Drosophila As A Model Organism For Ageing Studies

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Drosophila as a Model Organism for Ageing Studies

Author : Frédéric A. Lints
Publisher : Springer
ISBN 13 : 1489926836
Total Pages : 312 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Drosophila as a Model Organism for Ageing Studies by : Frédéric A. Lints

Download or read book Drosophila as a Model Organism for Ageing Studies written by Frédéric A. Lints and published by Springer. This book was released on 2013-11-21 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.

Drosophila as a Model Organism for Ageing Studies

Author : Frédéric A. Lints
Publisher : Springer
ISBN 13 : 9781489926845
Total Pages : 307 pages
Book Rating : 4.9/5 (268 download)

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Book Synopsis Drosophila as a Model Organism for Ageing Studies by : Frédéric A. Lints

Download or read book Drosophila as a Model Organism for Ageing Studies written by Frédéric A. Lints and published by Springer. This book was released on 2013-10-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.

Life Extension

Author : Alexander M. Vaiserman
Publisher : Springer
ISBN 13 : 3319183265
Total Pages : 353 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Life Extension by : Alexander M. Vaiserman

Download or read book Life Extension written by Alexander M. Vaiserman and published by Springer. This book was released on 2015-06-09 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

The Molecular Genetics of Aging

Author : Siegfried Hekimi
Publisher : Springer Science & Business Media
ISBN 13 : 354048003X
Total Pages : 254 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis The Molecular Genetics of Aging by : Siegfried Hekimi

Download or read book The Molecular Genetics of Aging written by Siegfried Hekimi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Aging of Organisms

Author : H.D. Osiewacz
Publisher : Springer Science & Business Media
ISBN 13 : 9401706719
Total Pages : 278 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Aging of Organisms by : H.D. Osiewacz

Download or read book Aging of Organisms written by H.D. Osiewacz and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological aging as the time-depending general decline of biological systems associated with a progressively increasing mortality risk is a general phenomenom of great significance. The underlying processes are very complex and depending on genetic and environment factors. These factors encode or affect a network of interconnected cellular pathways. In no system this network has been deciphered in greater detail. However, the strategy of studying various biological systems has let to the identification of pathways and specific modules and makes it obvious that aging is the result of different overlapping mechanisms and pathways. Some of these appear to be conserved ("public") among species, others are specific or "private" and only of significance in one or a few organisms. This volume in the series on "Biology of aging and its modulation" specifically focuses on organismic aging. The book covers research on organisms from lower to higher complexity representing examples from very diverse taxa like photosynthetic plants, fungi, sponges, nematodes, flies, birds and mammals. Such a broad treatise of this complex topic provides a comprehensive "flavor" about the current issues dealt with in this rapidly growing scientific discipline.

Topics in Biomedical Gerontology

Author : Pramod C. Rath
Publisher : Springer
ISBN 13 : 9789811095443
Total Pages : 355 pages
Book Rating : 4.0/5 (954 download)

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Book Synopsis Topics in Biomedical Gerontology by : Pramod C. Rath

Download or read book Topics in Biomedical Gerontology written by Pramod C. Rath and published by Springer. This book was released on 2018-04-22 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.

Drosophila melanogaster

Author : Farzana Khan Perveen
Publisher : BoD – Books on Demand
ISBN 13 : 9535138537
Total Pages : 270 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Drosophila melanogaster by : Farzana Khan Perveen

Download or read book Drosophila melanogaster written by Farzana Khan Perveen and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Comparative Biology of Aging

Author : Norman S. Wolf
Publisher : Springer Science & Business Media
ISBN 13 : 904813465X
Total Pages : 397 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Comparative Biology of Aging by : Norman S. Wolf

Download or read book Comparative Biology of Aging written by Norman S. Wolf and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

Yellow Biotechnology I

Author : Andreas Vilcinskas
Publisher : Springer
ISBN 13 : 3642398634
Total Pages : 201 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Yellow Biotechnology I by : Andreas Vilcinskas

Download or read book Yellow Biotechnology I written by Andreas Vilcinskas and published by Springer. This book was released on 2013-12-06 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Utility of Insects for Studying Human Pathogens and Evaluating New Antimicrobial Agents, by Yan Wang, De-Dong Li, Yuan-Ying Jiang and Eleftherios Mylonakis. Galleria Mellonella as a Model Host to Study Gut Microbe Homeostasis and Brain Infection by the Human Pathogen Listeria Monocytogenes, by Krishnendu Mukherjee, Ramya Raju, Rainer Fischer and Andreas Vilcinskas. Drosophila as a Model to Study Metabolic Disorders, by Julia Hoffmann, Renja Romey, Christine Fink and Thomas Roeder. The Fruit Fly Drosophila melanogaster as a Model for Aging Research, by Annely Brandt and Andreas Vilcinskas. Drosophila and the Hallmarks of Cancer, by Theodoulakis Christofi and Yiorgos Apidianakis. The red flour beetle Tribolium castaneum as a model to monitor food safety and functionality, by Stefanie Grünwald, Iris V. Adam, Ana-Maria Gurmai, Ludmila Bauer, Michael Boll, and Uwe Wenzel. Identification and Bioanalysis of Natural Products from Insect Symbionts and Pathogens, by Alexander O. Brachmann and Helge B. Bode. Antiparasitic Peptides, by Jette Pretzel, Franziska Mohring, Stefan Rahlfs and Katja Becker.

Aging in Drosophila

Author : Leslie P. Gartner
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Aging in Drosophila by : Leslie P. Gartner

Download or read book Aging in Drosophila written by Leslie P. Gartner and published by . This book was released on 1986 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Listing of 763 entries to literature published through 1985. Also includes foreign-language materials. Topical arrangement. Entries are partially annotated. No index.

Biological Aging

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
ISBN 13 : 1597453617
Total Pages : 844 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Biological Aging by : Trygve O. Tollefsbol

Download or read book Biological Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.

Aging Mechanisms II

Author : Nozomu Mori
Publisher :
ISBN 13 : 9789811679780
Total Pages : 0 pages
Book Rating : 4.6/5 (797 download)

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Book Synopsis Aging Mechanisms II by : Nozomu Mori

Download or read book Aging Mechanisms II written by Nozomu Mori and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

Obesity and Type 2 Diabetes Mellitus

Author : John Sheehan
Publisher : Oxford American Endocrinology
ISBN 13 : 0199740216
Total Pages : 90 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Obesity and Type 2 Diabetes Mellitus by : John Sheehan

Download or read book Obesity and Type 2 Diabetes Mellitus written by John Sheehan and published by Oxford American Endocrinology. This book was released on 2011 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of the worldwide obesity epidemic, a concurrent rise has occurred in the prevalence of type 2 diabetes mellitus and metabolic syndrome. Type 2 diabetes mellitus is affecting younger individuals-the disease is no longer exclusive to adulthood. Diabetic micro- and macrovascular complications are also occurring at an earlier age, leading to increasing demands and costs on the healthcare system. In addition, the morbidity, disability and premature death caused by diabetic complications create a huge burden to families, employers and society at large. Thankfully, there has been a tremendous growth in new therapeutic classes of medications to help manage type 2 diabetes mellitus. These agents target many of the pathophysiologic defects of the disease with fewer side effects than the older agents. Newer insulin formulations have more predictable kinetics so patients can achieve better glycemic control with less risk of hypoglycemia and weight gain. Insulin delivery devices have also improved to include higher quality insulin pens, finer and shorter pen needles, and more technologically advanced insulin pumps. As part of the Oxford American Endocrinology Library series, this handbook reviews the epidemiology and pathophysiology of obesity and type 2 diabetes mellitus. The content covers micro- and macrovascular diabetic complications, the array of glucose regulating therapies, treatment algorithms targeting the pathophysiologic defects of type 2 diabetes mellitus as well as strategies for macrovascular risk reduction via therapeutic lifestyle change (diet, exercise, smoking cessation), pharmacotherapeutic treatment of dyslipidemia and hypertension, bariatric surgery and subcutaneous insulin infusion therapy, among other topics. Because of the concise yet comprehensive nature of the handbook, this volume is an excellent point-of-care reference for the clinician who regulary treats obese and diabetic patients.

Cells and Surveys

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171431
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cells and Surveys by : National Research Council

Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.

Conn's Handbook of Models for Human Aging

Author : Jeffrey L. Ram
Publisher : Academic Press
ISBN 13 : 0128113545
Total Pages : 1218 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Conn's Handbook of Models for Human Aging by : Jeffrey L. Ram

Download or read book Conn's Handbook of Models for Human Aging written by Jeffrey L. Ram and published by Academic Press. This book was released on 2018-04-05 with total page 1218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Anti-Aging Pharmacology

Author : Vitaly Koltover
Publisher : Academic Press
ISBN 13 : 0128236809
Total Pages : 400 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Anti-Aging Pharmacology by : Vitaly Koltover

Download or read book Anti-Aging Pharmacology written by Vitaly Koltover and published by Academic Press. This book was released on 2022-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. Includes updated information about current developments in anti-aging pharmacology Offers practical advice on the applicability of certain healthspan-promoting medications Discusses potential challenges related to the translation of anti-aging drugs in clinical practice

Handbook of the Biology of Aging

Author : Matt Kaeberlein
Publisher : Academic Press
ISBN 13 : 0124116205
Total Pages : 576 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of the Biology of Aging by : Matt Kaeberlein

Download or read book Handbook of the Biology of Aging written by Matt Kaeberlein and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions