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Empirical Likelihood Methods In Biomedicine And Health
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Book Synopsis Empirical Likelihood Methods in Biomedicine and Health by : Albert Vexler
Download or read book Empirical Likelihood Methods in Biomedicine and Health written by Albert Vexler and published by CRC Press. This book was released on 2018-09-03 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. Provides a systematic overview of novel empirical likelihood techniques. Presents a good balance of theory, methods, and applications. Features detailed worked examples to illustrate the application of the methods. Includes R code for implementation. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.
Book Synopsis Empirical Likelihood Methods in Biomedicine and Health by : Albert Vexler
Download or read book Empirical Likelihood Methods in Biomedicine and Health written by Albert Vexler and published by CRC Press. This book was released on 2018-09-03 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. Provides a systematic overview of novel empirical likelihood techniques. Presents a good balance of theory, methods, and applications. Features detailed worked examples to illustrate the application of the methods. Includes R code for implementation. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.
Book Synopsis Modern Inference Based on Health-Related Markers by : Albert Vexler
Download or read book Modern Inference Based on Health-Related Markers written by Albert Vexler and published by Academic Press. This book was released on 2024-03-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Inference Based on Health Related Markers: Biomarkers and Statistical Decision Making provides a compendium of biomarkers based methodologies for respective health related fields and health related marker-specific biostatistical techniques. These methodologies may be applied to various problems encountered in medical and epidemiological studies. This book introduces correct and efficient testing mechanisms including procedures based on bootstrap and permutation methods with the aim of making these techniques assessable to practical researchers. In the biostatistical aspect, it describes how to correctly state testing problems, but it also includes novel results, which have appeared in current statistical publications. The book discusses also modern applied statistical developments that consider data-driven techniques, including empirical likelihood methods and other simple and efficient methods to derive statistical tools for use in health related studies. The title is a valuable source for biostaticians, practitioners, theoretical and applied investigators, and several members of the biomedical field who are interested in learning more about efficient evidence-based inference incorporating several forms of markers measurements. Combines modern epidemiological and public health discoveries with cutting-edge biostatistical tools, including relevant software codes, offering one full package to meet the demand of practical investigators Includes the emerging topics from real health fields in order to display recent advances and trends in Biomarkers and associated Decision Making areas Written by researchers who are leaders of Epidemiological and Biostatistical fields, presenting up-to-date investigations related to the measuring health issues, emerging fields of biomarkers, designing health studies and their implementations, clinical trials and their practices and applications, different aspects of genetic markers
Book Synopsis Empirical Likelihood Method in Survival Analysis by : Mai Zhou
Download or read book Empirical Likelihood Method in Survival Analysis written by Mai Zhou and published by CRC Press. This book was released on 2015-06-17 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Add the Empirical Likelihood to Your Nonparametric ToolboxEmpirical Likelihood Method in Survival Analysis explains how to use the empirical likelihood method for right censored survival data. The author uses R for calculating empirical likelihood and includes many worked out examples with the associated R code. The datasets and code are available
Book Synopsis Statistical Methods for Healthcare Performance Monitoring by : Alex Bottle
Download or read book Statistical Methods for Healthcare Performance Monitoring written by Alex Bottle and published by CRC Press. This book was released on 2016-08-05 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.
Book Synopsis Statistical Testing Strategies in the Health Sciences by : Albert Vexler
Download or read book Statistical Testing Strategies in the Health Sciences written by Albert Vexler and published by CRC Press. This book was released on 2017-12-19 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments. The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method, with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept, providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods for constructing correct and powerful statistical decision-making processes to be adapted for complex statistical applications. With techniques spanning robust statistical methods to more computationally intensive approaches, this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies, including clinical trials. Theoretical statisticians, medical researchers, and other practitioners in epidemiology and clinical research will appreciate the book’s novel theoretical and applied results. The book is also suitable for graduate students in biostatistics, epidemiology, health-related sciences, and areas pertaining to formal decision-making mechanisms.
