Dissecting Roles Of Estrogen Receptors In Breast Cancer Lymphatic Metastasis

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Dissecting Roles of Estrogen Receptors in Breast Cancer Lymphatic Metastasis

Author : Joshua C. Harrell
Publisher :
ISBN 13 : 9780549033110
Total Pages : 175 pages
Book Rating : 4.0/5 (331 download)

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Book Synopsis Dissecting Roles of Estrogen Receptors in Breast Cancer Lymphatic Metastasis by : Joshua C. Harrell

Download or read book Dissecting Roles of Estrogen Receptors in Breast Cancer Lymphatic Metastasis written by Joshua C. Harrell and published by . This book was released on 2007 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lymphatic system is a common avenue for the spread of breast cancer cells. If primary tumors are estrogen (ER) and/or progesterone (PR) receptor positive, then the likelihood that lymph node (LN) metastases express receptors exceeds 80%. However, little is known about the role of hormones in breast cancer spread or the effects of the LN microenvironment on hormone responsiveness. We developed ER+ metastasis models using ZsGreen labeled ER+ human breast cancer cells. Tumors and metastases were tracked in living mice by fluorescent whole-body and intravital imaging. Tumor growth was estrogen dependent and required for intratumoral lymphangiogenesis. Seventy-five percent of estrogen treated tumors generate LN metastases. "Triads" of primary tumors, tumor-filled draining lymphatic vessels, and tumor-filled LNs from the same mouse showed that: (a) proliferation was higher in the LN than in the primary tumor. (b) High ER levels were extensively downregulated by estradiol in primary tumors. However, there was partial failure of ER downregulation in LNs associated with (c) reduced PR expression. (d) The hyaluronan receptor, CD44 was sparsely expressed in primary tumor cells but homogeneously overexpressed in cells transiting the lymphatics and populating LNs, suggesting that CD44 targets tumor cells for transport to LNs. To follow up on the observations that ER have reduced function in the LN microenvironment we developed a fluorescent xenograft model in which estradiol was withdrawn after the development of ER+ LN metastasis. Estradiol-withdrawal combined with laser-capture microdissection, gene expression profiling, and immunohistochemistry was used to assess estrogen responsiveness of primary tumor xenografts and matched LN metastases. Genes regulated by the tumor cell microenvironment, by hormones, or both were identified. Gene expression data confirmed the estrogen insensitivity of ER+ LN metastases. Fewer genes were estradiol regulated in breast cancer cells at the metastatic site. Interestingly, seventy-five of the genes were estradiol regulated in the opposite direction in tumors and LN metastases. We speculate that current estrogen withdrawal or antiestrogen therapies may differentially affect breast cancer cells growing within the breast and in the LNs, and that the LN microenvironment renders cancer cells relatively resistant to estrogen suppression therapies.

Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (914 download)

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Book Synopsis Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells by :

Download or read book Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogen signaling is primarily mediated by two estrogen receptors (ERs), ER[alpha] and ER[beta]. ER[alpha] is expressed in ~70% of breast cancers and is an important diagnostic and therapeutic target. Developing better treatment options and overcoming limitations of endocrine therapy depend on a detailed understanding of ER[alpha]-signaling pathways. ER[alpha], a member of the class I nuclear receptor superfamily of transcription factors, localizes mainly to the nucleus and interacts with DNA regulatory sequences either directly or through interaction with other transcription factors to regulate gene transcription. ER[alpha] is also rapidly activates signaling cascades. S-palmitoylation, a reversible lipid modification is catalyzed by palmitoyl acyl-transferases (PAT), which increase affinity of proteins to the membrane. Based on the results of previous studies, it is hypothesized that palmitoylation of ER[alpha] regulates extranuclear and nuclear signaling of ER[alpha]. We utilized palmitoylation-defective mutant ER[alpha]C447A-expressing MDA-MB-468 breast cancer cells to dissect the role of palmitoylation in a breast cancer cell line model. The substitution of ER[alpha] palmitoylation site abrogated ER[alpha] palmitoylation, membrane localization and estrogen-dependent phosphorylation of ERK1/2 in MDA-MB-468 cell line. Besides loss of E2-dependent extranuclear signaling, the substitution of palmitoylation sites led to the loss of other ER[alpha]-dependent events in ER[alpha]C447A-expressing MDA-MB-468 cells, such as decreased E2-dependent S118 phosphorylation, impaired regulation of certain target genes, and loss of estrogen-dependent cell cycle inhibition. This study thus highlights the importance of ER[alpha] palmitoylation in both nuclear and extranuclear ER signaling pathways in breast cancer cells. A better understanding of the mechanisms of estrogen action will help us to design more effective drugs affecting signal pathways depending on both membrane and nuclear receptors.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Epithelial-Mesenchymal Plasticity in Cancer Metastasis

Author : Mohit Kumar Jolly
Publisher : MDPI
ISBN 13 : 3039367242
Total Pages : 512 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Epithelial-Mesenchymal Plasticity in Cancer Metastasis by : Mohit Kumar Jolly

Download or read book Epithelial-Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.

Biomarkers in Breast Cancer

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 2160 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Adjuvant Therapy for Breast Cancer

Author : Monica Castiglione
Publisher : Springer Science & Business Media
ISBN 13 : 0387751157
Total Pages : 483 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione

Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Decision Tools for Radiation Oncology

Author : Carsten Nieder
Publisher : Springer Science & Business Media
ISBN 13 : 3642371027
Total Pages : 307 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Decision Tools for Radiation Oncology by : Carsten Nieder

Download or read book Decision Tools for Radiation Oncology written by Carsten Nieder and published by Springer Science & Business Media. This book was released on 2014-03-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: A look at the recent oncology literature or a search of the common databases reveals a steadily increasing number of nomograms and other prognostic models. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, etc. Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts, the need for approaches that achieve a favorable balance between effectiveness and side-effects, and the goal of optimal resource utilization reflecting prognostic knowledge. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.>

Surgeon's Role in Multidisciplinary Breast Management, An Issue of Surgical Clinics

Author : George M. Fuhrman
Publisher : Elsevier Health Sciences
ISBN 13 : 1455773611
Total Pages : 340 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Surgeon's Role in Multidisciplinary Breast Management, An Issue of Surgical Clinics by : George M. Fuhrman

Download or read book Surgeon's Role in Multidisciplinary Breast Management, An Issue of Surgical Clinics written by George M. Fuhrman and published by Elsevier Health Sciences. This book was released on 2013-04-28 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and important issue devoted to multidisciplinary breast management! Topics will include neoadjuvant chemotherapy, pathology of invasive breast disease, management of high risk lesions, genetic predisposition syndromes, radiation therapy, surgical management of the breast–mastectomy and breast conservation, management of the axilla, management of ductal carcinoma in situ, breast reconstruction, adjuvant therapy, screening, imaging, and image guided biopsy techniques for breast cancer, benign breast disease, and much more!

Ferri's Clinical Advisor 2015 E-Book

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
ISBN 13 : 0323084303
Total Pages : 5177 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Ferri's Clinical Advisor 2015 E-Book by : Fred F. Ferri

Download or read book Ferri's Clinical Advisor 2015 E-Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2014-07-26 with total page 5177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ferri’s Clinical Advisor 2015 is the fastest, most effective way to access current diagnostic and therapeutic information on more than 700 common medical conditions. Dr. Ferri’s popular "5 books in 1" format provides quick guidance on short QT syndrome, microscopic polyangiitis, fungal meningitis, and much more. This medical reference makes the answers you need even easier to find - anytime, anywhere. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Review normal values and interpret results for more than 200 lab tests. Improve your family healthcare practice’s efficiency with cost-effective referral and consultation guidelines. Identify and treat a broader range of disorders, including diabetic foot infections, hypergonadism, and acute liver failure, with 22 new topics in the Diseases & Disorders section. Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables. Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets, tables, boxes, and algorithms to expedite your search. Expedite insurance reimbursements with current ICD-9 and future ICD-10 insurance billing codes. Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.

Basic Radiation Oncology

Author : Murat Beyzadeoglu
Publisher : Springer Nature
ISBN 13 : 3030873080
Total Pages : 541 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Basic Radiation Oncology by : Murat Beyzadeoglu

Download or read book Basic Radiation Oncology written by Murat Beyzadeoglu and published by Springer Nature. This book was released on 2022-01-01 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, up-to-date, bedside-oriented radiation oncology book encompasses the essential aspects of the subject with coverage on radiation physics, radiobiology, and clinical radiation oncology. The first two sections examine concepts that are crucial in radiation physics and radiobiology. The third section describes radiation treatment regimens appropriate for the main cancer sites and tumor types.

From Local Invasion to Metastatic Cancer

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
ISBN 13 : 1603270876
Total Pages : 624 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis From Local Invasion to Metastatic Cancer by : Stanley P. L. Leong

Download or read book From Local Invasion to Metastatic Cancer written by Stanley P. L. Leong and published by Springer Science & Business Media. This book was released on 2009-10-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Ferri's Clinical Advisor 2016 E-Book

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
ISBN 13 : 0323378226
Total Pages : 5308 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Ferri's Clinical Advisor 2016 E-Book by : Fred F. Ferri

Download or read book Ferri's Clinical Advisor 2016 E-Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2015-05-28 with total page 5308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ferri’s Clinical Advisor 2016 is simply the fastest, most effective way to access up-to-date diagnostic and treatment information on more than 700 common medical conditions. The popular "5 books in 1" format provides quick guidance on diseases and disorders, differential diagnoses, medical algorithms, laboratory tests, and clinical practice guidelines. An easy-to-use format with cross-references, outlines, bullets, tables, boxes, and algorithms to expedite your search More than 200 lab tests help hone your skills in reviewing normal values and interpreting results Electronic access to additional algorithms, new images and tables, EBM boxes, patient teaching guides, and extra topics. Links between each section allow you to navigate easily from a selected topic to relevant associated material and back again

Diagnosing and Treating Adult Cancers and Associated Impairments

Author : National Academies Of Sciences Engineeri
Publisher : National Academies Press
ISBN 13 : 9780309684002
Total Pages : pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Diagnosing and Treating Adult Cancers and Associated Impairments by : National Academies Of Sciences Engineeri

Download or read book Diagnosing and Treating Adult Cancers and Associated Impairments written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2021-11-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer.

Early Breast Cancer

Author : Guidubaldo Querci della Rovere
Publisher : CRC Press
ISBN 13 : 1439804931
Total Pages : 1018 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Early Breast Cancer by : Guidubaldo Querci della Rovere

Download or read book Early Breast Cancer written by Guidubaldo Querci della Rovere and published by CRC Press. This book was released on 2005-11-29 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Breast Cancer presents a wide-ranging analysis of diagnosis, pathology, and multidisciplinary management of the patient presenting with early breast cancer for radiologists, pathologists, surgeons, and medical oncologists. The second edition is fully updated to include changes in perspective on such issues as screening and conservative surgery.

Author :
Publisher : Wolters Kluwer India Pvt Ltd
ISBN 13 : 9390612470
Total Pages : pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis by :

Download or read book written by and published by Wolters Kluwer India Pvt Ltd. This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Preoperative (Neoadjuvant) Chemotherapy

Author : Joseph Ragaz
Publisher : Springer Science & Business Media
ISBN 13 : 3642826717
Total Pages : 172 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Preoperative (Neoadjuvant) Chemotherapy by : Joseph Ragaz

Download or read book Preoperative (Neoadjuvant) Chemotherapy written by Joseph Ragaz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.