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Development Of Novel Imaging Tools For Selected Biomedical Applications
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Book Synopsis Development of Novel Imaging Tools for Selected Biomedical Applications by : Omar E. Olarte
Download or read book Development of Novel Imaging Tools for Selected Biomedical Applications written by Omar E. Olarte and published by . This book was released on 2014 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the quest for better and faster images of cellular and subcellular structures, biology-oriented optical microscopes have advanced significantly in the last few decades. Novel microscopy techniques such as non-linear microscopy (NLM), including two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) microscopy, and light-sheet fluorescence microscopy (LSFM) are emerging as alternatives that overcome some the intrinsic limitations of standard microscopy systems. In this thesis I aimed to advance such techniques even more, and combine them with other photonic technologies to provide novel tools that would help to address complex biological questions. This thesis is organized in two main parts. The first part is dedicated to applications involving femtosecond lasers that are employed for precise microsurgery. For that, damage assessment methodologies based on NLM were developed and tested in relevant biomedical models. In the second part, wavefront engineering methods were employed to enhance the imaging capabilities of light-sheet microscopy systems. These novel methodologies were tested as well in relevant biological applications. This thesis is, therefore, organized as follows: In chapter 1, a brief and comprehensive review of the basic microscopy techniques employed in this thesis is presented, together with the challenges and achievements of this thesis in sequential order. In chapter 2, a multimodal imaging methodology for the assessment of laser induced collateral damage is presented. This was specifically developed for the control of the damage in femtosecond-laser dissection of single axons within a living Caenorhabditis elegans (C. elegans). Here, it is shown that collateral damages at the level of the myosin structure of the muscles adjacent to the axon, can be readily detected. In chapter 3, the optimized multimodal methodology developed in the chapter 2 was employed for minimally invasive dissection of axons of D-type motoneurons in C elegans. Here, a microfluidic chip for C elegans immobilization and a detailed protocol was employed to evaluate the axon regeneration of such neurons. The potential of such platform for testing drugs with regeneration-enhancing capabilities is also presented. In chapter 4, a novel use of TPEF microscopy is presented to characterize and fine tune the laser for photodisruption of excised human crystalline lens samples. In chapter 5, a thorough description of the implementation of a multimodal Digital Scanned Light-Sheet Microscope (DSLM) able to work in the linear and nonlinear regimes under either Gaussian or Bessel beam excitation schemes, is presented. The enhanced capabilities of the developed system is evaluated using in vivo C. elegans samples and multicellular tumor spheroids In chapter 6, the development of a completely new concept in light sheet-based imaging is presented. This is based on the extension of the depth-of-field of the lens in the emission path of the microscope by using wavefront coding (WFC) techniques. Furthermore, I demonstrate the application of the developed methodology for fast volumetric imaging of living biological specimens and 3D particle tracking.
Book Synopsis Medical Imaging Informatics by : Alex A.T. Bui
Download or read book Medical Imaging Informatics written by Alex A.T. Bui and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.
Book Synopsis Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition) by : Markus Rudin
Download or read book Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition) written by Markus Rudin and published by World Scientific. This book was released on 2013-07-04 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.
Book Synopsis Nanoparticles in Biomedical Imaging by : Jeff W.M. Bulte
Download or read book Nanoparticles in Biomedical Imaging written by Jeff W.M. Bulte and published by Springer Science & Business Media. This book was released on 2007-11-22 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.
Book Synopsis Development of Novel Optics and Analysis Tools for Enhancing Biomedical Imaging by Coherent Raman Scattering by : Christian Pilger
Download or read book Development of Novel Optics and Analysis Tools for Enhancing Biomedical Imaging by Coherent Raman Scattering written by Christian Pilger and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Biomedical Image Analysis by : David Wilson
Download or read book Handbook of Biomedical Image Analysis written by David Wilson and published by Springer Science & Business Media. This book was released on 2007-04-25 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our goal is to develop automated methods for the segmentation of thr- dimensional biomedical images. Here, we describe the segmentation of c- focal microscopy images of bee brains (20 individuals) by registration to one or several atlas images. Registration is performed by a highly parallel imp- mentation of an entropy-based nonrigid registration algorithm using B-spline transformations. We present and evaluate different methods to solve the cor- spondence problem in atlas based registration. An image can be segmented by registering it to an individual atlas, an average atlas, or multiple atlases. When registering to multiple atlases, combining the individual segmentations into a ?nalsegmentationcanbeachievedbyatlasselection,ormulticlassi?erdecision fusion. Wedescribeallthesemethodsandevaluatethesegmentationaccuracies that they achieve by performing experiments with electronic phantoms as well as by comparing their outputs to a manual gold standard. The present work is focused on the mathematical and computational t- ory behind a technique for deformable image registration termed Hyperelastic Warping, and demonstration of the technique via applications in image regist- tion and strain measurement. The approach combines well-established prin- ples of nonlinear continuum mechanics with forces derived directly from thr- dimensional image data to achieve registration. The general approach does not require the de?nition of landmarks, ?ducials, or surfaces, although it can - commodate these if available. Representative problems demonstrate the robust and ?exible nature of the approach. Three-dimensional registration methods are introduced for registering MRI volumes of the pelvis and prostate. The chapter ?rst reviews the applications, xi xii Preface challenges, and previous methods of image registration in the prostate.