Book Synopsis Statistical Testing Strategies in the Health Sciences by : Albert Vexler
Download or read book Statistical Testing Strategies in the Health Sciences written by Albert Vexler and published by CRC Press. This book was released on 2017-12-19 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments. The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method, with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept, providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods for constructing correct and powerful statistical decision-making processes to be adapted for complex statistical applications. With techniques spanning robust statistical methods to more computationally intensive approaches, this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies, including clinical trials. Theoretical statisticians, medical researchers, and other practitioners in epidemiology and clinical research will appreciate the book’s novel theoretical and applied results. The book is also suitable for graduate students in biostatistics, epidemiology, health-related sciences, and areas pertaining to formal decision-making mechanisms.
Book Synopsis Methods and Applications of Statistics in Clinical Trials, Volume 2 by : N. Balakrishnan
Download or read book Methods and Applications of Statistics in Clinical Trials, Volume 2 written by N. Balakrishnan and published by Wiley. This book was released on 2014-05-16 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This comprehensive book features both new and established material on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. It discusses the various kinds of trials that can be found in today's clinical setting including open-labeled trials, multicentered trials, and superiority trials. It also explores such ongoing, cutting-edge trials as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS"--Provided by publisher.
Book Synopsis Likelihood and Bayesian Inference by : Leonhard Held
Download or read book Likelihood and Bayesian Inference written by Leonhard Held and published by Springer. This book was released on 2021-04-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated textbook covers modern statistical methods with applications in medicine, epidemiology and biology. Firstly, it discusses the importance of statistical models in applied quantitative research and the central role of the likelihood function, describing likelihood-based inference from a frequentist viewpoint, and exploring the properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic. In the second part of the book, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. It includes a separate chapter on modern numerical techniques for Bayesian inference, and also addresses advanced topics, such as model choice and prediction from frequentist and Bayesian perspectives. This revised edition of the book “Applied Statistical Inference” has been expanded to include new material on Markov models for time series analysis. It also features a comprehensive appendix covering the prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis, and each chapter is complemented by exercises. The text is primarily intended for graduate statistics and biostatistics students with an interest in applications.
Book Synopsis Methods and Applications of Statistics in Clinical Trials, Volume 2 by : N. Balakrishnan
Download or read book Methods and Applications of Statistics in Clinical Trials, Volume 2 written by N. Balakrishnan and published by John Wiley & Sons. This book was released on 2014-06-16 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods and Applications of Statistics in Clinical Trials,Volume 2: Planning, Analysis, and Inferential Methods includesupdates of established literature from the Wiley Encyclopedia ofClinical Trials as well as original material based on the latestdevelopments in clinical trials. Prepared by a leading expert, thesecond volume includes numerous contributions from currentprominent experts in the field of medical research. In addition,the volume features: • Multiple new articles exploring emerging topics, such asevaluation methods with threshold, empirical likelihood methods,nonparametric ROC analysis, over- and under-dispersed models, andmulti-armed bandit problems • Up-to-date research on the Cox proportional hazardmodel, frailty models, trial reports, intrarater reliability,conditional power, and the kappa index • Key qualitative issues including cost-effectivenessanalysis, publication bias, and regulatory issues, which arecrucial to the planning and data management of clinical trials
Book Synopsis Methods in Comparative Effectiveness Research by : Constantine Gatsonis
Download or read book Methods in Comparative Effectiveness Research written by Constantine Gatsonis and published by CRC Press. This book was released on 2017-02-24 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies—experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections—causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.
Book Synopsis Applied Biclustering Methods for Big and High-Dimensional Data Using R by : Adetayo Kasim
Download or read book Applied Biclustering Methods for Big and High-Dimensional Data Using R written by Adetayo Kasim and published by CRC Press. This book was released on 2016-10-03 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proven Methods for Big Data Analysis As big data has become standard in many application areas, challenges have arisen related to methodology and software development, including how to discover meaningful patterns in the vast amounts of data. Addressing these problems, Applied Biclustering Methods for Big and High-Dimensional Data Using R shows how to apply biclustering methods to find local patterns in a big data matrix. The book presents an overview of data analysis using biclustering methods from a practical point of view. Real case studies in drug discovery, genetics, marketing research, biology, toxicity, and sports illustrate the use of several biclustering methods. References to technical details of the methods are provided for readers who wish to investigate the full theoretical background. All the methods are accompanied with R examples that show how to conduct the analyses. The examples, software, and other materials are available on a supplementary website.
