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Drug Stereochemistry
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Book Synopsis Drug Stereochemistry by : Irving Wainer
Download or read book Drug Stereochemistry written by Irving Wainer and published by CRC Press. This book was released on 1993-02-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.
Book Synopsis Stereochemical Aspects of Drug Action and Disposition by : Michel F. Eichelbaum
Download or read book Stereochemical Aspects of Drug Action and Disposition written by Michel F. Eichelbaum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.
Book Synopsis Drug Stereochemistry by : Krzysztof Jozwiak
Download or read book Drug Stereochemistry written by Krzysztof Jozwiak and published by CRC Press. This book was released on 2012-04-23 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology. Topics include:The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug disc
Book Synopsis The Impact of Stereochemistry on Drug Development and Use by : Hassan Y. Aboul-Enein
Download or read book The Impact of Stereochemistry on Drug Development and Use written by Hassan Y. Aboul-Enein and published by Wiley-Interscience. This book was released on 1997-04-11 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past fifteen years have seen a revolution in the field of stereochemistry, with breakthrough analytical techniques in enantiomeric separation profoundly affecting drug development and use. This practical reference written by leading researchers focuses on the important roles chirality and stereoisomerism play in drug development efforts--presenting for the first time a comprehensive overview of this rapidly evolving area of pharmacological research. The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops. The introductory chapters outline the pharmacological effects of stereochemistry, cover stereochemistry in drug metabolism, and discuss problems inherent in the duality of enantiomers--chemically identical yet spatially different molecules. Contributions on the specific aspects of chirality and drug activity explore the toxicological effects of stereoselectivity, illustrate how an understanding of the stereochemical composition of certain drugs can help avoid problems, and offer tips on new clinical applications for existing drugs. A full chapter is devoted to research opportunities in the development of new chirally pure drugs. Other practical research topics range from the preparation of chirally pure compounds to the analytical determination of stereochemical composition, to applications of circular dichroism (CD) spectroscopy. Regulatory issues concerning the development and approval of stereoisomeric drugs are discussed in the final chapters. This section offers an international perspective as well as a historical review of the ongoing debate surrounding regulatory guidelines. Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field. Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field. IMPACT OF STEREOCHEMISTRY ON DRUG DEVELOPMENT AND USE Twenty-three expert contributions on the "stereochemical revolution" of the last fifteen years--covering analytical, pharmacological, and regulatory topics--show that "drug development can no longer occur without consideration of drug stereochemistry." "We have...come full circle and stand alongside Pasteur in amazement of nature's duality, symmetry and dissymmetry, and its chemical and pharmacological consequences."--from the Preface
Book Synopsis Drug Stereochemistry by : Irving W. Wainer
Download or read book Drug Stereochemistry written by Irving W. Wainer and published by . This book was released on 1988 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chirality in Drug Research by : Eric Francotte
Download or read book Chirality in Drug Research written by Eric Francotte and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Book Synopsis Introduction to Stereochemistry by : Andrew Clark
Download or read book Introduction to Stereochemistry written by Andrew Clark and published by Royal Society of Chemistry. This book was released on 2020-10-23 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereochemistry is an important concept that often causes confusion amongst students when they learn it for the first time. In this book we deal with tricky concepts like conformation and configuration, how to represent them accurately and how to use the correct terms to describe them in both organic and inorganic chemistry.
Book Synopsis Stereoisomerism in Pharmaceuticals by : Thomas N. Riley
Download or read book Stereoisomerism in Pharmaceuticals written by Thomas N. Riley and published by . This book was released on 1990 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereochemistry written by and published by Elsevier. This book was released on 1982-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereochemistry
Book Synopsis The Organic Chemistry of Medicinal Agents by : Adam Renslo
Download or read book The Organic Chemistry of Medicinal Agents written by Adam Renslo and published by McGraw Hill Professional. This book was released on 2015-11-23 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most concise and streamlined textbook available on organic chemistry for the pharmacy student Organic Chemistry for Pharmacy is a textbook written specifically for the students taking the required Organic/Medical Pharmacy course. Using a building-block approach, the book delivers a basic, yet thorough discussion of the mode of action, therapeutic applications, and limitations of various pharmaceutical agents. Organic Chemistry for Pharmacy is especially written for students who have a limited background in chemistry. In order to make the learning/teaching experience as efficient as possible, Organic Chemistry for Pharmacy includes outstanding pedagogical features such as chapter outlines, chapter summaries, boxed “take away points”, quick-reference tables, and problems within each chapter. The focus and presentation of this text is particularly suited for Organic/Medical Pharmacy courses which are weighted heavily towards Organic, rather than Medical Pharmacy.
Book Synopsis Pharmacology of Drug Stereoisomers by : Alexander A. Spasov
Download or read book Pharmacology of Drug Stereoisomers written by Alexander A. Spasov and published by Springer Nature. This book was released on 2022-09-10 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
Book Synopsis Stereochemistry and Biological Activity of Drugs by : Everhardus Jacobus Ariëns
Download or read book Stereochemistry and Biological Activity of Drugs written by Everhardus Jacobus Ariëns and published by Wiley-Blackwell. This book was released on 1983-01-01 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Basic Concepts in Medicinal Chemistry by : Marc Harrold
Download or read book Basic Concepts in Medicinal Chemistry written by Marc Harrold and published by ASHP. This book was released on 2013-01-18 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Book Synopsis The Steric Factor in Medicinal Chemistry by : A.F. Casy
Download or read book The Steric Factor in Medicinal Chemistry written by A.F. Casy and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'It is indeed the merit of Dr. Alan F. Casy to bring in these pages a clear and comprehensive view of medicinal stereochemistry, a discipline in which he has been active and successful for many years both as a teacher and a researcher. Written for graduate students and research workers in medicinal chemistry and pharmacology, this book will contribute significantly towards a better education of scientists by removing the fear of stereochemistry caused by ignorance, moderating the overconfidence of possible zealots, and outlining a broader context.'-from the foreword by Bernard Testa
Book Synopsis Stereochemistry of Organic Compounds by : D. Nasipuri
Download or read book Stereochemistry of Organic Compounds written by D. Nasipuri and published by New Age International. This book was released on 1994 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: During Recent Years, Stereochemistry Has Undergone A Phenomenal Growth Both In Theory And Practice, With A Concomitant Increase Of Interest Among The Organic Chemists, Biological Chemists, Medicinal Chemists, And Pharmacologists. The Present Text Provides An Up-To-Date, Coherent; And Comprehensive Account Of The Subject Starting From The Fundamentals And Leading Up To The Latest Development As Far As Practicable. Emphasis Has Been Placed On Symmetry-Based Approach To Molecular Chirality, Stereochemical Terminologies (Modern Stereochemistry Is Replete, With Them), Topicity And Prostereoisomerism, Conformational Analysis, Dynamic Stereochemistry, Chiroptical Properties, And Assignment Of Absolute Configuration To Chiral Molecules.Dynamic Stereochemistry Has Been Discussed With Reference To Conformation-Reactivity Correlation, Stereoselective Syntheses, And Pericyclic Reactions. A Large Cross Section Of Organic Reactions With Stereochemical Implication Has Been Incorporated. Attempts Have Been Made To Familiarise The Readers With Modem Instrumental Techniques, Nuclear Magnetic Resonance In Particular, Used For Stereochemical Investigation. Each Chapter Is Provided With A Summary Which Highlights The Main Points Of The Text. Selective References, Mostly Of Textbooks, Monographs, Review Articles, And Significant Original Papers Have Been Given Extending Sometimes To Early 1991.The Book Is Expected To Fulfil The Long-Felt Need For A Comprehensive Text On Modern Organic Stereochemistry Which Is Conspicuously Absent Since The Publication Of Professor Eliels Book In 1962. The Text May Be Adopted At Any Stage Of The University Teaching And At The Same Time Be Useful To The Practising Organic Chemists.
Book Synopsis Stereochemistry and Organic Reactions by : Dipak Kumar Mandal
Download or read book Stereochemistry and Organic Reactions written by Dipak Kumar Mandal and published by Academic Press. This book was released on 2021-04-21 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists. Presents a holistic and unified approach to stereochemical understanding and predictions, covering reactions of all mechanistic classes Includes two background chapters on perturbation theory and stereoselective principles, along with asymmetric designs Features novel rules and mnemonics to delineate product stereochemistry Includes up-to-date coverage with over 1300 selective references
Book Synopsis Principles and Applications of Stereochemistry by : Michael North
Download or read book Principles and Applications of Stereochemistry written by Michael North and published by Routledge. This book was released on 2017-10-19 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough understanding of stereochemistry is essential for the comprehension of almost all aspects of modern organic chemistry. It is also of great significance in many biochemical and medicinal disciplines, since the stereoisomers of a compound can have dramatically different biological properties. This text explains how the different properties of stereoisomers of a compound arise, and what processes can be used to prepare and analyze stereoisomerically pure compounds. It also presents prominent coverage of the stereochemistry of inorganic and organometallic compounds, which is likely to increase in importance, as these compounds are used as symmetric catalysts in asymmetric synthesis. Modern stereochemical terminology is used throughout, although reference is also made to older terms which are still widely used. A set of problems at the end of each chapter aims to further the reader's understanding of how the content can be applied. The book is designed mainly as a textbook for undergraduate students and as a reference source for more advanced levels, but is also intended for academic and professional organic chemists.
