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Author : Norman S. Wolf
Publisher :
ISBN 13 : 9789048134816
Total Pages : 404 pages
Book Rating : 4.1/5 (348 download)
Download or read book Comparative Biology of Aging written by Norman S. Wolf and published by . This book was released on 2010-04-18 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Norman S. Wolf
Publisher : Springer Science & Business Media
ISBN 13 : 904813465X
Total Pages : 391 pages
Book Rating : 4.0/5 (481 download)
Download or read book Comparative Biology of Aging written by Norman S. Wolf and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].
Author : Michael R. Rose
Publisher : Oxford University Press
ISBN 13 : 0190282576
Total Pages : 240 pages
Book Rating : 4.1/5 (92 download)
Download or read book Evolutionary Biology of Aging written by Michael R. Rose and published by Oxford University Press. This book was released on 1994-10-27 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
Author : Michael R. Rose
Publisher : Oxford University Press
ISBN 13 : 0198022727
Total Pages : 236 pages
Book Rating : 4.1/5 (98 download)
Download or read book Evolutionary Biology of Aging written by Michael R. Rose and published by Oxford University Press. This book was released on 1994-10-27 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
Author : Richard A. Parent
Publisher : Academic Press
ISBN 13 : 0124047262
Total Pages : 834 pages
Book Rating : 4.1/5 (24 download)
Download or read book Comparative Biology of the Normal Lung written by Richard A. Parent and published by Academic Press. This book was released on 2015-03-13 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative Biology of the Normal Lung, 2nd Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
Author : Jeffrey L. Ram
Publisher : Academic Press
ISBN 13 : 0128113545
Total Pages : 1218 pages
Book Rating : 4.1/5 (281 download)
Download or read book Conn's Handbook of Models for Human Aging written by Jeffrey L. Ram and published by Academic Press. This book was released on 2018-04-05 with total page 1218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations
Author : Caleb E. Finch
Publisher : University of Chicago Press
ISBN 13 : 9780226248899
Total Pages : 948 pages
Book Rating : 4.2/5 (488 download)
Download or read book Longevity, Senescence, and the Genome written by Caleb E. Finch and published by University of Chicago Press. This book was released on 1994-05-16 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
Author : Matt Kaeberlein
Publisher : Academic Press
ISBN 13 : 0124116205
Total Pages : 576 pages
Book Rating : 4.1/5 (241 download)
Download or read book Handbook of the Biology of Aging written by Matt Kaeberlein and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
Author : Michael A. Singer
Publisher : Nova Science Publishers
ISBN 13 : 9781634830249
Total Pages : 0 pages
Book Rating : 4.8/5 (32 download)
Download or read book Are Chronic Degenerative Diseases Part of the Ageing Process? written by Michael A. Singer and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the DNA in the human genome does not encode proteins but is involved in regulatory functions. In addition, the human genome is characterized by an extensive array of structural DNA variants arising from de novo mutations plus accumulated structural variants transmitted through an individual's lineage. The result is that each person has a unique genome which is expressed as that person's unique phenotype. Ageing can be understood on both the species and individual level. Each species has a programmed ageing and mortality pattern, but within those broad species-specific boundaries there is considerable individual variation. At the individual level, ageing reflects the integrated effects of that individual's unique mix of DNA structural variants, unique experience-specific epigenetic marks and imperfectly repaired genomic and cellular damage. This book examines human "chronic degenerative" diseases which are not diseases, but rather variations of the ageing process across individuals.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309306647
Total Pages : 400 pages
Book Rating : 4.3/5 (93 download)
Download or read book Sociality, Hierarchy, Health written by National Research Council and published by National Academies Press. This book was released on 2014-09-16 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sociality, Hierarchy, Health: Comparative Biodemography is a collection of papers that examine cross-species comparisons of social environments with a focus on social behaviors along with social hierarchies and connections, to examine their effects on health, longevity, and life histories. This report covers a broad spectrum of nonhuman animals, exploring a variety of measures of position in social hierarchies and social networks, drawing links among these factors to health outcomes and trajectories, and comparing them to those in humans. Sociality, Hierarchy, Health revisits both the theoretical underpinnings of biodemography and the empirical findings that have emerged over the past two decades.
