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Author : Junwei Zhang
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (971 download)
Download or read book Development of Biodegradable Polymers for Efficient and Safe Gene Delivery written by Junwei Zhang and published by . This book was released on 2016 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nashid Farhan
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.:/5 (89 download)
Download or read book Development and Characterization of Biodegradable Polymeric Nanoparticles for Gene Delivery written by Nashid Farhan and published by . This book was released on 2012 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy offers the hope to alleviate the diseases for which there is no permanent cure including genetic disorders, HIV, and cancer. The nucleic acids cannot transfect the cells by themselves as the degradation occurs before they reach the nucleus. Viral vectors initially showed the promise to deliver the nucleic acids inside the cells; however, due to toxicity associated with the viral vectors, emphasis has been given to develop non-viral vectors. Nanoparticles synthesized from the biodegradable polymers such as PLGA, PLA, Chitosan hold the promise as a safe and efficient vector for gene delivery. This research project aims to develop a biodegradable non-viral polymericnanoparticle vehicle for efficient delivery of gene. We investigated the possibility of developing novel PLGA nanoparticles for gene delivery. One of the most common methods for entrapping genetic materials in the PLGA nanoparticles is the double emulsion solvent evaporation method. We have investigated various parameters of this method to establish an optimum formulation with high entrapment efficiency, small particle size, and sustained release of DNA. We found that at least 2% PVA is needed to synthesize monodispersed particles with a size below 300nm. Moreover, sonication time also plays a vital role in particle size and polydispersity. The entrapment of DNA was found to be largely dependent on the nature of organic solvent used in the double emulsion, with more hydrophobic solvent such as chloroform being most efficient to entrap water soluble genes. The in vitro release was, however, slower with more hydrophobic solvents. Similar trend was found with the molecular weight of PLGA. When the molecular weight was higher, it resulted in more entrapment and slower release. Furthermore, cations, such as calcium, can significantly improve the entrapment of genes inside the PLGA nanoparticles. To improve the release profile of the PLGA nanoparticles, we further introduced chitosan to condense DNA inside the PLGA core. We hypothesized that reducing the amount of PLGA in the nanoparticles would improve the release profile and at the same time, chitosan would hinder the escape of DNA from the PLGA core. Usage of chitosan in such formulation would compensate for the DNA loss associated with the reduction of the amount of PLGA. In concordance with other studies, we observed that a DNA- to- chitosan ratio of 1:2 is required to achieve complete condensation. The in vitro release profile of these particles, however, indicated that the chitosan-DNA complex was not inside the PLGA nanoparticles. This has led us to introduce a cholesterol group to the chitosan to anchor the chitosan-DNA complex inside the PLGA nanoparticle. The Chitosan-Cholesterol-PLGA nanoparticles showed superior release profile than the PLGA nanoparticles while maintaining high entrapment efficiency. Moreover, in our preliminary in vitro transfection study, these particles were able to transfect HaCaT cells.
Author : Yiyun Cheng
Publisher : Springer
ISBN 13 : 3319778668
Total Pages : 361 pages
Book Rating : 4.3/5 (197 download)
Download or read book Polymeric Gene Delivery Systems written by Yiyun Cheng and published by Springer. This book was released on 2018-09-04 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Mansoor M. Amiji
Publisher : CRC Press
ISBN 13 : 9780849319341
Total Pages : 704 pages
Book Rating : 4.3/5 (193 download)
Download or read book Polymeric Gene Delivery written by Mansoor M. Amiji and published by CRC Press. This book was released on 2004-09-29 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry, and limited scale of industrial production. Polymeric Gene Delivery: Principles and Applications is the first comprehensive book to specifically address polymeric gene delivery systems. Uniting the expertise of international academic and industrial scientists who are working in the area of polymeric vectors for gene delivery, it is written by prominent researchers directly involved in this field. The book is divided into five sections that deal with challenges and opportunities in gene delivery and the efficient delivery of genes into somatic cells using polymeric vectors. The authors discuss using biodegradable polymers, condensing and non-condensing polymeric systems, microspheres and nanospheres, and designing specialized delivery systems based on targeting strategies. Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers. This book is an up-to-date guide for researchers in the field and those interested in entering this dynamic field.
Author : Abraham J. Domb
Publisher : John Wiley & Sons
ISBN 13 : 1118015800
Total Pages : 594 pages
Book Rating : 4.1/5 (18 download)
Download or read book Biodegradable Polymers in Clinical Use and Clinical Development written by Abraham J. Domb and published by John Wiley & Sons. This book was released on 2011-05-12 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.
Author : Chih-Kuang Chen
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (9 download)
Download or read book Biodegradable Polymeric Materials for Gene and Drug Delivery written by Chih-Kuang Chen and published by . This book was released on 2013 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, gene therapy has been recognized as a powerful tool in cancer treatment as the genetic links to tumor growth have been identified and studied. For instance, small interfering RNAs (siRNAs) can induce down-regulation and knockdown expression of mutated genes and overexpressed proteins, respectively; as a result, RNA interference (RNAi) using siRNAs as therapeutic gene materials has been developed. Unfortunately, therapeutic genes are poorly internalized and are susceptible to degradation by ubiquitous nucleases, and there is serious biosafety concern on viral vectors. Thus, the development of safe and efficient non-viral gene therapy vectors addressing the aforementioned delivery problems is of high importance. Based on the practical needs of non-viral vectors, well-defined tertiary amine-functionalized cationic polylactides (CPLAs) were synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide (APLA).^They were further utilized for the delivery of interleukin-8 (IL-8) siRNA to prostate cancer cells (PC3 cells), via the formation of CPLA-IL-8 siRNA nanocomplexes by electrostatic interaction. The CPLAs possess high hydrolytic degradability and low cytotoxicity. The CPLA-IL-8 siRNA nanocomplexes are readily taken up by PC3 cells, resulting in statistically significant IL-8 gene silencing. It was determined that the degradability, as well as transfection efficiency of CPLAs, positively correlate with the amine mol% of CPLAs. In addition to siRNA delivery, CPLAs were successfully used to deliver plasmid DNA (pDNA) to two physiological distinct cell lines (macrophage and fibroblast) via the formation of CPLA/pDNA nanocomplexes. Biophysical characterization of charge densities at various CPLA/pDNA weight ratios revealed a positive correlation between surface charge and gene delivery. To be more relevant for clinical applications, well-defined poly(ethylene glycol)-block-cationic polylactides (PEG-b-CPLAs) functionalized with tertiary amine-based cationic groups were synthesized by thiol-ene functionalization of a PEG-b-APLA. Subsequently, the application of PEG-b-CPLAs as biodegradable vectors for the pDNA delivery was investigated. Via the formation of PEG-b-CPLA/pDNA nanocomplexes by spontaneous electrostatic interaction, pDNAs encoding luciferase or enhanced green fluorescent protein were successfully delivered to four physiologically distinct cell lines (including macrophage, fibroblast, epithelial, and stem cell). Biophysical characterization of charge densities of nanocomplexes at various polymer:pDNA weight ratios revealed a positive correlation between surface charge and gene delivery. With PEG shielding layers, these nanocomplexes exhibited much higher serum resistance as compared to positive controls using an in vitro serum gene delivery inhibition assay. Recently, the simultaneous delivery of small molecular drug with gene via a single platform has emerged as a novel strategy to combat cancer diseases. Cross-linked biodegradable CPLA nanocapasules (CPLA NCs) were synthesized by miniemulsion interfacial thiol-ene cross-linking of CPLA. CPLA NCs exhibit high hydrolytic degradability without noticeable cytotoxicity. With size ranging from 20 to 50 nm, these NCs can avoid fast clearance in a mouse model. Multidrug resistance (MDR) by cancer cells remains a major challenge in chemotherapy, in which P-glycoprotein (Pgp) plays a key role by enhanced efflux of anticancer drug. Through the encapusulation by NCs, Doxorubicin (Dox) can successfully bypass Pgp-mediated efflux pump, thereby resulting in increased intracellular drug concentration and enhanced therapeutic efficacy. Relative to free Dox, Dox-loaded CPLA NCs exhibited a significantly enhanced anti-proliferation effect in MCF7/ADR cells (a stable MDR model). Additionally, these NCs can in situ encapsulate Dox with inner cavities and bind IL-8 siRNA with cationic shells, thereby enabling the codelivery of drugs with genes. In vitro studies showed that the NCs loaded with Dox, IL-8 siRNA and both agents can be readily taken up by PC3 prostate cancer cells, resulting in significant chemotherapeutic effect and/or IL-8 gene silencing. In addition to CPLA-based nanocapsules, we are interested in synthesizing chitosan-based NCs due to the low synthetic cost and facile preparation procedures. Well-defined chitosan nanocapsules (CSNCs) with tunable sizes were synthesized through interfacial cross-linking of N-maleoyl-functionalized chitosan (MCS) in miniemulsions, and their application in the delivery of Dox was investigated. Thiol-ene interfacial cross-linking was conducted in oil-in-water miniemulsions at room temperature under UV irradiation for 1 h, using MCS as both surfactant and precursor polymer, 1,4-butanediol bis(3-mercapto-propionate) as cross-linker and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as co-surfactant. With the increase of co-surfactant concentration in the reaction systems, the sizes of the resulting CSNCs decreased steadily. Dox-loaded CSNCs were readily prepared by in situ encapsulation of Dox during miniemulsion cross-linking. With acid-labile β-thiopropionate cross-linkages, the Dox-loaded CSNCs demonstrated faster Dox release rate under acidic conditions. Relative to free Dox, Dox-loaded CSNCs exhibited enhanced cytotoxicity towards MCF-7 breast cancer cells while the empty CSNCs did not show noticeable cytotoxicity. Effective delivery of Dox into the cancer cells via Dox-loaded CSNCs was also observed. Overall, the results suggest promising potential applications of these novel CSNCs as nanoscopic scaffolds for therapeutic delivery.
Author : Mansoor M. Amiji
Publisher : CRC Press
ISBN 13 : 0203500474
Total Pages : 707 pages
Book Rating : 4.2/5 (35 download)
Download or read book Polymeric Gene Delivery written by Mansoor M. Amiji and published by CRC Press. This book was released on 2004-09-29 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry
Author : Iuliana Stoica
Publisher : CRC Press
ISBN 13 : 1000345653
Total Pages : 592 pages
Book Rating : 4.0/5 (3 download)
Download or read book Applications of Biodegradable and Bio-Based Polymers for Human Health and a Cleaner Environment written by Iuliana Stoica and published by CRC Press. This book was released on 2021-12-23 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world faces significant challenges as the population and consumption continue to grow while nonrenewable fossil fuels and other raw materials are depleted at ever-increasing rates. This informative volume provides a technical approach to address these issues using green design and analysis. It takes an interdisciplinary look at concepts that can be applied across engineering disciplines in the development of products, processes, and systems to minimize environmental impacts across all life cycle phases. Topics include polymers for pollutant removal, wood-based biopolymers, bio-based polymers for drug formulations, biomaterial-based medical implants, biodegradabilty of biopolymer materials, bio-based polymers for food packaging applications, biodegradable polymers for tissue engineering applications, and more.
Author : Sanjay K Sharma
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733457
Total Pages : 501 pages
Book Rating : 4.8/5 (497 download)
Download or read book A Handbook of Applied Biopolymer Technology written by Sanjay K Sharma and published by Royal Society of Chemistry. This book was released on 2011-06-20 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists are conducting active research in different fields of engineering, science and technology by adopting the Green Chemistry Principles and methodologies to devise new processes, with a view to help protect and ultimately save the environment from further anthropogenic interruptions and damage. With this in mind, the book provides an up-to-date, coherently written and objectively presented set of chapters from eminent international researchers who are actively involved in academic and technological research in the synthesis, (bio)degradation, testing and applications of biodegradable polymers and biopolymers. This pool of the latest ideas, recent research and technological progress, together with a high level of thinking with a comprehensive perspective, makes the emerging field of biodegradable polymer science and engineering (or bio-based polymers) linked to environmental sustainability, the essence of this key publication. The handbook consists of chapters written and contributed by international experts from academia who are world leaders in research and technology in sustainability and biopolymer and biodegradable polymer synthesis, characterisation, testing and use. The book highlights the following areas: green polymers; biopolymers and bionanocomposites; biodegradable and injectable polymers; biodegradable polyesters; synthesis and physical properties; discovery and characterization of biopolymers; degradable bioelastomers, lactic acid based biodegradable polymers; enzymatic degradation of biodegradable polymers; biodegradation of polymers in the composting environment; recent development in biodegradable polymers; research and applications and biodegradable foams. The book is aimed at technical, research-orientated and marketing people in industry, universities and institutions. It will also be of value to the worldwide public interested in sustainability issues and biopolymer development as well as others interested in the practical means that are being used to reduce the environmental impacts of chemical processes and products, to further eco-efficiency, and to advance the utilization of renewable resources for a bio-based production and supplier chain. Readers will gain a comprehensive and consolidated overview of the immense potential and ongoing research in bio-based and biodegradable polymer science, engineering and technology to make the world greener.
