Cooperativity Theory In Biochemistry

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Cooperativity Theory in Biochemistry

Author : T.L. Hill
Publisher : Springer Science & Business Media
ISBN 13 : 146125082X
Total Pages : 468 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Cooperativity Theory in Biochemistry by : T.L. Hill

Download or read book Cooperativity Theory in Biochemistry written by T.L. Hill and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a description of the frontiers of research where our knowledge is increasing steadily.

Cooperativity Theory in Biochemistry

Author : Terrell L. Hill
Publisher :
ISBN 13 : 9783540961031
Total Pages : 459 pages
Book Rating : 4.9/5 (61 download)

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Book Synopsis Cooperativity Theory in Biochemistry by : Terrell L. Hill

Download or read book Cooperativity Theory in Biochemistry written by Terrell L. Hill and published by . This book was released on 1985-01-01 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cooperativity and Regulation in Biochemical Processes

Author : Arieh Y. Ben-Naim
Publisher : Springer Science & Business Media
ISBN 13 : 147573302X
Total Pages : 358 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Cooperativity and Regulation in Biochemical Processes by : Arieh Y. Ben-Naim

Download or read book Cooperativity and Regulation in Biochemical Processes written by Arieh Y. Ben-Naim and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that attempts to study the origin of cooperatvity in binding systems from the molecular point of view. The molecular approach provides a deeper insight into the mechanism of cooperativity and regulation, than the traditional phenomenological approach. This book uses the tools of statistical mechanics to present the molecular theory of cooperativity. Cooperativity is used in a variety of processes-such as loading and unloading of oxygen at relatively small pressure differences; maintaining an almost constant concentration of various compounds in living cells; and switching on and off the reading of genetic information. This book may be used as a textbook by graduate students in Chemistry, Biochemistry and Biophysics, and will also be of interest to researchers in theoretical biochemistry.

Cooperative theory in biochemistry

Author : Terrell L. Hill
Publisher :
ISBN 13 :
Total Pages : 459 pages
Book Rating : 4.:/5 (246 download)

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Book Synopsis Cooperative theory in biochemistry by : Terrell L. Hill

Download or read book Cooperative theory in biochemistry written by Terrell L. Hill and published by . This book was released on 1985 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hemoglobin

Author : M. Weissbluth
Publisher : Springer Science & Business Media
ISBN 13 : 3642808018
Total Pages : 187 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Hemoglobin by : M. Weissbluth

Download or read book Hemoglobin written by M. Weissbluth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately one third of the mass of a mammalian red blood cell is hemo globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo globin is probably not unique; it may well be one instance of a general class of interactions that occur in biological molecules. Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites. But whereas we know very little of the structure of most enzymes of this type, hemo globin is one of a very small number of biological molecules whose immensely intricate machinery has been revealed to us. We owe this insight to the group under the leadership of M. F. PERUTZ in Cambridge, England, whose research over a period of several decades culminated in a detailed description of the three dimensional structure.

Cooperativity and Regulation in Biochemical Processes

Author : Arieh Ben-Naim
Publisher :
ISBN 13 : 9781475733037
Total Pages : 368 pages
Book Rating : 4.7/5 (33 download)

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Book Synopsis Cooperativity and Regulation in Biochemical Processes by : Arieh Ben-Naim

Download or read book Cooperativity and Regulation in Biochemical Processes written by Arieh Ben-Naim and published by . This book was released on 2014-01-15 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Self-Organizing Systems

Author : F.Eugene Yates
Publisher : Springer Science & Business Media
ISBN 13 : 1461308836
Total Pages : 658 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Self-Organizing Systems by : F.Eugene Yates

Download or read book Self-Organizing Systems written by F.Eugene Yates and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological systems become organized by commands from outside, as when human intentions lead to the building of structures or machines. But many nat ural systems become structured by their own internal processes: these are the self organizing systems, and the emergence of order within them is a complex phe nomenon that intrigues scientists from all disciplines. Unfortunately, complexity is ill-defined. Global explanatory constructs, such as cybernetics or general sys tems theory, which were intended to cope with complexity, produced instead a grandiosity that has now, mercifully, run its course and died. Most of us have become wary of proposals for an "integrated, systems approach" to complex matters; yet we must come to grips with complexity some how. Now is a good time to reexamine complex systems to determine whether or not various scientific specialties can discover common principles or properties in them. If they do, then a fresh, multidisciplinary attack on the difficulties would be a valid scientific task. Believing that complexity is a proper scientific issue, and that self-organizing systems are the foremost example, R. Tomovic, Z. Damjanovic, and I arranged a conference (August 26-September 1, 1979) in Dubrovnik, Yugoslavia, to address self-organizing systems. We invited 30 participants from seven countries. Included were biologists, geologists, physicists, chemists, mathematicians, bio physicists, and control engineers. Participants were asked not to bring manu scripts, but, rather, to present positions on an assigned topic. Any writing would be done after the conference, when the writers could benefit from their experi ences there.

Energetics of Biological Macromolecules, Part D

Author : Jo M. Holt
Publisher : Elsevier
ISBN 13 : 0080497179
Total Pages : 315 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part D by : Jo M. Holt

Download or read book Energetics of Biological Macromolecules, Part D written by Jo M. Holt and published by Elsevier. This book was released on 2004-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Protein Interactions

Author : Peter Schuck
Publisher : Springer Science & Business Media
ISBN 13 : 0387359664
Total Pages : 537 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Protein Interactions by : Peter Schuck

Download or read book Protein Interactions written by Peter Schuck and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.

