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Effects Of Mycotoxins On The Intestine
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Book Synopsis Effects of Mycotoxins on the Intestine by : Isabelle P. Oswald
Download or read book Effects of Mycotoxins on the Intestine written by Isabelle P. Oswald and published by MDPI. This book was released on 2019-04-30 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.
Book Synopsis Effects of Mycotoxins on the Intestine by : Imourana Alassane-Kpembi
Download or read book Effects of Mycotoxins on the Intestine written by Imourana Alassane-Kpembi and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota-now regarded as a fully-fledged organ associated with the gut-is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.
Book Synopsis Mycotoxin Contamination in Gastrointestinal Tract by : Javier Barkley
Download or read book Mycotoxin Contamination in Gastrointestinal Tract written by Javier Barkley and published by Foster Academics. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are toxic compounds that are produced naturally by certain types of molds such as fungi. These molds can grow on numerous foodstuffs such as cereals, nuts, spices, dried fruits, apples and coffee beans, often under warm and humid conditions. These toxins can cause adverse health effects that can range from acute poisoning to long-term effects such as immune deficiency and cancer. There are various types of mycotoxins such as Aflatoxins, Ochratoxin A, Patulin, and Fusarium fungi. Some negative effects of mycotoxins on intestinal health are decreased intestinal cell viability, reductions in short chain fatty acid (SCFA) concentrations, and elimination of beneficial bacteria. It also leads to an increased expression of genes involved in promoting inflammation and counteracting oxidative stress. The health risks of mycotoxins can be reduced by taking effective measures such as proper storage, inspection of whole grains, avoidance of foods kept for extended periods of time before being used, and consuming a balanced diet. This book traces the effects of mycotoxins on the gastrointestinal tract. Those with an interest in these toxic compounds would find it helpful.
Book Synopsis Masked Mycotoxins in Food by : Chiara Dall'Asta
Download or read book Masked Mycotoxins in Food written by Chiara Dall'Asta and published by Royal Society of Chemistry. This book was released on 2015-11-05 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover this fast developing field, Masked Mycotoxins in Food will provide a full overview of the issues relating to the toxicology of masked mycotoxins present in food products. Mycotoxins are naturally occurring chemicals produced by moulds that can grow on crops and foodstuffs. Masked mycotoxins are modified mycotoxins, due to this modification many cannot be detected using standard analytical techniques, for example HPLC and ELISA, and further research is needed to understand the health risks and threats from these modified compounds.Masked mycotoxin research is an area of toxicological research that has gained significant interest and momentum in recent years. The aim of this book is to provide a full picture of the topic, from the masked mycotoxin formation in plants to their catabolic fate in humans. The book also provides new insights and will highlight possible gaps in the knowledge base of this relatively new area. Edited and written by World renowned experts working within the field, this book is of interest to toxicologists and biochemists, but also food scientists and agricultural researchers working in industry and academia.
Book Synopsis Mycotoxin Control in Low- and Middle-Income Countries by : Christopher P. Wild
Download or read book Mycotoxin Control in Low- and Middle-Income Countries written by Christopher P. Wild and published by IARC Working Group Report. This book was released on 2016-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an evaluation of measures to reduce exposure to highly toxic and carcinogenic contaminants in staple diets in Africa as well as parts of Asia and Latin America. Many of the poorest people in these regions are exposed to the pervasive natural toxins, aflatoxins and fumonisins, on a daily basis by eating their staple diet of groundnuts, maize, and other cereals. Exposure to mycotoxins at these high levels substantially increases mortality and morbidity. Aflatoxins are a cause of human liver cancer, and fatalities from acute aflatoxin poisoning outbreaks occur in Africa and Asia. The International Agency for Research on Cancer convened a Working Group of world-leading experts to review the health effects of aflatoxins and fumonisins and to evaluate intervention measures. The panel concluded that these mycotoxins not only are a cause of acute poisoning and cancer but also are a likely contributor to the high levels of stunting in children in affected populations. The Working Group also identified effective measures to reduce exposure in developing countries. The panel evaluated 15 interventions, considering the strength of the evidence as well as its completeness and its transferability at an individual, community, or national level. Four of the interventions were judged to be ready for implementation: improvement of dietary diversity; crop sorting; post-harvest measures, including improved storage; and, in Latin America for maize, optimized nixtamalization. These recommendations would be relevant for investment of public, nongovernmental organization, and private funds at the scale of the subsistence farmer, the smallholder, and through to a more advanced value chain.