Book Synopsis Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications by : Exarchos, Themis P.
Download or read book Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications written by Exarchos, Themis P. and published by IGI Global. This book was released on 2009-04-30 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book includes state-of-the-art methodologies that introduce biomedical imaging in decision support systems and their applications in clinical practice"--Provided by publisher.
Book Synopsis Biomedical Imaging Instrumentation by : Mrutyunjay Suar
Download or read book Biomedical Imaging Instrumentation written by Mrutyunjay Suar and published by Academic Press. This book was released on 2021-11-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Imaging Instrumentation: Applications in Tissue, Cellular and Molecular Diagnostics provides foundational information about imaging modalities, reconstruction and processing, and their applications. The book provides insights into the fundamental of the important techniques in the biomedical imaging field and also discusses the various applications in the area of human health. Each chapter summarizes the overview of the technique, the various applications, and the challenges and recent innovations occurring to further improve the technique. Chapters include Biomedical Techniques in Cellular and Molecular Diagnostics, The Role of CT Scan in Medical and Dental Imaging, Ultrasonography - Technology & Applications in Clinical Radiology, Magnetic Resonance Imaging, Instrumentation and Utilization of PET-CT Scan in Oncology, Gamma Camera and SPECT, Sentinel of Breast Cancer Screening; Hyperspectral Imaging; PA Imaging; NIR Spectroscopy, and The Advances in Optical Microscopy and its Applications in Biomedical Research. This book is ideal for supporting learning, and is a key resource for students and early career researchers in fields such as medical imaging and biomedical instrumentation. A basic, fundamental, easy to understand introduction to medical imaging techniques Each technique is accompanied with detailed discussion on the application in the biomedical field in an accessible and easy to understand way Provides insights into the limitations of each technology and innovations that are occurring related to that technology
Book Synopsis 4D Imaging to 4D Printing by : Rupinder Singh
Download or read book 4D Imaging to 4D Printing written by Rupinder Singh and published by CRC Press. This book was released on 2022-12-30 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on applications of 4D imaging and 4D printing for development of low-cost, indigenous lab-scale solutions for various biomedical applications. It is based on a selection of benchmark open-source 4D imaging solutions including the effect of different stimulus (such as light, electric field, magnetic field, mechanical load, thermal, hydro, and so forth) to better understand 4D capabilities of printed components. The material is covered across nine chapters dedicated to 4D imaging, 4D printing, and their specific biomedical applications illustrated via case studies related to orthopaedic and dental requirements of veterinary patients. The book: •Presents exclusive material on the integration of 4D imaging and 4D printing •Demonstrates the industrial applications of 4D imaging in 4D printing using multiple case studies •Discusses use of open-source 4D imaging tools for biomedical applications •Includes in-house development of smart materials for 4D printing •Reviews low-cost, indigenous lab-scale solutions for various veterinary applications. This book is aimed at graduate students and researchers in Additive Manufacturing, Manufacturing Engineering, Production Engineering, Mechanical Engineering, and Materials Engineering.
Book Synopsis Biomedical Imaging by : Reiner Salzer
Download or read book Biomedical Imaging written by Reiner Salzer and published by John Wiley & Sons. This book was released on 2012-04-11 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may mean fewer animal lab tests and clinical trials.