Cooperative Equilibria in Physical Biochemistry

Author : Douglas Poland
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cooperative Equilibria in Physical Biochemistry by : Douglas Poland

Download or read book Cooperative Equilibria in Physical Biochemistry written by Douglas Poland and published by Oxford University Press, USA. This book was released on 1978 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Sliding-Filament Theory of Muscle Contraction

Author : David Aitchison Smith
Publisher : Springer
ISBN 13 : 3030035263
Total Pages : 426 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis The Sliding-Filament Theory of Muscle Contraction by : David Aitchison Smith

Download or read book The Sliding-Filament Theory of Muscle Contraction written by David Aitchison Smith and published by Springer. This book was released on 2019-02-05 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1060 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1068 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1988 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Topics in Cellular Regulation

Author : Bernard L. Horecker
Publisher : Elsevier
ISBN 13 : 1483217280
Total Pages : 365 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Current Topics in Cellular Regulation by : Bernard L. Horecker

Download or read book Current Topics in Cellular Regulation written by Bernard L. Horecker and published by Elsevier. This book was released on 2014-06-28 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Cellular Regulation: Volume 29 is a collection of papers that deals with dynamic macromolecular interactions, ligand binding, multi-enzyme complex formation, the regulation of fatty acid uptake, and synthesis in mammary or adipose tissues. Other papers explain the functional relationships of guanosine triphosphate binding proteins, the glycogen storage disease, the regulation of the pentose phosphate pathway in the brain, as well as the regulation of carotenoid biosynthesis. One paper discusses the dissociable enzyme complexes stabilized by weak interactions, particularly on the interaction of cytosolic enzymes with the contractile apparatus, with membranes, or with functionally related enzymes. Another paper investigates the mechanism of acute regulation, in mammary epithelial cells, of the processes which collaborate to supply fatty acids for esterification to form glycerolipids (which is predominantly triacylglycerol). Glycerolipids comprise mostly the total lipid content of the secretory product of those cells—mammalian milk. The paper notes that a counter-regulatory hormone collaborating with insulin in the regulation of lipid metabolism in the lactating mammary cell, does not act via cyclic AMP. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology or physiology.

Statistical Thermodynamics for Chemists and Biochemists

Author : Arieh Y. Ben-Naim
Publisher : Springer Science & Business Media
ISBN 13 : 1475715986
Total Pages : 700 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Statistical Thermodynamics for Chemists and Biochemists by : Arieh Y. Ben-Naim

Download or read book Statistical Thermodynamics for Chemists and Biochemists written by Arieh Y. Ben-Naim and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was planned and written with one central goal in mind: to demonstrate that statistical thermodynamics can be used successfully by a broad group of scientists, ranging from chemists through biochemists to biologists, who are not and do not intend to become specialists in statistical thermodynamics. The book is addressed mainly to gradu ate students and research scientists interested in designing experiments the results of which may be interpreted at the molecular level, or in interpreting such experimental results. It is not addressed to those who intend to practice statistical thermodynamics per se. With this goal in mind, I have expended a great deal of effort to make the book clear, readable, and, I hope, enjoyable. This does not necessarily mean that the book as a whole is easy to read. The first four chapters are very detailed. The last four become progressively more difficult to read, for several reasons. First, presuming that the reader has already acquired familiarity with the methods and arguments presented in the first part, I felt that similar arguments could be skipped later on, leaving the details to be filled in by the reader. Second, the systems themselves become progressively more com plicated as we proceed toward the last chapter.

Biomolecular and Bioanalytical Techniques

Author : Vasudevan Ramesh
Publisher : John Wiley & Sons
ISBN 13 : 1119483980
Total Pages : 576 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Biomolecular and Bioanalytical Techniques by : Vasudevan Ramesh

Download or read book Biomolecular and Bioanalytical Techniques written by Vasudevan Ramesh and published by John Wiley & Sons. This book was released on 2019-03-08 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to biomolecular and bioanalytical techniques and their applications Biomolecular and Bioanalytical Techniques offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications. The text explores the use of a variety of analytical tools to characterise biological samples. The contributors explain how to identify and quantify biochemically important molecules, including small molecules as well as biological macromolecules such as enzymes, antibodies, proteins, peptides and nucleic acids. This book is filled with essential knowledge and explores the skills needed to carry out the research and development roles in academic and industrial laboratories. A technique-focused book that bridges the gap between an introductory text and a book on advanced research methods Provides the necessary background and skills needed to advance the research methods Features a structured approach within each chapter Demonstrates an interdisciplinary approach that serves to develop independent thinking Written for students in chemistry, biological, medical, pharmaceutical, forensic and biophysical sciences, Biomolecular and Bioanalytical Techniques is an in-depth review of the most current biomolecular and bioanalytical techniques in the field.

Mathematical Models in Molecular Cellular Biology

Author : Lee A. Segel
Publisher : CUP Archive
ISBN 13 : 9780521229258
Total Pages : 776 pages
Book Rating : 4.2/5 (292 download)

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Book Synopsis Mathematical Models in Molecular Cellular Biology by : Lee A. Segel

Download or read book Mathematical Models in Molecular Cellular Biology written by Lee A. Segel and published by CUP Archive. This book was released on 1980 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in theoretical biology is rapidly growing and this 1981 book attempts to make the theory more accessible to experimentalists. Its primary purpose is to demonstrate to experimental molecular and cellular biologists the possible usefulness of mathematical models. Biologists with a basic command of calculus should be able to learn from the book what assumptions are implied by various types of equations, to understand in broad outline a number of major theoretical concepts, and to be aware of some of the difficulties connected with analytical and numerical solutions of mathematical problems. Thus they should be able to appreciate the significance of theoretical papers in their fields and to communicate usefully with theoreticians in the course of their work.