Book Synopsis Modern Statistical Methods for Health Research by : Yichuan Zhao
Download or read book Modern Statistical Methods for Health Research written by Yichuan Zhao and published by Springer Nature. This book was released on 2021-10-14 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the voices of leading experts in the frontiers of biostatistics, biomedicine, and the health sciences to discuss the statistical procedures, useful methods, and novel applications in biostatistics research. It also includes discussions of potential future directions of biomedicine and new statistical developments for health research, with the intent of stimulating research and fostering the interactions of scholars across health research related disciplines. Topics covered include: Health data analysis and applications to EHR data Clinical trials, FDR, and applications in health science Big network analytics and its applications in GWAS Survival analysis and functional data analysis Graphical modelling in genomic studies The book will be valuable to data scientists and statisticians who are working in biomedicine and health, other practitioners in the health sciences, and graduate students and researchers in biostatistics and health.
Book Synopsis Bayesian Designs for Phase I-II Clinical Trials by : Ying Yuan
Download or read book Bayesian Designs for Phase I-II Clinical Trials written by Ying Yuan and published by CRC Press. This book was released on 2017-12-19 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
Book Synopsis Essentials of a Successful Biostatistical Collaboration by : Arul Earnest
Download or read book Essentials of a Successful Biostatistical Collaboration written by Arul Earnest and published by CRC Press. This book was released on 2016-10-14 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to equip biostatisticians and other quantitative scientists with the necessary skills, knowledge, and habits to collaborate effectively with clinicians in the healthcare field. The book provides valuable insight on where to look for information and material on sample size and statistical techniques commonly used in clinical research, and on how best to communicate with clinicians. It also covers the best practices to adopt in terms of project, time, and data management; relationship with collaborators; etc.
Book Synopsis Applying Quantitative Bias Analysis to Epidemiologic Data by : Matthew P. Fox
Download or read book Applying Quantitative Bias Analysis to Epidemiologic Data written by Matthew P. Fox and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook and guide focuses on methodologies for bias analysis in epidemiology and public health, not only providing updates to the first edition but also further developing methods and adding new advanced methods. As computational power available to analysts has improved and epidemiologic problems have become more advanced, missing data, Bayes, and empirical methods have become more commonly used. This new edition features updated examples throughout and adds coverage addressing: Measurement error pertaining to continuous and polytomous variables Methods surrounding person-time (rate) data Bias analysis using missing data, empirical (likelihood), and Bayes methods A unique feature of this revision is its section on best practices for implementing, presenting, and interpreting bias analyses. Pedagogically, the text guides students and professionals through the planning stages of bias analysis, including the design of validation studies and the collection of validity data from other sources. Three chapters present methods for corrections to address selection bias, uncontrolled confounding, and measurement errors, and subsequent sections extend these methods to probabilistic bias analysis, missing data methods, likelihood-based approaches, Bayesian methods, and best practices.
Book Synopsis Analyzing Longitudinal Clinical Trial Data by : Craig Mallinckrodt
Download or read book Analyzing Longitudinal Clinical Trial Data written by Craig Mallinckrodt and published by CRC Press. This book was released on 2016-12-12 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzing Longitudinal Clinical Trial Data: A Practical Guide provides practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine practice.The book, with its example-oriented approach that includes numerous SAS and R code fragments, is an essential resource for statisticians and graduate students specializing in medical research. The authors provide clear descriptions of the relevant statistical theory and illustrate practical considerations for modeling longitudinal data. Topics covered include choice of endpoint and statistical test; modeling means and the correlations between repeated measurements; accounting for covariates; modeling categorical data; model verification; methods for incomplete (missing) data that includes the latest developments in sensitivity analyses, along with approaches for and issues in choosing estimands; and means for preventing missing data. Each chapter stands alone in its coverage of a topic. The concluding chapters provide detailed advice on how to integrate these independent topics into an over-arching study development process and statistical analysis plan.