Author : Wing T. Shum
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (776 download)
Download or read book The Effects of PVP(FE(III)) Catalyst and Polymer Molecular Weight on Gene Delivery Via Biodegradable Crosslinked Polyethylenimine written by Wing T. Shum and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Human gene therapy has faced many setbacks due to the immunogenicity and oncogenity of viruses. Safe and efficient alternative gene delivery vehicles are needed to implement gene therapy in clinical practice. Polymeric vectors are an attractive option due to their availability, simple chemistry, and low toxicity and immunogenicity. Our group has previously reported biodegradable polyethylenimines (PEI) that show high transfection efficiency and low toxicity by cross-linking 800 Da PEI with diacrylate cross-linkers using Michael addition. However, the synthesis was difficult to control, inconsistent, and resulted in polymers with a narrow range of molecular weights. In the present work, we utilized a heterogenous PVP(Fe(III)) catalyst to provide a more controllable PEI crosslinking reaction and wider range of biodegradable PEIs. The biodegradable PEIs reported here have molecular weights ranging from 1.2 kDa to 48 kDa, are nontoxic in MDA-MB-231 cells, and show low toxicity in HeLa cells. At their respective optimal polymer:DNA ratios, these biodegradable PEIs demonstrated about 2-5-fold higher transfection efficiency and 2-7-fold higher cellular uptake, compared unmodified 25 kDa PEI. The biodegradable PEIs show similar DNA condensation properties as unmodified PEI but more readily unpackage DNA, based on ethidium bromide exclusion and heparan sulfate competitive displacement assays, which could contribute to their improved transfection efficiency. Overall, the synthesis reported here provides a more robust, controlled reaction to produce cross-linked biodegradable PEIs that show enhanced gene delivery, low toxicity, and high cellular uptake and can potentially be used for future in vivo studies.
Author : Abraham J. Domb
Publisher : CRC Press
ISBN 13 : 9781420049367
Total Pages : 548 pages
Book Rating : 4.0/5 (493 download)
Download or read book Handbook of Biodegradable Polymers written by Abraham J. Domb and published by CRC Press. This book was released on 1998-02-04 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biodegradable Polymers, the seventh volume in the Drug Delivery and Targeting book series, provides a source manual for synthetic procedures, properties and applications of bioerodible polymers. The authors describe widely available materials such as polyactides, collagen and gelatin, as well as polymers of emerging importance, such as the genetically-engineered and elastin-based polymers which are either proprietary or in early stages of development. Section I addresses synthetic absorbable polymers, and Section 2 profiles natural, semi-synthetic and biosynthetic polymers. Section 3 discusses the surface characterization of degradable polymers, the modeling of biodegradation and non-medical polymers. This book is ideal for researchers from academia and industry as well as chemists, pharmacists and physicians who deal with biopolymers, drug delivery and targeting, bioengineering and implantable devices.
Author : Andreas Lendlein
Publisher : John Wiley & Sons
ISBN 13 : 3527324410
Total Pages : 65 pages
Book Rating : 4.5/5 (273 download)
Download or read book Handbook of Biodegradable Polymers written by Andreas Lendlein and published by John Wiley & Sons. This book was released on 2011-08-15 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.