Download or read book Fungal Toxins written by Solomon Kadis and published by Elsevier. This book was released on 2013-10-22 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Toxins: A Comprehensive Treatise, Volume VIII, Fungal Toxins is devoted to topics related to algal and fungal toxins and includes critically reviewed articles from different experts in related fields. The text is divided into three sections. Section A covers coumarins — its isolation, identification, biological action, natural occurrence, and uses. Section B deals with the epizootiology, clinical characteristics, and pathological findings of Stachybotryotoxicosis. Section C talks about phytopathogenic and helminthosporium toxins, toxic peptides found in Amanita species as well as other mushroom toxins, compounds accumulating in plants after an infection, and ergot. The book is recommended for microbiologists and toxicologists, especially those who would like to know more about the toxins produced by algae and fungi and their effects.
Book Synopsis Damp Indoor Spaces and Health by : Institute of Medicine
Download or read book Damp Indoor Spaces and Health written by Institute of Medicine and published by National Academies Press. This book was released on 2004-10-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost all homes, apartments, and commercial buildings will experience leaks, flooding, or other forms of excessive indoor dampness at some point. Not only is excessive dampness a health problem by itself, it also contributes to several other potentially problematic types of situations. Molds and other microbial agents favor damp indoor environments, and excess moisture may initiate the release of chemical emissions from damaged building materials and furnishings. This new book from the Institute of Medicine examines the health impact of exposures resulting from damp indoor environments and offers recommendations for public health interventions. Damp Indoor Spaces and Health covers a broad range of topics. The book not only examines the relationship between damp or moldy indoor environments and adverse health outcomes but also discusses how and where buildings get wet, how dampness influences microbial growth and chemical emissions, ways to prevent and remediate dampness, and elements of a public health response to the issues. A comprehensive literature review finds sufficient evidence of an association between damp indoor environments and some upper respiratory tract symptoms, coughing, wheezing, and asthma symptoms in sensitized persons. This important book will be of interest to a wide-ranging audience of science, health, engineering, and building professionals, government officials, and members of the public.
Book Synopsis The Effects of Fusarium Mycotoxins on the Intestinal Epithelial Cell-mediated Defense Response by : Lam-yim Wan
Download or read book The Effects of Fusarium Mycotoxins on the Intestinal Epithelial Cell-mediated Defense Response written by Lam-yim Wan and published by . This book was released on 2011 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Intestinal Toxicity of Mycotoxins by : Imourana Alassane-Kpembi
Download or read book The Intestinal Toxicity of Mycotoxins written by Imourana Alassane-Kpembi and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As for other food-born contaminants, the gastro-intestinal tract represents the first barrier against deoxynivalenol (DON). This mycotoxin frequently co-occurs with other type B trichothecenes (TCTs B) namely 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX). At the cellular level, DON binding to ribosomal RNA results in the inhibition of protein synthesis and triggers the mitogen-activated protein kinases (MAPKs) pathway that have been linked to immune response mechanisms. Thus, intestinal epithelial cell renewing is considered a putative target in DON toxicity. Moreover, based on the ability of DON to disturb the state of homeostasis of the inflammatory response in the intestine mimicking what is found in inflammatory bowel diseases (IBD), it is proposed that this mycotoxin may play a role in such diseases. However, very few is known about the intestinal toxicity of the other co-occuring TCT B, and their combined effects eventually. By means of in vitro human and porcine intestinal epithelial cells models and an ex vivo porcine jejunal explants model, we assessed the individual toxicity of five TCT B (DON, 3- and 15-ADON, NIV and FX) toward the intestine and we analyzed their combined toxicity in terms of additivity, synergy or antagonism. The tested TCT B significantly impaired the intestinal epithelial cell growth in the micromolar range, in increasing order of potency 3-ADON, DON, 15-ADON, NIV and FX. The toxicity of low doses of TCT B was synergistic. For mycotoxin concentrations corresponding to exposure levels reported for French and European consumers, the amplitude of this synergy ranged between 3 and 10. Benchmark dose analyses of the transcriptional data also showed that the exposure of the intestine to mycotoxin concentrations as low as 0.04μM for FX, 0.1μM for DON and 0.1μM for NIV could be associated to a significant activation of the inflammatory response mechanisms. Taken together, these results suggest that epithelial cell renewing and pro-inflammatory effects at the intestinal level may be consider very sensitive biomarkers for the assessment of the individual toxicity and interactions between the co-occurring TCTs B.
Book Synopsis Industrial Enzyme Applications by : Andreas Vogel
Download or read book Industrial Enzyme Applications written by Andreas Vogel and published by John Wiley & Sons. This book was released on 2019-10-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a "must-read": It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.
