tissue Engineering written by Julia M Polak and published by World Scientific. This book was released on 2008-08-20 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field./a

Innovations for Next-Generation Antibody-Drug Conjugates

Author : Marc Damelin
Publisher : Springer
ISBN 13 : 3319781545
Total Pages : 358 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Innovations for Next-Generation Antibody-Drug Conjugates by : Marc Damelin

Download or read book Innovations for Next-Generation Antibody-Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Biomaterials for Cancer Therapeutics

Author : Kinam Park
Publisher : Elsevier
ISBN 13 : 0857096761
Total Pages : 543 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biomaterials for Cancer Therapeutics by : Kinam Park

Download or read book Biomaterials for Cancer Therapeutics written by Kinam Park and published by Elsevier. This book was released on 2013-11-23 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. - A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer - Discusses the fundamentals of biomaterials for cancer therapeutics - Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Current Strategies in Cancer Gene Therapy

Author : Wolfgang Walther
Publisher : Springer
ISBN 13 : 3319429345
Total Pages : 124 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Current Strategies in Cancer Gene Therapy by : Wolfgang Walther

Download or read book Current Strategies in Cancer Gene Therapy written by Wolfgang Walther and published by Springer. This book was released on 2017-01-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 225 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Synthetic Biology

Author : Christina Smolke
Publisher : John Wiley & Sons
ISBN 13 : 3527688099
Total Pages : 532 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Synthetic Biology by : Christina Smolke

Download or read book Synthetic Biology written by Christina Smolke and published by John Wiley & Sons. This book was released on 2018-02-28 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.

Bioinformatics and Computational Biology

Author : Sanguthevar Rajasekaran
Publisher : Springer
ISBN 13 : 3642007279
Total Pages : 463 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Bioinformatics and Computational Biology by : Sanguthevar Rajasekaran

Download or read book Bioinformatics and Computational Biology written by Sanguthevar Rajasekaran and published by Springer. This book was released on 2009-04-22 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the First International on Bioinformatics and Computational Biology, BICoB 2007, held in New Orleans, LA, USA, in April 2007. The 30 revised full papers presented together with 10 invited lectures were carefully reviewed and selected from 72 initial submissions. The papers address current research in the area of bioinformatics and computational biology fostering the advancement of computing techniques and their application to life sciences in topics such as genome analysis sequence analysis, phylogenetics, structural bioinformatics, analysis of high-throughput biological data, genetics and population analysis, as well as systems biology.

Aggregation-Induced Emission (AIE)

Author : Jianwei Xu
Publisher : Elsevier
ISBN 13 : 0128243368
Total Pages : 698 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Aggregation-Induced Emission (AIE) by : Jianwei Xu

Download or read book Aggregation-Induced Emission (AIE) written by Jianwei Xu and published by Elsevier. This book was released on 2022-04-17 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggregation-Induced Emission (AIE): A Practical Guide introduces readers to the topic, guiding them through fundamental concepts and the latest advances in applications. The book covers concepts, principles and working mechanisms of AIE in AIE-active luminogens, with different classes of AIE luminogens reviewed, including polymers, three-dimensional frameworks (MOFs and COFs) and supramolecular gels. Special focus is given to the structure-property relationship, structural design strategies, targeted properties and application performance. The book provides readers with a deep understanding, not only on the fundamental principles of AIE, but more importantly, on how AIE luminogens and AIE properties can be incorporated in material development. - Provides the fundamental principles, design and synthesis strategies of aggregation induced emission materials - Reviews the most relevant applications in materials design for stimuli-responsive materials, biomedical applications, chemo-sensing and optoelectronics - Emphasizes structural design and its connection to aggregation induced emission properties, also exploring the structure-property relationship

Tumor Microenvironment and Cellular Stress

Author : Constantinos Koumenis
Publisher : Springer Science & Business Media
ISBN 13 : 146145915X
Total Pages : 293 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Tumor Microenvironment and Cellular Stress by : Constantinos Koumenis

Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Physics of Cancer

Author : Claudia Mierke
Publisher : Iph001
ISBN 13 : 9780750317511
Total Pages : 500 pages
Book Rating : 4.3/5 (175 download)

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Book Synopsis Physics of Cancer by : Claudia Mierke

Download or read book Physics of Cancer written by Claudia Mierke and published by Iph001. This book was released on 2018-10-24 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

Rethinking Cancer

Author : Bernhard Strauss
Publisher : MIT Press
ISBN 13 : 0262045214
Total Pages : 433 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Rethinking Cancer by : Bernhard Strauss

Download or read book Rethinking Cancer written by Bernhard Strauss and published by MIT Press. This book was released on 2021-04-27 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Patient Derived Tumor Xenograft Models

Author : Rajesh K. Uthamanthil
Publisher : Academic Press
ISBN 13 : 9780128040102
Total Pages : 0 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Patient Derived Tumor Xenograft Models by : Rajesh K. Uthamanthil

Download or read book Patient Derived Tumor Xenograft Models written by Rajesh K. Uthamanthil and published by Academic Press. This book was released on 2016-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory.