Drug Toxicity And Metabolism In Pediatrics

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Drug Toxicity and Metabolism in Pediatrics

Author : Sam Kacew
Publisher : CRC Press
ISBN 13 : 1351079972
Total Pages : 332 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Drug Toxicity and Metabolism in Pediatrics by : Sam Kacew

Download or read book Drug Toxicity and Metabolism in Pediatrics written by Sam Kacew and published by CRC Press. This book was released on 2018-01-18 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

Rational Therapeutics for Infants and Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309183642
Total Pages : 135 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rational Therapeutics for Infants and Children by : Institute of Medicine

Download or read book Rational Therapeutics for Infants and Children written by Institute of Medicine and published by National Academies Press. This book was released on 2000-04-07 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.

Drug Metabolism in Diseases

Author : Wen Xie
Publisher : Academic Press
ISBN 13 : 0128029633
Total Pages : 296 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Drug Metabolism in Diseases by : Wen Xie

Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Drug Metabolism in the Immature Human

Author : Lester F. Soyka
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis Drug Metabolism in the Immature Human by : Lester F. Soyka

Download or read book Drug Metabolism in the Immature Human written by Lester F. Soyka and published by Raven Press (ID). This book was released on 1981 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pediatric Drug Development

Author : Andrew E. Mulberg
Publisher : John Wiley & Sons
ISBN 13 : 1118210433
Total Pages : 843 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Pediatric Drug Development by : Andrew E. Mulberg

Download or read book Pediatric Drug Development written by Andrew E. Mulberg and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Drug Development: Concepts and Applications is designed as a reference and textbook and is meant to address the science of differences between the pediatric and adult subject in the development of pharmaceutical products. Considered are the ethics and medical needs of proper understanding the pediatric and adult differences, the business case for proper development of drugs for children, as well as the technical feasibility studies and processes that are necessary for a proper pediatric drug development program. The applications of these approaches will benefit all stakeholders and ultimately not only educate but also provide better and safer drugs for pediatric patients.

Pediatric Drug Development

Author : Andrew E. Mulberg
Publisher : John Wiley & Sons
ISBN 13 : 1118312058
Total Pages : 782 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Pediatric Drug Development by : Andrew E. Mulberg

Download or read book Pediatric Drug Development written by Andrew E. Mulberg and published by John Wiley & Sons. This book was released on 2013-05-20 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations. This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globally. From an international team of expert contributors Pediatric Drug Development: Concepts and Applications is the practical guide to all aspects of the research and development of safe and effective medicines for children.

Drug Metabolism and Drug Toxicity

Author : American Society for Pharmacology and Experimental Therapeutics
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Metabolism and Drug Toxicity by : American Society for Pharmacology and Experimental Therapeutics

Download or read book Drug Metabolism and Drug Toxicity written by American Society for Pharmacology and Experimental Therapeutics and published by . This book was released on 1984 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diseases of the Brain, Head and Neck, Spine 2020–2023

Author : Juerg Hodler
Publisher : Springer Nature
ISBN 13 : 303038490X
Total Pages : 252 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Diseases of the Brain, Head and Neck, Spine 2020–2023 by : Juerg Hodler

Download or read book Diseases of the Brain, Head and Neck, Spine 2020–2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Paediatric Clinical Pharmacology

Author : Evelyne Jacqz-Aigrain
Publisher : CRC Press
ISBN 13 : 0849374448
Total Pages : 830 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Paediatric Clinical Pharmacology by : Evelyne Jacqz-Aigrain

Download or read book Paediatric Clinical Pharmacology written by Evelyne Jacqz-Aigrain and published by CRC Press. This book was released on 2021-02-25 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.

Neonatal and Pediatric Pharmacology

Author : Sumner J. Yaffe
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781795389
Total Pages : 1072 pages
Book Rating : 4.7/5 (817 download)

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Book Synopsis Neonatal and Pediatric Pharmacology by : Sumner J. Yaffe

Download or read book Neonatal and Pediatric Pharmacology written by Sumner J. Yaffe and published by Lippincott Williams & Wilkins. This book was released on 2011 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neonatal and Pediatric Pharmacology offers guidelines for safe, effective, and rational drug therapy in newborns, children and adolescents. The book provides relevant and useful data on the molecular, physiologic, biochemical, and pharmacologic mechanisms of drug action and therapy in this population. The authors identify areas of innovative basic and translational research necessary for the continuing evaluation and development of drugs for the fetus, newborns, children and adolescents. Neonatal and Pediatric Pharmacology is is a valuable reference for all health care professionals who treat the fetus, newborns, children, and adolescents, including neonatologists, nurses, pediatricians, general practitioners, students, obstetricians, perinatologists, surgeons and allied health professionals. It will be useful anytime during the day and especially in the middle of the night when knowledge of appropriate indications, safe and effective use, dosage, and therapeutic regimen for a certain drug or molecular entity is immediately needed. The book is also directed to those involved in basic, clinical, and other academic pharmacological research, the pharmaceutical industry, and regulatory agencies dealing with drug and therapeutic developments for this population. Those teaching pharmacology and therapeutics will find this compilation of information extremely useful in preparing teaching materials"--Provided by publisher.

Paediatric Drug Handling

Author : Ian Costello
Publisher : Pharmaceutical Press
ISBN 13 : 9780853696865
Total Pages : 148 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Paediatric Drug Handling by : Ian Costello

Download or read book Paediatric Drug Handling written by Ian Costello and published by Pharmaceutical Press. This book was released on 2007 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of all of the issues pharmacists serving pediatric patients must consider. Chapters relating to pharmacogenomics, medication error prevention, compounding, and government regulations are extremely informative.

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Author : Albert P. Li
Publisher : John Wiley & Sons
ISBN 13 : 1119170842
Total Pages : 530 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Transporters and Drug-Metabolizing Enzymes in Drug Toxicity by : Albert P. Li

Download or read book Transporters and Drug-Metabolizing Enzymes in Drug Toxicity written by Albert P. Li and published by John Wiley & Sons. This book was released on 2021-07-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Drug Metabolism as a Cause of Drug Toxicity

Author :
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Drug Metabolism as a Cause of Drug Toxicity by :

Download or read book Drug Metabolism as a Cause of Drug Toxicity written by and published by . This book was released on 1995 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pediatric Drug Guide

Author : Ruth McGillis Bindler
Publisher :
ISBN 13 :
Total Pages : 1400 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pediatric Drug Guide by : Ruth McGillis Bindler

Download or read book Pediatric Drug Guide written by Ruth McGillis Bindler and published by . This book was released on 2005 with total page 1400 pages. Available in PDF, EPUB and Kindle. Book excerpt: To be used as a resource for any pediatric nursing and/or health professions course or for the clinical setting. This comprehensive drug guide addresses the specialty of pediatric pharmacology in the context of nursing care, containing most medications administered to children. The guide provides easy access to over 500 drugs organized alphabetically by generic name. For each drug in this book, the user will find Trade Names, Combination Drugs, Classifications, Pregnancy Category, Controlled Substance Status, Availability, Actions/Therapeutic Effects, Uses, Contraindications/Cautions Use, Routes/Dosages, Storage, Administration, Adverse Effects, Diagnostic Test Interference, Drug and Food/Herbal Interactions, Pharmacokinetics, and Nursing Implications. It highlights nursing implications for administration, monitoring, and teaching and focuses on the child, the adolescent, and the family.

The Pediatric Drug Handbook

Author : William E. Benitz
Publisher : CRC Press
ISBN 13 :
Total Pages : 722 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Pediatric Drug Handbook by : William E. Benitz

Download or read book The Pediatric Drug Handbook written by William E. Benitz and published by CRC Press. This book was released on 1988 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pediatric Non-Clinical Drug Testing

Author : Alan M. Hoberman
Publisher : John Wiley & Sons
ISBN 13 : 047044861X
Total Pages : 389 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Pediatric Non-Clinical Drug Testing by : Alan M. Hoberman

Download or read book Pediatric Non-Clinical Drug Testing written by Alan M. Hoberman and published by John Wiley & Sons. This book was released on 2012-03-13 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for submission to both agencies. It also provides practical study designs and approaches that can be used to meet international requirements. Covering the full scope of non-clinical testing, regulations, models, practice, and relation to clinical trials, this text offers a comprehensive and up-to-date resource.

Problems in Pediatric Drug Therapy

Author : Louis A. Pagliaro
Publisher : Washington, D.C. : American Pharmaceutical Association
ISBN 13 :
Total Pages : 862 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Problems in Pediatric Drug Therapy by : Louis A. Pagliaro

Download or read book Problems in Pediatric Drug Therapy written by Louis A. Pagliaro and published by Washington, D.C. : American Pharmaceutical Association. This book was released on 2002 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for all pediatric clinicians and students, Problems in Pediatric Drug Therapy is an authoritative, well-referenced, and accessible source of essential information on the use and effects of drugs in infants and children. Twenty widely published clinicians, educators, and researchers from pharmacy, medicine, and nursing have authored 14 chapters, each dealing with a major, potentially problematic area of pediatric drug therapy. Building on the well-received previous editions -- the third edition was named an American Journal of Nursing Book of the Year in the category of pediatric nursing -- the fourth edition focuses on the key concerns in pediatric drug therapy today: drug administration, pharmacokinetics, drugs as teratogens and fetotoxins, excretion of drugs into breast milk, pediatric poisoning, adverse reactions, drug interactions, drug abuse, IV drugs, and immunizations. Two new chapters cover the increasingly important areas of pediatric antineoplastic therapy and pharmacogenetics. The concluding two hallmark chapters on dosing in neonates and in infants, children, and adolescents, respectively, have been expanded and updated to reflect current trends in drug use.