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Dna And Peptide Functionalized Gold Nanoparticles For Biological Imaging And Transfection
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Book Synopsis DNA and Peptide Functionalized Gold Nanoparticles for Biological Imaging and Transfection by : Ziyan Zhang
Download or read book DNA and Peptide Functionalized Gold Nanoparticles for Biological Imaging and Transfection written by Ziyan Zhang and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on the development of DNA and peptide functionalized gold nanoparticles. Three nanoparticle systems have been developed: (1) nucleic acid-directed self-assembly of a gold nanoparticle PET imaging agent; (2) cationic peptide functionalized gold nanoparticles; (3) gold nanoparticle templated peptide nanoshells. The first functionalized gold nanoparticles were constructed by assembling ODN (oligodeoxynucleotide)-derivatized gold nanoparticles with functionalized complementary PNAs (peptide nucleic acids). The PNAs were conjugated with DOTA for chelating chelating 64Cu for PET imaging, PEG for conferring stealth properties, and Cy5 for fluorescent imaging. The resulting functionalized nanoparticles showed good stability both in vitro and in vivo and had biodistribution properties expected for a PEGylated gold nanoparticle rather than that for the functionalized PNAs used in the construction. The second nanoparticle system was arginine-rich peptide and lysine-rich peptide functionalized cationic gold nanoparticles as transfection agents. A series of cysteine containing oligoarginine was synthesized by automated solid phase Fmoc synthesis. chloroauric acid was reduced in the presence of the peptides. The resulting gold nanoparticles were around 13 nm in diameter with zeta potential around 29 mV. Compare to other reported cationic gold nanoparticles, the arginine-rich gold nanoparticles were highly stable in up to 0.6 M NaCl solutions and up to pH 8.5 in non-phosphate containing buffers. In phosphate buffers, however, the nanoparticles started to aggregate at above pH 6, though aggregation was reversible by lowering the pH. The strong affinity between arginine and phosphate groups also resulted in the nanoparticle's strong ODN binding ability. Despite of the reported cytotoxicity of oligoarginines, the arginine-rich gold nanoparticles showed no cytotoxicity even at a very high concentration. An improved assembly approach was also investigated. Cationic peptides were exchanged with cetyltrimethylammonium bromide (CTAB) on gold nanoparticles fabricated by seeded growth method. This approach allowed quick assembly of a library of different peptide on the gold surface. The approach was validated by synthesizing three cationic gold nanoparticles, R13C-AuNP, K10Y2C-AuNP and R13C/K10Y2C-AuNP. All of the nanoparticles retained the monodispersity of the original CTAB·AuNP colloid. Their stability and ODN binding ability showed distinct difference due to their different surface composition. All of the colloids were proved to be non-toxic at high concentration but further optimization is needed in the transfection efficiency. The third nanoparticle system was developed based on the ligand exchange approach. A cysteine containing lysine-rich peptide was deposited on CTAB·AuNP. Then the lysines were crosslinked by a biodegradable crosslinker, Sulfo-EGS (Ethylene glycol bis[sulfosuccinimidylsuccinate]), at various peptide/crosslinker ratio. The gold core was then removed by potassium cyanide. The resulting peptide nanoshells were about 40 nm in diameter, compare to the 15 nm diameter before the gold core was removed. Crosslinking also resulted in dramatic decrease of the ODN binding ability of the nanoparticle and the nanoshells. This approach showed great potential of making a combinatorial library of biodegradable nanostructures quickly for a broad range of applications.
Book Synopsis Gold Nanoparticles in Biomedical Applications by : Lev Dykman
Download or read book Gold Nanoparticles in Biomedical Applications written by Lev Dykman and published by CRC Press. This book was released on 2017-12-12 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.
Book Synopsis DNA-functionalized Gold Nanoparticles for Enhanced Molecular Sensing by : Stephen Randall Jackson
Download or read book DNA-functionalized Gold Nanoparticles for Enhanced Molecular Sensing written by Stephen Randall Jackson and published by . This book was released on 2014 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) by : Catherine Louis
Download or read book Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) written by Catherine Louis and published by World Scientific. This book was released on 2017-06-02 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Physics, Chemistry and Biology offers an overview of recent research into gold nanoparticles, covering their discovery, usage and contemporary practical applications.This Second Edition begins with a history of over 2000 years of the use of gold nanoparticles, with a review of the specific properties which make gold unique. Updated chapters include gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties and their future technological applications. New chapters have been included, and reveal the growing impact of plasmonics in research, with an introduction to quantum plasmonics, plasmon assisted catalysis and electro-photon conversion. The growing field of nanoparticles for health is also addressed with a study of gold nanoparticles as radiosensibiliser for radiotherapy, and of gold nanoparticle functionalisation. This new edition also considers the relevance of bimetallic nanoparticles for specific applications.World-class scientists provide the most up-to-date findings for an introduction to gold nanoparticles within the related areas of chemistry, biology, material science, optics and physics. It is perfectly suited to advanced level students and researchers looking to enhance their knowledge in the study of gold nanoparticles.
Book Synopsis Nanoparticles and their Biomedical Applications by : Ashutosh Kumar Shukla
Download or read book Nanoparticles and their Biomedical Applications written by Ashutosh Kumar Shukla and published by Springer. This book was released on 2020-03-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.
Book Synopsis DNA-functionalized Gold Nanoparticles for Chemiresistive Vapor Sensing by : Kan Fu
Download or read book DNA-functionalized Gold Nanoparticles for Chemiresistive Vapor Sensing written by Kan Fu and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gold Nanoparticles by : Mohammed Muzibur Rahman
Download or read book Gold Nanoparticles written by Mohammed Muzibur Rahman and published by BoD – Books on Demand. This book was released on 2019-02-13 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles - Reaching New Heights contains recent research on the preparation, characterization, fabrication, and potential of optical and biological applications of gold nanoparticles (AuNPs). It is promising novel research that has received a lot of interest over the last few decades. It covers advanced topics on optical, physical, medicinal, and biological applications of AuNPs. Development of green nanotechnology is generating the interest of researchers towards the synthesis of eco-friendly, safe, non-toxic applications, which can be used for manufacture at a large scale. These are simple, cost-effective, stable, enduring, and reproducible aqueous room temperature synthesis applications to obtain the self-assembly of AuNPs. This potentially unique work offers various approaches to R
Book Synopsis Probing the Cellular Uptake of DNA Functionalized Gold Nanoparticles by : Alexis Camille Wong
Download or read book Probing the Cellular Uptake of DNA Functionalized Gold Nanoparticles written by Alexis Camille Wong and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Theoretical Modeling from Functionalized Gold Nanoparticles to Repair of Lesions in DNA for Cancer Radiotherapy by : Chen Hui Chan
Download or read book Theoretical Modeling from Functionalized Gold Nanoparticles to Repair of Lesions in DNA for Cancer Radiotherapy written by Chen Hui Chan and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential of gold nanoparticles (AuNPs) to improve the performance of radiotherapy is demonstrated by numerous in vivo and in vitro experimental studies. These metallic particles increase significantly the radiosensitization effect. Upon water radiolysis, AuNPs generate reactive oxygen species that amplify DNA damage and lead to a greater destruction of cancerous cells. Nevertheless, for a more optimal therapeutic efficacy, several properties of AuNPs must be taken into account during the synthesis, such as their size, shape and surface which can tune their catalytic effects in the biological environment (mainly liquid water). These structural aspects are not yet examined in the state-of-the-art, either experimentally or theoretically. This thesis aims to rationalize the stability of AuNPs in the presence of chemical or biological environment before irradiation by using theoretical approaches. Firstly, we have modeled the stability of AuNPs in the range 1- 3.4 nm. We have then studied the behavior of these nanoparticles in a biological (hydration) and chemical (PEGylation) model environment, and the combination of the two environments. When 0.9-1.8 nm nanoclusters interact with a complete shell of water molecules, we have shown that metastable ino-decahedrons (in vacuum) are transformed into more favourable metastable icosahedrons. While in the presence of monoshell of PEG ligands, the strong Au-S bond and the hydrogen bonds between the ligands induce a significant deformation on the nanoparticle morphology, i.e. stellation of the Au54 decahedron. In addition, we have shown that PEG ligands promote the confinement of a few water molecules in the vicinity of AuNPs. Our conclusions open interesting perspectives for the theoretical modeling of water radiolysis. In parallel with these studies, we have focused on the characterization of different types of DNA lesions. Two projects have been performed: firstly, we have studied the interaction of a trilysine peptide with an oligonucleotide which could lead to the formation of DNA-polyamine cross link. Then, the second project focuses on rationalizing different repair rates of cyclobutane pyrimidine dimers in the presence of the DDB2 recognition enzyme at the atomic scale.
Book Synopsis Gold Nanostars by : Giuseppe Chirico
Download or read book Gold Nanostars written by Giuseppe Chirico and published by Springer. This book was released on 2015-08-03 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief focuses on the synthesis, functionalization techniques, optical properties and biomedical application of gold nanostars (GNS). Various facilities of gold nanostars synthesis as well as functionalization of GNS with PEG, organic dyes, bioactive compounds are discussed. The authors discuss physical origin of the Localized Surface Plasmon Resonances and the way the nano-environment affects them. The implication of the LSPR of gold nanostars surface enhanced Raman scattering is also discussed. The emphasis has been done on the application of GNS for current and emerge needs of medicine, biology and pharmacy. Moreover, properties of gold nanostars as contrast agents for in vivo imaging and interaction of GNS with cells are also discussed in this Brief.
Book Synopsis One-Dimensional Nanostructures by : Zhiming M Wang
Download or read book One-Dimensional Nanostructures written by Zhiming M Wang and published by Springer Science & Business Media. This book was released on 2008-07-20 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: One-dimensional (1D) nanostructures, including nanowires, nanotubes and quantum wires, have been regarded as the most promising building blocks for nanoscale electronic and optoelectronic devices. This book presents exciting, state-of-the-art developments in synthesis and properties of 1D nanostructures with many kinds of morphologies and compositions as well as their considerable impact on spintronics, information storage, and the design of field-effect transistors.
Download or read book Nanotechnology written by Cherry Bhargava and published by CRC Press. This book was released on 2020-10-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology: Advances and Real-Life Applications offers a comprehensive reference text about advanced concepts and applications in the field of nanotechnology. The text – written by researchers practicing in the field – presents a detailed discussion of key concepts including nanomaterials and their synthesis, fabrication and characterization of nanomaterials, carbon-based nanomaterials, nano-bio interface, and nanoelectronics. The applications of nanotechnology in the fields of renewable energy, medicine and agriculture are each covered in a dedicated chapter. The text will be invaluable for senior undergraduate and graduate students in the fields of electrical engineering, electronics engineering, nanotechnology and nanoscience. Dr. Cherry Bhargava is an Associate Professor and Head, VLSI domain, at the School of Electrical and Electronics Engineering of Lovely Professional University, Jalandhar, India. Dr. Amit Sachdeva is an Associate Professor at Lovely Professional University, Jalandhar, India.
Book Synopsis Functionalized Nanomaterials by : Vineet Kumar
Download or read book Functionalized Nanomaterials written by Vineet Kumar and published by CRC Press. This book was released on 2021-07-28 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials contain some unique properties due to their nanometric size and surface functionalization. Nanomaterial functionalization also affects their compatibility to biocompatibility and toxicity behaviors. environment and living organism. This makes functionalized nanomaterials a material with huge scope and few challenges. This book provides detailed information about the nanomaterial functionalization and their application. Recent advancements, challenges and opportunities in the preparation and applications of functionalized nanomaterials are also highlighted. This book can serve as a reference book for scientific investigators, doctoral and post-doctoral scholars; undergrad and grad. This book is very useful for multidisciplinary researchers, industry personnel’s, journalists, and policy makers. Features: Covers all aspects of Nanomaterial functionalization and its applications Describes and methods of functionalized nanomaterials synthesis for different applications Discusses the challenges, recent findings, and cutting-edge global research trends on functionalization of nanomaterials and its applications It discusses the regulatory frameworks for the safe use of functionalized nanomaterials. It contains contributions from international experts from multiple disciplines.
Book Synopsis Gold Nanoparticles by : Valerio Voliani
Download or read book Gold Nanoparticles written by Valerio Voliani and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-04-20 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticles provide a platform for the development of new and efficient diagnostic and therapeutic tools.This book offers a general guide to the synthesis and coating of gold nanoparticles. It describes the links between optical features and geometries of gold nanoparticles and provides a readily comprehensible connection in all the chapters between the geometry of gold nanoparticles and their final applications.
Book Synopsis Update on Gold Nanoparticles by : Valerio Voliani
Download or read book Update on Gold Nanoparticles written by Valerio Voliani and published by Smithers Rapra. This book was released on 2013-01-29 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, gold nanoparticles have provided a suitable platform for the development of novel and efficient diagnostic and therapeutic tools, which avoid the typical drawbacks of the old systems. They are biocompatible and they can be easily synthesised, encapsulated and functionalised with (bio)molecules. Nanoparticles produced by a wet chemistry synthesis have the geometry, which enables the complete control of their optical and physical properties. It is also possible to influence the targeting and stability/release behaviour by coating the nanoparticle surface. In this Update the reader can find in a single volume the methods used most often for the synthesis and coating of gold nanoparticles (spheres, cages, cubes, rods), the links between optical features and geometries of gold nanoparticles, and the novel applications in nanomedicine of gold nanoparticles determined by their geometry. One of the main objectives of this Update is to provide, a readily comprehensible connection in all the chapters between the geometry of gold nanoparticles and their final applications. Another target of this book is to provide information about efficient processes for the synthesis and the coating of gold nanoparticles, all of which have been directly tested by the author. This Update offers comprehensive information on the whole topic from the synthesis of the gold nanoparticles to their medical applications; this is accompanied by a complete and recent bibliography, in order to give to the readers the opportunity to research further the topics addressed in the book. In this way, students and researchers from academia and industry can have a complete picture of gold nanostructures, physicians and biologists can develop ideas and applications for the new nano-tools, and chemists can have a general guide to the synthesis of gold nanoparticles. This is a state-of-the-art guide for the synthesis and uses of gold nanoparticles.
Book Synopsis Intracellular Delivery by : Aleš Prokop
Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
Book Synopsis Inorganic Nanoprobes for Biological Sensing and Imaging by : Hedi Mattoussi
Download or read book Inorganic Nanoprobes for Biological Sensing and Imaging written by Hedi Mattoussi and published by Artech House. This book was released on 2009 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking resource offers you an up-to-date account of the pioneering activity pushing new boundaries in the emerging area of inorganic nanoprobes and their use in biology and medicine. Written and edited by leading experts in the field, this unique book places particular emphasis nanoprobes made of luminescent semiconductor nanocrystals (quantum dots or QDs) and magnetic nanoparticles (MNPs). You find an insightful discussion on the synthesis, characterization, and analysis of the unique properties of luminescent QDs and MNPs.
