Development Of A Tailorable And Tunable Mechanism For Cell Responsive Substrate Mediated Gene Delivery

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Development of a Tailorable and Tunable Mechanism for Cell-responsive Substrate-mediated Gene Delivery

Author : Kory M. Blocker
Publisher :
ISBN 13 : 9781267213792
Total Pages : pages
Book Rating : 4.2/5 (137 download)

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Book Synopsis Development of a Tailorable and Tunable Mechanism for Cell-responsive Substrate-mediated Gene Delivery by : Kory M. Blocker

Download or read book Development of a Tailorable and Tunable Mechanism for Cell-responsive Substrate-mediated Gene Delivery written by Kory M. Blocker and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the spatial and temporal control as well as the cell-type specificity necessary to extend gene delivery to therapeutic applications, there exists a need to create systems capable of gene transfer that are well-understood and easily manipulated. Furthermore, the creation of such materials will enable further exploration of the correlation between biochemical cues and the resulting cellular responses. In response to this as yet unmet need, a method to promote cell-responsive substrate-mediated gene delivery was developed for this dissertation. Through the use of non-viral gene delivery, flexibility of the vehicle design was incorporated into the system. Using PNA technology, pDNA was able to be specifically tethered to a self-assembled monolayer via an enzymatically-labile peptide tether. This construct was shown to promote cell-responsive delivery while retaining flexibility over the chemical and physical properties of the vehicle and substrate. By alteration of some design parameters including tether number, pDNA surface coverage, and complexation agent, temporal control over the release profile was demonstrated. Furthermore, the ability to extend the applicability of the system was detailed by transitioning to a poly-D-lysine coated substrate upon which the pDNA is immobilized. This dissertation details proof-of-principle work in the formation of a controlled release gene delivery mechanism that may be used to promote understanding of cellular responses to biochemical signaling as well as be extended to use in tissue engineering applications.

Bone Tissue Engineering

Author : Jeffrey O. Hollinger
Publisher : CRC Press
ISBN 13 : 1135501912
Total Pages : 500 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Bone Tissue Engineering by : Jeffrey O. Hollinger

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Polymeric Gels

Author : Kunal Pal
Publisher : Woodhead Publishing
ISBN 13 : 0081021801
Total Pages : 570 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Polymeric Gels by : Kunal Pal

Download or read book Polymeric Gels written by Kunal Pal and published by Woodhead Publishing. This book was released on 2018-06-15 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks Analyzes and compares experimental data Presents in-depth information on the physical properties of polymeric gels using mathematical models Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances

Miktoarm Star Polymers

Author : Ashok Kakkar
Publisher : Royal Society of Chemistry
ISBN 13 : 1788010426
Total Pages : 241 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Miktoarm Star Polymers by : Ashok Kakkar

Download or read book Miktoarm Star Polymers written by Ashok Kakkar and published by Royal Society of Chemistry. This book was released on 2017-04-13 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term ‘miktoarm polymers’ refers to asymmetric branched macromolecules, a relatively new entry to the macromolecular field. Recent advances in their synthesis and intriguing supramolecular chemistry in a desired medium has seen a fast expansion of their applications. The composition of miktoarm polymers can be tailored and even pre-defined to allow a desired combination of functions, meaning polymer chemists can have complete control of the overall architecture of these macromolecules. By carefully selecting the composition, they can create supramolecular structures with intriguing properties, particularly for applications in biology. Miktoarm Star Polymers features chapters from experts actively working in this field, and provides the reader with a unique introduction to the fundamental principles of this exciting macromolecular system. Topics covered include the design, synthesis, characterization, self-assembly and applications of miktoarm polymers. The book is an excellent overview and up to date guide to those working in research in polymer chemistry, materials science, and polymers for medical applications.

Biotextiles as Medical Implants

Author : M W King
Publisher : Elsevier
ISBN 13 : 0857095609
Total Pages : 739 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biotextiles as Medical Implants by : M W King

Download or read book Biotextiles as Medical Implants written by M W King and published by Elsevier. This book was released on 2013-10-31 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textiles play a vital role in the manufacture of various medical devices, including the replacement of diseased, injured or non-functioning organs within the body. Biotextiles as medical implants provides an invaluable single source of information on the main types of textile materials and products used for medical implants. The first part of the book focuses on polymers, fibers and textile technologies, and these chapters discuss the manufacture, sterilization, properties and types of biotextiles used for medical applications, including nanofibers, resorbable polymers and shaped biotextiles. The chapters in part two provide a comprehensive discussion of a range of different clinical applications of biotextiles, including surgical sutures, arterial prostheses, stent grafts, percutaneous heart valves and drug delivery systems.This book provides a concise review of the technologies, properties and types of biotextiles used as medical devices. In addition, it addresses the biological dimension of how to design devices for different clinical applications, providing an invaluable reference for biomedical engineers of medical textiles, quality control and risk assessment specialists, as well as managers of regulatory affairs. The subject matter will also be of interest to professionals within the healthcare system including surgeons, nurses, therapists, sourcing and purchasing agents, researchers and students in different disciplines. Provides an invaluable single source of information on the main types of textile materials and products used for medical implants Addresses the technologies used and discusses the manufacture, properties and types of biotextiles Examines applications of biotextiles as medical implants, including drug delivery systems and stent grafts and percutaneous heart valves

Bone Substitute Biomaterials

Author : K Mallick
Publisher : Woodhead Publishing
ISBN 13 : 9780857094971
Total Pages : 0 pages
Book Rating : 4.0/5 (949 download)

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Book Synopsis Bone Substitute Biomaterials by : K Mallick

Download or read book Bone Substitute Biomaterials written by K Mallick and published by Woodhead Publishing. This book was released on 2014-07-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms.

Preprosthetic and Maxillofacial Surgery

Author : J Ferri
Publisher : Elsevier
ISBN 13 : 0857092421
Total Pages : 404 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Preprosthetic and Maxillofacial Surgery by : J Ferri

Download or read book Preprosthetic and Maxillofacial Surgery written by J Ferri and published by Elsevier. This book was released on 2011-03-28 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important factors in ensuring successful osseointegration is the stability of the implant after its insertion. In order to achieve optimum conditions for implantation, it is often necessary to prepare the area and reconstruct the bone to ensure that it is the correct shape and size for the implant. Preprosthetic and maxillofacial surgery provides a thorough review of the current status and future direction of this important field. Part one reviews bone grafting for implantology and reconstructive preprosthetic surgery. Chapters in part two discuss reconstruction and rehabilitation whilst the final group of chapters analyse tissue engineering applications. Provides readers with the fundamentals of the biology and physiology of maxillofacial bone reconstruction Examines bone reconstruction in implantology and reconstructive preprosthetic surgery considering the fundamentals of bone grafting and alveolar reconstruction Explores construction in particular situations, beginning with applications of biomaterials in alveolar and maxillofacial bone reconstruction and moving on to describe implants in congenital missing teeth

Peptide-Based Materials

Author : Timothy Deming
Publisher : Springer Science & Business Media
ISBN 13 : 3642271391
Total Pages : 184 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Peptide-Based Materials by : Timothy Deming

Download or read book Peptide-Based Materials written by Timothy Deming and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

Implantable Electronic Medical Devices

Author : Dennis Fitzpatrick
Publisher : Elsevier
ISBN 13 : 012416577X
Total Pages : 194 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Implantable Electronic Medical Devices by : Dennis Fitzpatrick

Download or read book Implantable Electronic Medical Devices written by Dennis Fitzpatrick and published by Elsevier. This book was released on 2014-11-05 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantable Electronic Medical Devices provides a thorough review of the application of implantable devices, illustrating the techniques currently being used together with overviews of the latest commercially available medical devices. This book provides an overview of the design of medical devices and is a reference on existing medical devices. The book groups devices with similar functionality into distinct chapters, looking at the latest design ideas and techniques in each area, including retinal implants, glucose biosensors, cochlear implants, pacemakers, electrical stimulation therapy devices, and much more. Implantable Electronic Medical Devices equips the reader with essential background knowledge on the application of existing medical devices as well as providing an introduction to the latest techniques being used. A catalogue of existing implantable electronic medical devices Up-to-date information on the design of implantable electronic medical devices Background information and reviews on the application and design of up-to-date implantable electronic medical devices

Activity-Based Protein Profiling

Author : Benjamin F. Cravatt
Publisher : Springer
ISBN 13 : 3030111431
Total Pages : 417 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Activity-Based Protein Profiling by : Benjamin F. Cravatt

Download or read book Activity-Based Protein Profiling written by Benjamin F. Cravatt and published by Springer. This book was released on 2019-01-25 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

Detection of Non-Amplified Genomic DNA

Author : Giuseppe Spoto
Publisher : Springer Science & Business Media
ISBN 13 : 940071226X
Total Pages : 320 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Detection of Non-Amplified Genomic DNA by : Giuseppe Spoto

Download or read book Detection of Non-Amplified Genomic DNA written by Giuseppe Spoto and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field.

