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Effects Of Subchronic Dietary Lead Exposure On Dmtp And Dnmtp Performance In Fisher 344 Rats
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Book Synopsis Effects of Subchronic Dietary Lead Exposure on DMTP and DNMTP Performance in Fisher 344 Rats by : Joshua D. Vardigan
Download or read book Effects of Subchronic Dietary Lead Exposure on DMTP and DNMTP Performance in Fisher 344 Rats written by Joshua D. Vardigan and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent attention has focused on the possibility that even low-level Pb exposure can produce subtle neurological impairments in the absence of overt signs of toxicity. Previous behavioral assessments of learning and memory using DMTS procedures have documented learning impairments in monkeys exposed to Pb during early postnatal development, and although a variety of operant behavioral assays have documented detrimental effects of dietary Pb treatment in rats, the DMTS procedure has not been examined in rats following short-term low levels of Pb through dietary exposure. Thus, the objective of this study was to measure the degree of cognitive impairment produced by chronic dietary Pb exposure in rats and to determine the degree to which the separate aspects of this test are sensitive to that impairment. Animals exposed to Pb acetate for a 90 day period were trained on a DMTP task. Following acquisition, animals were introduced to a non-matching reversal of the DMTP design (DNMTP). Delay-dependent significant differences in response accuracy and number of sessions until criterion was met were found between treatment groups on the reversal task only. These results indicate that a sub-chronic duration of dietary Pb exposure does produce significant cognitive impairment in rats which are measurable not through the initial acquisition of the DMTP task, but in the subsequent acquisition of the reversal of that task.
Book Synopsis Animal and Translational Models for CNS Drug Discovery by : Robert A. McArthur
Download or read book Animal and Translational Models for CNS Drug Discovery written by Robert A. McArthur and published by Academic Press. This book was released on 2008-11-27 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for understanding fundamental neurobiology of CNS disorders and the application of this knowledge to CNS drug discovery, and clinical investigators involved in clinical trials, drug development and eventual registration of novel pharmaceuticals. Each volume of the Animal and Translational Models for CNS Drug Discovery series is dedicated to the development and use of animal models in key therapeutic areas in psychiatric, neurologic and reward deficit disorders. Each volume has introductory chapters expressing the view of the role and relevance of animal models for CNS drug discovery and development from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in relevant therapeutic areas and discusses the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. - Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process - Critical evaluation of animal and translational models improving transition from drug discovery and clinical development - Emphasizes what results mean to the overall drug discovery process - Explores issues in clinical trial design and conductance in each therapeutic area - Each volume is available for purchase individually.
Book Synopsis The Neurobiology of Schizophrenia by : Ted Abel
Download or read book The Neurobiology of Schizophrenia written by Ted Abel and published by Academic Press. This book was released on 2016-07-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. Provides a comprehensive overview of neurobiological aspects of schizophrenia Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance Elucidates connections between the various systems depicted, when possible
Book Synopsis The Psychopharmacology of Schizophrenia by : Michael A. Reveley
Download or read book The Psychopharmacology of Schizophrenia written by Michael A. Reveley and published by CRC Press. This book was released on 2000-01-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique and timely book examines the basic and clinical sciences relevant to schizophrenia and relates them to current treatment strategies. Through describing current thinking on the aetiology and pathophysiology of schizophrenia as relevant to the psychopharmacology of the disorder, the reader gains a fuller understanding of the rationale for psychopharmacological approaches to treatment. Neuroimaging and neuropsychology are covered in detail as well as further chapters on clinical strategies for treatment of schizophrenia with both conventional and atypical antipsychotic treatments. Practical advice on the management of schizophrenia in the community is also given. Bringing together new developments and advances in the field, while discussing important issues relevant to the long-term treatment necessary for this disorder, the result is an essential book for psychiatrists and psychopharmacologists at all levels.
