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Demystifying The Role Of The Cap Binding Complex Cbc Within The Gene Expression Network In Saccharomyces Cerevisiae
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Book Synopsis Demystifying the Role of the Cap Binding Complex (CBC) Within the Gene Expression Network in Saccharomyces Cerevisiae by : Julia McBride Claggett
Download or read book Demystifying the Role of the Cap Binding Complex (CBC) Within the Gene Expression Network in Saccharomyces Cerevisiae written by Julia McBride Claggett and published by . This book was released on 2011 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highly conserved Cap Binding Complex (CBC) is comprised of two subunits, Cbp20 and Cbp80, and binds to the 5' end of pre-mRNA as it emerges from the transcribing RNA polymerase (Pol II). Evidence suggesting a role for the CBC in multiple reactions during gene expression, including transcription, splicing, 3' end processing, and RNA export, prompted us to hypothesize that the CBC is involved in coupling these reactions, and that this coordinated regulation facilitates the ability of a cell to respond to stress. The research presented in this dissertation specifically dissects the roles of the CBC in splicing and in transcription and provides insight into a mechanism by which the CBC might contribute to the coupling of these two reactions in Saccharomyces cerevisiae. We have demonstrated that the CBC is specifically required for the splicing of two intron-containing genes with a particular non-consensus 5' splice site, SUS1 and GCR1. Through its effects on splicing, we found that the CBC contributes to the regulation of a histone modification and the acitivity of a key glycolytic transcription factor, resulting in genome-wide changes to gene expression when the CBC is deleted. We discovered that the CBC is down-regulated at multiple levels in response to nutrient stress, suggesting that the coordinated activities of the CBC are particularly important under these conditions. One of these levels of regulation appears to be proteolysis by the proteasome. Furthermore, a role for the CBC in repressing expression of Rpn4, a critical regulator of proteasome levels, suggests that the CBC is involved in a feedback loop in which its targeting to the proteasome is determined by its ability to influence gene expression. Directed mutagenesis of evolutionarily-conserved domains of Cbp80 allowed us to uncouple the functions of the CBC in gene expression revealing a role for the CBC in transcription that is independent of its ability to act in splicing. In sum, the findings presented here demystify the role of the CBC in gene expression by enhancing our understanding of the CBC's role in splicing, demonstrating novel functions for the CBC in transcription, identifying multiple mechanisms by which the CBC is regulated, and illustrating a requirement for the CBC in the cellular stress response.
Book Synopsis The Saccharomyces Cerevisiae Nuclear Cap Binding Complex Regulates RNA Synthesis and Processing Through Interactions with RNA Polymerase II by : Christina Chung (Ph. D.)
Download or read book The Saccharomyces Cerevisiae Nuclear Cap Binding Complex Regulates RNA Synthesis and Processing Through Interactions with RNA Polymerase II written by Christina Chung (Ph. D.) and published by . This book was released on 2009 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nuclear Cap Binding Complex (CBC), which consists of a large subunit CBP80 and a small subunit CBP20, is structurally conserved from yeast to mammals. The complex has been implicated in multiple steps in mRNA processing including mRNA stability, pre-mRNA splicing, and mRNA export. The research described here provides evidence that the CBC plays a novel role in transcription through interactions with the RNA polymerase II (RNAPII), particularly through the C-terminal domain of the largest subunit (CTD). These interactions appear at least partially RNA independent and occur during active transcription. Although the CBC does not possess kinase or phosphatase activity, it does appear to affect CTD phosphorylation. One effect of this CBC-CTD interaction is regulation of the Nrd1 termination complex activity in attenuation of the IMP dehydrogenase gene IMD2 and its constituent cryptic unstable transcripts (CUTs). The involvement of the CBC with the RNA from capping to export and with RNAPII places it in an ideal position to provide regulatory feedback from the nascent RNA and RNA processing factors to the transcriptional machinery.
Book Synopsis Investigating the Role of the Saccharomyces Cerevisiae Poly(A) Binding Protein in 5-cap Complex Formation in Vitro by : Jennifer Marie Blanchette
Download or read book Investigating the Role of the Saccharomyces Cerevisiae Poly(A) Binding Protein in 5-cap Complex Formation in Vitro written by Jennifer Marie Blanchette and published by . This book was released on 2000 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Contribution of Saccharomyces Cerevisiae Cap Binding Complex to Small Nuclear and Small Nucleolar RNA Processing by : Sylwia Szczepaniak
Download or read book The Contribution of Saccharomyces Cerevisiae Cap Binding Complex to Small Nuclear and Small Nucleolar RNA Processing written by Sylwia Szczepaniak and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Słowa kluczowe: sn/snoRNA RNA maturation, 5' cap, 3' processing, CBC, NNS, Rnt1.
Book Synopsis Alphaherpesviruses by : Sandra Knowles Weller
Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love
Book Synopsis Emerging Trends in International Law on Secession by : Jelena Pifat
Download or read book Emerging Trends in International Law on Secession written by Jelena Pifat and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2014-04-30 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades were the age of secession - many ethnic groups have claimed the right to secede, and their independence results in the disruption of the unity of a state which they no longer regard as their sovereign. This study identifies the emerging trends in international law on secession, then compares them with the remedial right to secede in political theories, and in the end examines the elements of remedial right to secession in the case of Kosovo. In international law, only mandated, trust and non-self-governing territories and peoples under foreign domination are entitled to external self-determination, but the emerging trends allow remedial secession in cases where a territorially concentrated sub-state group is oppressed for a long period of time. Kosovo had two grounds for remedial secession: the denial of the right to representation and human rights violations. The partition option should be considered - the recognition of an independent Kosovo by Serbia and the incorporation of the northern part of the province, mostly inhabited by Serbs, into Serbia.
Book Synopsis Charles Pettigrew, First Bishop-elect of the North Carolina Episcopal Church by : Bennett H Wall
Download or read book Charles Pettigrew, First Bishop-elect of the North Carolina Episcopal Church written by Bennett H Wall and published by Hassell Street Press. This book was released on 2021-09-10 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Book Synopsis Human Trafficking in South Asia by : Vinod K. Bhardwaj
Download or read book Human Trafficking in South Asia written by Vinod K. Bhardwaj and published by . This book was released on 2014 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