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Author : Lisa C. du Toit
Publisher : Elsevier
ISBN 13 : 0128184728
Total Pages : 318 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering by : Lisa C. du Toit

Download or read book Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering written by Lisa C. du Toit and published by Elsevier. This book was released on 2020-03-08 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Principles of Biomedical Engineering, Second Edition

Author : Sundararajan Madihally
Publisher : Artech House
ISBN 13 : 1630817120
Total Pages : 510 pages
Book Rating : 4.6/5 (38 download)

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Book Synopsis Principles of Biomedical Engineering, Second Edition by : Sundararajan Madihally

Download or read book Principles of Biomedical Engineering, Second Edition written by Sundararajan Madihally and published by Artech House. This book was released on 2019-12-31 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition of an Artech House classic introduces readers to the importance of engineering in medicine. Bioelectrical phenomena, principles of mass and momentum transport to the analysis of physiological systems, the importance of mechanical analysis in biological tissues/ organs and biomaterial selection are discussed in detail. Readers learn about the concepts of using living cells in various therapeutics and diagnostics, compartmental modeling, and biomedical instrumentation. The book explores fluid mechanics, strength of materials, statics and dynamics, basic thermodynamics, electrical circuits, and material science. A significant number of numerical problems have been generated using data from recent literature and are given as examples as well as exercise problems. These problems provide an opportunity for comprehensive understanding of the basic concepts, cutting edge technologies and emerging challenges. Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics. Structured as a complete text for students with some engineering background, the book also makes a valuable reference for professionals new to the bioengineering field. This authoritative textbook features numerous exercises and problems in each chapter to help ensure a solid understanding of the material.

Nanobiomaterials

Author : Roger Narayan
Publisher : Woodhead Publishing
ISBN 13 : 0081007256
Total Pages : 578 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Nanobiomaterials by : Roger Narayan

Download or read book Nanobiomaterials written by Roger Narayan and published by Woodhead Publishing. This book was released on 2017-09-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials

Intelligent Surfaces in Biotechnology

Author : H. Michelle Grandin
Publisher : John Wiley & Sons
ISBN 13 : 1118181239
Total Pages : 428 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Intelligent Surfaces in Biotechnology by : H. Michelle Grandin

Download or read book Intelligent Surfaces in Biotechnology written by H. Michelle Grandin and published by John Wiley & Sons. This book was released on 2012-02-03 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of smart and responsive surfaces in biotechnology and their applications A wave of recent advances in cell biology, biophysics, chemistry, and materials science has enabled the development of a new generation of smart biomaterials. Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications provides readers with a comprehensive overview of surface modifications and their applications, including coverage of the physico-chemical properties, characterization methods, smart coating technologies, and demonstration of performance in vitro and in vivo. The first part of the book covers applications in the fields of biosensing and biodiagnostics, while the second part focuses more on coatings for medical devices, drug delivery, and tailored cell-surface interactions. The book explores intelligent surface applications such as tissue engineering, drug targeting and delivery, wound healing and anti-infection strategies, biosensors, nanopatterning, and bioinspired design of novel responsive materials and multifunctional surfaces. Designed to aid scientists and engineers in understanding the rapidly developing field of biofunctional surfaces, Intelligent Surfaces in Biotechnology is an edited volume with each chapter written by a respected expert and featuring examples taken from the most state-of-the-art developments in the discipline. Cover Image: Design concept for a diagnostic microfluidic system based on responsive polymer- and antibody-conjugated nanobeads (see Chapter 2 of this book, Figure 2.5; reproduced by permission from the Royal Society of Chemistry).

Lab-on-Fiber Technology

Author : Andrea Cusano
Publisher : Springer
ISBN 13 : 3319069985
Total Pages : 377 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Lab-on-Fiber Technology by : Andrea Cusano

Download or read book Lab-on-Fiber Technology written by Andrea Cusano and published by Springer. This book was released on 2014-07-29 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the “lab-on-fiber” technology. Inspired by the well-established "lab on-a-chip" concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications. Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate description of the main developments and achievements in the lab-on-fiber technology roadmap, also highlighting the new perspectives and challenges to be faced. This book is essential for scientists interested in the cutting-edge fiber optic technology, but also for graduate students.

Algae

Author : Nooruddin Thajuddin
Publisher : BoD – Books on Demand
ISBN 13 : 9535124315
Total Pages : 344 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Algae by : Nooruddin Thajuddin

Download or read book Algae written by Nooruddin Thajuddin and published by BoD – Books on Demand. This book was released on 2016-06-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Algae - Organisms for Imminent Biotechnology will be useful source of information on basic and applied aspects of algae for post graduate students, researchers, scientists, agriculturists, and decision makers. The book comprises a total of 12 chapters covering various aspects of algae particularly on microalgal biotechnology, bloom dynamics, photobioreactor design and operation of microalgal mass cultivation, algae used as indicator of water quality, microalgal biosensors for ecological monitoring in aquatic environment, carbon capture and storage by microalgae to enhancing CO2 removal, synthesis and biotechnological potentials of algal nanoparticles, biofilms, silica-based nanovectors, challenges and opportunities in marine algae, and genetic identification and mass propagation of economically important seaweeds and seaweeds as source of new bioactive prototypes.