Author : Caleb E. Finch
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.1/5 (323 download)
Download or read book Between Zeus and the Salmon written by Caleb E. Finch and published by . This book was released on 1997-10-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
Author : Suzanne R. Kunkel, PhD
Publisher : Springer Publishing Company
ISBN 13 : 0826105467
Total Pages : 328 pages
Book Rating : 4.8/5 (261 download)
Download or read book Global Aging written by Suzanne R. Kunkel, PhD and published by Springer Publishing Company. This book was released on 2014-02-03 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Print+CourseSmart
Author : Robert Arking
Publisher : Oxford University Press
ISBN 13 : 9780199727629
Total Pages : 624 pages
Book Rating : 4.7/5 (276 download)
Download or read book Biology of Aging written by Robert Arking and published by Oxford University Press. This book was released on 2006-02-02 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.
Author : Jean Woo
Publisher : Springer Science & Business Media
ISBN 13 : 1441983546
Total Pages : 288 pages
Book Rating : 4.4/5 (419 download)
Download or read book Aging in Hong Kong written by Jean Woo and published by Springer Science & Business Media. This book was released on 2012-09-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the longest life expectancy for men and the second longest for women, Hong Kong typifies our planet’s aging population. The daily lives of its older adults closely match the advantages and disadvantages experienced by urban elders in other developed countries. For these reasons, Hong Kong’s elderly serve as a salient guide to older people’s social, psychological, and healthcare needs—concerns of increasing importance as the world grows older. Aging in Hong Kong examines this emblematic population as a case study specifically in comparison with their counterparts in the West, shedding light on diverse, interrelated currents in the aging experience. Referencing numerous international studies, the book contrasts different health service arrangements and social factors and relates them to a variety of health outcomes. Its wide-ranging coverage documents health and illness trends, reviews age-friendly policy initiatives, relates health literacy to patients’ active role in their own care, and discusses elders as an underserved group in the division of limited health funding and resources. This multiple focus draws readers’ attention to policies that need revisiting or retooling as chapters analyze major life areas including: Living environment. Retirement and post-retirement employment issues. Financial asset management. Health literacy regarding aging issues. Elder-positive service delivery models. Ageism in the prioritization of healthcare. End-of-life issues. By assembling such a wealth of data on its subject, Aging in Hong Kong puts ongoing challenges into clear focus for gerontologists, sociologists, health and cross-cultural psychologists, public health policymakers, and others involved in improving the quality of elders’ lives.
Author : Klaus-Günter Collatz
Publisher : Springer Science & Business Media
ISBN 13 : 3642708536
Total Pages : 249 pages
Book Rating : 4.6/5 (427 download)
Download or read book Insect Aging written by Klaus-Günter Collatz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Leben ist die schonste Erfindung der Natur und der Tod ist ihr Kunstgriff, viel Leben zu haben" . J. W. v. Goethe Life is the most beautiful invention of nature, and death is her device to exhibit most life. The eminent British biologist Sir Vincent B. Wigglesworth noted in 1939 that insects are an ideal medium in which to study all problems of physiology. Many fundamental discoveries in biology, particularly genetics and development, have been made on the basis of studies conducted in insects. Because of their ex treme adaptability and diversity, an appropriate insect model is available for the study of virtually any biological problems. The applicability to other groups, including mammals, of basic studies conducted on insects has helped in the gradual acceptance of the fundamental unity of biochemical principles as a dogma among biologists, as well as among enlightened medical scientists. With the recent upsurge of interest in the study of the aging process, in sects have been increasingly employed not only for the investigation of basic mechanisms of aging, but also to gain insight into the evolution of aging and senescence. If only one aging mechanism exists, it is foreseeable that some in sects, especially Drosophila, will help to unravel its molecular basis. Because of their diversity, existing studies in the gerontology of insects are widely scat tered in various specialized journals. This wealth of existing information has not, as yet, been brought together in a synthesized and comprehensive form.
Author : Leonard Guarente
Publisher : CSHL Press
ISBN 13 : 0879698241
Total Pages : 610 pages
Book Rating : 4.8/5 (796 download)
Download or read book Molecular Biology of Aging written by Leonard Guarente and published by CSHL Press. This book was released on 2008 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
Author : P. Michael Conn
Publisher : Elsevier
ISBN 13 : 9780080460062
Total Pages : 1075 pages
Book Rating : 4.4/5 (6 download)
Download or read book Handbook of Models for Human Aging written by P. Michael Conn and published by Elsevier. This book was released on 2011-04-28 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations
