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Developpement Et Validation De Methodes Analytiques Pour Lanalyse De Composes Pharmaceutiques Par Electrophorese Capillaire Couplee A Un Spectrophotometre Uv Ou A Un Spectrometre De Masse
Download Developpement Et Validation De Methodes Analytiques Pour Lanalyse De Composes Pharmaceutiques Par Electrophorese Capillaire Couplee A Un Spectrophotometre Uv Ou A Un Spectrometre De Masse full books in PDF, epub, and Kindle. Read online Developpement Et Validation De Methodes Analytiques Pour Lanalyse De Composes Pharmaceutiques Par Electrophorese Capillaire Couplee A Un Spectrophotometre Uv Ou A Un Spectrometre De Masse ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Capillary Electrophoresis by : Suvardhan Kanchi
Download or read book Capillary Electrophoresis written by Suvardhan Kanchi and published by CRC Press. This book was released on 2017-08-21 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.
Book Synopsis Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics by : Reinhard H. H. Neubert
Download or read book Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics written by Reinhard H. H. Neubert and published by CRC Press. This book was released on 2003-01-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate devel
Book Synopsis Capillary Electrophoresis - Mass Spectrometry for Proteomics and Metabolomics by : Rawi Ramautar
Download or read book Capillary Electrophoresis - Mass Spectrometry for Proteomics and Metabolomics written by Rawi Ramautar and published by John Wiley & Sons. This book was released on 2022-10-03 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.
Book Synopsis Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis by : Peter Mikuš
Download or read book Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis written by Peter Mikuš and published by BoD – Books on Demand. This book was released on 2012-08-29 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
Book Synopsis Capillary Electrophoresis Methods for Pharmaceutical Analysis by : Satinder Ahuja
Download or read book Capillary Electrophoresis Methods for Pharmaceutical Analysis written by Satinder Ahuja and published by Elsevier. This book was released on 2011-08-09 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.- Provides current status and future developments in CE analysis of pharmaceuticals.- Explains how to develop and validate methods.- Includes major pharmaceutical applications including assays and impurity testing.
Book Synopsis Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics by : Reinhard H. H. Neubert
Download or read book Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics written by Reinhard H. H. Neubert and published by CRC Press. This book was released on 2003-01-14 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting. The book contains current applications and procedures to identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids, increase drug bioavailability, enhance the permeability, solubility, strength, and function of drug formulations, examine protein-protein exchanges and reactions, and calculate pKa values.
Book Synopsis Méthodes instrumentales d'analyse chimique et applications by : Gwenola Burgot
Download or read book Méthodes instrumentales d'analyse chimique et applications written by Gwenola Burgot and published by Lavoisier. This book was released on 2011-02-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioanalysis of Pharmaceuticals by : Steen Honoré Hansen
Download or read book Bioanalysis of Pharmaceuticals written by Steen Honoré Hansen and published by John Wiley & Sons. This book was released on 2015-10-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Book Synopsis Analytical Techniques in the Pharmaceutical Sciences by : Anette Müllertz
Download or read book Analytical Techniques in the Pharmaceutical Sciences written by Anette Müllertz and published by Springer. This book was released on 2016-08-30 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
Book Synopsis Capillary Electrophoresis of Proteins and Peptides by : Mark A. Strege
Download or read book Capillary Electrophoresis of Proteins and Peptides written by Mark A. Strege and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the more than 20 years that have followed the beginnings of capillary electrophoresis (CE), its application to the analysis of proteins and peptides has continued to be reliable, versatile, and productive. Over time, CE has matured to become a superb complement to HLPC, and in many cases has also evolved as an automated and quantitative replacement for conventional slab gel electrophoresis methods such as SDS-PAGE and isoelectric focusing. Within Capillary Electrophoresis of Proteins and Peptides, we have assembled contributions from researchers who are applying state-of-the-art CE for protein and peptide analysis, including topics that we believe are of great potential both in the present and for the future. In comparison to traditional separation methods, CE represents a miniaturized analysis technique (especially in its microchip-based format) that is highly dependent upon the basic fundamentals of effective sample recovery and high sensitivity detection. With these issues in mind, Chapters 1–4 describe recently developed approaches for both capillary coatings and analyte detection via laser-induced fluorescence. Since the discipline of biotechnology has established itself as a primary platform for the application of CE to the analysis of proteins and peptides, Chapters 5–7 demonstrate a variety of examples of the specific techniques that have been applied for the development of biopharmaceuticals and their commercialization. The methods covered here include also the analysis of oligosaccharides from glycoproteins.
Book Synopsis Analyse chimique by : Francis Rouessac
Download or read book Analyse chimique written by Francis Rouessac and published by . This book was released on 2009-06-03 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ce livre s'adresse à un large public d'étudiants en Licences de Sciences de la Matière ou de Sciences de la Vie, en pharmacie, ainsi qu'en IUT. Il offre un panorama détaillé des méthodes d'analyse présentes dans des secteurs aussi variés que les industries chimiques, agroalimentaires, les laboratoires d'analyse médicale, les sciences de l'environnement. Le principe de ce cours est de relier les aspects pratiques de chaque méthode étudiée aux notions scientifiques qui l'expliquent. Abondamment illustré par plus de 300 figures et photos originales, ce livre est organisé en trois sections : les méthodes séparatives (les différentes techniques de chromatographie et d'électrophorèse), les méthodes spectrométriques (UV, IR et Raman, fluorimétrie, fluorescence X, absorption et émission atomique, RMN), et les autres méthodes (spectrométrie de masse, analyses isotopiques et méthodes de marquage, analyseurs spécifiques, électrochimie). Dans cette nouvelle édition, le cours a été entièrement mis à jour pour tenir compte des progrès technologiques les plus récents (chromatographies, spectrométries, RMN...). Des exercices corrigés ont également été ajoutés.
Book Synopsis Pharmaceutical Analysis E-Book by : David G. Watson
Download or read book Pharmaceutical Analysis E-Book written by David G. Watson and published by Elsevier Health Sciences. This book was released on 2020-06-10 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of analyses, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals.The mathematics involved is notoriously difficult, but this much-praised and well established textbook, now revised and updated for its fifth edition, guides a student through the complexities with clear writing and the author's expertise from many years' teaching pharmacy students. Worked calculation examples and self-assessment test questions aid continuous learning reinforcement throughout Frequent use of figures and diagrams clarify points made in the text Practical examples are used to show the application of techniques Key points boxes summarise the need to know information for each topic Focuses on the most relevant and frequently used techniques within the field
Download or read book Analyse chimique written by Daniel Cruché and published by . This book was released on 2019-07-10 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cet ouvrage offre un panorama détaillé des méthodes d'analyse présentes dans des secteurs aussi variés que les industries chimiques ou agroalimentaires, les laboratoires d'analyses médicales, les sciences de l'environnement. Les aspects pratiques de chaque méthode sont associés aux notions scientifiques qui l'expliquent. Des exercices corrigés complètent chaque chapitre. Cette nouvelle édition entièrement actualisée tient compte des avancées technologiques les plus récentes. Des compléments sur les paramètres statistiques de base et les normes à connaître sont disponibles sur le site dunod. com.
Book Synopsis Capillary Electrophoresis by : Heinz Engelhardt
Download or read book Capillary Electrophoresis written by Heinz Engelhardt and published by Springer. This book was released on 2012-06-12 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE), also designated by the acronym HPCE for "High Per formance Capillary Electrophoresis" is a rapidly growing analytical separation method. It unites the separation technique of classical electrophoresis on plates with the instrumental methods of chromatography with respect to direct detection of the solutes separated in the capillary and their ready identification and quantification. The initial problems of inadequate reproducibility in quantitative analysis, due to the necessity of handling extremely small volumes, have largely been solved in the sec ond generation commercial instruments. Hence, a rapid and reliable separation sys tem is available for ionic compounds from the smallest cation (the lithium ion) up to poly anions with molecular weights ranging in the millions (such as DNA molecules). The methods of gel electrophoresis and isoelectric focusing can be readily extended to separation techniques carried out in a capillary. For nonionic compounds an addi tional separation method is available in the form of micellar electrokinetic chroma tography (MEKC). This involves a true chromatographic separation process because the distribution of the analytes between the buffer and the micelles is superimposed on the electrophoretic migration, which contributes substantially to the selectivity.
Book Synopsis Capillary Electrophoresis in the Life Sciences by : Ante M. Krstulović
Download or read book Capillary Electrophoresis in the Life Sciences written by Ante M. Krstulović and published by Elsevier Science & Technology. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-performance capillary electrophoresis (CE) is at present widely considered as the most important milestone in the field of separation science of the last decade. The current developments in modern biology and medicine necessitate high-resolution microtechniques for the analysis of large biological molecules. Due to its high resolving power, high speed of analysis and low cost operation, CE has been extensively used in the analysis of proteins, peptides, oligonucleotides, DNA, DNA sequencing of genomic material, double-stranded DNA fragments in mutational analysis, restriction fragment mapping, etc. Its hybrids with liquid chromatography, such as micellar electrokinetic capillary chromatography and capillary electrochromatography have extended the use to relatively small organic molecules encountered in pharmaceutical, environmental, forensic and clinical analysis, as well as combinatorial chemistry and fundamental research, where its role has been complimentary to that of the well established HPLC techniques. Because of the dramatic decrease in sample volume (nanoliters and picoliters) even the analysis of single cell contents has been made possible. In order to overcome the problem of low sensitivity, on-line preconcentration techniques (isotachophoretic) sample stacking, electrochromatographic, affinity, microchips, etc.), as well as laser-induced fluorescence and various mass spectrometric techniques have been used. While the use of CE in the area of biomolecular separations is now well-established, its usefulness as an orthogonal technique with respect to HPLC in the analysis of small molecules is yet to be developed. It is hoped that the selected papers of this volume will illustrate further the tremendous potential of CE in the life sciences.
Book Synopsis Analyse chimique by : Francis Rouessac
Download or read book Analyse chimique written by Francis Rouessac and published by Elsevier Masson. This book was released on 1997-01-01 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le principe adopté est de relier les aspects pratiques de chaque méthode étudiée aux notions scientifiques qui l'expliquent. L'ouvrage est divisé en trois sections : Les méthodes séparatives (chromatographie et électrophorèse), Les méthodes d'analyse spectrales (RMN, IR, UV, fluorimétrie, fluorescence X, absorption et émission atomique), les autres méthodes (spectrométrie de masse, méthodes avec marquage, électro-chimie)
Book Synopsis Bioanalysis of Pharmaceuticals by : Steen Honor? Hansen
Download or read book Bioanalysis of Pharmaceuticals written by Steen Honor? Hansen and published by Wiley. This book was released on 2015-06-25 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