Author : Shakeel Ahmed
Publisher : CRC Press
ISBN 13 : 1003846610
Total Pages : 672 pages
Book Rating : 4.0/5 (38 download)
Download or read book Handbook of Biodegradable Polymers written by Shakeel Ahmed and published by CRC Press. This book was released on 2024-08-02 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and authoritative review of the recent developments and advances in biodegradable polymers and their biomedical applications. Following an interdisciplinary approach, it combines the medical and pharmaceutical fields in conjunction with biomedical engineering, polymer science, materials science, and pharmacological aspects of biodegradable polymers. The text covers the synthesis, properties, and characterization of biodegradable polymers and systems and their applications in sustained drug delivery, anticancer therapy, vaccine delivery, gene delivery, surgery, wound care, cardiology, dentistry, orthopedics, medical devices, tissue engineering, and cosmeceuticals. It also details the safety aspects, market economy, challenges, and opportunities related to biodegradable polymers, providing an understanding of the commercial and translational aspects of these crucial biomaterials. Edited and authored by renowned scientists working on biodegradable polymers, biocomposites, biodegradable systems, and implants, the book is an important resource for academicians, researchers, students, professionals, and general readers interested in exploring the potential biomedical applications of biodegradable polymers.
Author : Ariella Shikanov
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783843359863
Total Pages : 144 pages
Book Rating : 4.3/5 (598 download)
Download or read book Development of Biodegradable Polymer for Treatment of Solid Tumor written by Ariella Shikanov and published by LAP Lambert Academic Publishing. This book was released on 2010-10 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the synthesis, characterization, formulation design and in vivo efficacy of novel biodegrdable polymers based on natural fatty acids. Effective drug therapy has maximum therapeutic effect in the desired site of action with minimal adverse effects. When a drug is administered systemically by intravenous, intramuscular or oral dosing, it is distributed in the body to various organs perfused with blood, and only a relatively small amount reaches its target tissue. Locally injected formulation releases the drug at a slow rate for a prolonged period of time while providing high local therapeutic concentrations in the diseased site with minimal body distribution of toxic drugs resulting in less side effects and toxicity. We have developed a biodegradable formulation that can be injected in the tumor and deliver anticancer drugs at the site of action with low systemic exposure and complete degradation in the end of action. This formulation proved to be efficient in several cancer models treated with different anticancer agents.
Author : Glen S. Kwon
Publisher : CRC Press
ISBN 13 : 9780824725327
Total Pages : 680 pages
Book Rating : 4.7/5 (253 download)
Download or read book Polymeric Drug Delivery Systems written by Glen S. Kwon and published by CRC Press. This book was released on 2005-04-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Author : Shalaby W. Shalaby
Publisher : CRC Press
ISBN 13 : 1135507791
Total Pages : 374 pages
Book Rating : 4.1/5 (355 download)
Download or read book Absorbable and Biodegradable Polymers written by Shalaby W. Shalaby and published by CRC Press. This book was released on 2003-10-27 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in biodegradable and absorbable polymers is growing rapidly in large part because of their biomedical implant and drug delivery applications. This text illustrates creative approaches to custom designing unique, fiber-forming materials for equally unique applications. It includes an example of the development and application of a new absor
Author : Susheel Kalia
Publisher : John Wiley & Sons
ISBN 13 : 1119117356
Total Pages : 448 pages
Book Rating : 4.1/5 (191 download)
Download or read book Biodegradable and Biobased Polymers for Environmental and Biomedical Applications written by Susheel Kalia and published by John Wiley & Sons. This book was released on 2016-01-29 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications. Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants, tissue engineering and scaffolds The synthesis and elaboration of cellulose microfibrils from sisal fibres for high performance engineering applications in various sectors such as the automotive and aerospace industries, or for building and construction The different classes and chemical modifications of tannins Electro-activity and applications of Jatropha latex and seed The synthesis, properties and applications of poly(lactic acid) The synthesis, processing and properties of poly(butylene succinate), its copolymers, composites and nanocomposites The different routes for preparation polymers from vegetable oil and the effects of reinforcement and nano-reinforcement on the physical properties of such biobased polymers The different types of modified drug delivery systems together with the concept of the drug delivery matrix for controlled release of drugs and for antitumor drugs The use of nanocellulose as sustainable adsorbents for the removal of water pollutants mainly heavy metal ions, organic molecules, dyes, oil and CO2 The main extraction techniques, structure, properties and different chemical modifications of lignins Proteins and nucleic acids based biopolymers The role of tamarind seed polysaccharide-based multiple-unit systems in sustained drug release
