Dynamics Of Cyclic Nucleotide Signaling In Neurons

Download Dynamics Of Cyclic Nucleotide Signaling In Neurons full books in PDF, epub, and Kindle. Read online Dynamics Of Cyclic Nucleotide Signaling In Neurons ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Dynamics of cyclic nucleotide signaling in neurons

Author : Pierre Vincent
Publisher : Frontiers Media SA
ISBN 13 : 2889196461
Total Pages : 94 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!

Book Synopsis Dynamics of cyclic nucleotide signaling in neurons by : Pierre Vincent

Download or read book Dynamics of cyclic nucleotide signaling in neurons written by Pierre Vincent and published by Frontiers Media SA. This book was released on 2015-09-16 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons.

Cyclic Nucleotide Signaling

Author : Xiaodong Cheng
Publisher : CRC Press
ISBN 13 : 1482235579
Total Pages : 282 pages
Book Rating : 4.4/5 (822 download)

DOWNLOAD NOW!

Book Synopsis Cyclic Nucleotide Signaling by : Xiaodong Cheng

Download or read book Cyclic Nucleotide Signaling written by Xiaodong Cheng and published by CRC Press. This book was released on 2015-05-07 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly inform

Non-canonical Cyclic Nucleotides

Author : Roland Seifert
Publisher : Springer
ISBN 13 : 3319526731
Total Pages : 387 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Non-canonical Cyclic Nucleotides by : Roland Seifert

Download or read book Non-canonical Cyclic Nucleotides written by Roland Seifert and published by Springer. This book was released on 2017-04-28 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Dynamic Biological Networks

Author : Ronald M. Harris-Warrick
Publisher : MIT Press
ISBN 13 : 9780262082143
Total Pages : 366 pages
Book Rating : 4.0/5 (821 download)

DOWNLOAD NOW!

Book Synopsis Dynamic Biological Networks by : Ronald M. Harris-Warrick

Download or read book Dynamic Biological Networks written by Ronald M. Harris-Warrick and published by MIT Press. This book was released on 1992 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to the crustacean stomatogastric nervous system (STNS) describes some of the best-understood neural networks in the animal kingdom at cellular, network, behavioural, comparative and evolutionary levels of analysis.

Dendrites

Author : Greg Stuart
Publisher : Oxford University Press
ISBN 13 : 0191062472
Total Pages : 616 pages
Book Rating : 4.1/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Dendrites by : Greg Stuart

Download or read book Dendrites written by Greg Stuart and published by Oxford University Press. This book was released on 2017-04-13 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with the addition of a number of new chapters and comprehensive updates or rewrites of existing chapters by leading experts. "Dendrites" will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.

Cyclic Nucleotide Signaling and the Cardiovascular System

Author : Thomas Brand
Publisher : MDPI
ISBN 13 : 3038429899
Total Pages : 307 pages
Book Rating : 4.0/5 (384 download)

DOWNLOAD NOW!

Book Synopsis Cyclic Nucleotide Signaling and the Cardiovascular System by : Thomas Brand

Download or read book Cyclic Nucleotide Signaling and the Cardiovascular System written by Thomas Brand and published by MDPI. This book was released on 2018-07-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD

Optogenetics

Author : Hiromu Yawo
Publisher : Springer Nature
ISBN 13 : 9811587639
Total Pages : 648 pages
Book Rating : 4.8/5 (115 download)

DOWNLOAD NOW!

Book Synopsis Optogenetics by : Hiromu Yawo

Download or read book Optogenetics written by Hiromu Yawo and published by Springer Nature. This book was released on 2021-01-05 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

cGMP: Generators, Effectors and Therapeutic Implications

Author : Harald H. H. W. Schmidt
Publisher : Springer Science & Business Media
ISBN 13 : 3540689648
Total Pages : 581 pages
Book Rating : 4.5/5 (46 download)

DOWNLOAD NOW!

Book Synopsis cGMP: Generators, Effectors and Therapeutic Implications by : Harald H. H. W. Schmidt

Download or read book cGMP: Generators, Effectors and Therapeutic Implications written by Harald H. H. W. Schmidt and published by Springer Science & Business Media. This book was released on 2008-12-17 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Advances In Cognitive Science

Author : Manfred Kochen
Publisher : CRC Press
ISBN 13 : 0429713061
Total Pages : 264 pages
Book Rating : 4.4/5 (297 download)

DOWNLOAD NOW!

Book Synopsis Advances In Cognitive Science by : Manfred Kochen

Download or read book Advances In Cognitive Science written by Manfred Kochen and published by CRC Press. This book was released on 2019-04-23 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a collection of papers on both natural (biological) and artificial (computer) approaches to several facets of intelligent behavior from the primary viewpoint of the convergence of computer science and biology in the theory of cognitive science. .

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
ISBN 13 : 9535134515
Total Pages : 320 pages
Book Rating : 4.5/5 (351 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu

Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Chemosensory Transduction

Author : Frank Zufall
Publisher : Academic Press
ISBN 13 : 0128017864
Total Pages : 430 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Chemosensory Transduction by : Frank Zufall

Download or read book Chemosensory Transduction written by Frank Zufall and published by Academic Press. This book was released on 2016-02-18 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included

Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections

Author : K.C. Flynn
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012806255X
Total Pages : 1080 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections by : K.C. Flynn

Download or read book Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections written by K.C. Flynn and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Signal Transduction and the Gasotransmitters

Author : Rui Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1592598064
Total Pages : 372 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Signal Transduction and the Gasotransmitters by : Rui Wang

Download or read book Signal Transduction and the Gasotransmitters written by Rui Wang and published by Springer Science & Business Media. This book was released on 2004-06-11 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

Author : George S. Baillie
Publisher : Frontiers Media SA
ISBN 13 : 2889198154
Total Pages : 193 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!

Book Synopsis Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels by : George S. Baillie

Download or read book Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels written by George S. Baillie and published by Frontiers Media SA. This book was released on 2016-04-08 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Membrane Dynamics and Calcium Signaling

Author : Joachim Krebs
Publisher : Springer
ISBN 13 : 3319558587
Total Pages : 412 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Membrane Dynamics and Calcium Signaling by : Joachim Krebs

Download or read book Membrane Dynamics and Calcium Signaling written by Joachim Krebs and published by Springer. This book was released on 2018-03-28 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field. Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.

Dynamic Studies in Biology

Author : Maurice Goeldner
Publisher : John Wiley & Sons
ISBN 13 : 3527605541
Total Pages : 584 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Dynamic Studies in Biology by : Maurice Goeldner

Download or read book Dynamic Studies in Biology written by Maurice Goeldner and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by more than 30 expert researchers, this handbook covers the whole spectrum from chemistry to cell biology and from theory to application. In so doing, it deals with a broad range of topics from the chemistry and biophysics of caged compounds to their application in time-resolved studies, comparing the properties of different caging groups. The authors describe in detail light-activation of proteins as well as nucleic acids, while a special section is devoted to multiphoton phototriggers. A must-have for every biochemist, biophysicist and molecular biologist developing and working with these novel methods.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey L. Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

DOWNLOAD NOW!

Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey L. Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey L. Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.