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Author : Andrew Jauregui
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (891 download)
Download or read book Elucidating the Role of the C. Elegans Nephrocystins in Cilia written by Andrew Jauregui and published by . This book was released on 2007 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 994 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)
Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author : David B. Mount
Publisher : Elsevier Health Sciences
ISBN 13 : 1416002529
Total Pages : 604 pages
Book Rating : 4.4/5 (16 download)
Download or read book Molecular and Genetic Basis of Renal Disease written by David B. Mount and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
Author :
Publisher : Academic Press
ISBN 13 : 0080962823
Total Pages : 423 pages
Book Rating : 4.0/5 (89 download)
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Author : Bradley Yoder
Publisher : Academic Press
ISBN 13 : 0080922473
Total Pages : 517 pages
Book Rating : 4.0/5 (89 download)
Download or read book Ciliary Function in Mammalian Development written by Bradley Yoder and published by Academic Press. This book was released on 2011-09-06 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia--the tiny hairlike structures on the surface of cells—-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.
Author : Edward Bittar
Publisher : Academic Press
ISBN 13 : 1559383100
Total Pages : 542 pages
Book Rating : 4.5/5 (593 download)
Download or read book Metabolic Pumps and Intracellular Homeostasis, Hormones and Cell Function, Intercellular Communication, Cell Motility and Contractility, Part B written by Edward Bittar and published by Academic Press. This book was released on 1992-01-08 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes 5A and 5B of Fundamentals of Medical Cell Biology are a treatment of several key subjects, including cellular signaling. One profitable way to tackle both volumes is to read them with care but without endeavouring to master most of the details. Then should follow a more plodding study, chapter by chapter. Such a strategy is also urged in respect of the preceding volumes. Although each chapter is only as detailed as space permits, it should in the case of the student serve as an incentive to the study of the original papers.
Author : Peter Satir
Publisher : Humana
ISBN 13 : 9781493937875
Total Pages : 0 pages
Book Rating : 4.9/5 (378 download)
Download or read book Cilia written by Peter Satir and published by Humana. This book was released on 2016-08-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the result of an explosion of molecular-based research on Cilia, which began with the discovery of the universality of intraflagellar transport (IFT) and ciliary genomics/proteomics. The chapters in this book cover topics such as: high resolution imaging and functional characterization of sensory and primary cilia in mammalian cells and zebrafish, methods to study ciliary-mediated chemoresponse in Paramecium, and methods to study centrosomes and cilia in C. elegans and Drosophila. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Cilia: Methods and Protocols is broad and covers motile, sensory, and primary cells. It is a valuable resource to anyone interested in entering the field of ciliary biology using model organisms, including flagellate algae, ciliates, planaria, nematodes, insects, zebrafish, and mammalian cells.
Author : Benjamin D. Cowley, Jr.
Publisher : Springer
ISBN 13 : 1493977849
Total Pages : 274 pages
Book Rating : 4.4/5 (939 download)
Download or read book Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and published by Springer. This book was released on 2018-05-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
Author : Great Britain. Home Office
Publisher :
ISBN 13 : 9780105567066
Total Pages : 103 pages
Book Rating : 4.5/5 (67 download)
Download or read book Animals (Scientific Procedures) Act 1986 written by Great Britain. Home Office and published by . This book was released on 2000 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guidance on the Operation of the Animals (Scientific Procedures) ACT 1986
Author : Melissa Helen Little
Publisher : Academic Press
ISBN 13 : 012800438X
Total Pages : 615 pages
Book Rating : 4.1/5 (28 download)
Download or read book Kidney Development, Disease, Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
Author : Rachel K. Miller
Publisher : Springer
ISBN 13 : 3319514369
Total Pages : 373 pages
Book Rating : 4.3/5 (195 download)
Download or read book Kidney Development and Disease written by Rachel K. Miller and published by Springer. This book was released on 2017-04-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.
Author : Reed Wickner
Publisher : Springer Science & Business Media
ISBN 13 : 1468452517
Total Pages : 550 pages
Book Rating : 4.4/5 (684 download)
Download or read book Extrachromosomal Elements in Lower Eukaryotes written by Reed Wickner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frances Flinter
Publisher :
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Genetics of Renal Disease written by Frances Flinter and published by . This book was released on 2003 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Renal genetic disorders may become apparent at any time in life and recognition of specific renal disorders is important in allowing accurate genetic counselling. Active counselling requires knowledge about the natural history of the disorder, an understanding of the genetic component and mode of inheritance, risk of the disorder in other family members, information about patient attitudes towards family planning and the possibility of pre-natal diagnosis. The Genetics of Renal Disease covers these issues in detail. The book provides a comprehensive account of both the hereditary nephropathies and more generalised disorders which may affect the renal tract. It includes comprehensive guidelines from an international group of authors on renal function and development, choromosomal disorders, dysmorphic syndromes, inherited predisposition to kidney cancer and gene therapy for renal cancer. Specific chapters deal with individual renal tract disorders such as an extensive discussion of Alport's disease, cystic renal diseases, the Bardet-Biedl and Alstrom syndromes. Each section gives a brief description of the clinical and pathological features of a particular disorder, followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract. These are incorporated within the book. Aimed primarily at clinical and medical geneticists, this book will also appeal to researchers into genetic kidney disease and genetic counsellors as well as nephrologists with an interest in this area.
Author : Jacob Peedicayil
Publisher : Academic Press
ISBN 13 : 0128235780
Total Pages : 848 pages
Book Rating : 4.1/5 (282 download)
Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. - Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease - Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins - Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery - Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) - Features chapter contributions from international leaders in the field
Author : Enza Maria Valente
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128084596
Total Pages : 29 pages
Book Rating : 4.1/5 (28 download)
Download or read book Pediatric Neurology Part III written by Enza Maria Valente and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joubert syndrome (JS) is a rare autosomal recessive condition characterized by a peculiar midbrain-hindbrain malformation, known as the molar tooth sign (MTS). The neurological presentation of JS includes hypotonia that evolves into ataxia, developmental delay, abnormal eye movements, and neonatal breathing abnormalities. This picture is often associated with variable multiorgan involvement, mainly of the retina, kidneys, and liver, defining a group of conditions termed Joubert syndrome and related disorders (JSRDs), that share the MTS. To date, 16 causative genes have been identified, all encoding for proteins expressed in the primary cilium or its apparatus. Indeed, JSRD present clinical and genetic overlap with a growing field of disorders due to mutations in ciliary proteins, that are collectively known as “ciliopathies.” These include isolated nephronophthisis, Senior–Løken syndrome, Bardet–Biedl syndrome and, in particular, Meckel syndrome, which is allelic at JSRD at seven distinct loci. Significant genotype-phenotype correlates are emerging between specific clinical presentations and mutations in JSRD genes, with relevant implications in terms of molecular diagnosis, clinical follow-up, and management of mutated patients. Moreover, the identification of mutations allows early prenatal diagnosis in couples at risk, while fetal neuroimaging may remain uninformative until the late second trimester of pregnancy.
Author :
Publisher : Academic Press
ISBN 13 : 0123973481
Total Pages : 993 pages
Book Rating : 4.1/5 (239 download)
Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