Book Synopsis Biomedical Imaging by : Karen M. Mudry
Download or read book Biomedical Imaging written by Karen M. Mudry and published by CRC Press. This book was released on 2003-03-26 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprised of chapters carefully selected from CRC‘s best-selling engineering handbooks, volumes in the Principles and Applications in Engineering series provide convenient, economical references sharply focused on particular engineering topics and subspecialties. Culled from the Biomedical Engineering Handbook, Biomedical Imaging
Author :Thomas Martin Deserno Publisher :Springer Science & Business Media ISBN 13 :3642158161 Total Pages :617 pages Book Rating :4.6/5 (421 download)
Book Synopsis Biomedical Image Processing by : Thomas Martin Deserno
Download or read book Biomedical Image Processing written by Thomas Martin Deserno and published by Springer Science & Business Media. This book was released on 2011-03-01 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: In modern medicine, imaging is the most effective tool for diagnostics, treatment planning and therapy. Almost all modalities have went to directly digital acquisition techniques and processing of this image data have become an important option for health care in future. This book is written by a team of internationally recognized experts from all over the world. It provides a brief but complete overview on medical image processing and analysis highlighting recent advances that have been made in academics. Color figures are used extensively to illustrate the methods and help the reader to understand the complex topics.
Book Synopsis Design, Development, and Validation of a Novel Optical Imaging Device for Biomedical Applications by : Ashley Christine Dacy
Download or read book Design, Development, and Validation of a Novel Optical Imaging Device for Biomedical Applications written by Ashley Christine Dacy and published by . This book was released on 2022 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a lack of imaging devices in research and commercially available that are capable of these imaging modalities in large animal applications. This work describes the progressive development of several optical imaging devices to fill this void, culminating in a final design with robust fluorescence and luminescence functionality designed for large animal and human applications. These devices are used to gather new data about various physical parameters in small and large animal models. First, a portable imager developed for real-time imaging of cutaneous wounds in research settings is described. The device is demonstrated to have competitive performance with a commercial animal imaging enclosure box setup in beam uniformity and sensitivity. Specifically, the device was used to visualize the bioluminescence associated with increased reactive oxygen species (ROS) activity during the wound healing process in a cutaneous wound inflammation model. In addition, this device was employed to observe the fluorescence associated with the activity of matrix metalloproteinases (MMPs) in a mouse lipopolysaccharide (LPS)-induced infection model. Our results support the use of the portable imager design as a non-invasive and real-time imaging tool to assess the extent of wound inflammation and infection. The second component of this work details the development and characterization of a portable luminescence imaging device for detecting inflammatory responses and infection in skin wounds. This imager was used to quantify in real time the extent of 2D reactive oxygen species (ROS) activity distribution using a porcine wound infection model. The imager was used to successfully visualize ROS-associated luminescent activities in vitro and in vivo. Using a pig full-thickness cutaneous wound model, the luminescence imager was further demonstrated to be capable of detecting the change of ROS activities and their relationship with vasculature in the wound environment. Finally, by analyzing ROS intensity and distribution, an imaging method was developed to distinguish infected from uninfected wounds. These results demonstrate the potential discovery of a distinct ROS pattern between bacteria-infected and control wounds corresponding to the microvasculature. The final piece of this work describes the design, manufacture, and testing of several fluorescence imagers improving on the design developed in the first part of this work, as well as the development of a penultimate combination fluorescence/luminescence imaging device. This device is compared against a robust industry-standard device and found to be suitable for large animal and potential clinical applications.
Book Synopsis Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) by : Markus Rudin
Download or read book Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) written by Markus Rudin and published by World Scientific. This book was released on 2020-04-04 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.
Book Synopsis Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by : Manju Rawat Singh
Download or read book Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents written by Manju Rawat Singh and published by Academic Press. This book was released on 2020-04-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives
Book Synopsis Biomedical Image Processing and Classification by : Luca Mesin
Download or read book Biomedical Image Processing and Classification written by Luca Mesin and published by MDPI. This book was released on 2021-05-26 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical image processing is an interdisciplinary field involving a variety of disciplines, e.g., electronics, computer science, physics, mathematics, physiology, and medicine. Several imaging techniques have been developed, providing many approaches to the study of the human body. Biomedical image processing is finding an increasing number of important applications in, for example, the study of the internal structure or function of an organ and the diagnosis or treatment of a disease. If associated with classification methods, it can support the development of computer-aided diagnosis (CAD) systems, which could help medical doctors in refining their clinical picture.
Book Synopsis Technological Innovation by : Annetine C. Gelijns
Download or read book Technological Innovation written by Annetine C. Gelijns and published by National Academies. This book was released on 1989 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
