Drugs of Abuse, Immunity, and Infections

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Author :
Publisher : CRC Press
ISBN 13 : 9781439805596
Total Pages : 216 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Drugs of Abuse, Immunity, and Infections by : Herman Friedman

Download or read book Drugs of Abuse, Immunity, and Infections written by Herman Friedman and published by CRC Press. This book was released on 1995-12-18 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades, drugs of abuse, including marijuana, cocaine, opiates, and alcohol have been studied in detail by biomedical scientists in terms of their effects on the neurophysiology and psychological responses of individuals. Research over the last few years has provided increased knowledge about possible mechanisms by which such drugs increase the likelihood of infections in humans and experimental animals. In Drugs of Abuse, Immunity, and Infections prominent investigators review important new information concerning the effects of recreational drugs on susceptibility to infection by microorganisms. The volume examines the effects of drugs such as cocaine, morphine, marijuana, and opiates on immunity in humans and animals. It covers the molecular and cellular mechanisms of drug-induced immunosuppression and describes the overall enhanced susceptibility to infection in recreational drug users. It discusses the alteration of susceptibility to the retrovirus that causes the acquired immunodeficiency syndrome (AIDS) and the consensus that drugs of abuse may serve as a possible cofactor in the progression of AIDS. Drugs of Abuse, Immunity, and Infections also includes important information concerning public health aspects of drugs of abuse and infection.

Drugs of Abuse, Immunity, and AIDS

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461529808
Total Pages : 284 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Drugs of Abuse, Immunity, and AIDS by : Pawel Migula

Download or read book Drugs of Abuse, Immunity, and AIDS written by Pawel Migula and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine with financial assistance from the National Institute on Drug Abuse. The focus of this conference was the effects of drugs of abuse on immunity. It is now widely recognized that psychoactive drugs of abuse, including marijuana, cocaine, and opiates, as well as alcohol, have marked effects in an individual, including effects on their nervous system and behavior. In the past two decades, the scope of studies concerning the effects of some drugs of abuse have also involved investigations of alterations of various physiologic parameters including effects on the immune system. and the influence of such immune alterations on normal physiological responses. In this regard, participants in this Second International Conference provided newer information concerning both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiencies. In this regard, advances have been made in recent years concerning the nature and mechanisms whereby the immune system is regulated and the possible mechanisms by which drugs of abuse influence such immune systems. In particular, the emergence of psychoneuroimmunology as a new discipline the last decade has heightened interest in the immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving both clinical and basic scientists, including microbiologists, immunologists, physiologists, psychiatrists, oncologists, psychologists, etc.

Drugs of Abuse, Immunity, and Immunodeficiency

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468459252
Total Pages : 317 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Drugs of Abuse, Immunity, and Immunodeficiency by : Herman Friedman

Download or read book Drugs of Abuse, Immunity, and Immunodeficiency written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the program of the International Conference on Drugs of Abuse, Immunity and Immunodeficiency held in Clearwater Beach, Florida. It was sponsored by the University of South Florida College of Medicine with the support of the National Institute on Drug Abuse. During the past few decades, drugs of abuse, including marijuana, cocaine, opiates and alcohol, have been studied by biomedical scientists in terms of the systemic effects of the drugs as well as alterations in neurophysiology and the psychology. More recently, the scope of such investigations has been broadened to include alterations within the immune system, and the influence of altered immunity on physiological and psychological consequences of drug abuse. In this regard, participants in the Clearwater Beach conference provided new information concern ing both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiency. Advances have been made in recent years in understanding the nature and mechanisms regulating the immune response and the mechanisms by which drugs may influence immune responses. In particular, the emergence of psychoneuroimmunology as a new discipline has heightened interest in immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving clinical and basic scientists including microbiologists, immu nologists, physiologists, psychiatrists, oncologists and others. The recreational use of the above mentioned drugs by large numbers of individuals has aroused serious concern about the consequences of this activity.

Drugs of Abuse, Immunomodulation, and Aids

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461553474
Total Pages : 315 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Drugs of Abuse, Immunomodulation, and Aids by : Herman Friedman

Download or read book Drugs of Abuse, Immunomodulation, and Aids written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and Perspectives This volume represents the Proceedings of the Fifth Annual Symposium on Drugs of Abuse, Immunomodulation, and AIDS. The meeting was held in Nashville, Tennessee, June 12-14, 1997. In this symposium, as in the past, newer knowledge was reviewed concerning the relationship between the immune and the nervous systems with regard to the effects of drugs of abuse. This symposium focused on the relationship between the immune system and the nervous system with regard to the effects of drugs of abuse and infections such as the immunodeficiency virus that causes AIDS. As in the past symposia, presentations fo cused on the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The aim of this series of conferences has been to clarify the consequences ofimmunomodulation induced by drugs of abuse on susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems. Recreational use of drugs of abuse, such as morphine, cocaine, and marijuana, as well as alcohol, by large numbers of individuals in this country and around the world has aroused serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune mechanisms. It is now widely known that many drugs of abuse, including marijuana, are used by millions ofindi viduals in this country and by even more abroad.

Drugs of Abuse, Immunity, and Infections

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Author :
Publisher : CRC Press
ISBN 13 : 9780849376375
Total Pages : 208 pages
Book Rating : 4.3/5 (763 download)

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Book Synopsis Drugs of Abuse, Immunity, and Infections by : Herman Friedman

Download or read book Drugs of Abuse, Immunity, and Infections written by Herman Friedman and published by CRC Press. This book was released on 1995-12-18 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades, drugs of abuse, including marijuana, cocaine, opiates, and alcohol have been studied in detail by biomedical scientists in terms of their effects on the neurophysiology and psychological responses of individuals. Research over the last few years has provided increased knowledge about possible mechanisms by which such drugs increase the likelihood of infections in humans and experimental animals. In Drugs of Abuse, Immunity, and Infections prominent investigators review important new information concerning the effects of recreational drugs on susceptibility to infection by microorganisms. The volume examines the effects of drugs such as cocaine, morphine, marijuana, and opiates on immunity in humans and animals. It covers the molecular and cellular mechanisms of drug-induced immunosuppression and describes the overall enhanced susceptibility to infection in recreational drug users. It discusses the alteration of susceptibility to the retrovirus that causes the acquired immunodeficiency syndrome (AIDS) and the consensus that drugs of abuse may serve as a possible cofactor in the progression of AIDS. Drugs of Abuse, Immunity, and Infections also includes important information concerning public health aspects of drugs of abuse and infection.

Infectious Diseases and Substance Abuse

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0306486881
Total Pages : 219 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Infectious Diseases and Substance Abuse by : Herman Friedman

Download or read book Infectious Diseases and Substance Abuse written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2006-05-28 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of recreational drugs of abuse by large numbers of individuals in this country and abroad has aroused serious concerns about the consequences of this activity. For example, it is recognized that marijuana is currently widely used as a recreational drug in the United States as well as other countries. Similarly, abuse of cocaine, especially crack cocaine, is considered to be an epidemic. “The war on drugs” by the US Government was directly aimed at the illicit use of cocaine, marijuana, and opiates as well as other drugs of abuse. Furthermore, alcohol is also considered a major problem of abuse in this country as well as in many other countries. It is estimated there are at least 10 million alcoholics in the United States alone. A signi?cant portion of those hospitalized with infectious diseases are alcoholics. Similarly, there have been many reports of association between marijuana use and increased susceptibility to infection as well as a re- tion between use of opiates and infections. The relationship between drug abuse and increased incidence of various infections has stimulated increased investi- tion of whether and how such drugs affect immune function, especially imp- tant for resistance against infectious agents. During the last decades, a wide variety of studies have shown that drugs of abuse, including marijuana, cocaine, or opiates, as well as alcohol, alter both neurophysiological as well as pathological responses of individuals.

Drugs of Abuse and Immune Function

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Author :
Publisher : CRC Press
ISBN 13 : 9780849367472
Total Pages : 256 pages
Book Rating : 4.3/5 (674 download)

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Book Synopsis Drugs of Abuse and Immune Function by : Ronald Ross Watson

Download or read book Drugs of Abuse and Immune Function written by Ronald Ross Watson and published by CRC Press. This book was released on 1990-07-25 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important publication provides up-to-date reviews using data from human patients and animal models. The goal is to understand the relationship between immunological modification by drugs of abuse and disease resistance. Examined are the major drugs of abuse and their effects on lymphoid cell function, numbers, development, and interactions. Also addressed are reviews of how ethanol, cocaine, morphine, and marijuana effect the immune function. The book includes evaluations of the relationship of immunomodulation by drugs of abuse on resistance to infectious diseases. This is critical to understanding how drugs modulate diseases and cancer development. This invaluable publication is important to those in biochemistry, physiology, chemistry, biology, immunology, cancer, medicine, pharmacology, microbiology, psychology, psychiatry, and additive studies. It is also of value to those in nutrition, pathology, pediatrics, family medicine, gerontology, surgery, sociology, and anatomy. Specialty groups, such as those in tropical medicine and public policy, will have a strong interest in the book. It is also of significant interest to organizations that deal with major numbers of patients using drugs of abuse and with their associated diseases including AIDS.

AIDS, Drugs of Abuse, and the Neuroimmune Axis

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461304075
Total Pages : 229 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis AIDS, Drugs of Abuse, and the Neuroimmune Axis by : Herman Friedman

Download or read book AIDS, Drugs of Abuse, and the Neuroimmune Axis written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the Proceedings of the Symposium on AIDS, Drugs of Abuse and the Neuroimmune Axis. This meeting was held in San Diego, California, November 11-13, 1995. As in the previous symposia in this series, productive studies were reviewed concerning the relationship between the nervous and the immune systems in regards to the relationship between drugs of abuse and infections, especially infections by the immunode ficiency virus that causes AIDS. In recent years, various investigators have begun to describe the role of illicit drugs and their endogenous counterparts on the brain-immune axis. It is widely recognized that the neuroendocrine system is intimately involved in the effects and manifestations of the interactions of drugs of abuse and the immune system. The meeting on which the chapters in this book are based brought together many biological scientists from an array of various scientific disciplines whose work is focused on the effects of drugs of abuse on the neuroendocrine-immune axis and its relationships to immunodeficiency caused by the AIDS virus. As in the past, the symposium was unique in focusing on the . brain-immune axis from the viewpoint of drugs of abuse rather than from the viewpoint of immunity or the brain itself.

The Brain Immune Axis and Substance Abuse

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461519519
Total Pages : 240 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Brain Immune Axis and Substance Abuse by : Burt M. Sharp

Download or read book The Brain Immune Axis and Substance Abuse written by Burt M. Sharp and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the proceedings of the 2nd annual symposium on the Brain Immune Axis and Substance Abuse held at the Breakers Hotel in Palm Beach, FL in June 1994. The history of productive studies concerning the relationship between the nervous and the immune systems is relatively recent. Studies on the effects of drugs of abuse on the immune system and on infections among individuals who abuse drugs are also of recent vintage. Only in the last decade have investigators begun to describe the role of drugs of abuse and their endogenous counterparts on the brain-immune axis. Thus, the involvement of the neuroendocrine system in the interactions of drugs of abuse and the immune system has only recently been appreciated. In addition, it has been recognized that direct neural inputs impact immune function. Given the complexity of these interactions, characterization of biologically significant phenomena and elucidation of their mechanisms of action often requires a multidisciplinary approach. This meeting, on which the chapters in this book are based, brought together scientists from an array of biomedical disciplines whose work is focused on the effects of drugs of abuse on the neuro-endocrine immune axis. The meeting was unique in focusing on the brain-immune axis from the viewpoint of drugs of abuse rather than either immunity itself or the brain itself. Presentations addressed the direct effects of drugs of abuse on various components of the immune system, as well as those mediated indirectly by the central nervous system and the neuroendocrine system.

Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0306476118
Total Pages : 271 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases by : Herman Friedman

Download or read book Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and Perspectives This volume is based on the proceedings of the 7th annual symposium on the topic Neuroimmune Circuits, Infectious Diseases and Drugs of Abuse, Bethesda, Maryland, Oc- ber 7–9, 1999. This symposium, as in the past, focused on newer knowledge concerning the relationship between the immune and nervous systems with regards to the effects of drugs of abuse and infections, including AIDS, caused by the immunodeficiency virus. Presentations discussed the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The major aim of this series of conferences has been to clarify the consequences of immunomodulation induced by drugs of abuse in regards to susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems. The recreational use of drugs of abuse such as morphine, cocaine, and marijuana by large numbers of individuals in this country and around the world has continued to arouse serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune responses. Much of the recent data accumulated by investigators show that drugs of abuse, especially opioids and cannabinoids, markedly alter immune responses in human populations as well as in experimental animals, both in vivo and in vitro.

Alcohol, Drugs of Abuse, and Immune Functions

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Author :
Publisher : CRC Press
ISBN 13 : 9780849383120
Total Pages : 280 pages
Book Rating : 4.3/5 (831 download)

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Book Synopsis Alcohol, Drugs of Abuse, and Immune Functions by : Ronald R. Watson

Download or read book Alcohol, Drugs of Abuse, and Immune Functions written by Ronald R. Watson and published by CRC Press. This book was released on 1995-05-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substance abusers are an immunocompromised population, vulnerable to a wide array of new and resurgent infectious diseases - in spite of modern treatment. For example, opportunistic infections like tuberculosis are the principal cause of morbidity and mortality in HIV positive patients. Alcohol- and drug-induced disorders are wide-ranging, gaining prominence as the spectrum of emerging diseases broadens. Alcohol, Drugs of Abuse, and Immune Functions reviews the role of these immunosuppressants as cofactors in disease. It covers the basic biology and immunology of impairments to defense against infectious disease. Alcohol and drug use is consistently associated with immunosuppression, although it isn't known if it is the substance itself, a metabolite, or an indirect effect that alters disease resistance. This text explores the advances toward answering this question, examines alcohol in different settings, its relationship to important cells, and the effects it can have on vital organs such as the liver and the lungs.

Infectious Diseases and Substance Abuse

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Author :
Publisher : Springer
ISBN 13 : 9780387500645
Total Pages : 0 pages
Book Rating : 4.5/5 (6 download)

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Book Synopsis Infectious Diseases and Substance Abuse by : Herman Friedman

Download or read book Infectious Diseases and Substance Abuse written by Herman Friedman and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of recreational drugs of abuse by large numbers of individuals in this country and abroad has aroused serious concerns about the consequences of this activity. For example, it is recognized that marijuana is currently widely used as a recreational drug in the United States as well as other countries. Similarly, abuse of cocaine, especially crack cocaine, is considered to be an epidemic. “The war on drugs” by the US Government was directly aimed at the illicit use of cocaine, marijuana, and opiates as well as other drugs of abuse. Furthermore, alcohol is also considered a major problem of abuse in this country as well as in many other countries. It is estimated there are at least 10 million alcoholics in the United States alone. A signi?cant portion of those hospitalized with infectious diseases are alcoholics. Similarly, there have been many reports of association between marijuana use and increased susceptibility to infection as well as a re- tion between use of opiates and infections. The relationship between drug abuse and increased incidence of various infections has stimulated increased investi- tion of whether and how such drugs affect immune function, especially imp- tant for resistance against infectious agents. During the last decades, a wide variety of studies have shown that drugs of abuse, including marijuana, cocaine, or opiates, as well as alcohol, alter both neurophysiological as well as pathological responses of individuals.

Neuroimmune Pharmacology

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Author :
Publisher : Springer
ISBN 13 : 3319440225
Total Pages : 1045 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu

Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer. This book was released on 2016-12-22 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse

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Author :
Publisher :
ISBN 13 :
Total Pages : 91 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse by : Jones Mutune Mutua

Download or read book Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse written by Jones Mutune Mutua and published by . This book was released on 2018 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: The frequent use of drugs of abuse among HIV infected individuals is a major concern. Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression, and diminishing host-immune responses. Moreover, opiates such as morphine have also been associated with decreasing the viral mutation rate. The rapid replication of HIV may result in increased production of mutant viruses that can escape detection by the host’s immune system. This shows that the use of drugs of abuse can make it harder to effectively manage HIV infections. It is thus important to gain insights into the effects of drugs of abuse on HIV dynamics. This dissertation presents mathematical models that help investigate the effects of morphine-altered antibody responses on SIV dynamics, effects of morphine pharmacodynamics on HIV dynamics, and effects of morphine on HIV infections with two viral species. Using our models, we show that in a subpopulation of SIV infected morphine addicted macaques, the presence of drugs of abuse may cause significantly diminished antibody responses, resulting in more severe infection with increased SIV infectivity, a decreased viral clearance rate, increased viral load, and higher CD4+ T cell loss. We also show that the infection threshold, the viral load, and the CD4+ T cell count largely depend on morphine pharmacodynamic parameters. Magnitudes of the basic reproduction number, and the numerical simulations results of our two viral species model show that the wild type virus dominates both in the presence of morphine and in the absence of morphine. The presence of morphine generally results in higher proportion of wild-type virus than mutant virus thereby resulting into a higher total viral load. Results in this dissertation may be useful to develop HIV control strategies, such as antibody based vaccines, for drug abuse groups.

The Health Effects of Cannabis and Cannabinoids

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Author :
Publisher : National Academies Press
ISBN 13 : 0309453070
Total Pages : 487 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Health Effects of Cannabis and Cannabinoids by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Drugs of Abuse

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (497 download)

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Book Synopsis Drugs of Abuse by :

Download or read book Drugs of Abuse written by and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Treatments for Addiction

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Author :
Publisher : National Academies Press
ISBN 13 : 0309166659
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis New Treatments for Addiction by : National Research Council

Download or read book New Treatments for Addiction written by National Research Council and published by National Academies Press. This book was released on 2004-06-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and improved therapies to treat and protect against drug dependence and abuse are urgently needed. In the United States alone about 50 million people regularly smoke tobacco and another 5 million are addicted to other drugs. In a given year, millions of these individuals attemptâ€"with or without medical assistanceâ€"to quit using drugs, though relapse remains the norm. Furthermore, each year several million teenagers start smoking and nearly as many take illicit drugs for the first time. Research is advancing on promising new means of treating drug addiction using immunotherapies and sustained-release (depot) medications. The aim of this research is to develop medications that can block or significantly attenuate the psychoactive effects of such drugs as cocaine, nicotine, heroin, phencyclidine, and methamphetamine for weeks or months at a time. This represents a fundamentally new therapeutic approach that shows promise for treating drug addiction problems that were difficult to treat in the past. Despite their potential benefits, however, several characteristics of these new methods pose distinct behavioral, ethical, legal, and social challenges that require careful scrutiny. Such issues can be considered unique aspects of safety and efficacy that are fundamentally related to the distinct nature and properties of these new types of medications.