Book Synopsis Mycotoxins by : Patrick Berka Njobeh
Download or read book Mycotoxins written by Patrick Berka Njobeh and published by BoD – Books on Demand. This book was released on 2019-08-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Edited Volume Mycotoxins - Impact and Management Strategies is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of Mycotoxicology. The book comprises of single chapters authored by various researchers and edited by an expert active in this research area. This book is divided into three sections. Section 1 consists of one chapter that gives an overview of the socioeconomic impact of mycotoxins. Section 2 has five chapters that address the prevention and control of aflatoxins both at pre- and post-harvest stages. Section 3 has two chapters that deal with health impact and control in the poultry industry. This publication aims at providing a thorough overview of the latest research efforts in the field and opens new possible research paths for further novel developments in addressing the problem of mycotoxins.
Book Synopsis Neuro-Immuno-Gastroenterology by : Cris S. Constantinescu
Download or read book Neuro-Immuno-Gastroenterology written by Cris S. Constantinescu and published by Springer. This book was released on 2016-05-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
Book Synopsis Aflatoxin B1 Occurrence, Detection and Toxicological Effects by :
Download or read book Aflatoxin B1 Occurrence, Detection and Toxicological Effects written by and published by BoD – Books on Demand. This book was released on 2020-06-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of 11 chapters, divided into four parts. The chapters are written by experts in the field of aflatoxins. Select topics are presented here to provide a snapshot of current understanding of the occurrence and metabolism of aflatoxin B1, the contamination, exposure, and detection of aflatoxin B1, and the toxicological effects and detoxification of aflatoxin. The book is intended for students and scientists working in the field of aflatoxins.
Book Synopsis The Mycotoxin Blue Book by : Duarte Diaz
Download or read book The Mycotoxin Blue Book written by Duarte Diaz and published by Context Products. This book was released on 2005-01-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moulds and the mycotoxins they produce, have a wide-ranging economic impact on animal agriculture on every continent of the globe. Mould growth robs feed nutritive value and reduces intake, which lowers efficiency. Mycotoxins, even when present at levels previously considered 'trace', have negative effects on performance and health, particularly in the context of today's more highly productive modern livestock genetics. Food-borne toxins also threaten human health through contaminated cereal and protein sources and transfer of toxins in food animal products. The Mycotoxin Blue Book focuses on the physiological effects and field occurrence of mycotoxins. Detailed information on types of moulds and mycotoxins and the conditions under which moulds flourish is included. Implications of mycotoxin contamination of feedstuffs for all major food animal species are presented in addition to aquaculture and companion animals. Sampling and analytical issues are covered in depth; as is the topic of mycotoxins in human foods. Finally, practical means of ameliorating mycotoxin effects are addressed. It is the hope of the editor and authors that the material herein will lead to clearer recognition of mycotoxin problems and ultimately to ways of reducing their impact on food animal production. An excellent guide for nutritionists, advisors, farmers and students involved with and using animal feed. Contents: Sampling feeds for mycotoxin analysis Mycotoxins: their effects in poultry and some practical solutions Effects of mycotoxins in horses Effects of mycotoxins on domestic pet species Effects of mycotoxins on antioxidant status and immunity Mycotoxins in aquaculture Principles and applications of mycotoxin analysis Mycotoxins in the human food chain Mould growth and mycotoxin production Current concepts in mycotoxicoses in swine Mycotoxins in forages Mycotoxin interactions Mycotoxins: metabolism, mechanisms and biochemical markers Effects of mycotoxins in ruminants Mycotoxin sequestering agents: practical tools for the neutralisation of mycotoxins Index
Book Synopsis Control of Mycotoxins by : Palle Krogh
Download or read book Control of Mycotoxins written by Palle Krogh and published by Butterworth-Heinemann. This book was released on 1973-01-01 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diseases of Poultry written by and published by John Wiley & Sons. This book was released on 2019-11-19 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most complete and definitive reference to all aspects of poultry diseases, Diseases of Poultry, Fourteenth Edition has been fully revised and updated to offer a comprehensive survey of current knowledge. Updates the definitive reference of poultry health and disease Provides more clinically relevant information on management of specific diseases, contributed by clinical poultry veterinarians Offers information on disease control in organic and antibiotic-free production Presents more concise, streamlined chapters for ease of use Incorporates advances in the field, from new diagnostic tools and information to changes brought about by the increasing globalization and the re-emergence of zoonotic pathogens
Book Synopsis Aflatoxins by : Mehdi Razzaghi-Abyaneh
Download or read book Aflatoxins written by Mehdi Razzaghi-Abyaneh and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is broadly divided into five sections and 17 chapters, highlighting recent advances in aflatoxin research from epidemiology to molecular genomics and control measures, biocontrol approaches, modern analytical techniques, economic concerns and underlying mechanisms of contamination processes. This book will update readers on several cutting-edge aspects of aflatoxins research with useful up-to-date information for mycologists, toxicologists, microbiologists, agriculture scientists, plant pathologists and pharmacologists, who may be interest to understanding of the impact, significance and recent advances within the field of of aflatoxins with a focus on control strategy.
